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Aliases for NDUFB8 Gene

Aliases for NDUFB8 Gene

  • NADH:Ubiquinone Oxidoreductase Subunit B8 2 3 5
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 8, 19kDa 2 3
  • Complex I ASHI Subunit 2 3
  • Complex I-ASHI 3 4
  • CI-ASHI 3 4
  • NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 8, Mitochondrial 3
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 8 (19kD, ASHI) 2
  • NADH:Ubiquinone Oxidoreductase ASHI Subunit 3
  • NADH-Ubiquinone Oxidoreductase ASHI Subunit 4
  • ASHI 3

External Ids for NDUFB8 Gene

Previous GeneCards Identifiers for NDUFB8 Gene

  • GC10M101140
  • GC10M101517
  • GC10M102414
  • GC10M101948
  • GC10M102273
  • GC10M095912

Summaries for NDUFB8 Gene

GeneCards Summary for NDUFB8 Gene

NDUFB8 (NADH:Ubiquinone Oxidoreductase Subunit B8) is a Protein Coding gene. Diseases associated with NDUFB8 include Epicondylitis and Hordeolum. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include NADH dehydrogenase (ubiquinone) activity and NADH dehydrogenase activity. An important paralog of this gene is ENSG00000255339.

UniProtKB/Swiss-Prot for NDUFB8 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Wiki entry for NDUFB8 Gene

Additional gene information for NDUFB8 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFB8 Gene

Genomics for NDUFB8 Gene

GeneHancer (GH) Regulatory Elements for NDUFB8 Gene

Promoters and enhancers for NDUFB8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J100528 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.7 679 2.5 PKNOX1 ATF1 ZFP64 SIN3A DMAP1 ZNF48 YY1 ETS1 POLR2B ZNF143 HIF1AN NDUFB8 ENSG00000255339 SEC31B
GH10J100369 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +157.6 157556 6.8 MLX FEZF1 DMAP1 YY1 ZNF143 ZNF548 SP3 NFYC MEF2D GLIS1 OLMALINC PHBP9 ENSG00000231188 SEC31B HIF1AN EBAG9P1 SPCS2P2 TPM4P1 SCD DNMBP
GH10J100481 Enhancer 1.1 Ensembl ENCODE 11.1 +47.6 47575 2 CLOCK ATF1 ARID4B SIN3A GLI4 ZNF2 BRCA1 ZNF48 YY1 ZNF121 SEC31B MRPL43 ENSG00000255339 NDUFB8 HIF1AN SLC25A28 LZTS2 LOC105378452 WNT8B GC10M100500
GH10J100339 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.1 +190.7 190722 1 CTCF AHR FOXA2 SIN3A RAD21 ZNF335 CC2D1A POLR2A FOXK2 ARID2 PKD2L1 SEC31B HIF1AN ENSG00000255339 NDUFB8 ENSG00000231188 BLOC1S2
GH10J100434 Enhancer 1 ENCODE 10.4 +96.0 96041 0.2 HDGF ATF1 ARNT ARID4B SIN3A ZNF2 ZNF48 SLC30A9 ZNF213 ARID2 SEC31B SCD ENSG00000231188 WNT8B NDUFB8 HIF1AN ENSG00000255339 ENSG00000212325 OLMALINC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NDUFB8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NDUFB8 gene promoter:
  • CUTL1
  • RP58
  • IRF-7A
  • MIF-1
  • AP-1
  • AML1a
  • E47
  • Tal-1beta

Genomic Locations for NDUFB8 Gene

Genomic Locations for NDUFB8 Gene
6,272 bases
Minus strand
22,555 bases
Minus strand

Genomic View for NDUFB8 Gene

Genes around NDUFB8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDUFB8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDUFB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFB8 Gene

Proteins for NDUFB8 Gene

  • Protein details for NDUFB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A8K0L4
    • Q5W143
    • Q5W144
    • Q5W145
    • Q9UG53
    • Q9UJR4
    • Q9UQF3

    Protein attributes for NDUFB8 Gene

    186 amino acids
    Molecular mass:
    21766 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.

    Three dimensional structures from OCA and Proteopedia for NDUFB8 Gene

    Alternative splice isoforms for NDUFB8 Gene


neXtProt entry for NDUFB8 Gene

Post-translational modifications for NDUFB8 Gene

  • Ubiquitination at isoforms=234
  • Modification sites at PhosphoSitePlus

Other Protein References for NDUFB8 Gene

No data available for DME Specific Peptides for NDUFB8 Gene

Domains & Families for NDUFB8 Gene

Gene Families for NDUFB8 Gene

Protein Domains for NDUFB8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the complex I NDUFB8 subunit family.
  • Belongs to the complex I NDUFB8 subunit family.
genes like me logo Genes that share domains with NDUFB8: view

Function for NDUFB8 Gene

Molecular function for NDUFB8 Gene

UniProtKB/Swiss-Prot Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
GENATLAS Biochemistry:
NADH ubiquinone oxidoreductase (Q reductase),21.8kDa,component beta 8,hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane

Phenotypes From GWAS Catalog for NDUFB8 Gene

Gene Ontology (GO) - Molecular Function for NDUFB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity IEA,NAS 9878551
genes like me logo Genes that share ontologies with NDUFB8: view
genes like me logo Genes that share phenotypes with NDUFB8: view

