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Aliases for NDUFS6 Gene

Aliases for NDUFS6 Gene

  • NADH:Ubiquinone Oxidoreductase Subunit S6 2 3 5
  • NADH Dehydrogenase (Ubiquinone) Fe-S Protein 6, 13kDa (NADH-Coenzyme Q Reductase) 2 3
  • NADH Dehydrogenase [Ubiquinone] Iron-Sulfur Protein 6, Mitochondrial 2 3
  • NADH-Ubiquinone Oxidoreductase 13 KDa-A Subunit 3 4
  • Complex I 13kDa Subunit A 2 3
  • CI-13kD-A 3 4
  • NADH Dehydrogenase (Ubiquinone) Fe-S Protein 6 (13kD) (NADH-Coenzyme Q Reductase) 2
  • Complex I, Mitochondrial Respiratory Chain, 13-KD Subunit 3
  • NADH:Ubiquinone Oxidoreductase NDUFS6 Subunit 3
  • Complex I-13kD-A 4
  • CI-13kA 3
  • CI13KDA 3

External Ids for NDUFS6 Gene

Previous GeneCards Identifiers for NDUFS6 Gene

  • GC05P001942
  • GC05P001834
  • GC05P001854

Summaries for NDUFS6 Gene

Entrez Gene Summary for NDUFS6 Gene

  • This gene encodes a subunit of the NADH:ubiquinone oxidoreductase (complex I), which is the first enzyme complex in the electron transport chain of mitochondria. This complex functions in the transfer of electrons from NADH to the respiratory chain. The subunit encoded by this gene is one of seven subunits in the iron-sulfur protein fraction. Mutations in this gene cause mitochondrial complex I deficiency, a disease that causes a wide variety of clinical disorders, including neonatal disease and adult-onset neurodegenerative disorders.[provided by RefSeq, Oct 2009]

GeneCards Summary for NDUFS6 Gene

NDUFS6 (NADH:Ubiquinone Oxidoreductase Subunit S6) is a Protein Coding gene. Diseases associated with NDUFS6 include Mitochondrial Complex I Deficiency and Leigh Syndrome. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include electron transfer activity and NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFS6 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Wiki entry for NDUFS6 Gene

Additional gene information for NDUFS6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFS6 Gene

Genomics for NDUFS6 Gene

GeneHancer (GH) Regulatory Elements for NDUFS6 Gene

Promoters and enhancers for NDUFS6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J001798 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 -0.6 -640 4.1 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 MRPL36 NDUFS6 GC05P001799 SDHAP3 BRD9 LOC100132773 LOC728613 ENSG00000271119
GH05J001788 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 650.4 -9.2 -9181 6.6 HDGF PKNOX1 SMAD1 FEZF1 ZNF2 IRF4 YY1 ZNF207 ZNF143 ATF7 LOC101929003 NDUFS6 BRD9 LOC100132773 MRPL36 PIR36348
GH05J001948 Enhancer 1.1 ENCODE dbSUPER 10.5 +148.1 148090 2.7 ZNF493 ZNF133 ZNF2 GLIS2 ZNF416 ZNF548 FOS KLF13 SP3 YY2 SDHAP3 ENSG00000271119 LOC728613 LOC100132773 CTD-2194D22.4 LINC02116 MTCO2P32 LOC105374620 NDUFS6 MRPL36
GH05J001641 Enhancer 0.9 ENCODE 10.8 -159.6 -159631 0.2 ATF1 ARNT ARID4B ZNF2 ZNF143 DEK SP5 REST MIER2 ZNF592 GC05M001591 SDHAP3 LOC728613 NDUFS6 MRPL36 ENSG00000250173
GH05J001644 Enhancer 0.9 ENCODE 10.8 -156.3 -156311 0.2 ATF1 ARID4B SIN3A ZNF2 ZNF48 GLIS2 E2F8 ZNF143 ATF7 RUNX3 GC05M001591 LOC728613 NDUFS6 MRPL36 ENSG00000250173 PIR51678
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NDUFS6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NDUFS6 gene promoter:
  • ER-alpha
  • Pax-2a
  • Pax-2
  • MIF-1
  • MEF-2A
  • aMEF-2
  • GATA-1
  • c-Myb
  • RFX1
  • Nkx2-5

Genomic Locations for NDUFS6 Gene

Genomic Locations for NDUFS6 Gene
15,224 bases
Plus strand
15,224 bases
Plus strand

Genomic View for NDUFS6 Gene

Genes around NDUFS6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDUFS6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDUFS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFS6 Gene

Proteins for NDUFS6 Gene

  • Protein details for NDUFS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
    Protein Accession:

    Protein attributes for NDUFS6 Gene

    124 amino acids
    Molecular mass:
    13712 Da
    Quaternary structure:
    • Mammalian complex I is composed of 45 different subunits (PubMed:12611891, PubMed:27626371). This is a component of the iron-sulfur (IP) fragment of the enzyme (PubMed:12611891).

