This gene produces a long non-coding RNA (lncRNA) transcribed from the multiple endocrine neoplasia locus. This lncRNA is retained in the nucleus where it forms the core structural component of the paraspeckle sub-organelles. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer progression. [provided by RefSeq, Mar 2015] See more...

Aliases for NEAT1 Gene

Data sources for NEAT1 Gene:

Subcategory (RNA class) for NEAT1 Gene

lncRNA

Aliases for NEAT1 Gene

External Ids for NEAT1 Gene

Previous HGNC Symbols for NEAT1 Gene

  • NCRNA00084

Previous GeneCards Identifiers for NEAT1 Gene

  • GC11U901304
  • GC11P065190
  • GC11P065438
  • GC11P065457
  • GC11P065539
  • GC11P065550
  • GC11P065417
  • GC11P065418
  • GC11P065471
  • GC11P065478
  • GC11P065490
  • GC11P065501
  • GC11P065512
  • GC11P065521
  • GC11P065531
  • GC11P065533
  • GC11P065794

Summaries for NEAT1 Gene

Entrez Gene Summary for NEAT1 Gene

  • This gene produces a long non-coding RNA (lncRNA) transcribed from the multiple endocrine neoplasia locus. This lncRNA is retained in the nucleus where it forms the core structural component of the paraspeckle sub-organelles. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer progression. [provided by RefSeq, Mar 2015]

GeneCards Summary for NEAT1 Gene

NEAT1 (Nuclear Paraspeckle Assembly Transcript 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with NEAT1 include Dengue Disease and Relapsing-Remitting Multiple Sclerosis.

Gene Wiki entry for NEAT1 Gene

Rfam classification for NEAT1 Gene

  • Nuclear enriched abundant transcript 1 conserved region 1
  • Nuclear enriched abundant transcript 1 conserved region 2
  • Nuclear enriched abundant transcript 1 conserved region 3
  • microRNA mir-612
  • MALAT1-associated small cytoplasmic RNA/MEN beta RNA

Additional gene information for NEAT1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for NEAT1 Gene

Genomics for NEAT1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NEAT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NEAT1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for NEAT1 Gene

Latest Assembly
chr11:65,416,581-65,450,093
(GRCh38/hg38)
Size:
33,513 bases
Orientation:
Plus strand

Previous Assembly
chr11:65,190,269-65,213,011
(GRCh37/hg19 by Entrez Gene)
Size:
22,743 bases
Orientation:
Plus strand

chr11:65,190,245-65,213,011
(GRCh37/hg19 by Ensembl)
Size:
22,767 bases
Orientation:
Plus strand

Genomic View for NEAT1 Gene

Genes around NEAT1 on UCSC Golden Path with GeneCards custom track
NEAT1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
NEAT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEAT1 Gene

Proteins for NEAT1 Gene

Post-translational modifications for NEAT1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NEAT1 Gene

Domains & Families for NEAT1 Gene

Gene Families for NEAT1 Gene

genes like me logo Genes that share domains with NEAT1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NEAT1 Gene

Function for NEAT1 Gene

Phenotypes From GWAS Catalog for NEAT1 Gene

Gene Ontology (GO) - Molecular Function for NEAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0035198 miRNA binding IDA 28379604
GO:1905172 RISC complex binding IDA 28379604
genes like me logo Genes that share ontologies with NEAT1: view

CRISPR products for research

miRNA for NEAT1 Gene

miRTarBase miRNAs that target NEAT1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NEAT1 Gene

Localization for NEAT1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEAT1 gene
Compartment Confidence
nucleus 3
extracellular 2
cytoskeleton 2
mitochondrion 2
cytosol 2
plasma membrane 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NEAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042382 paraspeckles IEA --
genes like me logo Genes that share ontologies with NEAT1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for NEAT1 Gene

Pathways & Interactions for NEAT1 Gene

PathCards logo

SuperPathways for NEAT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NEAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
GO:0050729 positive regulation of inflammatory response IMP 28379604
GO:0060965 negative regulation of gene silencing by miRNA IMP 28379604
GO:1901647 positive regulation of synoviocyte proliferation IMP 28379604
genes like me logo Genes that share ontologies with NEAT1: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for NEAT1 Gene

