Aliases for NECTIN2 Gene
External Ids for NECTIN2 Gene
Previous HGNC Symbols for NECTIN2 Gene
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for NECTIN2 Gene
NECTIN2 (Nectin Cell Adhesion Molecule 2) is a Protein Coding gene. Diseases associated with NECTIN2 include Herpes Simplex and Cleft Lip/Palate-Ectodermal Dysplasia Syndrome. Among its related pathways are Adherens junction and Cell junction organization. An important paralog of this gene is PVR.
UniProtKB/Swiss-Prot Summary for NECTIN2 Gene
Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005).
(Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).