    Three dimensional structures from OCA and Proteopedia for NDUFS6 Gene

neXtProt entry for NDUFS6 Gene

Post-translational modifications for NDUFS6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NDUFS6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NDUFS6 Gene

Domains & Families for NDUFS6 Gene

Gene Families for NDUFS6 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NDUFS6 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the complex I NDUFS6 subunit family.
  • Belongs to the complex I NDUFS6 subunit family.
genes like me logo Genes that share domains with NDUFS6: view

Function for NDUFS6 Gene

Molecular function for NDUFS6 Gene

UniProtKB/Swiss-Prot Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
GENATLAS Biochemistry:
NADH ubiquinone oxidoreductase (Q reductase),13kDa,component of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),iron-sulfur protein 6,inner mitochondrial membrane

Phenotypes From GWAS Catalog for NDUFS6 Gene

Gene Ontology (GO) - Molecular Function for NDUFS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS 9647766
GO:0009055 electron transfer activity NAS 9647766
genes like me logo Genes that share ontologies with NDUFS6: view
genes like me logo Genes that share phenotypes with NDUFS6: view

Human Phenotype Ontology for NDUFS6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for NDUFS6 Gene

miRTarBase miRNAs that target NDUFS6

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NDUFS6

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NDUFS6 Gene

Localization for NDUFS6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFS6 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NDUFS6 gene
Compartment Confidence
mitochondrion 5
plasma membrane 1
extracellular 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for NDUFS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS 9878551
GO:0016020 membrane IEA --
GO:0070469 respiratory chain IEA --
genes like me logo Genes that share ontologies with NDUFS6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NDUFS6 Gene

Pathways & Interactions for NDUFS6 Gene

genes like me logo Genes that share pathways with NDUFS6: view

Gene Ontology (GO) - Biological Process for NDUFS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone IBA,TAS --
GO:0006631 fatty acid metabolic process IEA --
GO:0006936 muscle contraction IEA --
GO:0010259 multicellular organism aging IEA --
GO:0022904 respiratory electron transport chain IEA --
genes like me logo Genes that share ontologies with NDUFS6: view

No data available for SIGNOR curated interactions for NDUFS6 Gene

Drugs & Compounds for NDUFS6 Gene

(5) Drugs for NDUFS6 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Approved Nutra Target 0
FAD Approved Pharma 0
Ubiquinone-1 Experimental Pharma 0
Ubiquinone-2 Experimental Pharma 0
NAD Pharma Full agonist, Agonist, Activator 0

(3) Additional Compounds for NDUFS6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • FE (II) ion
  • Fe(II)
  • Fe(2+)
  • Ferrous ion
  • Iron ion(2+)
  • CoQH2
  • Coenzymes QH2
  • Reduced ubiquinone
  • Ubiquinol
  • Ubiquinone-1
  • S(2-)
  • Sulphide
  • Sulfanediide
  • Sulfur
genes like me logo Genes that share compounds with NDUFS6: view

Transcripts for NDUFS6 Gene

mRNA/cDNA for NDUFS6 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(234) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NDUFS6 Gene

NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NDUFS6

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFS6 Gene

No ASD Table

Relevant External Links for NDUFS6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NDUFS6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NDUFS6 Gene

mRNA differential expression in normal tissues according to GTEx for NDUFS6 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.1).

