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The protein encoded by this gene is a neuronal calcium-binding protein that binds to and modulates the function of at least two receptors, adenosine A(2A) receptor and metabotropic glutamate receptor type 5. [provided by RefSeq, Jul 2016] See more...
Aliases for NECAB2 Gene
Aliases for NECAB2 Gene
External Ids for NECAB2 Gene
- HGNC: 23746
- Entrez Gene: 54550
- Ensembl: ENSG00000103154
- OMIM: 618130
- UniProtKB: Q7Z6G3
Previous HGNC Symbols for NECAB2 Gene
- EFCBP2
Previous GeneCards Identifiers for NECAB2 Gene
- GC16P083744
- GC16P082560
- GC16P069754
Summaries for NECAB2 Gene
-
The protein encoded by this gene is a neuronal calcium-binding protein that binds to and modulates the function of at least two receptors, adenosine A(2A) receptor and metabotropic glutamate receptor type 5. [provided by RefSeq, Jul 2016]
GeneCards Summary for NECAB2 Gene
NECAB2 (N-Terminal EF-Hand Calcium Binding Protein 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is NECAB1.
UniProtKB/Swiss-Prot Summary for NECAB2 Gene
-
May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation.
Additional gene information for NECAB2 Gene
- HGNC(23746)
- Entrez Gene(54550)
- Ensembl(ENSG00000103154)
- OMIM(618130)
- UniProtKB(Q7Z6G3)
- Open Targets Platform(ENSG00000103154)
- Search for NECAB2 at DataMed
- Search for NECAB2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NECAB2 Gene
Genomics for NECAB2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for NECAB2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NECAB2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NECAB2
- Top Transcription factor binding sites by QIAGEN in the NECAB2 gene promoter:
-
- AML1a
- E47
- ER-alpha
- GATA-2
- HNF-4alpha1
- HNF-4alpha2
- HOXA3
- MyoD
- MZF-1
- YY1
Genomic Locations for NECAB2 Gene
Genomic Locations for NECAB2 Gene
- chr16:83,968,632-84,002,776
- (GRCh38/hg38)
- Size:
- 34,145 bases
- Orientation:
- Plus strand
- chr16:84,002,237-84,036,381
- (GRCh37/hg19)
- Size:
- 34,145 bases
- Orientation:
- Plus strand
Genomic View for NECAB2 Gene
Genes around NECAB2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q23.3 by HGNC
- 16q23.3 by Entrez Gene
- 16q23.3 by Ensembl
NECAB2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NECAB2 Gene
Proteins for NECAB2 Gene
-
Protein details for NECAB2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7Z6G3-NECA2_HUMAN
- Recommended name:
- N-terminal EF-hand calcium-binding protein 2
- Protein Accession:
- Q7Z6G3
- A2RRG3
- H3BTW2
- O75547
- Q6ZSK0
Protein attributes for NECAB2 Gene
- Size:
- 386 amino acids
- Molecular mass:
- 43194 Da
- Quaternary structure:
-
- Interacts (calcium-dependent) with ADORA2A and GRM5.
- SequenceCaution:
-
- Sequence=AAI31616.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC86948.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for NECAB2 Gene
Post-translational modifications for NECAB2 Gene
Other Protein References for NECAB2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for NECAB2
- Invitrogen Antibodies for NECAB2 (AFLGC-NECAB2)
- antibodies-online: Show 11 available NECAB2 Antibodies ranked by validation data
- Sino Biological Antibodies for NECAB2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for NECAB2
- Origene Custom Protein Services for NECAB2
No data available for DME Specific Peptides for NECAB2 Gene
Domains & Families for NECAB2 Gene
Gene Families for NECAB2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for NECAB2 Gene
- InterPro:
- Blocks:
-
- Antibiotic biosynthesis monooxygenase
- ProtoNet:
Suggested Antigen Peptide Sequences for NECAB2 Gene
- GenScript: Design optimal peptide antigens:
-
- Synaptotagmin-interacting protein 2 (NECA2_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NECAB2 Gene
Function for NECAB2 Gene
Molecular function for NECAB2 Gene
- UniProtKB/Swiss-Prot Function:
- May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation.
