Aliases for NECTIN3 Gene
External Ids for NECTIN3 Gene
Previous HGNC Symbols for NECTIN3 Gene
This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
GeneCards Summary for NECTIN3 Gene
NECTIN3 (Nectin Cell Adhesion Molecule 3) is a Protein Coding gene. Diseases associated with NECTIN3 include Cleft Lip/Palate-Ectodermal Dysplasia Syndrome and Clostridium Difficile Colitis. Among its related pathways are Adherens junction and Cell junction organization. An important paralog of this gene is NECTIN1.
UniProtKB/Swiss-Prot Summary for NECTIN3 Gene
Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.