Protein differential expression in normal tissues from HIPED for NDUFS6 Gene

This gene is overexpressed in Heart (11.2), Peripheral blood mononuclear cells (7.4), and Brain (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NDUFS6 Gene

Protein tissue co-expression partners for NDUFS6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NDUFS6 Gene:


SOURCE GeneReport for Unigene cluster for NDUFS6 Gene:


Evidence on tissue expression from TISSUES for NDUFS6 Gene

  • Liver(4.4)
  • Lung(4.3)
  • Skin(4.3)
  • Heart(2.3)
  • Muscle(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for NDUFS6 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • endocrine
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Head and neck:
  • brain
  • cerebellum
  • cerebrospinal fluid
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • head
  • meninges
  • neck
  • skull
  • esophagus
  • heart
  • heart valve
  • lung
  • adrenal gland
  • liver
  • stomach
  • foot
  • lower limb
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal cord
  • sweat gland
genes like me logo Genes that share expression patterns with NDUFS6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NDUFS6 Gene

Orthologs for NDUFS6 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDUFS6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NDUFS6 34 33
  • 99.73 (n)
(Canis familiaris)
Mammalia NDUFS6 34
  • 85 (a)
(Bos Taurus)
Mammalia NDUFS6 34 33
  • 83.06 (n)
(Mus musculus)
Mammalia Ndufs6 34 33
  • 82.76 (n)
Ndufs6b 16
(Rattus norvegicus)
Mammalia LOC679739 33
  • 81.9 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 79 (a)
-- 34
  • 77 (a)
-- 34
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia NDUFS6 34
  • 76 (a)
(Gallus gallus)
Aves NDUFS6 34 33
  • 71 (n)
(Anolis carolinensis)
Reptilia NDUFS6 34
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufs6 33
  • 70.59 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7070 33
(Danio rerio)
Actinopterygii ndufs6 34 33
  • 66.67 (n)
Dr.15123 33
fruit fly
(Drosophila melanogaster)
Insecta CG8680 34 33
  • 59 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009072 33
  • 55.26 (n)
(Caenorhabditis elegans)
Secernentea nduf-6 34 33
  • 53.1 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5753 34
  • 38 (a)
Species where no ortholog for NDUFS6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDUFS6 Gene

Gene Tree for NDUFS6 (if available)
Gene Tree for NDUFS6 (if available)
Evolutionary constrained regions (ECRs) for NDUFS6: view image

Paralogs for NDUFS6 Gene Pseudogenes for NDUFS6 Gene

genes like me logo Genes that share paralogs with NDUFS6: view

No data available for Paralogs for NDUFS6 Gene

Variants for NDUFS6 Gene

Sequence variations from dbSNP and Humsavar for NDUFS6 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs10058270 likely-benign, Mitochondrial complex I deficiency 1,815,836(+) T/C intron_variant
rs140887831 uncertain-significance, Mitochondrial complex I deficiency 1,814,350(+) C/T coding_sequence_variant, synonymous_variant
rs145747389 benign, uncertain-significance, not specified, Mitochondrial complex I deficiency 1,801,406(+) C/T 5_prime_UTR_variant
rs200445799 uncertain-significance, likely-benign, Mitochondrial complex I deficiency, not specified 1,815,931(+) C/T 3_prime_UTR_variant
rs267606913 pathogenic, Mitochondrial complex I deficiency, Mitochondrial complex I deficiency (MT-C1D) [MIM:252010] 1,815,885(+) G/A coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for NDUFS6 Gene

Variant ID Type Subtype PubMed ID
esv3603817 CNV gain 21293372
nsv1033147 CNV gain 25217958
nsv1140355 OTHER inversion 24896259

Variation tolerance for NDUFS6 Gene

Residual Variation Intolerance Score: 49.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NDUFS6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFS6 Gene

Disorders for NDUFS6 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NDUFS6 Gene - From: HGMD, OMIM, ClinVar, GTR, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
mitochondrial complex i deficiency
  • nadh:q(1) oxidoreductase deficiency
leigh syndrome
  • ls
leber hereditary optic neuropathy
  • leber optic atrophy
- elite association - COSMIC cancer census association via MalaCards


  • Mitochondrial complex I deficiency (MT-C1D) [MIM:252010]: A disorder of the mitochondrial respiratory chain that causes a wide range of clinical manifestations from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. {ECO:0000269 PubMed:15372108, ECO:0000269 PubMed:19259137}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for NDUFS6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NDUFS6: view

No data available for Genatlas for NDUFS6 Gene

Publications for NDUFS6 Gene

  1. Accessory subunits are integral for assembly and function of human mitochondrial complex I. (PMID: 27626371) Stroud DA … Ryan MT (Nature 2016) 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 44 58
  4. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PMID: 18977241) Starr JM … Deary IJ (Mechanisms of ageing and development 2008) 3 44 58
  5. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L … Thibodeau SN (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 44 58

Products for NDUFS6 Gene

Sources for NDUFS6 Gene

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