Aliases for NEDD1 Gene

Aliases for NEDD1 Gene

  • NEDD1 Gamma-Tubulin Ring Complex Targeting Factor 2 3
  • Neural Precursor Cell Expressed, Developmentally Down-Regulated 1 2 3 5
  • Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 1 3 4
  • Tubulin Gamma Complex Associated Protein 7 2 3
  • Protein NEDD1 3 4
  • NEDD-1 3 4
  • TUBGCP7 3
  • GCP-WD 3

External Ids for NEDD1 Gene

Previous GeneCards Identifiers for NEDD1 Gene

  • GC12U990062
  • GC12P097798
  • GC12P097233
  • GC12P095803
  • GC12P094363
  • GC12P097301

Summaries for NEDD1 Gene

GeneCards Summary for NEDD1 Gene

NEDD1 (NEDD1 Gamma-Tubulin Ring Complex Targeting Factor) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Regulation of PLK1 Activity at G2/M Transition. An important paralog of this gene is COP1.

UniProtKB/Swiss-Prot Summary for NEDD1 Gene

  • Required for mitosis progression. Promotes the nucleation of microtubules from the spindle.

Gene Wiki entry for NEDD1 Gene

Additional gene information for NEDD1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NEDD1 Gene

Genomics for NEDD1 Gene

GeneHancer (GH) Regulatory Elements for NEDD1 Gene

Promoters and enhancers for NEDD1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J096906 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 812.8 +0.3 250 2.7 SIN3A ZNF24 ZBTB40 RBPJ POLR2A NR2F1 ATF1 CREB1 ZNF133 MYC NEDD1 HSALNG0093312 lnc-CDK17-12 ELK3 ENSG00000257878 LTA4H HSALNG0093318
GH12J096892 Promoter 0.3 EPDnew 750.4 -14.8 -14768 0.1 piR-36588-105 piR-32325-044 NEDD1 piR-60146-031
GH12J096486 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 23.6 -418.6 -418584 3.6 SIN3A ZNF24 ZBTB40 CTCF RBPJ POLR2A CTBP1 HCFC1 MYC MAX CFAP54 NEDD1 ENSG00000257878 LTA4H CDK17 SNRPF ELK3 ENSG00000258272
GH12J096033 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 21 -873.3 -873271 5.5 GTF3C2 ZNF785 ZNF24 ZBTB40 SIX5 ZBTB6 RBPJ SMARCE1 POLR2A ATF1 LTA4H NONHSAG011990.2 NR2C1 HAL ENSG00000257878 NEDD1 METAP2 ENSG00000258272 ENSG00000258313 ENSG00000202368
GH12J096889 Enhancer 0.7 Ensembl ENCODE 44.2 -17.3 -17332 2.2 ZBTB40 POLR2A FOS FOSL2 JUN JUND NEDD1 piR-36588-105 piR-60146-031
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NEDD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NEDD1 gene promoter:
  • AREB6
  • E2F
  • E2F-1
  • SRF
  • SRF (504 AA)

Genomic Locations for NEDD1 Gene

Genomic Locations for NEDD1 Gene
46,555 bases
Plus strand
46,469 bases
Plus strand

Genomic View for NEDD1 Gene

Genes around NEDD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEDD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEDD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEDD1 Gene

Proteins for NEDD1 Gene

  • Protein details for NEDD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein NEDD1
    Protein Accession:
    Secondary Accessions:
    • B0AZN0
    • B4E145
    • G3V3F1
    • Q8NA30

    Protein attributes for NEDD1 Gene

    660 amino acids
    Molecular mass:
    71966 Da
    Quaternary structure:
    • Interacts with FAM29A (PubMed:19029337). Interacts with HSPA1A and HSPA1B. Interacts with gamma-tubulin in a HSPA1A/B-dependent manner (PubMed:27137183).
    • Sequence=AAH27605.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for NEDD1 Gene


neXtProt entry for NEDD1 Gene

Post-translational modifications for NEDD1 Gene

  • During mitosis, prior phosphorylation on Thr-550 by CDK1 promotes subsequent phosphorylation by PLK1 on Thr-382, Ser-397, Ser-426 and Ser-637. Phosphorylated NEDD1 can interact with gamma-tubulin for targeting the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NEDD1 Gene

Domains & Families for NEDD1 Gene

Gene Families for NEDD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for NEDD1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58662, highly similar to Protein NEDD1 (B4E145_HUMAN)
  • Neural precursor cell expressed developmentally down-regulated protein 1 (NEDD1_HUMAN)
  • NEDD1 protein (Q05CT8_HUMAN)
genes like me logo Genes that share domains with NEDD1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NEDD1 Gene