Phenotypes From GWAS Catalog for NECAB2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 17689978 |
| GO:0031687 | A2A adenosine receptor binding | IDA | 17689978 |
| GO:0031802 | type 5 metabotropic glutamate receptor binding | IDA | 19694902 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for NECAB2 Gene
- MGI mutant phenotypes for NECAB2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for NECAB2:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased vaccinia virus (VACV) infection
- Decreased viability
- Synthetic lethal with Ras
- Decreased viability in glioblastoma multiforme (GBM) lineage
- Increased shRNA abundance (Z-score > 2)
- Increased virus production
- Negative genetic interaction between PTEN-/- and PTEN+/+
Animal Models for NECAB2 Gene
- MGI Knock Outs for NECAB2:
-
- Necab2 Necab2<tm1a(KOMP)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NECAB2 - Select products 50% OFF >
- * NECAB2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NECAB2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NECAB2
-
Santa Cruz Biotechnology (SCBT) CRISPR for NECAB2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NECAB2
- Browse OriGene Inhibitory RNA Products For NECAB2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NECAB2
Clone Products
- Applied Biological Materials (abm): Clones for NECAB2 - Select products 50% OFF >
- * NECAB2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for NECAB2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NECAB2
Cell Line Products
-
Horizon Cell Lines for NECAB2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NECAB2 Gene
Localization for NECAB2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NECAB2 Gene
- Cytoplasm. Cell projection, dendrite. Cell projection, axon. Cell membrane. Note=Colocalizes with ADORA2A and/or mGluR5/GRM5 at the plasma membrane (PubMed:17689978, PubMed:19694902). Found in neuronal somata (PubMed:26843217). Detected in the cytoplasm of striatal neurons, at postsynaptic sites, filling dendritic shafts and spines, and at presynaptic sites, filling axon terminals (By similarity). {ECO:0000250 UniProtKB:F1LQY6, ECO:0000269 PubMed:17689978, ECO:0000269 PubMed:19694902, ECO:0000269 PubMed:26843217}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| mitochondrion | 2 |
| nucleus | 2 |
| cytosol | 2 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005886 | plasma membrane | IEA,IDA | 19694902 |
| GO:0016020 | membrane | IEA | -- |
| GO:0030424 | axon | IEA | -- |
| GO:0030425 | dendrite | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for NECAB2 Gene
Pathways & Interactions for NECAB2 Gene
Interacting Proteins for NECAB2 Gene
Selected Interacting proteins:
Q7Z6G3-NECA2_HUMAN
ENSP00000307449
for NECAB2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for NECAB2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0042984 | regulation of amyloid precursor protein biosynthetic process | IBA | 21873635 |
| GO:0060168 | positive regulation of adenosine receptor signaling pathway | IDA | 17689978 |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | IDA | 19694902 |
| GO:1900451 | positive regulation of glutamate receptor signaling pathway | IDA | 19694902 |
| GO:1904021 | negative regulation of G protein-coupled receptor internalization | IDA | 17689978 |
No data available for Pathways by source and SIGNOR curated interactions for NECAB2 Gene
Transcripts for NECAB2 Gene
mRNA/cDNA for NECAB2 Gene
- 3 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000305202 1608 nts (view in UCSC)
- ENST00000564166 617 nts (view in UCSC)
- ENST00000565691 2064 nts (view in UCSC)
- ENST00000566836 549 nts (view in UCSC)
- ENST00000567703 559 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NECAB2 - Select products 50% OFF >
- * NECAB2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NECAB2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NECAB2
-
Santa Cruz Biotechnology (SCBT) CRISPR for NECAB2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NECAB2
- Browse OriGene Inhibitory RNA Products For NECAB2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NECAB2
Clone Products
- Applied Biological Materials (abm): Clones for NECAB2 - Select products 50% OFF >
- * NECAB2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for NECAB2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NECAB2
Relevant External Links for NECAB2 Gene
- GeneLoc Exon Structure for
- NECAB2
Expression for NECAB2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Eye (Sensory Organs)
- Cholinergic Amacrine Cells Inner Nuclear Layer
- Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Neurons
- Cholinergic Amacrine Cells Inner Nuclear Layer
-
Epithelial Cells
- Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
mRNA differential expression in normal tissues according to GTEx for NECAB2 Gene
This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x7.9), Brain - Amygdala (x7.0), Brain - Caudate (basal ganglia) (x6.5), Brain - Putamen (basal ganglia) (x5.7), Brain - Anterior cingulate cortex (BA24) (x4.9), and Brain - Hypothalamus (x4.1).
This gene is overexpressed in Fetal Brain (24.4), Brain (21.2), and Frontal cortex (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NECAB2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NECAB2
SOURCE GeneReport for Unigene cluster for NECAB2 Gene:
Hs.140950mRNA Expression by UniProt/SwissProt for NECAB2 Gene:
Q7Z6G3-NECA2_HUMAN
Tissue specificity:
Expressed in brain. Expressed in the spinal dorsal horn with especially strong expression in lamina IIi; found in excitory synaptic boutons and in ependymal cells (at protein level).
