Aliases for NECAP1 Gene
External Ids for NECAP1 Gene
Previous GeneCards Identifiers for NECAP1 Gene
This gene encodes a protein containing two characteristic WXXF motifs. The encoded protein localizes to clathrin-coated vesicles, where it binds components of the adapter protein complexes and aids in endocytosis. Loss of function of this gene results in early infantile epileptic encephalopathy-21. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
GeneCards Summary for NECAP1 Gene
NECAP1 (NECAP Endocytosis Associated 1) is a Protein Coding gene. Diseases associated with NECAP1 include Epileptic Encephalopathy, Early Infantile, 21 and Undetermined Early-Onset Epileptic Encephalopathy. Among its related pathways are Vesicle-mediated transport and Clathrin-mediated endocytosis. An important paralog of this gene is NECAP2.
UniProtKB/Swiss-Prot Summary for NECAP1 Gene
Involved in endocytosis.