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Aliases for NECAP2 Gene

Aliases for NECAP2 Gene

  • NECAP Endocytosis Associated 2 2 3 5
  • NECAP Endocytosis-Associated Protein 2 4
  • NECAP-2 4

External Ids for NECAP2 Gene

Previous GeneCards Identifiers for NECAP2 Gene

  • GC01P016513
  • GC01P016639
  • GC01P016767
  • GC01P015284

Summaries for NECAP2 Gene

Entrez Gene Summary for NECAP2 Gene

  • This gene likely encodes a member of the adaptin-ear-binding coat-associated protein family. Studies of a similar protein in rat suggest a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

GeneCards Summary for NECAP2 Gene

NECAP2 (NECAP Endocytosis Associated 2) is a Protein Coding gene. Diseases associated with NECAP2 include Cataract 8, Multiple Types. Among its related pathways are Vesicle-mediated transport and Clathrin-mediated endocytosis. An important paralog of this gene is NECAP1.

UniProtKB/Swiss-Prot for NECAP2 Gene

  • Involved in endocytosis.

Gene Wiki entry for NECAP2 Gene

Additional gene information for NECAP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NECAP2 Gene

Genomics for NECAP2 Gene

GeneHancer (GH) Regulatory Elements for NECAP2 Gene

Promoters and enhancers for NECAP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I016440 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 564.2 +2.0 1967 5.2 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC NECAP2 ENSG00000237938 SPEN LOC100421279 ZBTB17 SZRD1 RPS16P1 RPL22P3 MFAP2 LINC01783
GH01I016902 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 23.7 +464.4 464378 4.9 ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ENSG00000272426 CROCC ZBTB17 CROCCP3 LINC01772 RPL22P3 ARHGEF19 MFAP2 NBPF1 NECAP2
GH01I015846 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15 -591.0 -590973 6.4 CLOCK FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 MEF2D SPEN FLJ37453 ENSG00000237938 ZBTB17 ARHGEF19 HSPB7 CLCNKA NECAP2 RPS16P1 RPL22P3
GH01I016236 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 15 -203.5 -203505 2.3 HDGF SMAD1 ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 ZNF213 E2F8 RSG1 ARHGEF19 NECAP2 ARHGEF19-AS1 FAM131C ZBTB17 LINC01783 GC01M016230
GH01I016498 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 17 +58.4 58399 2 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 GTF3C2 ZNF121 GLIS2 ZNF213 E2F8 CROCCP3 NECAP2 SPATA21 FAM131C LOC100421279 NBPF1 SRARP GC01M016499 PIR40208
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NECAP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NECAP2 gene promoter:

Genomic Locations for NECAP2 Gene

Genomic Locations for NECAP2 Gene
19,419 bases
Plus strand

Genomic View for NECAP2 Gene

Genes around NECAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NECAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NECAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NECAP2 Gene

Proteins for NECAP2 Gene

  • Protein details for NECAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adaptin ear-binding coat-associated protein 2
    Protein Accession:
    Secondary Accessions:
    • B4DY19
    • E9PGQ8
    • Q5VSU4
    • Q5VSU5
    • Q9H7L1
    • Q9H8L1

    Protein attributes for NECAP2 Gene

    263 amino acids
    Molecular mass:
    28339 Da
    Quaternary structure:
    • Interacts with AP1G1 and AP2A1 components of the adapter protein complexes AP-1 and AP-2. Interacts with the GAE domain proteins GGA1, GGA2 and GGA3 (By similarity).
    • Sequence=BAB15758.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NECAP2 Gene


neXtProt entry for NECAP2 Gene

Post-translational modifications for NECAP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NECAP2 Gene

Domains & Families for NECAP2 Gene

Gene Families for NECAP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NECAP2 Gene

Suggested Antigen Peptide Sequences for NECAP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself (By similarity).
  • Belongs to the NECAP family.
  • The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself (By similarity).
  • Belongs to the NECAP family.
genes like me logo Genes that share domains with NECAP2: view

Function for NECAP2 Gene

Molecular function for NECAP2 Gene

UniProtKB/Swiss-Prot Function:
Involved in endocytosis.

