Aliases for NEDD1 Gene

Aliases for NEDD1 Gene

  • NEDD1 Gamma-Tubulin Ring Complex Targeting Factor 2 3 5
  • Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 1 3 4
  • Neural Precursor Cell Expressed, Developmentally Down-Regulated 1 2 3
  • Tubulin Gamma Complex Associated Protein 7 2 3
  • Protein NEDD1 3 4
  • TUBGCP7 2 3
  • GCP-WD 2 3
  • NEDD-1 3 4
  • NEDD1 5

External Ids for NEDD1 Gene

Previous GeneCards Identifiers for NEDD1 Gene

  • GC12U990062
  • GC12P097798
  • GC12P097233
  • GC12P095803
  • GC12P094363
  • GC12P097301

Summaries for NEDD1 Gene

GeneCards Summary for NEDD1 Gene

NEDD1 (NEDD1 Gamma-Tubulin Ring Complex Targeting Factor) is a Protein Coding gene. Diseases associated with NEDD1 include Seckel Syndrome 7 and Orofaciodigital Syndrome Ix. Among its related pathways are Organelle biogenesis and maintenance and Regulation of PLK1 Activity at G2/M Transition. An important paralog of this gene is WDR62.

UniProtKB/Swiss-Prot Summary for NEDD1 Gene

  • Required for mitosis progression. Promotes the nucleation of microtubules from the spindle.

Gene Wiki entry for NEDD1 Gene

Additional gene information for NEDD1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NEDD1 Gene

Genomics for NEDD1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NEDD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J096906 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 654.4 +0.3 251 2.7 CREB1 ATF7 ZNF629 KDM1A ZNF692 POLR2A RCOR2 BACH1 JUND FOXA1 NEDD1 HSALNG0093312 lnc-CDK17-12 MN297181
GH12J096892 Promoter 0.3 EPDnew 600.4 -14.8 -14767 0.1 piR-36588-105 piR-32325-044 NEDD1 piR-60146-031 CFAP54
GH12J096889 Enhancer 0.7 Ensembl ENCODE 44.2 -17.3 -17331 2.2 JUND FOS FOSL2 JUN ZNF660 ZBTB40 POLR2A NEDD1 piR-36588-105 piR-60146-031 CFAP54
GH12J096886 Enhancer 0.6 Ensembl ENCODE 44.5 -19.9 -19921 1 TEAD4 ZNF316 EMSY NEDD1 piR-36588-105 piR-60146-031 CFAP54
GH12J096809 Enhancer 1 FANTOM5 Ensembl ENCODE 21.7 -95.8 -95835 3.6 CEBPB SP1 JUND ATF3 ZNF316 JUN MAFF MAFK PKNOX1 MAFG NEDD1 lnc-CDK17-9 piR-43164-011 CFAP54
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NEDD1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NEDD1

Top Transcription factor binding sites by QIAGEN in the NEDD1 gene promoter:
  • AREB6
  • E2F
  • E2F-1
  • SRF
  • SRF (504 AA)

Genomic Locations for NEDD1 Gene

Genomic Locations for NEDD1 Gene
chr12:96,907,222-96,953,780
(GRCh38/hg38)
Size:
46,559 bases
Orientation:
Plus strand
chr12:97,301,001-97,347,469
(GRCh37/hg19)
Size:
46,469 bases
Orientation:
Plus strand

Genomic View for NEDD1 Gene

Genes around NEDD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEDD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEDD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEDD1 Gene

Proteins for NEDD1 Gene

  • Protein details for NEDD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHV4-NEDD1_HUMAN
    Recommended name:
    Protein NEDD1
    Protein Accession:
    Q8NHV4
    Secondary Accessions:
    • B0AZN0
    • B4E145
    • G3V3F1
    • Q8NA30

    Protein attributes for NEDD1 Gene

    Size:
    660 amino acids
    Molecular mass:
    71966 Da
    Quaternary structure:
    • Interacts with FAM29A (PubMed:19029337). Interacts with HSPA1A and HSPA1B. Interacts with gamma-tubulin in a HSPA1A/B-dependent manner (PubMed:27137183).
    SequenceCaution:
    • Sequence=AAH27605.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for NEDD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEDD1 Gene

Post-translational modifications for NEDD1 Gene

  • During mitosis, prior phosphorylation on Thr-550 by CDK1 promotes subsequent phosphorylation by PLK1 on Thr-382, Ser-397, Ser-426 and Ser-637. Phosphorylated NEDD1 can interact with gamma-tubulin for targeting the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NEDD1 Gene

Domains & Families for NEDD1 Gene

Gene Families for NEDD1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for NEDD1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58662, highly similar to Protein NEDD1 (B4E145_HUMAN)
  • Neural precursor cell expressed developmentally down-regulated protein 1 (NEDD1_HUMAN)
  • NEDD1 protein (Q05CT8_HUMAN)
genes like me logo Genes that share domains with NEDD1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NEDD1 Gene