Evidence on tissue expression from TISSUES for NECAB2 Gene
- Nervous system(4.5)
Primer Products
-
OriGene qPCR primer pairs for NECAB2
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NECAB2 Gene
Orthologs for NECAB2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | NECAB2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | NECAB2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | NECAB2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Necab2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Necab2 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | NECAB2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | NECAB2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | NECAB2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | NECAB2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC101731915 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | necab2 30 31 |
|
OneToOne |
- Species where no ortholog for NECAB2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for NECAB2 Gene
- ENSEMBL:
- Gene Tree for NECAB2 (if available)
- TreeFam:
- Gene Tree for NECAB2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NECAB2: view image
Paralogs for NECAB2 Gene
Variants for NECAB2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NECAB2 Gene
| SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs113413576 | Benign: not specified | 84,001,919(+) | A/AG | INTRON_VARIANT | |
| rs2271298 | - | p.Leu353Val | |||
| rs2292323 | - | p.Gly233Ser | |||
| rs2292324 | - | p.Thr235Ser | |||
| rs2292329 | - | p.Gln308His |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3056n100 | CNV | loss | 25217958 |
| dgv357n27 | CNV | loss | 19166990 |
| dgv5259n54 | CNV | loss | 21841781 |
| dgv5260n54 | CNV | loss | 21841781 |
| esv28321 | CNV | loss | 19812545 |
| esv3572242 | CNV | gain | 25503493 |
| esv3639405 | CNV | loss | 21293372 |
| nsv1065790 | CNV | loss | 25217958 |
| nsv1067050 | CNV | loss | 25217958 |
| nsv1070361 | CNV | deletion | 25765185 |
| nsv1126437 | CNV | deletion | 24896259 |
| nsv1136220 | CNV | deletion | 24896259 |
| nsv457591 | CNV | loss | 19166990 |
| nsv457594 | CNV | loss | 19166990 |
| nsv471106 | CNV | gain | 18288195 |
| nsv517566 | CNV | gain+loss | 19592680 |
| nsv528396 | CNV | loss | 19592680 |
| nsv573409 | CNV | loss | 21841781 |
| nsv573413 | CNV | loss | 21841781 |
| nsv573415 | CNV | loss | 21841781 |
| nsv573417 | CNV | loss | 21841781 |
| nsv573418 | CNV | loss | 21841781 |
| nsv827780 | CNV | loss | 20364138 |
Residual Variation Intolerance Score:
31.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.05;
90.12% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NECAB2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NECAB2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NECAB2 Gene
Disorders for NECAB2 Gene
Additional Disease Information for NECAB2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for NECAB2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NECAB2 Gene
Publications for NECAB2 Gene
- NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern. (PMID: 12044471) Sugita S … Südhof TC (Neuroscience 2002) 2 3 4
- Comparative anatomical distribution of neuronal calcium-binding protein (NECAB) 1 and -2 in rodent and human spinal cord. (PMID: 26843217) Zhang MD … Hökfelt T (Brain structure & function 2016) 3 4
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- The association of metabotropic glutamate receptor type 5 with the neuronal Ca2+-binding protein 2 modulates receptor function. (PMID: 19694902) Canela L … Ciruela F (Journal of neurochemistry 2009) 3 4
- Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PMID: 18519826) Uhl GR … Lerman C (Archives of general psychiatry 2008) 3 41
ExternalLinks
Products for NECAB2 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for NECAB2
- Origene Custom Protein Services for NECAB2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NECAB2
- Browse OriGene Inhibitory RNA Products For NECAB2
- OriGene qPCR primer pairs for NECAB2
- OriGene CRISPR knockouts for NECAB2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NECAB2
- Sino Biological Human cDNA Clone for NECAB2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for NECAB2
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for NECAB2
- Novus Biologicals proteins and lysates for NECAB2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for NECAB2 (AFLGC-NECAB2)
- VectorBuilder Custom and pre-made DNA vectors for NECAB2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for NECAB2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for NECAB2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for NECAB2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for NECAB2
- antibodies-online: Show 11 available NECAB2 Antibodies ranked by validation data
- antibodies-online: Search results for available NECAB2 related products ranked by validation data
- antibodies-online: Search results for available NECAB2 related products ranked by validation data
- Horizon Cell Lines for NECAB2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NECAB2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NECAB2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for NECAB2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NECAB2
Sources for NECAB2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
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