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Aliases for NECTIN3 Gene

Aliases for NECTIN3 Gene

  • Nectin Cell Adhesion Molecule 3 2 3 4 5
  • Poliovirus Receptor-Related Protein 3 3 4
  • Poliovirus Receptor-Related 3 2 3
  • PVRL3 3 4
  • PRR3 3 4
  • CD113 Antigen 4
  • NECTIN-3 3
  • Nectin 3 3
  • Nectin-3 3
  • CDW113 3
  • CDw113 4
  • CD113 3
  • PVRR3 3
  • PPR3 3

External Ids for NECTIN3 Gene

Previous HGNC Symbols for NECTIN3 Gene

  • PVRL3

Summaries for NECTIN3 Gene

Entrez Gene Summary for NECTIN3 Gene

  • This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for NECTIN3 Gene

NECTIN3 (Nectin Cell Adhesion Molecule 3) is a Protein Coding gene. Diseases associated with NECTIN3 include Megaesophagus. Among its related pathways are Nectin adhesion pathway and Adherens junction. An important paralog of this gene is NECTIN1.

UniProtKB/Swiss-Prot for NECTIN3 Gene

  • Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.

Gene Wiki entry for NECTIN3 Gene

Additional gene information for NECTIN3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NECTIN3 Gene

Genomics for NECTIN3 Gene

GeneHancer (GH) Regulatory Elements for NECTIN3 Gene

Promoters and enhancers for NECTIN3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J111069 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 650.7 +2.1 2102 4.5 ARID4B SIN3A ZNF48 YY1 GLIS2 ATF7 SP3 RXRA REST KAT8 NECTIN3 NECTIN3-AS1 GC03M111070
GH03J110526 Enhancer 1 Ensembl ENCODE 20.1 -542.2 -542237 3.3 ARNT NFRKB CHAMP1 TCF12 FOS CEBPB ZNF592 NFIC SMARCA4 GMEB1 ENSG00000240895 NECTIN3 RNU6ATAC15P LOC105374036
GH03J110520 Enhancer 0.9 ENCODE 20.1 -548.7 -548719 2.5 HDAC1 ATF1 TAF9B CHAMP1 TCF12 CBX5 GATA2 ARID2 SIRT6 FOS NECTIN3 ENSG00000240895 LOC105374036
GH03J110575 Enhancer 0.9 Ensembl ENCODE 19.1 -492.1 -492106 4.9 CTCF JUN BACH1 POLR2A FOSL2 FOS MAFK NFE2L2 NANOG CEBPB NECTIN3 RNU6ATAC15P GC03M110552 LOC105374037
GH03J111047 Enhancer 0.8 ENCODE dbSUPER 11.6 -21.7 -21749 1 SOX5 SOX13 FOXA2 RXRA FOXA3 MAX ETV5 YY1 SP1 CEBPA NECTIN3-AS1 NECTIN3 PIR53960 GC03M111020
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NECTIN3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NECTIN3 Gene

Genomic Locations for NECTIN3 Gene
chr3:111,070,071-111,275,563
(GRCh38/hg38)
Size:
205,493 bases
Orientation:
Plus strand
chr3:110,788,918-110,994,410
(GRCh37/hg19)
Size:
205,493 bases
Orientation:
Plus strand

Genomic View for NECTIN3 Gene

Genes around NECTIN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NECTIN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NECTIN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NECTIN3 Gene

Proteins for NECTIN3 Gene

  • Protein details for NECTIN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQS3-NECT3_HUMAN
    Recommended name:
    Nectin-3
    Protein Accession:
    Q9NQS3
    Secondary Accessions:
    • E9PFR0
    • Q6NVZ3
    • Q8NC05
    • Q8WVU4
    • Q9BVA9
    • Q9Y412

    Protein attributes for NECTIN3 Gene

    Size:
    549 amino acids
    Molecular mass:
    61002 Da
    Quaternary structure:
    • Cis- and trans-homodimer. Can form trans-heterodimers with NECTIN1, NECTIN2, PVR, IGSF4B/Necl-1 and with IGSF4. Interaction between NECTIN1 and NECTIN3 on the pre- and postsynaptic sites, respectively, initiates the formation of puncta adherentia junctions between axons and dendrites. Interacts (via Cytoplasmic domain) with AFDN, providing a connection with the actin cytoskeleton. Binds with low affinity to TIGIT.
    SequenceCaution:
    • Sequence=AAH17572.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NECTIN3 Gene

    Alternative splice isoforms for NECTIN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NECTIN3 Gene

Post-translational modifications for NECTIN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NECTIN3 Gene

Domains & Families for NECTIN3 Gene

Suggested Antigen Peptide Sequences for NECTIN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQS3

UniProtKB/Swiss-Prot:

NECT3_HUMAN :
  • Belongs to the nectin family.
Family:
  • Belongs to the nectin family.
genes like me logo Genes that share domains with NECTIN3: view

Function for NECTIN3 Gene

Molecular function for NECTIN3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.

