This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in ... See more...

Aliases for NECTIN2 Gene

Aliases for NECTIN2 Gene

  • Nectin Cell Adhesion Molecule 2 2 3 4 5
  • Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) 2 3
  • Nectin-2 3 4
  • PVRL2 3 4
  • HVEB 3 4
  • PRR2 3 4
  • Poliovirus Receptor-Related Protein 2 4
  • Herpes Virus Entry Mediator B 4
  • Herpesvirus Entry Mediator B 4
  • Herpesvirus Entry Protein B 3
  • Poliovirus Receptor-Like 2 3
  • CD112 Antigen 4
  • CD112 3
  • PVRR2 3
  • HveB 4

External Ids for NECTIN2 Gene

Previous HGNC Symbols for NECTIN2 Gene

  • HVEB
  • PVRL2

Summaries for NECTIN2 Gene

Entrez Gene Summary for NECTIN2 Gene

  • This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for NECTIN2 Gene

NECTIN2 (Nectin Cell Adhesion Molecule 2) is a Protein Coding gene. Diseases associated with NECTIN2 include Herpes Simplex and Ovarian Cystic Teratoma. Among its related pathways are Cell junction organization and Adherens junction. An important paralog of this gene is PVR.

UniProtKB/Swiss-Prot Summary for NECTIN2 Gene

  • Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005).
  • (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).

Gene Wiki entry for NECTIN2 Gene

Additional gene information for NECTIN2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NECTIN2 Gene

Genomics for NECTIN2 Gene

GeneHancer (GH) Regulatory Elements for NECTIN2 Gene

Promoters and enhancers for NECTIN2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NECTIN2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NECTIN2 Gene

Genomic Locations for NECTIN2 Gene
chr19:44,846,136-44,889,228
(GRCh38/hg38)
Size:
43,093 bases
Orientation:
Plus strand
chr19:45,349,393-45,392,485
(GRCh37/hg19)
Size:
43,093 bases
Orientation:
Plus strand

Genomic View for NECTIN2 Gene

Genes around NECTIN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NECTIN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NECTIN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NECTIN2 Gene

Proteins for NECTIN2 Gene

  • Protein details for NECTIN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92692-NECT2_HUMAN
    Recommended name:
    Nectin-2
    Protein Accession:
    Q92692
    Secondary Accessions:
    • A8K5L5
    • O75455
    • Q6IBI6
    • Q96J29

    Protein attributes for NECTIN2 Gene

    Size:
    538 amino acids
    Molecular mass:
    57742 Da
    Quaternary structure:
    • Can form trans-heterodimers with NECTIN3 (By similarity). Interacts with CD226 or with PVRIG; these interactions are competitive and have a differential functional outcome on T-cell activation, either positive or negative, respectively. Binds with low affinity to TIGIT.
    • (Microbial infection) Interacts with herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV) envelope glycoprotein D (PubMed:11602758, PubMed:9657005).

    Three dimensional structures from OCA and Proteopedia for NECTIN2 Gene

    Alternative splice isoforms for NECTIN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NECTIN2 Gene

Post-translational modifications for NECTIN2 Gene

  • Glycosylation at Ser95, Asn137, and Asn324
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • NECT2_HUMAN (1537)

Other Protein References for NECTIN2 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for NECTIN2

No data available for DME Specific Peptides for NECTIN2 Gene

Domains & Families for NECTIN2 Gene

Gene Families for NECTIN2 Gene

Suggested Antigen Peptide Sequences for NECTIN2 Gene

GenScript: Design optimal peptide antigens:
  • Nectin-2 (PVRL2_HUMAN)
  • Poliovirus receptor related 2 (Q7Z456_HUMAN)
  • Poliovirus receptor related 2 (Q7Z457_HUMAN)
  • Poliovirus receptor related 2 (Q7Z458_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92692

UniProtKB/Swiss-Prot:

NECT2_HUMAN :
  • Belongs to the nectin family.
Family:
  • Belongs to the nectin family.
genes like me logo Genes that share domains with NECTIN2: view

Function for NECTIN2 Gene

Molecular function for NECTIN2 Gene

UniProtKB/Swiss-Prot Function:
Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).

Phenotypes From GWAS Catalog for NECTIN2 Gene

Gene Ontology (GO) - Molecular Function for NECTIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0015026 coreceptor activity TAS 9657005
GO:0042802 identical protein binding IPI 21982860
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with NECTIN2: view
genes like me logo Genes that share phenotypes with NECTIN2: view

Animal Models for NECTIN2 Gene

MGI Knock Outs for NECTIN2:

Animal Model Products

  • Taconic Biosciences Mouse Models for NECTIN2

CRISPR Products

miRNA for NECTIN2 Gene

miRTarBase miRNAs that target NECTIN2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NECTIN2 Gene

Localization for NECTIN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NECTIN2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NECTIN2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
endosome 1
lysosome 1
golgi apparatus 1
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NECTIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction IDA 9845526
GO:0005915 zonula adherens IEA,ISS 10225955
GO:0005925 focal adhesion HDA 21423176
GO:0009986 cell surface IDA 16831868
genes like me logo Genes that share ontologies with NECTIN2: view

