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This gene produces a long non-coding RNA (lncRNA) transcribed from the multiple endocrine neoplasia locus. This lncRNA is retained in the nucleus where it forms the core structural component of the paraspeckle sub-organelles. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer progression. [provided by RefSeq, Mar 2015] See more...
Aliases for NEAT1 Gene
Subcategory (RNA class) for NEAT1 Gene
lncRNA
Number of RNA Genes sources:
4 / 17
Aliases for NEAT1 Gene
External Ids for NEAT1 Gene
- HGNC: 30815
- Entrez Gene: 283131
- Ensembl: ENSG00000245532
- OMIM: 612769
Previous HGNC Symbols for NEAT1 Gene
- NCRNA00084
Previous GeneCards Identifiers for NEAT1 Gene
- GC11U901304
- GC11P065190
- GC11P065438
- GC11P065457
- GC11P065539
- GC11P065550
- GC11P065417
- GC11P065418
- GC11P065471
- GC11P065478
- GC11P065490
- GC11P065501
- GC11P065512
- GC11P065521
- GC11P065531
- GC11P065533
Summaries for NEAT1 Gene
-
This gene produces a long non-coding RNA (lncRNA) transcribed from the multiple endocrine neoplasia locus. This lncRNA is retained in the nucleus where it forms the core structural component of the paraspeckle sub-organelles. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer progression. [provided by RefSeq, Mar 2015]
GeneCards Summary for NEAT1 Gene
NEAT1 (Nuclear Paraspeckle Assembly Transcript 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with NEAT1 include Dengue Disease and Relapsing-Remitting Multiple Sclerosis.
Rfam classification for NEAT1 Gene
Additional gene information for NEAT1 Gene
- HGNC(30815)
- Entrez Gene(283131)
- Ensembl(ENSG00000245532)
- OMIM(612769)
- Open Targets Platform(ENSG00000245532)
- Search for NEAT1 at DataMed
- Search for NEAT1 at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for NEAT1 Gene
Genomics for NEAT1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for NEAT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NEAT1 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for NEAT1 Gene
Genomic Locations for NEAT1 Gene
- chr11:65,416,582-65,450,093
- (GRCh38/hg38)
- Size:
- 33,512 bases
- Orientation:
- Plus strand
- chr11:65,190,245-65,213,011
- (GRCh37/hg19)
- Size:
- 22,767 bases
- Orientation:
- Plus strand
Genomic View for NEAT1 Gene
Genes around NEAT1 on UCSC Golden Path with GeneCards custom track
NEAT1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
- Cytogenetic band:
-
- 11q13.1 by HGNC
- 11q13.1 by Entrez Gene
- 11q13.1 by Ensembl
NEAT1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NEAT1 Gene
Proteins for NEAT1 Gene
Post-translational modifications for NEAT1 Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for NEAT1
- Origene Custom Protein Services for NEAT1
No data available for DME Specific Peptides for NEAT1 Gene
Domains & Families for NEAT1 Gene
Gene Families for NEAT1 Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NEAT1 Gene
Function for NEAT1 Gene
Phenotypes From GWAS Catalog for NEAT1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IEA | -- |
| GO:0035198 | miRNA binding | IDA | 28379604 |
| GO:1905172 | RISC complex binding | IDA | 28379604 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NEAT1 - Select products 50% OFF >
- * NEAT1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NEAT1
miRNA for NEAT1 Gene
- miRTarBase miRNAs that target NEAT1
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for NEAT1 - Select products 50% OFF >
- * NEAT1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Addgene plasmids for NEAT1
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NEAT1 Gene
Localization for NEAT1 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| cytosol | 2 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0042382 | paraspeckles | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for NEAT1 Gene
Pathways & Interactions for NEAT1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0035195 | gene silencing by miRNA | IEA | -- |
| GO:0050729 | positive regulation of inflammatory response | IMP | 28379604 |
| GO:0060965 | negative regulation of gene silencing by miRNA | IMP | 28379604 |
| GO:1901647 | positive regulation of synoviocyte proliferation | IMP | 28379604 |
No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for NEAT1 Gene
Transcripts for NEAT1 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for NEAT1 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS0000204428_9606 | lncRNA | 22743 | 5 |
RefSeq: NR_131012, Ensembl: ENST00000501122 (view in UCSC) , NONCODE: NONHSAT022112.2, |
| URS000075DAEC_9606 | lncRNA | 3735 | 2 |
HGNC: 30815, RefSeq: NR_028272, |
| URS0000D64901_9606 | lncRNA | 3524 | 2 |
Ensembl: ENST00000601801 (view in UCSC) , LNCipedia: NEAT1:31, |
| URS0000D6218A_9606 | lncRNA | 3441 | 2 |
Ensembl: ENST00000499732 (view in UCSC) , LNCipedia: NEAT1:30, |
| URS0000D5EDFE_9606 | lncRNA | 3300 | 2 |
Ensembl: ENST00000645023 (view in UCSC) , LNCipedia: NEAT1:34, |
