Aliases for NDUFS6 Gene
- NADH:Ubiquinone Oxidoreductase Subunit S6 2 3 5
- NADH Dehydrogenase [Ubiquinone] Iron-Sulfur Protein 6, Mitochondrial 2 3 4
- NADH Dehydrogenase (Ubiquinone) Fe-S Protein 6, 13kDa (NADH-Coenzyme Q Reductase) 2 3
- NADH-Ubiquinone Oxidoreductase 13 KDa-A Subunit 3 4
- Complex I 13kDa Subunit A 2 3
- CI-13kD-A 3 4
External Ids for NDUFS6 Gene
Previous GeneCards Identifiers for NDUFS6 Gene
This gene encodes a subunit of the NADH:ubiquinone oxidoreductase (complex I), which is the first enzyme complex in the electron transport chain of mitochondria. This complex functions in the transfer of electrons from NADH to the respiratory chain. The subunit encoded by this gene is one of seven subunits in the iron-sulfur protein fraction. Mutations in this gene cause mitochondrial complex I deficiency, a disease that causes a wide variety of clinical disorders, including neonatal disease and adult-onset neurodegenerative disorders.[provided by RefSeq, Oct 2009]
GeneCards Summary for NDUFS6 Gene
NDUFS6 (NADH:Ubiquinone Oxidoreductase Subunit S6) is a Protein Coding gene. Diseases associated with NDUFS6 include Mitochondrial Complex I Deficiency, Nuclear Type 9 and Mitochondrial Complex I Deficiency, Nuclear Type 1. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and GABAergic synapse. Gene Ontology (GO) annotations related to this gene include electron transfer activity and NADH dehydrogenase (ubiquinone) activity.
UniProtKB/Swiss-Prot Summary for NDUFS6 Gene
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.