This gene produces a long non-coding RNA (lncRNA) transcribed from the multiple endocrine neoplasia locus. This lncRNA is retained in the nucleus where it forms the core structural component of the paraspeckle sub-organelles. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer progression. [provided by RefSeq, Mar 2015] See more...

Aliases for NEAT1 Gene

Subcategory (RNA class) for NEAT1 Gene

lncRNA

Quality Score for this RNA gene is

16

Aliases for NEAT1 Gene

  • Nuclear Paraspeckle Assembly Transcript 1 2 3 5
  • Nuclear Paraspeckle Assembly Transcript 1 (Non-Protein Coding) 2 3
  • Long Intergenic Non-Protein Coding RNA 84 2 3
  • Nuclear Enriched Abundant Transcript 1 2 3
  • Virus Inducible Non-Coding RNA 2 3
  • NEAT1 2 170
  • Trophoblast Derived Non-Protein Coding RNA 2
  • Trophoblast MHC Class II Suppressor 3
  • Trophoblast-Derived Noncoding RNA 3
  • Non-Protein Coding RNA 84 2
  • MENepsilon/Beta 3
  • HSALNG0084892 169
  • NONHSAG008670 94
  • NCRNA00084 3
  • LINC00084 3
  • TncRNA 3
  • VINC 3

External Ids for NEAT1 Gene

Previous HGNC Symbols for NEAT1 Gene

  • NCRNA00084

Previous GeneCards Identifiers for NEAT1 Gene

  • GC11U901304
  • GC11P065190
  • GC11P065438
  • GC11P065457
  • GC11P065539
  • GC11P065550
  • GC11P065471
  • GC11P065478
  • GC11P065490
  • GC11P065501
  • GC11P065512
  • GC11P065521
  • GC11P065531
  • GC11P065533

Summaries for NEAT1 Gene

Entrez Gene Summary for NEAT1 Gene

  • This gene produces a long non-coding RNA (lncRNA) transcribed from the multiple endocrine neoplasia locus. This lncRNA is retained in the nucleus where it forms the core structural component of the paraspeckle sub-organelles. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer progression. [provided by RefSeq, Mar 2015]

GeneCards Summary for NEAT1 Gene

NEAT1 (Nuclear Paraspeckle Assembly Transcript 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with NEAT1 include Dengue Disease and Relapsing-Remitting Multiple Sclerosis.

Gene Wiki entry for NEAT1 Gene

Rfam classification for NEAT1 Gene

  • Nuclear enriched abundant transcript 1 conserved region 1
  • Nuclear enriched abundant transcript 1 conserved region 2
  • Nuclear enriched abundant transcript 1 conserved region 3
  • microRNA mir-612
  • MALAT1-associated small cytoplasmic RNA/MEN beta RNA

Additional gene information for NEAT1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for NEAT1 Gene

Genomics for NEAT1 Gene

GeneHancer (GH) Regulatory Elements for NEAT1 Gene

Promoters and enhancers for NEAT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NEAT1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NEAT1 Gene

Genomic Locations for NEAT1 Gene
chr11:65,416,582-65,450,093
(GRCh38/hg38)
Size:
33,512 bases
Orientation:
Plus strand
chr11:65,190,245-65,213,011
(GRCh37/hg19)
Size:
22,767 bases
Orientation:
Plus strand

Genomic View for NEAT1 Gene

Genes around NEAT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEAT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEAT1 Gene

Proteins for NEAT1 Gene

No data available for DME Specific Peptides for NEAT1 Gene

Domains & Families for NEAT1 Gene

Gene Families for NEAT1 Gene

genes like me logo Genes that share domains with NEAT1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NEAT1 Gene

Function for NEAT1 Gene

Phenotypes From GWAS Catalog for NEAT1 Gene

Gene Ontology (GO) - Molecular Function for NEAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0035198 miRNA binding IDA 28379604
GO:1905172 RISC complex binding IDA 28379604
genes like me logo Genes that share ontologies with NEAT1: view