Phenotypes From GWAS Catalog for NECTIN3 Gene

Gene Ontology (GO) - Molecular Function for NECTIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IBA --
GO:0005515 protein binding IPI 11024295
GO:0042803 protein homodimerization activity IEA,ISS --
GO:0046982 protein heterodimerization activity IEA --
GO:0050839 cell adhesion molecule binding IEA,IPI 12438620
genes like me logo Genes that share ontologies with NECTIN3: view
genes like me logo Genes that share phenotypes with NECTIN3: view

Animal Models for NECTIN3 Gene

MGI Knock Outs for NECTIN3:

Animal Model Products

  • Taconic Biosciences Mouse Models for NECTIN3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NECTIN3 Gene

Localization for NECTIN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NECTIN3 Gene

Cell membrane; Single-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NECTIN3 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3
nucleus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubule organizing center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NECTIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,ISS --
GO:0005887 integral component of plasma membrane IBA --
GO:0005911 cell-cell junction IEA --
GO:0005913 cell-cell adherens junction IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NECTIN3: view

Pathways & Interactions for NECTIN3 Gene

genes like me logo Genes that share pathways with NECTIN3: view

Gene Ontology (GO) - Biological Process for NECTIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002089 lens morphogenesis in camera-type eye IEA --
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISS --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA --
GO:0007286 spermatid development IEA --
genes like me logo Genes that share ontologies with NECTIN3: view

No data available for SIGNOR curated interactions for NECTIN3 Gene

Drugs & Compounds for NECTIN3 Gene

No Compound Related Data Available

Transcripts for NECTIN3 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NECTIN3 Gene

No ASD Table

Relevant External Links for NECTIN3 Gene

GeneLoc Exon Structure for
NECTIN3
ECgene alternative splicing isoforms for
NECTIN3

Expression for NECTIN3 Gene

NURSA nuclear receptor signaling pathways regulating expression of NECTIN3 Gene:

NECTIN3

mRNA Expression by UniProt/SwissProt for NECTIN3 Gene:

Q9NQS3-NECT3_HUMAN
Tissue specificity: Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.

Evidence on tissue expression from TISSUES for NECTIN3 Gene

  • Nervous system(4.5)
  • Kidney(4.3)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NECTIN3 Gene

Orthologs for NECTIN3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NECTIN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PVRL3 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PVRL3 34 33
  • 93.84 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PVRL3 34 33
  • 92.25 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Pvrl3 34 33
  • 87.78 (n)
OneToOne
Nectin3 16
rat
(Rattus norvegicus)
Mammalia Pvrl3 33
  • 87.18 (n)
oppossum
(Monodelphis domestica)
Mammalia PVRL3 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PVRL3 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves PVRL3 34 33
  • 73.54 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PVRL3 34
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12547 33
zebrafish
(Danio rerio)
Actinopterygii pvrl3b 34
  • 38 (a)
OneToMany
PVRL3 (2 of 2) 34
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 18 (a)
OneToMany
Species where no ortholog for NECTIN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NECTIN3 Gene

ENSEMBL:
Gene Tree for NECTIN3 (if available)
TreeFam:
Gene Tree for NECTIN3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NECTIN3: view image

Paralogs for NECTIN3 Gene

Paralogs for NECTIN3 Gene

genes like me logo Genes that share paralogs with NECTIN3: view

Variants for NECTIN3 Gene

Sequence variations from dbSNP and Humsavar for NECTIN3 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs79006549 likely-pathogenic, Congenital cataract 111,122,207(+) A/C coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000001747 -- 111,114,520(+) G/C intron_variant
rs1000081016 -- 111,096,754(+) T/A intron_variant
rs1000082548 -- 111,137,180(+) C/T 3_prime_UTR_variant, intron_variant
rs1000082678 -- 111,201,771(+) T/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NECTIN3 Gene

Variant ID Type Subtype PubMed ID
esv2658467 CNV deletion 23128226
esv2676144 CNV deletion 23128226
esv2725772 CNV deletion 23290073
esv3306847 CNV mobile element insertion 20981092
esv3387578 CNV insertion 20981092
esv3562375 CNV deletion 23714750
esv3597384 CNV loss 21293372
esv3597385 CNV gain 21293372
esv3597387 CNV loss 21293372
nsv1008308 CNV loss 25217958
nsv1073670 CNV deletion 25765185
nsv1117017 CNV deletion 24896259
nsv460821 CNV gain 19166990
nsv591275 CNV gain 21841781
nsv591276 CNV loss 21841781
nsv829675 CNV gain 17160897
nsv963553 CNV deletion 23825009

Variation tolerance for NECTIN3 Gene

Residual Variation Intolerance Score: 23.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NECTIN3 Gene

Human Gene Mutation Database (HGMD)
NECTIN3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NECTIN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NECTIN3 Gene

Disorders for NECTIN3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NECTIN3 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
megaesophagus
  • esophageal achalasia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NECTIN3

genes like me logo Genes that share disorders with NECTIN3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NECTIN3 Gene

Publications for NECTIN3 Gene

  1. Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin. (PMID: 11024295) Reymond N … Lopez M (Gene 2000) 2 3 4 58
  2. The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. (PMID: 19011627) Yu X … Grogan JL (Nature immunology 2009) 3 4 58
  3. Inhibition of cell movement and proliferation by cell-cell contact-induced interaction of Necl-5 with nectin-3. (PMID: 16216929) Fujito T … Takai Y (The Journal of cell biology 2005) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for NECTIN3 Gene

Sources for NECTIN3 Gene

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