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Aliases for NEDD1 Gene

Aliases for NEDD1 Gene

  • Neural Precursor Cell Expressed, Developmentally Down-Regulated 1 2 3 5
  • Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 1 3 4
  • NEDD-1 3 4
  • Protein NEDD1 3
  • TUBGCP7 3
  • GCP-WD 3

External Ids for NEDD1 Gene

Previous GeneCards Identifiers for NEDD1 Gene

  • GC12U990062
  • GC12P097798
  • GC12P097233
  • GC12P095803
  • GC12P094363
  • GC12P097301

Summaries for NEDD1 Gene

GeneCards Summary for NEDD1 Gene

NEDD1 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 1) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Regulation of PLK1 Activity at G2/M Transition.

UniProtKB/Swiss-Prot for NEDD1 Gene

  • Required for mitosis progression. Promotes the nucleation of microtubules from the spindle.

Gene Wiki entry for NEDD1 Gene

Additional gene information for NEDD1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEDD1 Gene

Genomics for NEDD1 Gene

GeneHancer (GH) Regulatory Elements for NEDD1 Gene

Promoters and enhancers for NEDD1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I096906 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 604.5 +0.2 233 2.6 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B NEDD1 GC12M096855
GH12I096889 Enhancer 0.7 Ensembl ENCODE 44.2 -17.2 -17202 1.9 JUND POLR2A JUN FOSL2 FOS ZBTB40 NEDD1 EEF1A1P33 GC12M096855 GC12P096819
GH12I096911 Enhancer 0.4 Ensembl 57.6 +4.3 4278 0.2 ZNF664 SCRT2 NEDD1 GC12M096855 GC12M096980 ENSG00000202368
GH12I096809 Enhancer 0.9 FANTOM5 ENCODE 21.7 -96.4 -96411 2.1 PKNOX1 JUN HLF BACH1 MAFG CEBPB SP1 MAFF JUND ZNF316 NEDD1 GC12P096819 GC12P096683 GC12P096684 CFAP54
GH12I096980 Enhancer 0.7 Ensembl ENCODE 26.8 +73.8 73830 1.4 MXI1 RFX1 JUN FOS BMI1 ENSG00000202368 GC12M096980 NEDD1 LOC105369928
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NEDD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NEDD1 gene promoter:

Genomic Locations for NEDD1 Gene

Genomic Locations for NEDD1 Gene
46,555 bases
Plus strand

Genomic View for NEDD1 Gene

Genes around NEDD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEDD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEDD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEDD1 Gene

Proteins for NEDD1 Gene

  • Protein details for NEDD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein NEDD1
    Protein Accession:
    Secondary Accessions:
    • B0AZN0
    • B4E145
    • G3V3F1
    • Q8NA30

    Protein attributes for NEDD1 Gene

    660 amino acids
    Molecular mass:
    71966 Da
    Quaternary structure:
    • Interacts with FAM29A (PubMed:19029337). Interacts with HSPA1A and HSPA1B. Interacts with gamma-tubulin in a HSPA1A/B-dependent manner (PubMed:27137183).
    • Sequence=AAH27605.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for NEDD1 Gene


neXtProt entry for NEDD1 Gene

Post-translational modifications for NEDD1 Gene

  • During mitosis, prior phosphorylation on Thr-550 by CDK1 promotes subsequent phosphorylation by PLK1 on Thr-382, Ser-397, Ser-426 and Ser-637. Phosphorylated NEDD1 can interact with gamma-tubulin for targeting the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation.

No data available for DME Specific Peptides for NEDD1 Gene

Domains & Families for NEDD1 Gene

Gene Families for NEDD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NEDD1: view

No data available for UniProtKB/Swiss-Prot for NEDD1 Gene

Function for NEDD1 Gene

Molecular function for NEDD1 Gene

GENATLAS Biochemistry:
neural precursor cell expressed gene 1,71kDa,strongly expressed in embryonic brain developmentally downregulated 1,with similarities with beta subunit of GTP binding protein,transducin
UniProtKB/Swiss-Prot Function:
Required for mitosis progression. Promotes the nucleation of microtubules from the spindle.

