Aliases for NECAB2 Gene
External Ids for NECAB2 Gene
Previous HGNC Symbols for NECAB2 Gene
Previous GeneCards Identifiers for NECAB2 Gene
The protein encoded by this gene is a neuronal calcium-binding protein that binds to and modulates the function of at least two receptors, adenosine A(2A) receptor and metabotropic glutamate receptor type 5. [provided by RefSeq, Jul 2016]
GeneCards Summary for NECAB2 Gene
NECAB2 (N-Terminal EF-Hand Calcium Binding Protein 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is NECAB1.
UniProtKB/Swiss-Prot Summary for NECAB2 Gene
May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation.