Aliases for NDUFS8 Gene
- NADH:Ubiquinone Oxidoreductase Core Subunit S8 2 3 5
- NADH Dehydrogenase [Ubiquinone] Iron-Sulfur Protein 8, Mitochondrial 2 3 4
- NADH Dehydrogenase (Ubiquinone) Fe-S Protein 8, 23kDa (NADH-Coenzyme Q Reductase) 2 3
- NADH-Ubiquinone Oxidoreductase 23 KDa Subunit 3 4
- Complex I 23kDa Subunit 2 3
- Complex I-23kD 3 4
- NADH Dehydrogenase (Ubiquinone) Fe-S Protein 8 (23kD) (NADH-Coenzyme Q Reductase) 2
- TYKY Subunit 4
External Ids for NDUFS8 Gene
Previous GeneCards Identifiers for NDUFS8 Gene
This gene encodes a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or Complex I, a multimeric enzyme of the respiratory chain responsible for NADH oxidation, ubiquinone reduction, and the ejection of protons from mitochondria. The encoded protein is involved in the binding of two of the six to eight iron-sulfur clusters of Complex I and, as such, is required in the electron transfer process. Mutations in this gene have been associated with Leigh syndrome. [provided by RefSeq, Mar 2010]
GeneCards Summary for NDUFS8 Gene
NDUFS8 (NADH:Ubiquinone Oxidoreductase Core Subunit S8) is a Protein Coding gene. Diseases associated with NDUFS8 include Mitochondrial Complex I Deficiency, Nuclear Type 2 and Leigh Syndrome With Leukodystrophy. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and GABAergic synapse. Gene Ontology (GO) annotations related to this gene include NADH dehydrogenase (ubiquinone) activity and iron-sulfur cluster binding.
UniProtKB/Swiss-Prot Summary for NDUFS8 Gene
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone.