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This gene produces a long non-coding RNA (lncRNA) transcribed from the multiple endocrine neoplasia locus. This lncRNA is retained in the nucleus where it forms the core structural component of the paraspeckle sub-organelles. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer progression. [provided by RefSeq, Mar 2015]
NEAT1 (Nuclear Paraspeckle Assembly Transcript 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with NEAT1 include Dengue Disease and Relapsing-Remitting Multiple Sclerosis.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IEA | -- |
GO:0035198 | miRNA binding | IDA | 28379604 |
GO:1905172 | RISC complex binding | IDA | 28379604 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0042382 | paraspeckles | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0035195 | gene silencing by miRNA | IEA | -- |
GO:0050729 | positive regulation of inflammatory response | IMP | 28379604 |
GO:0060965 | negative regulation of gene silencing by miRNA | IMP | 28379604 |
GO:1901647 | positive regulation of synoviocyte proliferation | IMP | 28379604 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS0000204428_9606 | lncRNA | 22743 | 5 |
RefSeq: NR_131012, Ensembl: ENST00000501122 (view in UCSC) , NONCODE: NONHSAT022112.2, |
URS000075DAEC_9606 | lncRNA | 3735 | 2 |
HGNC: 30815, RefSeq: NR_028272, |
URS0000D64901_9606 | lncRNA | 3524 | 2 |
Ensembl: ENST00000601801 (view in UCSC) , LNCipedia: NEAT1:31, |
URS0000D6218A_9606 | lncRNA | 3441 | 2 |
Ensembl: ENST00000499732 (view in UCSC) , LNCipedia: NEAT1:30, |
URS0000D5EDFE_9606 | lncRNA | 3300 | 2 |
Ensembl: ENST00000645023 (view in UCSC) , LNCipedia: NEAT1:34, |
This gene was present in the common ancestor of human and chimp.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-612 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2422285 | CNV | deletion | 17116639 |
esv3626673 | CNV | loss | 21293372 |
nsv526181 | CNV | gain | 19592680 |
nsv951016 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
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dengue disease |
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relapsing-remitting multiple sclerosis |
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thyroid carcinoma |
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intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies |
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leukemia |
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