Function for NEDD1 Gene

Molecular function for NEDD1 Gene

UniProtKB/Swiss-Prot Function:
Required for mitosis progression. Promotes the nucleation of microtubules from the spindle.
GENATLAS Biochemistry:
neural precursor cell expressed gene 1,71kDa,strongly expressed in embryonic brain developmentally downregulated 1,with similarities with beta subunit of GTP binding protein,transducin

Phenotypes From GWAS Catalog for NEDD1 Gene

Gene Ontology (GO) - Molecular Function for NEDD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19369198
genes like me logo Genes that share ontologies with NEDD1: view
genes like me logo Genes that share phenotypes with NEDD1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NEDD1 Gene

Localization for NEDD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEDD1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEDD1 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 2
plasma membrane 1
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for NEDD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material IBA 21873635
GO:0000922 spindle pole IBA 21873635
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005814 centriole IBA 21873635
genes like me logo Genes that share ontologies with NEDD1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NEDD1 Gene

Pathways & Interactions for NEDD1 Gene

genes like me logo Genes that share pathways with NEDD1: view

Gene Ontology (GO) - Biological Process for NEDD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0007049 cell cycle IEA --
GO:0010389 regulation of G2/M transition of mitotic cell cycle TAS --
GO:0051301 cell division IEA --
GO:0071539 protein localization to centrosome IBA 21873635
genes like me logo Genes that share ontologies with NEDD1: view

No data available for SIGNOR curated interactions for NEDD1 Gene

Drugs & Compounds for NEDD1 Gene

No Compound Related Data Available

Transcripts for NEDD1 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEDD1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a ·
SP1: - - - -
SP2: - -
SP3: -
SP5: - - - -
SP6: - -
SP7: - - - - -
SP8: - - - - - - -

ExUns: 16b · 16c

Relevant External Links for NEDD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NEDD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NEDD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NEDD1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.3), Plasma (12.6), Fetal heart (8.2), and CD8 Tcells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NEDD1 Gene

Protein tissue co-expression partners for NEDD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NEDD1 Gene:


SOURCE GeneReport for Unigene cluster for NEDD1 Gene:

genes like me logo Genes that share expression patterns with NEDD1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEDD1 Gene

Orthologs for NEDD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEDD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NEDD1 33 32
  • 99.34 (n)
(Canis familiaris)
Mammalia NEDD1 33 32
  • 91.49 (n)
(Bos Taurus)
Mammalia NEDD1 33 32
  • 91.15 (n)
(Mus musculus)
Mammalia Nedd1 17 33 32
  • 85.2 (n)
(Rattus norvegicus)
Mammalia Nedd1 32
  • 84.17 (n)
(Monodelphis domestica)
Mammalia NEDD1 33
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia NEDD1 33
  • 72 (a)
(Gallus gallus)
Aves NEDD1 33 32
  • 69.93 (n)
(Anolis carolinensis)
Reptilia NEDD1 33
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nedd1 32
  • 66.11 (n)
Str.17693 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.24393 32
(Danio rerio)
Actinopterygii nedd1 33 32
  • 56.16 (n)
wufb78g03 32
fruit fly
(Drosophila melanogaster)
Insecta Grip71 33
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 35 (a)
Species where no ortholog for NEDD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEDD1 Gene

Gene Tree for NEDD1 (if available)
Gene Tree for NEDD1 (if available)
Evolutionary constrained regions (ECRs) for NEDD1: view image

Paralogs for NEDD1 Gene

Variants for NEDD1 Gene

Sequence variations from dbSNP and Humsavar for NEDD1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000028426 -- 96,932,607(+) A/C intron_variant
rs1000088472 -- 96,932,019(+) A/T intron_variant
rs1000120968 -- 96,924,618(+) A/T intron_variant
rs1000166492 -- 96,915,543(+) A/G intron_variant
rs1000220189 -- 96,932,862(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NEDD1 Gene

Variant ID Type Subtype PubMed ID
esv2136665 CNV deletion 18987734
esv2507346 CNV insertion 19546169
esv7477 CNV gain 19470904
nsv7234 OTHER inversion 18451855

Variation tolerance for NEDD1 Gene

Residual Variation Intolerance Score: 20.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NEDD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEDD1 Gene

Disorders for NEDD1 Gene

Additional Disease Information for NEDD1

No disorders were found for NEDD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEDD1 Gene

Publications for NEDD1 Gene

  1. HSP70 regulates the function of mitotic centrosomes. (PMID: 27137183) Fang CT … Yih LH (Cellular and molecular life sciences : CMLS 2016) 3 4 56
  2. Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome. (PMID: 19509060) Zhang X … Zhang C (Journal of cell science 2009) 3 4 56
  3. FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle. (PMID: 19029337) Zhu H … Fang G (The Journal of cell biology 2008) 3 4 56
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56

Products for NEDD1 Gene

Sources for NEDD1 Gene