NEAT1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for NEAT1 Gene
- 7 NCBI additional mRNA sequence :
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NEAT1 - Select products 50% OFF >
- * NEAT1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NEAT1
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for NEAT1 - Select products 50% OFF >
- * NEAT1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Addgene plasmids for NEAT1
Relevant External Links for NEAT1 Gene
- GeneLoc Exon Structure for
- NEAT1
Expression for NEAT1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NEAT1
SOURCE GeneReport for Unigene cluster for NEAT1 Gene:
Hs.523789Evidence on tissue expression from TISSUES for NEAT1 Gene
- Blood(2.2)
- Nervous system(2.1)
- Skin(2.1)
Primer Products
-
OriGene qPCR primer pairs for NEAT1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEAT1 Gene
Orthologs for NEAT1 Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-612 31 |
|
OneToOne |
- Species where no ortholog for NEAT1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Cow (Bos Taurus)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Mouse (Mus musculus)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Paralogs for NEAT1 Gene
No data available for Paralogs for NEAT1 Gene
Variants for NEAT1 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2422285 | CNV | deletion | 17116639 |
| esv3626673 | CNV | loss | 21293372 |
| nsv526181 | CNV | gain | 19592680 |
| nsv951016 | CNV | deletion | 24416366 |
Additional Variant Information for NEAT1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NEAT1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for NEAT1 Gene
Disorders for NEAT1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dengue disease |
|
|
| relapsing-remitting multiple sclerosis |
|
|
| thyroid carcinoma |
|
|
| intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies |
|
|
| leukemia |
|
Search NEAT1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NEAT1
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for NEAT1 Gene
Publications for NEAT1 Gene
- An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles. (PMID: 19217333) Clemson CM … Lawrence JB (Molecular cell 2009) 2 3
- Repression of major histocompatibility complex genes by a human trophoblast ribonucleic acid. (PMID: 9858482) Peyman JA (Biology of reproduction 1999) 2 3
- A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. (PMID: 9253601) Guru SC … Chandrasekharappa SC (Genome research 1997) 2 3
- LncRNA NEAT1 sponges miR-214 to regulate M2 macrophage polarization by regulation of B7-H3 in multiple myeloma. (PMID: 31731055) Gao Y … Chen FP (Molecular immunology 2020) 3
- Long non-coding RNA NEAT1 promotes bladder progression through regulating miR-410 mediated HMGB1. (PMID: 31734579) Shan G … Qian HJ (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020) 3
ExternalLinks
Products for NEAT1 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for NEAT1
- Origene Custom Protein Services for NEAT1
- Browse OriGene Inhibitory RNA Products For NEAT1
- OriGene qPCR primer pairs for NEAT1
- OriGene CRISPR knockouts for NEAT1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NEAT1
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Addgene plasmids for NEAT1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for NEAT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for NEAT1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for NEAT1
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for NEAT1
Sources for NEAT1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
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- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
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- (48) IMGT
- (49) Leiden
- (50) miRBase
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- (52) OriGene
- (53) PubMed
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- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
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- (90) CYP
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- (93) PathCards
- (94) GeneReviews
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- (96) Taconic Biosciences
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- (98) ProteomicsDB
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- (104) diseasecard
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- (115) NCBI Bookshelf
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- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
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- (148) RNACentral
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- (159) GeneImprint
- (160) Synthego
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- (163) LncBase
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- (165) LNCipedia
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