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The protein encoded by this gene is one of at least forty-one subunits that make up the NADH-ubiquinone oxidoreductase complex. This complex is part of the mitochondrial respiratory chain and serves to catalyze the rotenone-sensitive oxidation of NADH and the reduction of ubiquinone. The encoded protein is one of three proteins found in the flavoprotein fraction of the complex.... See more...
Aliases for NDUFV3 Gene
Aliases for NDUFV3 Gene
- NADH:Ubiquinone Oxidoreductase Subunit V3 2 3 5
- NADH Dehydrogenase [Ubiquinone] Flavoprotein 3, Mitochondrial 3 4
- NADH Dehydrogenase (Ubiquinone) Flavoprotein 3, 10kDa 2 3
- NADH-Ubiquinone Oxidoreductase 9 KDa Subunit 3 4
- Renal Carcinoma Antigen NY-REN-4 3 4
- Complex I 10kDa Subunit 2 3
- Complex I-9kD 3 4
External Ids for NDUFV3 Gene
- HGNC: 7719
- Entrez Gene: 4731
- Ensembl: ENSG00000160194
- OMIM: 602184
- UniProtKB: P56181
Previous GeneCards Identifiers for NDUFV3 Gene
- GC21P040847
- GC21P043194
- GC21P043193
- GC21P043172
- GC21P044299
Summaries for NDUFV3 Gene
-
The protein encoded by this gene is one of at least forty-one subunits that make up the NADH-ubiquinone oxidoreductase complex. This complex is part of the mitochondrial respiratory chain and serves to catalyze the rotenone-sensitive oxidation of NADH and the reduction of ubiquinone. The encoded protein is one of three proteins found in the flavoprotein fraction of the complex. The specific function of the encoded protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for NDUFV3 Gene
NDUFV3 (NADH:Ubiquinone Oxidoreductase Subunit V3) is a Protein Coding gene. Diseases associated with NDUFV3 include Nonsyndromic Deafness and Visual Epilepsy. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and GABAergic synapse. Gene Ontology (GO) annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.
UniProtKB/Swiss-Prot Summary for NDUFV3 Gene
-
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.
Additional gene information for NDUFV3 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NDUFV3 Gene
Genomics for NDUFV3 Gene
GeneHancer (GH) Regulatory Elements for NDUFV3 Gene
Promoters and enhancers for NDUFV3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NDUFV3 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NDUFV3
- Top Transcription factor binding sites by QIAGEN in the NDUFV3 gene promoter:
-
- ATF-2
- c-Jun
- E47
- Hand1
- HEN1
- POU2F1
- POU2F1a
- PPAR-gamma1
- PPAR-gamma2
- Zic3
Genomic Locations for NDUFV3 Gene
Genomic Locations for NDUFV3 Gene
- chr21:42,879,644-42,913,304
- (GRCh38/hg38)
- Size:
- 33,661 bases
- Orientation:
- Plus strand
- chr21:44,299,754-44,333,414
- (GRCh37/hg19)
- Size:
- 33,661 bases
- Orientation:
- Plus strand
Genomic View for NDUFV3 Gene
Genes around NDUFV3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.3 by HGNC
- 21q22.3 by Entrez Gene
- 21q22.3 by Ensembl
NDUFV3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NDUFV3 Gene
Proteins for NDUFV3 Gene
-
Protein details for NDUFV3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P56181-NDUV3_HUMAN
- Recommended name:
- NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
- Protein Accession:
- P56181
- A8K0M1
- J3KNX7
- Q6FGD3
- Q8WU60
- Q9HCR5
Protein attributes for NDUFV3 Gene
- Size:
- 108 amino acids
- Molecular mass:
- 11941 Da
- Quaternary structure:
-
- Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.
Three dimensional structures from OCA and Proteopedia for NDUFV3 Gene
Protein Expression for NDUFV3 Gene
Post-translational modifications for NDUFV3 Gene
Other Protein References for NDUFV3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-NDUFV3 (aa 1-100) polyclonal antibody
- Creative Biolabs Recombinant Anti-Human NDUFV3 Antibody
- Novus Biologicals Antibodies for NDUFV3
-
Abcam antibodies for NDUFV3
- Invitrogen Antibodies for NDUFV3 (AFLGC-NDUFV3)
- antibodies-online: Show 7 available NDUFV3 Antibodies ranked by validation data
-
Biorbyt antibodies for NDUFV3
-
Boster Bio Antibodies for NDUFV3
Protein Products
-
OriGene Purified Proteins for NDUFV3
- Search Origene for MassSpec and Protein Over-expression Lysates for NDUFV3
- Origene Custom Protein Services for NDUFV3
- ProSpec Recombinant Proteins for NDUFV3
- antibodies-online: Show 10 available NDUFV3 Proteins ranked by validation data
- Compare Top NDUFV3 Proteins
-
Quality Products:
-
Abcam proteins for NDUFV3
No data available for DME Specific Peptides for NDUFV3 Gene
Domains & Families for NDUFV3 Gene
Gene Families for NDUFV3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for NDUFV3 Gene
- GenScript: Design optimal peptide antigens:
-
- Renal carcinoma antigen NY-REN-4 (NDUV3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P56181- Family:
-
- Belongs to the complex I NDUFV3 subunit family.