Pathways & Interactions for NECTIN2 Gene

genes like me logo Genes that share pathways with NECTIN2: view

Pathways by source for NECTIN2 Gene

1 R&D Systems pathway for NECTIN2 Gene
3 Qiagen pathways for NECTIN2 Gene
  • Epithelial Adherens Junctions
  • Germ Cell-Sertoli Cell Junction Dynamics
  • Sertoli-Sertoli Cell Junction Dynamics

Gene Ontology (GO) - Biological Process for NECTIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001675 acrosome assembly IEA --
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP 12913096
GO:0002891 positive regulation of immunoglobulin mediated immune response IMP 16831868
GO:0007010 cytoskeleton organization IEA --
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with NECTIN2: view

No data available for SIGNOR curated interactions for NECTIN2 Gene

Drugs & Compounds for NECTIN2 Gene

(2) Drugs for NECTIN2 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CMX001 Pharma Broad spectrum antiviral drug 0

(1) Additional Compounds for NECTIN2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for NECTIN2 Gene

Compound Action Cas Number
CMX001 Broad spectrum antiviral drug 444805-28-1
genes like me logo Genes that share compounds with NECTIN2: view

Transcripts for NECTIN2 Gene

mRNA/cDNA for NECTIN2 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NECTIN2 Gene

No ASD Table

Relevant External Links for NECTIN2 Gene

GeneLoc Exon Structure for
NECTIN2
ECgene alternative splicing isoforms for
NECTIN2

Expression for NECTIN2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NECTIN2 Gene:

NECTIN2

mRNA Expression by UniProt/SwissProt for NECTIN2 Gene:

Q92692-NECT2_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for NECTIN2 Gene

  • Nervous system(4.6)
  • Liver(4.3)
  • Intestine(3)
  • Lung(2.7)
  • Pancreas(2.4)
  • Eye(2.2)
  • Blood(2.1)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NECTIN2 Gene

Orthologs for NECTIN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NECTIN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PVRL2 32
  • 99.32 (n)
PRR2 33
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PVRL2 32
  • 82.78 (n)
PRR2 33
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pvrl2 32
  • 78.39 (n)
mouse
(Mus musculus)
Mammalia Pvrl2 33 32
  • 78.32 (n)
OneToOne
Nectin2 17
cow
(Bos Taurus)
Mammalia PVRL2 33
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 54 (a)
ManyToMany
-- 33
  • 51 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 50 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch73-22o12.1 33
  • 29 (a)
ManyToMany
pvrl2l 33
  • 29 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 15 (a)
OneToMany
Species where no ortholog for NECTIN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NECTIN2 Gene

ENSEMBL:
Gene Tree for NECTIN2 (if available)
TreeFam:
Gene Tree for NECTIN2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NECTIN2: view image

Paralogs for NECTIN2 Gene

Pseudogenes.org Pseudogenes for NECTIN2 Gene

genes like me logo Genes that share paralogs with NECTIN2: view

Variants for NECTIN2 Gene

Sequence variations from dbSNP and Humsavar for NECTIN2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000036120 -- 44,862,610(+) C/T intron_variant
rs1000043449 -- 44,879,120(+) C/T downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000144131 -- 44,856,896(+) G/A intron_variant
rs1000145354 -- 44,879,971(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000150404 -- 44,887,513(+) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NECTIN2 Gene

Variant ID Type Subtype PubMed ID
dgv12e24 CNV gain 17666407
dgv13e24 CNV loss 17666407
esv2750597 CNV loss 17666407
nsv509747 CNV insertion 20534489

Variation tolerance for NECTIN2 Gene

Residual Variation Intolerance Score: 89.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.86; 58.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NECTIN2 Gene

Human Gene Mutation Database (HGMD)
NECTIN2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NECTIN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NECTIN2 Gene

Disorders for NECTIN2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for NECTIN2 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NECTIN2

genes like me logo Genes that share disorders with NECTIN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NECTIN2 Gene

Publications for NECTIN2 Gene

  1. The human PRR2 gene, related to the human poliovirus receptor gene (PVR), is the true homolog of the murine MPH gene. (PMID: 7622062) Eberlé F … Lopez M (Gene 1995) 2 3 4 23 56
  2. PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis. (PMID: 15607800) Pende D … Moretta A (Molecular immunology 2005) 3 4 23 56
  3. Structural features of nectin-2 (HveB) required for herpes simplex virus entry. (PMID: 11602758) Martinez WM … Spear PG (Journal of virology 2001) 3 4 23 56
  4. The murine homolog (Mph) of human herpesvirus entry protein B (HveB) mediates entry of pseudorabies virus but not herpes simplex virus types 1 and 2. (PMID: 10196354) Shukla D … Spear PG (Journal of virology 1999) 2 3 23 56
  5. Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1. (PMID: 10520737) Freitas EM … Dawkins RL (DNA sequence : the journal of DNA sequencing and mapping 1998) 3 4 23 56

Products for NECTIN2 Gene

Sources for NECTIN2 Gene