Animal Model Products

CRISPR Products

miRNA for NEAT1 Gene

miRTarBase miRNAs that target NEAT1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NEAT1 Gene

Localization for NEAT1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEAT1 gene
Compartment Confidence
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for NEAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016442 RISC complex IEA --
GO:0042382 paraspeckles IEA --
genes like me logo Genes that share ontologies with NEAT1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for NEAT1 Gene

Pathways & Interactions for NEAT1 Gene

PathCards logo

SuperPathways for NEAT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NEAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
GO:0050729 positive regulation of inflammatory response IMP 28379604
GO:0060965 negative regulation of gene silencing by miRNA IMP 28379604
GO:1901647 positive regulation of synoviocyte proliferation IMP 28379604
genes like me logo Genes that share ontologies with NEAT1: view

No data available for Pathways by source and SIGNOR curated interactions for NEAT1 Gene

Drugs & Compounds for NEAT1 Gene

No Compound Related Data Available

Transcripts for NEAT1 Gene

mRNA/cDNA for NEAT1 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(9) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(37) RNACentral transcripts :
(13) LncBook transcripts :
(35) LNCipedia transcripts :
(7) NONCODE transcripts :
(1) ENA transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEAT1 Gene

No ASD Table

Relevant External Links for NEAT1 Gene

GeneLoc Exon Structure for
NEAT1
ECgene alternative splicing isoforms for
NEAT1

Expression for NEAT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NEAT1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NEAT1 Gene:

NEAT1

SOURCE GeneReport for Unigene cluster for NEAT1 Gene:

Hs.523789
genes like me logo Genes that share expression patterns with NEAT1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEAT1 Gene

Orthologs for NEAT1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NEAT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-612 33
  • 100 (a)
OneToOne
Species where no ortholog for NEAT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NEAT1 Gene

ENSEMBL:
Gene Tree for NEAT1 (if available)
TreeFam:
Gene Tree for NEAT1 (if available)

Paralogs for NEAT1 Gene

No data available for Paralogs for NEAT1 Gene

Variants for NEAT1 Gene

Sequence variations from dbSNP and Humsavar for NEAT1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000725681 -- 65,441,914(+) G/A genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000833787 -- 65,428,851(+) C/T genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000889900 -- 65,429,742(+) C/T genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000995374 -- 65,424,017(+) G/A non_coding_transcript_variant
rs1001200330 -- 65,436,570(+) T/C/G genic_downstream_transcript_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NEAT1 Gene

Variant ID Type Subtype PubMed ID
esv2422285 CNV deletion 17116639
esv3626673 CNV loss 21293372
nsv526181 CNV gain 19592680
nsv951016 CNV deletion 24416366

Additional Variant Information for NEAT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEAT1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for NEAT1 Gene

Disorders for NEAT1 Gene

MalaCards: The human disease database

(36) MalaCards diseases for NEAT1 Gene - From: LncRNADisease, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search NEAT1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NEAT1

genes like me logo Genes that share disorders with NEAT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEAT1 Gene

Publications for NEAT1 Gene

  1. An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles. (PMID: 19217333) Clemson CM … Lawrence JB (Molecular cell 2009) 2 3 56
  2. Repression of major histocompatibility complex genes by a human trophoblast ribonucleic acid. (PMID: 9858482) Peyman JA (Biology of reproduction 1999) 2 3 56
  3. A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. (PMID: 9253601) Guru SC … Chandrasekharappa SC (Genome research 1997) 2 3 56
  4. LncRNA NEAT1/miR-29b-3p/BMP1 axis promotes osteogenic differentiation in human bone marrow-derived mesenchymal stem cells. (PMID: 30638953) Zhang Y … Chen Z (Pathology, research and practice 2019) 3 56
  5. Dysregulation of miR-335-3p, targeted by NEAT1 and MALAT1 long non-coding RNAs, is associated with poor prognosis in childhood acute lymphoblastic leukemia. (PMID: 30639603) Pouyanrad S … Ghodousi ES (Gene 2019) 3 56

Products for NEAT1 Gene

Sources for NEAT1 Gene