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Aliases for NECAB1 Gene

Aliases for NECAB1 Gene

  • N-Terminal EF-Hand Calcium Binding Protein 1 2 3 5
  • Neuronal Calcium-Binding Protein 1 3 4
  • EF-Hand Calcium-Binding Protein 1 3 4
  • EFCBP1 3 4
  • N-Terminal EF-Hand Calcium-Binding Protein 1 3
  • Synaptotagmin Interacting Protein 1 3
  • EF-Hand Calcium Binding Protein 1 2
  • Neuronal Calcium Binding Protein 3
  • STIP-1 3

External Ids for NECAB1 Gene

Previous HGNC Symbols for NECAB1 Gene

  • EFCBP1

Previous GeneCards Identifiers for NECAB1 Gene

  • GC08P091873
  • GC08P087013

Summaries for NECAB1 Gene

GeneCards Summary for NECAB1 Gene

NECAB1 (N-Terminal EF-Hand Calcium Binding Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is NECAB3.

Additional gene information for NECAB1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NECAB1 Gene

Genomics for NECAB1 Gene

GeneHancer (GH) Regulatory Elements for NECAB1 Gene

Promoters and enhancers for NECAB1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I090791 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 550.8 +0.2 176 1 ZNF777 ZNF449 SIN3A E2F1 ZFHX2 CTBP1 POLR2A ZBTB48 ZNF600 EGR2 NECAB1 LOC105375633 TMEM64 LOC105375635
GH08I090640 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 10.4 -147.8 -147763 7.6 HDGF PKNOX1 SMAD1 FOXA2 ARNT SIN3A DMAP1 ZNF2 ZBTB7B YY1 TMEM64 NECAB1 LINC01030 ENSG00000254180 LOC102724670
GH08I090698 Enhancer 0.9 ENCODE dbSUPER 11.6 -91.1 -91072 3 NFIB JUN CEBPG ZNF316 NFE2 FOSL2 FOS MAFK NFE2L2 TCF7L2 ENSG00000254182 NECAB1 TMEM64 LOC102724670 LOC105375633
GH08I090692 Enhancer 0.9 ENCODE dbSUPER 10.8 -98.0 -98000 2.8 HDGF NCOA3 ESRRA JUN NEUROD1 SIN3A NFXL1 CTBP1 GATA3 FOS TMEM64 NECAB1 ENSG00000254182 LOC102724670 LOC105375633
GH08I090927 Enhancer 0.5 ENCODE 10.4 +136.4 136428 0.2 USF1 POLR2A POU5F1 ETS1 TMEM64 NECAB1 LOC105375634 LOC105375635
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NECAB1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NECAB1 gene promoter:

Genomic Locations for NECAB1 Gene

Genomic Locations for NECAB1 Gene
167,859 bases
Plus strand

Genomic View for NECAB1 Gene

Genes around NECAB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NECAB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NECAB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NECAB1 Gene

Proteins for NECAB1 Gene

  • Protein details for NECAB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    N-terminal EF-hand calcium-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • Q6NUS7
    • Q96AZ7
    • Q9HBW8

    Protein attributes for NECAB1 Gene

    351 amino acids
    Molecular mass:
    40571 Da
    Quaternary structure:
    • Interacts with STX1 (PubMed:12044471). May interact with CPNE6 (PubMed:12044471).

    Alternative splice isoforms for NECAB1 Gene


neXtProt entry for NECAB1 Gene

Post-translational modifications for NECAB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NECAB1 Gene

No data available for DME Specific Peptides for NECAB1 Gene

Domains & Families for NECAB1 Gene

Gene Families for NECAB1 Gene

Suggested Antigen Peptide Sequences for NECAB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NECAB1: view

No data available for UniProtKB/Swiss-Prot for NECAB1 Gene

Function for NECAB1 Gene

Gene Ontology (GO) - Molecular Function for NECAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005509 calcium ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NECAB1: view

Phenotypes for NECAB1 Gene

genes like me logo Genes that share phenotypes with NECAB1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NECAB1 Gene

Localization for NECAB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NECAB1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NECAB1 gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NECAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm ISS 12044471
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with NECAB1: view

