Aliases for NECTIN1 Gene
- Nectin Cell Adhesion Molecule 1 2 3 4 5
- HIgR 2 3 4
- PRR1 2 3 4
- Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) 2 3
- Poliovirus Receptor-Related Protein 1 3 4
- Herpes Virus Entry Mediator C 3 4
- Herpesvirus Ig-Like Receptor 3 4
- Nectin-1 3 4
- CLPED1 2 3
- CD111 2 3
- PVRL1 3 4
- PVRR1 2 3
- SK-12 2 3
- HVEC 3 4
External Ids for NECTIN1 Gene
Previous HGNC Symbols for NECTIN1 Gene
This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009]
GeneCards Summary for NECTIN1 Gene
NECTIN1 (Nectin Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with NECTIN1 include Cleft Lip/Palate-Ectodermal Dysplasia Syndrome and Herpes Simplex. Among its related pathways are Cell junction organization and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. An important paralog of this gene is NECTIN3.
UniProtKB/Swiss-Prot Summary for NECTIN1 Gene
Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4. Has some neurite outgrowth-promoting activity.
(Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1, herpes simplex virus 2/HHV-2, and pseudorabies virus/PRV.