Phenotypes From GWAS Catalog for NEDD1 Gene

Gene Ontology (GO) - Molecular Function for NEDD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19369198
genes like me logo Genes that share ontologies with NEDD1: view
genes like me logo Genes that share phenotypes with NEDD1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NEDD1 Gene

Localization for NEDD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEDD1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEDD1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3
plasma membrane 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NEDD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material IBA --
GO:0000922 spindle pole IBA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005814 centriole IBA --
genes like me logo Genes that share ontologies with NEDD1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NEDD1 Gene

Pathways & Interactions for NEDD1 Gene

genes like me logo Genes that share pathways with NEDD1: view

Gene Ontology (GO) - Biological Process for NEDD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0007049 cell cycle IEA --
GO:0010389 regulation of G2/M transition of mitotic cell cycle TAS --
GO:0051301 cell division IEA --
GO:0071539 protein localization to centrosome IBA --
genes like me logo Genes that share ontologies with NEDD1: view

No data available for SIGNOR curated interactions for NEDD1 Gene

Drugs & Compounds for NEDD1 Gene

No Compound Related Data Available

Transcripts for NEDD1 Gene

Unigene Clusters for NEDD1 Gene

Neural precursor cell expressed, developmentally down-regulated 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEDD1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a ·
SP1: - - - -
SP2: - -
SP3: -
SP5: - - - -
SP6: - -
SP7: - - - - -
SP8: - - - - - - -

ExUns: 16b · 16c

Relevant External Links for NEDD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NEDD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NEDD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NEDD1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.3), Plasma (12.6), Fetal heart (8.2), and CD8 Tcells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NEDD1 Gene

Protein tissue co-expression partners for NEDD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NEDD1 Gene:


SOURCE GeneReport for Unigene cluster for NEDD1 Gene:

genes like me logo Genes that share expression patterns with NEDD1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEDD1 Gene

Orthologs for NEDD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEDD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NEDD1 33 34
  • 99.34 (n)
(Canis familiaris)
Mammalia NEDD1 33 34
  • 91.49 (n)
(Bos Taurus)
Mammalia NEDD1 33 34
  • 91.15 (n)
(Mus musculus)
Mammalia Nedd1 33 16 34
  • 85.2 (n)
(Rattus norvegicus)
Mammalia Nedd1 33
  • 84.17 (n)
(Monodelphis domestica)
Mammalia NEDD1 34
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia NEDD1 34
  • 72 (a)
(Gallus gallus)
Aves NEDD1 33 34
  • 69.93 (n)
(Anolis carolinensis)
Reptilia NEDD1 34
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nedd1 33
  • 66.11 (n)
Str.17693 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24393 33
(Danio rerio)
Actinopterygii nedd1 33 34
  • 56.16 (n)
wufb78g03 33
fruit fly
(Drosophila melanogaster)
Insecta Grip71 34
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
Species where no ortholog for NEDD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEDD1 Gene

Gene Tree for NEDD1 (if available)
Gene Tree for NEDD1 (if available)

Paralogs for NEDD1 Gene

No data available for Paralogs for NEDD1 Gene

Variants for NEDD1 Gene

Sequence variations from dbSNP and Humsavar for NEDD1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000028426 -- 96,932,607(+) A/C intron_variant
rs1000088472 -- 96,932,019(+) A/T intron_variant
rs1000120968 -- 96,924,618(+) A/T intron_variant
rs1000166492 -- 96,915,543(+) A/G intron_variant
rs1000220189 -- 96,932,862(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NEDD1 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER inversion 18451855
esv7477 CNV gain 19470904
esv2507346 CNV insertion 19546169
esv2136665 CNV deletion 18987734

Variation tolerance for NEDD1 Gene

Residual Variation Intolerance Score: 20.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NEDD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEDD1 Gene

Disorders for NEDD1 Gene

Additional Disease Information for NEDD1

No disorders were found for NEDD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEDD1 Gene

Publications for NEDD1 Gene

  1. HSP70 regulates the function of mitotic centrosomes. (PMID: 27137183) Fang CT … Yih LH (Cellular and molecular life sciences : CMLS 2016) 3 4 58
  2. Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome. (PMID: 19509060) Zhang X … Zhang C (Journal of cell science 2009) 3 4 58
  3. FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle. (PMID: 19029337) Zhu H … Fang G (The Journal of cell biology 2008) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for NEDD1 Gene

Sources for NEDD1 Gene

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