This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the c... See more...

Aliases for NECTIN3 Gene

Aliases for NECTIN3 Gene

  • Nectin Cell Adhesion Molecule 3 2 3 4 5
  • Poliovirus Receptor-Related Protein 3 3 4
  • Poliovirus Receptor-Related 3 2 3
  • Nectin-3 3 4
  • PVRL3 3 4
  • PRR3 3 4
  • CD113 Antigen 4
  • NECTIN-3 3
  • Nectin 3 3
  • CDW113 3
  • CDw113 4
  • CD113 3
  • PVRR3 3
  • PPR3 3

External Ids for NECTIN3 Gene

Previous HGNC Symbols for NECTIN3 Gene

  • PVRL3

Summaries for NECTIN3 Gene

Entrez Gene Summary for NECTIN3 Gene

  • This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for NECTIN3 Gene

NECTIN3 (Nectin Cell Adhesion Molecule 3) is a Protein Coding gene. Diseases associated with NECTIN3 include Cleft Lip/Palate-Ectodermal Dysplasia Syndrome. Among its related pathways are Cell adhesion molecules (CAMs) and T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. An important paralog of this gene is NECTIN1.

UniProtKB/Swiss-Prot Summary for NECTIN3 Gene

  • Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.

Gene Wiki entry for NECTIN3 Gene

Additional gene information for NECTIN3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NECTIN3 Gene

Genomics for NECTIN3 Gene

GeneHancer (GH) Regulatory Elements for NECTIN3 Gene

Promoters and enhancers for NECTIN3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J111069 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +2.2 2207 5 FOXK2 EP300 NRF1 TCF12 POLR2G JUND POLR2A ZBTB26 SAP30 ZBTB7A NONHSAG035714.2 NECTIN3 NECTIN3-AS1 RF01045-101
GH03J110520 Enhancer 1 Ensembl ENCODE 20.1 -548.7 -548719 2.5 JUND FOS MYC TAF9B HDAC3 NCOR1 ZNF316 NFIC FOSL1 MYNN NECTIN3 ENSG00000240895 piR-38352-392
GH03J110526 Enhancer 0.9 Ensembl ENCODE 20.1 -542.2 -542239 3.3 JUND FOS JUN NFRKB HDAC3 NCOR1 NFIC FOSL1 FOSL2 ATF3 ENSG00000240895 NECTIN3 RNU6ATAC15P piR-38352-392
GH03J110575 Enhancer 0.9 Ensembl ENCODE 19 -491.9 -491915 5.3 TCF12 JUND FOS CTCF HDAC2 ESRRA FOSL2 YY1 NANOG CEBPB NECTIN3 piR-56133-147 piR-36588-289
GH03J111045 Enhancer 1 Ensembl ENCODE dbSUPER 11.6 -22.5 -22475 4.4 TCF7 FOXA2 HDAC2 FOS FOXP1 ZGPAT JUN RXRA MAX HMG20A NECTIN3 NECTIN3-AS1 piR-59961 LOC151760
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NECTIN3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NECTIN3

Genomic Locations for NECTIN3 Gene

Genomic Locations for NECTIN3 Gene
chr3:111,070,071-111,275,563
(GRCh38/hg38)
Size:
205,493 bases
Orientation:
Plus strand
chr3:110,788,918-110,994,410
(GRCh37/hg19)
Size:
205,493 bases
Orientation:
Plus strand

Genomic View for NECTIN3 Gene

Genes around NECTIN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NECTIN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NECTIN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NECTIN3 Gene

Proteins for NECTIN3 Gene

  • Protein details for NECTIN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQS3-NECT3_HUMAN
    Recommended name:
    Nectin-3
    Protein Accession:
    Q9NQS3
    Secondary Accessions:
    • E9PFR0
    • Q6NVZ3
    • Q8NC05
    • Q8WVU4
    • Q9BVA9
    • Q9Y412

    Protein attributes for NECTIN3 Gene

    Size:
    549 amino acids
    Molecular mass:
    61002 Da
    Quaternary structure:
    • Cis- and trans-homodimer. Can form trans-heterodimers with NECTIN1, NECTIN2, PVR, IGSF4B/Necl-1 and with IGSF4. Interaction between NECTIN1 and NECTIN3 on the pre- and postsynaptic sites, respectively, initiates the formation of puncta adherentia junctions between axons and dendrites. Interacts (via Cytoplasmic domain) with AFDN, providing a connection with the actin cytoskeleton. Binds with low affinity to TIGIT.
    SequenceCaution:

    Three dimensional structures from OCA and Proteopedia for NECTIN3 Gene

    Alternative splice isoforms for NECTIN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NECTIN3 Gene

Post-translational modifications for NECTIN3 Gene

  • Glycosylation at Asn73, Asn83, Asn125, Asn186, Asn222, and Asn331
  • Modification sites at PhosphoSitePlus

Protein Products

Assay Products

  • Boster Bio ELISA Kits for NECTIN3
  • Signalway ELISA kits for NECTIN3

No data available for DME Specific Peptides for NECTIN3 Gene

Domains & Families for NECTIN3 Gene

Gene Families for NECTIN3 Gene

Protein Domains for NECTIN3 Gene

Blocks:
  • Immunoglobulin subtype
  • Immunoglobulin V-set
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NECTIN3 Gene

GenScript: Design optimal peptide antigens:
  • Nectin-3 (PVRL3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NQS3

UniProtKB/Swiss-Prot:

NECT3_HUMAN :
  • Belongs to the nectin family.
Family:
  • Belongs to the nectin family.
genes like me logo Genes that share domains with NECTIN3: view

Function for NECTIN3 Gene

Molecular function for NECTIN3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.