Function for NDUFV3 Gene
Molecular function for NDUFV3 Gene
- UniProtKB/Swiss-Prot Function:
- Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.
- GENATLAS Biochemistry:
- NADH ubiquinone dehydrogenase (Q reductase),component of the complex I multi-subunit of the phosphorylation (OXPHOS),flavoprotein 3,inner mitochondrial membrane,ubiquitously expressed
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0005515 | protein binding | IPI | 24344204 |
| GO:0008137 | NADH dehydrogenase (ubiquinone) activity | NAS,TAS | 9878551 |
Phenotypes for NDUFV3 Gene
- GenomeRNAi human phenotypes for NDUFV3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NDUFV3 - Select products 50% OFF >
- * NDUFV3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NDUFV3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NDUFV3
- genomics-online: gRNA clones - Search results for available NDUFV3 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for NDUFV3
miRNA for NDUFV3 Gene
- miRTarBase miRNAs that target NDUFV3
-
- hsa-mir-30a-5p (MIRT028497)
- hsa-mir-1226-3p (MIRT036526)
- hsa-mir-92a-3p (MIRT049551)
- hsa-mir-17-3p (MIRT050773)
- hsa-mir-4777-5p (MIRT441991)
- hsa-mir-526a (MIRT441992)
- hsa-mir-523-5p (MIRT441993)
- hsa-mir-522-5p (MIRT441994)
- hsa-mir-520c-5p (MIRT441995)
- hsa-mir-519c-5p (MIRT441996)
- hsa-mir-519b-5p (MIRT441997)
- hsa-mir-519a-5p (MIRT441998)
- hsa-mir-518f-5p (MIRT441999)
- hsa-mir-518e-5p (MIRT442000)
- hsa-mir-518d-5p (MIRT442001)
- hsa-mir-8067 (MIRT442002)
- hsa-mir-3974 (MIRT442003)
- hsa-mir-6508-5p (MIRT442004)
- hsa-mir-4753-5p (MIRT442005)
- hsa-mir-4484 (MIRT442006)
- hsa-mir-6768-3p (MIRT442007)
- hsa-mir-548an (MIRT442008)
- hsa-mir-1303 (MIRT517102)
- hsa-mir-129-5p (MIRT517103)
- hsa-mir-3149 (MIRT517104)
- hsa-mir-4775 (MIRT517105)
- hsa-mir-633 (MIRT517106)
- hsa-mir-193b-5p (MIRT517107)
- hsa-mir-4735-5p (MIRT517108)
- hsa-mir-6872-3p (MIRT517109)
- hsa-mir-3976 (MIRT517110)
- hsa-mir-483-5p (MIRT517111)
- hsa-mir-7153-3p (MIRT517112)
- hsa-mir-590-3p (MIRT517113)
- hsa-mir-6855-5p (MIRT517114)
- hsa-mir-3170 (MIRT517115)
- hsa-mir-411-5p (MIRT517116)
- hsa-mir-6832-5p (MIRT517117)
- hsa-mir-661 (MIRT517118)
- hsa-mir-3116 (MIRT517119)
- hsa-mir-1254 (MIRT517120)
- hsa-mir-1273f (MIRT517121)
- hsa-mir-6504-5p (MIRT517122)
- hsa-mir-3064-5p (MIRT517123)
- hsa-mir-29a-5p (MIRT517124)
- hsa-mir-6890-5p (MIRT517125)
- hsa-mir-378a-5p (MIRT629651)
- hsa-mir-6778-3p (MIRT629652)
- hsa-mir-6821-3p (MIRT629653)
- hsa-mir-6790-3p (MIRT629654)
- hsa-mir-18a-3p (MIRT629655)
- hsa-mir-324-3p (MIRT629656)
- hsa-mir-1913 (MIRT629657)
- hsa-mir-1976 (MIRT629658)
- hsa-mir-3653-5p (MIRT629659)
- hsa-mir-1224-3p (MIRT629660)
- hsa-mir-6836-3p (MIRT631654)
- hsa-mir-5001-3p (MIRT631655)
- hsa-mir-4279 (MIRT631656)
- hsa-mir-23c (MIRT631657)
- hsa-mir-23b-3p (MIRT631658)
- hsa-mir-23a-3p (MIRT631659)
- hsa-mir-130a-5p (MIRT631660)
- hsa-mir-3194-3p (MIRT631661)
- hsa-mir-6829-3p (MIRT631662)
- hsa-mir-6791-3p (MIRT631663)
- hsa-mir-4532 (MIRT631664)
- hsa-mir-1247-3p (MIRT631665)
- hsa-mir-382-3p (MIRT631666)
- hsa-mir-6848-3p (MIRT710517)
- hsa-mir-6843-3p (MIRT710518)
- hsa-mir-6131 (MIRT710519)
- hsa-mir-3663-5p (MIRT710520)
- hsa-mir-150-5p (MIRT710521)
- hsa-mir-372-5p (MIRT710522)
- hsa-mir-371a-5p (MIRT710523)
- hsa-mir-616-5p (MIRT710524)
- hsa-mir-373-5p (MIRT710525)
- hsa-mir-371b-5p (MIRT710526)
- hsa-mir-484 (MIRT710527)
- hsa-mir-3155b (MIRT710528)
- hsa-mir-3155a (MIRT710529)
- hsa-mir-328-3p (MIRT714045)
- hsa-mir-874-3p (MIRT714046)
- hsa-mir-6851-3p (MIRT714047)
- hsa-mir-6775-3p (MIRT714048)
- hsa-mir-1291 (MIRT714049)
- hsa-mir-146b-3p (MIRT714050)
- hsa-mir-6799-3p (MIRT714051)
- hsa-mir-3173-5p (MIRT714052)
- hsa-mir-7976 (MIRT714053)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NDUFV3
- Browse OriGene Inhibitory RNA Products For NDUFV3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NDUFV3
- genomics-online: shRNA clones - Search results for available NDUFV3 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for NDUFV3 - Select products 50% OFF >
