Aliases for NDUFS5 Gene
External Ids for NDUFS5 Gene
Previous GeneCards Identifiers for NDUFS5 Gene
This gene is a member of the NADH dehydrogenase (ubiquinone) iron-sulfur protein family. The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 1, 4 and 17. [provided by RefSeq, May 2010]
GeneCards Summary for NDUFS5 Gene
NDUFS5 (NADH:Ubiquinone Oxidoreductase Subunit S5) is a Protein Coding gene. Diseases associated with NDUFS5 include Mitochondrial Complex I Deficiency, Nuclear Type 1 and Visual Epilepsy. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and GABAergic synapse. Gene Ontology (GO) annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.
UniProtKB/Swiss-Prot Summary for NDUFS5 Gene
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.