Phenotypes From GWAS Catalog for NECAP2 Gene

genes like me logo Genes that share phenotypes with NECAP2: view

Animal Model Products

miRNA for NECAP2 Gene

miRTarBase miRNAs that target NECAP2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NECAP2 Gene

Localization for NECAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NECAP2 Gene

Cytoplasmic vesicle, clathrin-coated vesicle membrane. Cell membrane. Note=Colocalizes with AP-2 at the plasma membrane. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NECAP2 gene
Compartment Confidence
plasma membrane 3
nucleus 2
cytosol 2
extracellular 1
cytoskeleton 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NECAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005886 plasma membrane IEA --
GO:0005905 clathrin-coated pit ISS --
GO:0016020 membrane IEA --
GO:0030125 clathrin vesicle coat ISS --
genes like me logo Genes that share ontologies with NECAP2: view

Pathways & Interactions for NECAP2 Gene

genes like me logo Genes that share pathways with NECAP2: view

Gene Ontology (GO) - Biological Process for NECAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006897 endocytosis ISS,IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with NECAP2: view

No data available for SIGNOR curated interactions for NECAP2 Gene

Drugs & Compounds for NECAP2 Gene

No Compound Related Data Available

Transcripts for NECAP2 Gene

Unigene Clusters for NECAP2 Gene

NECAP endocytosis associated 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NECAP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - - - - -
SP5: - - - -
SP6: -

Relevant External Links for NECAP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NECAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NECAP2 Gene

Protein differential expression in normal tissues from HIPED for NECAP2 Gene

This gene is overexpressed in Lymph node (11.7) and Peripheral blood mononuclear cells (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NECAP2 Gene

Protein tissue co-expression partners for NECAP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NECAP2 Gene:


SOURCE GeneReport for Unigene cluster for NECAP2 Gene:


Evidence on tissue expression from TISSUES for NECAP2 Gene

  • Intestine(4.4)
  • Liver(4.3)
  • Spleen(4.3)
  • Eye(4.1)
  • Nervous system(3.6)
  • Lung(2.6)
genes like me logo Genes that share expression patterns with NECAP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NECAP2 Gene

Orthologs for NECAP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NECAP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NECAP2 33 34
  • 99.11 (n)
(Canis familiaris)
Mammalia NECAP2 33 34
  • 91.63 (n)
(Bos Taurus)
Mammalia NECAP2 33 34
  • 89.73 (n)
(Mus musculus)
Mammalia Necap2 33 16 34
  • 86.06 (n)
(Rattus norvegicus)
Mammalia Necap2 33
  • 85.61 (n)
(Ornithorhynchus anatinus)
Mammalia NECAP2 34
  • 81 (a)
(Monodelphis domestica)
Mammalia NECAP2 34
  • 71 (a)
(Gallus gallus)
Aves NECAP2 33 34
  • 76.01 (n)
(Anolis carolinensis)
Reptilia NECAP2 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia necap2 33
  • 71.81 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4159 33
(Danio rerio)
Actinopterygii necap2 33 34
  • 64.52 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13473 33
fruit fly
(Drosophila melanogaster)
Insecta CG9132 34
  • 51 (a)
(Caenorhabditis elegans)
Secernentea CELE_Y110A2AR.3 33
  • 52.05 (n)
Y110A2AR.3 34
  • 48 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons NAP4 33
  • 49.8 (n)
(Oryza sativa)
Liliopsida Os10g0476000 33
  • 50 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2050 34
  • 51 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04345 33
  • 48.18 (n)
Species where no ortholog for NECAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NECAP2 Gene

Gene Tree for NECAP2 (if available)
Gene Tree for NECAP2 (if available)

Paralogs for NECAP2 Gene

Paralogs for NECAP2 Gene

(1) SIMAP similar genes for NECAP2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NECAP2: view

Variants for NECAP2 Gene

Sequence variations from dbSNP and Humsavar for NECAP2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs193921123 uncertain-significance, Malignant tumor of prostate 16,449,174(+) G/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000033591 -- 16,450,199(+) C/T intron_variant, non_coding_transcript_variant
rs1000147663 -- 16,457,761(+) G/A intron_variant
rs1000164239 -- 16,457,514(+) G/C intron_variant
rs1000181434 -- 16,440,369(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NECAP2 Gene

Variant ID Type Subtype PubMed ID
dgv1n68 CNV loss 17160897
dgv39n100 CNV gain 25217958
esv2758925 CNV gain+loss 17122850
nsv428421 CNV gain+loss 18775914
nsv9213 CNV loss 18304495

Variation tolerance for NECAP2 Gene

Residual Variation Intolerance Score: 57.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NECAP2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NECAP2 Gene

Disorders for NECAP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NECAP2 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
cataract 8, multiple types
  • ctrct8
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NECAP2

genes like me logo Genes that share disorders with NECAP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NECAP2 Gene

Publications for NECAP2 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Identification of a family of endocytic proteins that define a new alpha-adaptin ear-binding motif. (PMID: 14555962) Ritter B … McPherson PS (EMBO reports 2003) 2 3 58
  5. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 58

Products for NECAP2 Gene

Sources for NECAP2 Gene

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