- * NDUFV3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG207506
- MG215953
- MR207506
- MR207506L3
- MR207506L4
- MR215953
- MR215953L3
- MR215953L4
- RC202915
- RC202915L3
- RC202915L4
- RC215334
- RC215334L3
- RC215334L4
- RG202915
- RG215334
- RR200315
- RR200315L3
- RR200315L4
- RR200316
- RR200316L3
- RR200316L4
- MR207506L3V
- MR207506L4V
- MR215953L3V
- MR215953L4V
- RC202915L3V
- RC202915L4V
- RC215334L3V
- RC215334L4V
- RR200315L3V
- RR200315L4V
- RR200316L3V
- RR200316L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NDUFV3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NDUFV3
- genomics-online: cdna clones - Search results for available NDUFV3 gene related products
- orf clones - Search results for available NDUFV3 gene related products
Cell Line Products
-
Horizon Cell Lines for NDUFV3
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NDUFV3 Gene
Localization for NDUFV3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NDUFV3 Gene
- Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 4 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
- Mitochondria (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005739 | mitochondrion | HDA,IEA | 20833797 |
| GO:0005743 | mitochondrial inner membrane | TAS | -- |
| GO:0005747 | mitochondrial respiratory chain complex I | IMP,NAS | 9878551 |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for NDUFV3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
.40
|
|
| 2 | Metabolism |
.40
|
|
| 3 | GABAergic synapse | ||
| 4 | FOXA1 transcription factor network | ||
Pathways by source for NDUFV3 Gene
3 BioSystems pathways for NDUFV3 Gene
8 KEGG pathways for NDUFV3 Gene
Interacting Proteins for NDUFV3 Gene
Selected Interacting proteins:
P56181-NDUV3_HUMAN
ENSP00000346196
for NDUFV3 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for NDUFV3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006120 | mitochondrial electron transport, NADH to ubiquinone | TAS | -- |
| GO:0032981 | mitochondrial respiratory chain complex I assembly | TAS | -- |
| GO:0042775 | mitochondrial ATP synthesis coupled electron transport | IMP | 24746669 |
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for SIGNOR curated interactions for NDUFV3 Gene
Transcripts for NDUFV3 Gene
mRNA/cDNA for NDUFV3 Gene
- 2 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000340344 4676 bps (ENST00000340344.4)
- ENST00000354250 5725 bps (ENST00000354250.7)
- ENST00000460259 2029 bps (ENST00000460259.1)
- ENST00000460740 811 bps (ENST00000460740.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NDUFV3 - Select products 50% OFF >
- * NDUFV3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NDUFV3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NDUFV3
- genomics-online: gRNA clones - Search results for available NDUFV3 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for NDUFV3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NDUFV3
- Browse OriGene Inhibitory RNA Products For NDUFV3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NDUFV3
- genomics-online: shRNA clones - Search results for available NDUFV3 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for NDUFV3 - Select products 50% OFF >
- * NDUFV3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG207506
- MG215953
- MR207506
- MR207506L3
- MR207506L4
- MR215953
- MR215953L3
- MR215953L4
- RC202915
- RC202915L3
- RC202915L4
- RC215334
- RC215334L3
- RC215334L4
- RG202915
- RG215334
- RR200315
- RR200315L3
- RR200315L4
- RR200316
- RR200316L3
- RR200316L4
- MR207506L3V
- MR207506L4V
- MR215953L3V
- MR215953L4V
- RC202915L3V
- RC202915L4V
- RC215334L3V
- RC215334L4V
- RR200315L3V
- RR200315L4V
- RR200316L3V
- RR200316L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NDUFV3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NDUFV3
- genomics-online: cdna clones - Search results for available NDUFV3 gene related products
- orf clones - Search results for available NDUFV3 gene related products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||