Animal Models for NDUFB8 Gene

MGI Knock Outs for NDUFB8:
  • Ndufb8 Ndufb8<tm1a(EUCOMM)Wtsi>

Animal Model Products

miRNA for NDUFB8 Gene

miRTarBase miRNAs that target NDUFB8

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NDUFB8 Gene

Localization for NDUFB8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFB8 Gene

Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NDUFB8 gene
Compartment Confidence
mitochondrion 5
endoplasmic reticulum 4
extracellular 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NDUFB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I IMP,NAS 9878551
GO:0005759 mitochondrial matrix TAS --
GO:0005783 endoplasmic reticulum IDA --
genes like me logo Genes that share ontologies with NDUFB8: view

Pathways & Interactions for NDUFB8 Gene

genes like me logo Genes that share pathways with NDUFB8: view

Gene Ontology (GO) - Biological Process for NDUFB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone TAS --
GO:0006626 protein targeting to mitochondrion TAS --
GO:0032981 mitochondrial respiratory chain complex I assembly TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with NDUFB8: view

No data available for SIGNOR curated interactions for NDUFB8 Gene

Drugs & Compounds for NDUFB8 Gene

(1) Drugs for NDUFB8 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Approved Nutra Target 0
genes like me logo Genes that share compounds with NDUFB8: view

Transcripts for NDUFB8 Gene

mRNA/cDNA for NDUFB8 Gene

Unigene Clusters for NDUFB8 Gene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB8 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - - - - - - -
SP9: - - -
SP10: - -
SP11: - - - -
SP12: -
SP13: -

Relevant External Links for NDUFB8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NDUFB8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NDUFB8 Gene

Protein differential expression in normal tissues from HIPED for NDUFB8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.2) and Bone (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NDUFB8 Gene

Protein tissue co-expression partners for NDUFB8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NDUFB8 Gene:


SOURCE GeneReport for Unigene cluster for NDUFB8 Gene:


Evidence on tissue expression from TISSUES for NDUFB8 Gene

  • Nervous system(4.9)
  • Lung(4.8)
  • Blood(4.4)
  • Intestine(3.4)
  • Pancreas(3.4)
  • Muscle(3.3)
  • Skin(3.1)
  • Heart(2.9)
  • Kidney(2.8)
  • Liver(2.7)
  • Eye(2.4)
  • Gall bladder(2.4)
  • Stomach(2.4)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with NDUFB8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NDUFB8 Gene

Orthologs for NDUFB8 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDUFB8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NDUFB8 34 33
  • 99.64 (n)
(Bos Taurus)
Mammalia NDUFB8 33
  • 87.63 (n)
-- 34
  • 53 (a)
(Canis familiaris)
Mammalia NDUFB8 33
  • 87.1 (n)
-- 34
  • 84 (a)
(Rattus norvegicus)
Mammalia Ndufb8 33
  • 86.92 (n)
(Mus musculus)
Mammalia Ndufb8 16 34 33
  • 84.23 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 80 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 74 (a)
(Gallus gallus)
Aves NDUFB8 34 33
  • 68.12 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufb8 33
  • 66.67 (n)
Str.15125 33
(Danio rerio)
Actinopterygii ndufb8 34 33
  • 64.7 (n)
zgc77718 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9112 33
fruit fly
(Drosophila melanogaster)
Insecta CG3192 34 33
  • 47.92 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002020 33
  • 46.67 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4923 34
  • 29 (a)
Species where no ortholog for NDUFB8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFB8 Gene

Gene Tree for NDUFB8 (if available)
Gene Tree for NDUFB8 (if available)
Evolutionary constrained regions (ECRs) for NDUFB8: view image

Paralogs for NDUFB8 Gene

Paralogs for NDUFB8 Gene Pseudogenes for NDUFB8 Gene

genes like me logo Genes that share paralogs with NDUFB8: view

Variants for NDUFB8 Gene

Sequence variations from dbSNP and Humsavar for NDUFB8 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000314319 -- 100,527,149(-) T/C intron_variant
rs1000645379 -- 100,528,807(-) T/C intron_variant
rs1000941200 -- 100,527,602(-) A/G intron_variant
rs1001527503 -- 100,527,615(-) A/C intron_variant
rs1002011999 -- 100,530,692(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NDUFB8 Gene

Variant ID Type Subtype PubMed ID
esv2759779 CNV gain+loss 17122850
esv3624363 CNV loss 21293372
nsv7519 CNV insertion 18451855
nsv831962 CNV gain 17160897
nsv831963 CNV loss 17160897

Variation tolerance for NDUFB8 Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NDUFB8 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFB8 Gene

Disorders for NDUFB8 Gene

MalaCards: The human disease database

(5) MalaCards diseases for NDUFB8 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
  • andrel epicondylitis
  • hordeolum externum
myofascial pain syndrome
  • fibromyalgia
breast abscess
  • abscess of breast
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NDUFB8

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NDUFB8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NDUFB8 Gene

Publications for NDUFB8 Gene

  1. Accessory subunits are integral for assembly and function of human mitochondrial complex I. (PMID: 27626371) Stroud DA … Ryan MT (Nature 2016) 3 4 58
  2. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PMID: 18977241) Starr JM … Deary IJ (Mechanisms of ageing and development 2008) 3 44 58
  3. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L … Thibodeau SN (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 44 58
  4. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PMID: 17601350) Harris SE … Deary IJ (BMC genetics 2007) 3 44 58
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58

Products for NDUFB8 Gene

Sources for NDUFB8 Gene

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