Function for NEDD1 Gene

Molecular function for NEDD1 Gene

UniProtKB/Swiss-Prot Function:
Required for mitosis progression. Promotes the nucleation of microtubules from the spindle.
GENATLAS Biochemistry:
neural precursor cell expressed gene 1,71kDa,strongly expressed in embryonic brain developmentally downregulated 1,with similarities with beta subunit of GTP binding protein,transducin

Phenotypes From GWAS Catalog for NEDD1 Gene

Gene Ontology (GO) - Molecular Function for NEDD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19369198
genes like me logo Genes that share ontologies with NEDD1: view
genes like me logo Genes that share phenotypes with NEDD1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NEDD1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NEDD1 Gene

Localization for NEDD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEDD1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEDD1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 4
cytosol 4
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (3)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NEDD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material IBA 21873635
GO:0000922 spindle pole IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
genes like me logo Genes that share ontologies with NEDD1: view

Pathways & Interactions for NEDD1 Gene

genes like me logo Genes that share pathways with NEDD1: view

Gene Ontology (GO) - Biological Process for NEDD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0007049 cell cycle IEA --
GO:0010389 regulation of G2/M transition of mitotic cell cycle TAS --
GO:0051301 cell division IEA --
GO:0071539 protein localization to centrosome IBA 21873635
genes like me logo Genes that share ontologies with NEDD1: view

No data available for SIGNOR curated interactions for NEDD1 Gene

Drugs & Compounds for NEDD1 Gene

No Compound Related Data Available

Transcripts for NEDD1 Gene

mRNA/cDNA for NEDD1 Gene

4 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NEDD1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEDD1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a ·
SP1: - - - -
SP2: - -
SP3: -
SP4:
SP5: - - - -
SP6: - -
SP7: - - - - -
SP8: - - - - - - -

ExUns: 16b · 16c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for NEDD1 Gene

GeneLoc Exon Structure for
NEDD1

Expression for NEDD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NEDD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NEDD1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.3), Plasma (12.6), Fetal heart (8.2), and CD8 Tcells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NEDD1 Gene



Protein tissue co-expression partners for NEDD1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NEDD1

SOURCE GeneReport for Unigene cluster for NEDD1 Gene:

Hs.270084

Evidence on tissue expression from TISSUES for NEDD1 Gene

  • Blood(4.3)
  • Skin(2.6)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with NEDD1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEDD1 Gene

Orthologs for NEDD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEDD1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NEDD1 30 31
  • 99.34 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NEDD1 30 31
  • 91.49 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NEDD1 30 31
  • 91.15 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Nedd1 30 17 31
  • 85.2 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nedd1 30
  • 84.17 (n)
Oppossum
(Monodelphis domestica)
Mammalia NEDD1 31
  • 74 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia NEDD1 31
  • 72 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NEDD1 30 31
  • 69.93 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NEDD1 31
  • 61 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nedd1 30
  • 66.11 (n)
Str.17693 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.24393 30
Zebrafish
(Danio rerio)
Actinopterygii nedd1 30 31
  • 56.16 (n)
OneToOne
wufb78g03 30
Fruit Fly
(Drosophila melanogaster)
Insecta Grip71 31
  • 15 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 35 (a)
OneToOne
Species where no ortholog for NEDD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NEDD1 Gene

ENSEMBL:
Gene Tree for NEDD1 (if available)
TreeFam:
Gene Tree for NEDD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NEDD1: view image

Paralogs for NEDD1 Gene

Variants for NEDD1 Gene

Additional dbSNP identifiers (rs#s) for NEDD1 Gene

Structural Variations from Database of Genomic Variants (DGV) for NEDD1 Gene

Variant ID Type Subtype PubMed ID
esv2136665 CNV deletion 18987734
esv2507346 CNV insertion 19546169
esv7477 CNV gain 19470904
nsv7234 OTHER inversion 18451855

Variation tolerance for NEDD1 Gene

Residual Variation Intolerance Score: 20.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NEDD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEDD1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NEDD1 Gene

Disorders for NEDD1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for NEDD1 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search NEDD1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NEDD1

genes like me logo Genes that share disorders with NEDD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEDD1 Gene

Publications for NEDD1 Gene

  1. HSP70 regulates the function of mitotic centrosomes. (PMID: 27137183) Fang CT … Yih LH (Cellular and molecular life sciences : CMLS 2016) 3 4
  2. Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome. (PMID: 19509060) Zhang X … Zhang C (Journal of cell science 2009) 3 4
  3. FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle. (PMID: 19029337) Zhu H … Fang G (The Journal of cell biology 2008) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for NEDD1 Gene

Sources for NEDD1 Gene