Phenotypes From GWAS Catalog for NECTIN3 Gene

Gene Ontology (GO) - Molecular Function for NECTIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19011627
GO:0038023 signaling receptor activity IBA 21873635
GO:0042803 protein homodimerization activity ISS,IEA --
GO:0050839 cell adhesion molecule binding IPI,IEA 12438620
genes like me logo Genes that share ontologies with NECTIN3: view
genes like me logo Genes that share phenotypes with NECTIN3: view

Animal Models for NECTIN3 Gene

MGI Knock Outs for NECTIN3:

Animal Model Products

  • Taconic Biosciences Mouse Models for NECTIN3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NECTIN3 Gene

Localization for NECTIN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NECTIN3 Gene

Cell membrane; Single-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NECTIN3 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 3
extracellular 2
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centriolar satellite (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NECTIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,ISS --
GO:0005911 cell-cell junction ISS,IEA --
GO:0005913 cell-cell adherens junction IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NECTIN3: view

Pathways & Interactions for NECTIN3 Gene

genes like me logo Genes that share pathways with NECTIN3: view

Pathways by source for NECTIN3 Gene

1 R&D Systems pathway for NECTIN3 Gene
3 Qiagen pathways for NECTIN3 Gene
  • Epithelial Adherens Junctions
  • Germ Cell-Sertoli Cell Junction Dynamics
  • Sertoli-Sertoli Cell Junction Dynamics

Gene Ontology (GO) - Biological Process for NECTIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002089 lens morphogenesis in camera-type eye IEA --
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISS --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA 21873635
GO:0007286 spermatid development IEA --
genes like me logo Genes that share ontologies with NECTIN3: view

No data available for SIGNOR curated interactions for NECTIN3 Gene

Drugs & Compounds for NECTIN3 Gene

No Compound Related Data Available

Transcripts for NECTIN3 Gene

mRNA/cDNA for NECTIN3 Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NECTIN3 Gene

No ASD Table

Relevant External Links for NECTIN3 Gene

GeneLoc Exon Structure for
NECTIN3

Expression for NECTIN3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NECTIN3

mRNA Expression by UniProt/SwissProt for NECTIN3 Gene:

Q9NQS3-NECT3_HUMAN
Tissue specificity: Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.

Evidence on tissue expression from TISSUES for NECTIN3 Gene

  • Nervous system(4.5)
  • Kidney(4.3)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NECTIN3 Gene

Orthologs for NECTIN3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NECTIN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PVRL3 31
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PVRL3 31 30
  • 93.84 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PVRL3 31 30
  • 92.25 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Pvrl3 31 30
  • 87.78 (n)
OneToOne
Nectin3 17
rat
(Rattus norvegicus)
Mammalia Pvrl3 30
  • 87.18 (n)
oppossum
(Monodelphis domestica)
Mammalia PVRL3 31
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PVRL3 31
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves PVRL3 31 30
  • 73.54 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PVRL3 31
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12547 30
zebrafish
(Danio rerio)
Actinopterygii pvrl3b 31
  • 38 (a)
OneToMany
PVRL3 (2 of 2) 31
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 18 (a)
OneToMany
Species where no ortholog for NECTIN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NECTIN3 Gene

ENSEMBL:
Gene Tree for NECTIN3 (if available)
TreeFam:
Gene Tree for NECTIN3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NECTIN3: view image

Paralogs for NECTIN3 Gene

genes like me logo Genes that share paralogs with NECTIN3: view

Variants for NECTIN3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NECTIN3 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs79006549 Likely Pathogenic: Congenital cataract 111,122,207(+) A/C MISSENSE_VARIANT
rs15611 - p.Arg432Leu

Additional dbSNP identifiers (rs#s) for NECTIN3 Gene

Structural Variations from Database of Genomic Variants (DGV) for NECTIN3 Gene

Variant ID Type Subtype PubMed ID
esv2658467 CNV deletion 23128226
esv2676144 CNV deletion 23128226
esv2725772 CNV deletion 23290073
esv3306847 CNV mobile element insertion 20981092
esv3387578 CNV insertion 20981092
esv3562375 CNV deletion 23714750
esv3597384 CNV loss 21293372
esv3597385 CNV gain 21293372
esv3597387 CNV loss 21293372
nsv1008308 CNV loss 25217958
nsv1073670 CNV deletion 25765185
nsv1117017 CNV deletion 24896259
nsv460821 CNV gain 19166990
nsv591275 CNV gain 21841781
nsv591276 CNV loss 21841781
nsv829675 CNV gain 17160897
nsv963553 CNV deletion 23825009

Variation tolerance for NECTIN3 Gene

Residual Variation Intolerance Score: 23.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NECTIN3 Gene

Human Gene Mutation Database (HGMD)
NECTIN3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NECTIN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NECTIN3 Gene

Disorders for NECTIN3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NECTIN3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cleft lip/palate-ectodermal dysplasia syndrome
  • clped1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NECTIN3

genes like me logo Genes that share disorders with NECTIN3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NECTIN3 Gene

Publications for NECTIN3 Gene

  1. Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin. (PMID: 11024295) Reymond N … Lopez M (Gene 2000) 2 3 4 54
  2. The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. (PMID: 19011627) Yu X … Grogan JL (Nature immunology 2009) 3 4 54
  3. Inhibition of cell movement and proliferation by cell-cell contact-induced interaction of Necl-5 with nectin-3. (PMID: 16216929) Fujito T … Takai Y (The Journal of cell biology 2005) 3 4 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54

Products for NECTIN3 Gene

  • Boster Bio Antibodies for NECTIN3
  • Boster Bio ELISA Kits for NECTIN3

Sources for NECTIN3 Gene