| SP2: | - | - | - | - | |||||||||||||
| SP3: | |||||||||||||||||
| SP4: | - | - | |||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||
| SP6: |
Relevant External Links for NDUFV3 Gene
- GeneLoc Exon Structure for
- NDUFV3
Expression for NDUFV3 Gene
mRNA differential expression in normal tissues according to GTEx for NDUFV3 Gene
This gene is overexpressed in Muscle - Skeletal (x4.1) and Heart - Left Ventricle (x4.0).
This gene is overexpressed in Heart (23.1) and Fetal Brain (10.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NDUFV3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NDUFV3
SOURCE GeneReport for Unigene cluster for NDUFV3 Gene:
Hs.473937Evidence on tissue expression from TISSUES for NDUFV3 Gene
- Nervous system(4.5)
- Liver(4.2)
Primer Products
-
OriGene qPCR primer pairs for NDUFV3
-
OriGene qPCR primer pairs and template standards for NDUFV3
- genomics-online: primer clones - Search results for available NDUFV3 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NDUFV3 Gene
Orthologs for NDUFV3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NDUFV3 31 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | NDUFV3 31 30 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ndufv3 17 31 30 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ndufv3 30 |
|
||
| cow (Bos Taurus) |
Mammalia | NDUFV3 31 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | NDUFV3 31 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | NDUFV3 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NDUFV3 31 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | ndufv3 31 31 |
|
OneToMany | |
| wufl83h06 30 |
|
- Species where no ortholog for NDUFV3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for NDUFV3 Gene
- ENSEMBL:
- Gene Tree for NDUFV3 (if available)
- TreeFam:
- Gene Tree for NDUFV3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NDUFV3: view image
Paralogs for NDUFV3 Gene
No data available for Paralogs for NDUFV3 Gene
Variants for NDUFV3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NDUFV3 Gene
| SNP ID | Clinical significance and condition | Chr 21 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 781907 | Likely Benign: not provided | 42,893,344(+) | C/G | MISSENSE_VARIANT | |
| rs141922962 | Likely Benign: not specified | 42,897,046(+) | A/C | MISSENSE_VARIANT | |
| rs368251445 | Uncertain Significance: not provided | 42,904,261(+) | C/T | NONSENSE,INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1340851 | CNV | insertion | 17803354 |
| esv1737156 | CNV | insertion | 17803354 |
| esv2652948 | CNV | insertion | 19546169 |
| esv2666871 | CNV | deletion | 23128226 |
| esv3568210 | CNV | loss | 25503493 |
| esv3584478 | CNV | gain | 24956385 |
| nsv187067 | CNV | insertion | 16902084 |
| nsv587657 | CNV | gain | 21841781 |
| nsv834105 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
44.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.11;
69.19% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NDUFV3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFV3 Gene
Disorders for NDUFV3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| nonsyndromic deafness |
|
|
| visual epilepsy |
|
|
Search NDUFV3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NDUFV3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for NDUFV3 Gene
Publications for NDUFV3 Gene
- Molecular cloning and characterization of the human mitochondrial NADH:oxidoreductase 10-kDa gene (NDUFV3). (PMID: 9344673) de Coo RF … van Oost BA (Genomics 1997) 2 3 4 23 54
- Accessory subunits are integral for assembly and function of human mitochondrial complex I. (PMID: 27626371) Stroud DA … Ryan MT (Nature 2016) 3 4 54
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41 54
- Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 41 54
- Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L … Thibodeau SN (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 41 54
ExternalLinks
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