Drugs & Compounds for NEAT1 Gene

No Compound Related Data Available

Transcripts for NEAT1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for NEAT1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000204428_9606 lncRNA 22743 5

RefSeq: NR_131012,

Ensembl: ENST00000501122 (view in UCSC) ,

LNCipedia: NEAT1:27, NEAT1:6,

NONCODE: NONHSAT022112.2,

ENA: GQ859162.1:1..22743:ncRNA,

URS0000D64901_9606 lncRNA 3524 2

Ensembl: ENST00000601801 (view in UCSC) ,

LNCipedia: NEAT1:31,

URS0000D6218A_9606 lncRNA 3443 2

Ensembl: ENST00000499732 (view in UCSC) ,

LNCipedia: NEAT1:30,

URS0000D5EDFE_9606 lncRNA 3302 2

Ensembl: ENST00000645023 (view in UCSC) ,

LNCipedia: NEAT1:34,

URS0000D5EA03_9606 lncRNA 2994 2

Ensembl: ENST00000646243 (view in UCSC) ,

LNCipedia: NEAT1:33,

NEAT1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for NEAT1 Gene

7 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for NEAT1 Gene

No ASD Table

Relevant External Links for NEAT1 Gene

GeneLoc Exon Structure for
NEAT1

Expression for NEAT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NEAT1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NEAT1

SOURCE GeneReport for Unigene cluster for NEAT1 Gene:

Hs.523789
genes like me logo Genes that share expression patterns with NEAT1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEAT1 Gene

Orthologs for NEAT1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NEAT1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-612 31
  • 100 (a)
OneToOne
Species where no ortholog for NEAT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for NEAT1 Gene

ENSEMBL:
Gene Tree for NEAT1 (if available)
TreeFam:
Gene Tree for NEAT1 (if available)

Paralogs for NEAT1 Gene

No data available for Paralogs for NEAT1 Gene

Variants for NEAT1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NEAT1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NEAT1 Gene

Variant ID Type Subtype PubMed ID
esv2422285 CNV deletion 17116639
esv3626673 CNV loss 21293372
nsv526181 CNV gain 19592680
nsv951016 CNV deletion 24416366

Additional Variant Information for NEAT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEAT1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for NEAT1 Gene

Disorders for NEAT1 Gene

MalaCards: The human disease database

(40) MalaCards diseases for NEAT1 Gene - From: LNC, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search NEAT1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NEAT1

Genetic Association Database
(GAD)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with NEAT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEAT1 Gene

Publications for NEAT1 Gene

  1. Long noncoding RNA NEAT1-modulated miR-506 regulates gastric cancer development through targeting STAT3. (PMID: 29363783) Tan HY … Zhou X (Journal of cellular biochemistry 2019) 3 74
  2. Long non-coding RNA NEAT1 regulates the proliferation, migration and invasion of gastric cancer cells via targeting miR-335-5p/ROCK1 axis. (PMID: 29544562) Wang H … Sun G (Die Pharmazie 2018) 3 74
  3. Long Noncoding RNA NEAT1 Promotes Proliferation and Invasion via Targeting miR-181a-5p in Non-Small Cell Lung Cancer. (PMID: 28762332) Li S … Yang KP (Oncology research 2018) 3 74
  4. Silence of Long Noncoding RNA NEAT1 Inhibits Malignant Biological Behaviors and Chemotherapy Resistance in Gastric Cancer. (PMID: 28401449) Zhang J … Huang B (Pathology oncology research : POR 2018) 3 74
  5. The long non-coding RNA NEAT1 contributes to extracellular matrix degradation in degenerative human nucleus pulposus cells. (PMID: 29534600) Ruan Z … Li F (Experimental biology and medicine (Maywood, N.J.) 2018) 3 74

Products for NEAT1 Gene

Sources for NEAT1 Gene