Pathways & Interactions for NECAB1 Gene

SuperPathways for NECAB1 Gene

No Data Available

Interacting Proteins for NECAB1 Gene

Gene Ontology (GO) - Biological Process for NECAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NECAB1: view

No data available for Pathways by source and SIGNOR curated interactions for NECAB1 Gene

Drugs & Compounds for NECAB1 Gene

(1) Drugs for NECAB1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with NECAB1: view

Transcripts for NECAB1 Gene

Unigene Clusters for NECAB1 Gene

N-terminal EF-hand calcium binding protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NECAB1 Gene

No ASD Table

Relevant External Links for NECAB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NECAB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NECAB1 Gene

mRNA differential expression in normal tissues according to GTEx for NECAB1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x8.3), Brain - Anterior cingulate cortex (BA24) (x6.5), Brain - Spinal cord (cervical c-1) (x6.1), Brain - Cortex (x5.2), and Brain - Hippocampus (x4.0).

Protein differential expression in normal tissues from HIPED for NECAB1 Gene

This gene is overexpressed in Brain (33.6) and Frontal cortex (27.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NECAB1 Gene

Protein tissue co-expression partners for NECAB1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NECAB1 Gene:


SOURCE GeneReport for Unigene cluster for NECAB1 Gene:


mRNA Expression by UniProt/SwissProt for NECAB1 Gene:

Tissue specificity: Expressed in brain (at protein level).

Evidence on tissue expression from TISSUES for NECAB1 Gene

  • Nervous system(4.9)
  • Kidney(4.3)
genes like me logo Genes that share expression patterns with NECAB1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NECAB1 Gene

Orthologs for NECAB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NECAB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NECAB1 33 34
  • 99.26 (n)
(Monodelphis domestica)
Mammalia NECAB1 34
  • 92 (a)
(Canis familiaris)
Mammalia NECAB1 33 34
  • 91.3 (n)
(Rattus norvegicus)
Mammalia Necab1 33
  • 91.26 (n)
(Mus musculus)
Mammalia Necab1 16 34 33
  • 91.07 (n)
(Ornithorhynchus anatinus)
Mammalia NECAB1 34
  • 57 (a)
(Gallus gallus)
Aves NECAB1 34 33
  • 78.56 (n)
(Anolis carolinensis)
Reptilia NECAB1 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia necab1 33
  • 76.93 (n)
(Danio rerio)
Actinopterygii necab1 33 34
  • 70 (n)
Species where no ortholog for NECAB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NECAB1 Gene

Gene Tree for NECAB1 (if available)
Gene Tree for NECAB1 (if available)

Paralogs for NECAB1 Gene

Paralogs for NECAB1 Gene

(3) SIMAP similar genes for NECAB1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NECAB1: view

Variants for NECAB1 Gene

Sequence variations from dbSNP and Humsavar for NECAB1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000041604 -- 90,804,238(+) G/A intron_variant
rs1000101798 -- 90,946,990(+) C/G intron_variant
rs1000102138 -- 90,895,251(+) A/G intron_variant
rs1000125843 -- 90,837,128(+) C/A intron_variant
rs1000139746 -- 90,949,961(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NECAB1 Gene

Variant ID Type Subtype PubMed ID
esv3305668 CNV mobile element insertion 20981092
esv3307995 CNV mobile element insertion 20981092
esv3361095 CNV insertion 20981092
esv3375473 CNV insertion 20981092
nsv1028201 CNV loss 25217958

Variation tolerance for NECAB1 Gene

Residual Variation Intolerance Score: 40.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NECAB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NECAB1 Gene

Disorders for NECAB1 Gene

Additional Disease Information for NECAB1

No disorders were found for NECAB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NECAB1 Gene

Publications for NECAB1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern. (PMID: 12044471) Sugita S … Südhof TC (Neuroscience 2002) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Comparative anatomical distribution of neuronal calcium-binding protein (NECAB) 1 and -2 in rodent and human spinal cord. (PMID: 26843217) Zhang MD … Hökfelt T (Brain structure & function 2016) 3 58

Products for NECAB1 Gene

Sources for NECAB1 Gene

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