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Aliases for NDUFB7 Gene

Aliases for NDUFB7 Gene

  • NADH:Ubiquinone Oxidoreductase Subunit B7 2 3 5
  • NADH-Ubiquinone Oxidoreductase B18 Subunit 2 3 4
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 7, 18kDa 2 3
  • Cell Adhesion Protein SQM1 3 4
  • Complex I B18 Subunit 2 3
  • Complex I-B18 3 4
  • CI-B18 3 4
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 7 (18kD, B18) 2
  • NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 7 3
  • B18 3

External Ids for NDUFB7 Gene

Previous GeneCards Identifiers for NDUFB7 Gene

  • GC19M015031
  • GC19M014522
  • GC19M014537
  • GC19M014676
  • GC19M014246

Summaries for NDUFB7 Gene

Entrez Gene Summary for NDUFB7 Gene

  • The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It is located at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. [provided by RefSeq, Jul 2008]

GeneCards Summary for NDUFB7 Gene

NDUFB7 (NADH:Ubiquinone Oxidoreductase Subunit B7) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. Gene Ontology (GO) annotations related to this gene include NADH dehydrogenase (ubiquinone) activity and NADH dehydrogenase activity.

UniProtKB/Swiss-Prot for NDUFB7 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Wiki entry for NDUFB7 Gene

Additional gene information for NDUFB7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFB7 Gene

Genomics for NDUFB7 Gene

GeneHancer (GH) Regulatory Elements for NDUFB7 Gene

Promoters and enhancers for NDUFB7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I014570 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 556.8 +0.3 280 1.8 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B NDUFB7 AKAP8 CCDC130 DDX39A DCAF15 BRD4 RFX1 ENSG00000268189 WIZ DNAJB1
GH19I014689 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.8 -117.9 -117924 2 PKNOX1 SMAD1 ATF1 ARID4B SIN3A YY1 ETS1 POLR2B ZNF213 E2F8 ZNF333 ADGRE3 NDUFB7
GH19I014542 Enhancer 0.9 Ensembl ENCODE dbSUPER 12.9 +29.2 29209 1.1 ZNF121 KLF1 HDAC2 HLF ZMYM3 KDM1A NDUFB7 GIPC1 TECR LOC100507373 DNAJB1
GH19I014546 Enhancer 0.8 ENCODE dbSUPER 12.9 +26.3 26286 2.3 HLF MAX ZBTB8A ZIC2 ZNF623 YY1 ZNF121 ZNF316 FOXP2 HNF4A NDUFB7 GIPC1 TECR SLC1A6 DNAJB1
GH19I014545 Enhancer 0.7 ENCODE dbSUPER 12.9 +27.7 27709 0.1 FOSL1 MEIS2 TCF12 HDAC2 CBFA2T3 CBFA2T2 NDUFB7 GIPC1 DNAJB1 TECR
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NDUFB7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NDUFB7 gene promoter:

Genomic Locations for NDUFB7 Gene

Genomic Locations for NDUFB7 Gene
chr19:14,566,078-14,572,077
(GRCh38/hg38)
Size:
6,000 bases
Orientation:
Minus strand
chr19:14,676,890-14,682,889
(GRCh37/hg19)

Genomic View for NDUFB7 Gene

Genes around NDUFB7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDUFB7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDUFB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFB7 Gene

Proteins for NDUFB7 Gene

  • Protein details for NDUFB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17568-NDUB7_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
    Protein Accession:
    P17568
    Secondary Accessions:
    • Q6ICN9
    • Q9UI16

    Protein attributes for NDUFB7 Gene

    Size:
    137 amino acids
    Molecular mass:
    16402 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.
    SequenceCaution:
    • Sequence=AAA35675.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NDUFB7 Gene

neXtProt entry for NDUFB7 Gene

Post-translational modifications for NDUFB7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NDUFB7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NDUFB7 Gene

Domains & Families for NDUFB7 Gene

Gene Families for NDUFB7 Gene

Protein Domains for NDUFB7 Gene

Suggested Antigen Peptide Sequences for NDUFB7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17568

UniProtKB/Swiss-Prot:

NDUB7_HUMAN :
  • Contains two C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.
  • Belongs to the complex I NDUFB7 subunit family.
Domain:
  • Contains two C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.
Family:
  • Belongs to the complex I NDUFB7 subunit family.
genes like me logo Genes that share domains with NDUFB7: view

Function for NDUFB7 Gene

Molecular function for NDUFB7 Gene

GENATLAS Biochemistry:
NADH ubiquinone oxidoreductase (Q reductase),18kDa,component beta 7,hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Ontology (GO) - Molecular Function for NDUFB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS 9878551
genes like me logo Genes that share ontologies with NDUFB7: view
genes like me logo Genes that share phenotypes with NDUFB7: view

Animal Model Products

miRNA for NDUFB7 Gene

miRTarBase miRNAs that target NDUFB7

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NDUFB7 Gene

Localization for NDUFB7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFB7 Gene

Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NDUFB7 gene
Compartment Confidence
mitochondrion 5
extracellular 2
nucleus 2
plasma membrane 1
cytosol 1

Gene Ontology (GO) - Cellular Components for NDUFB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion HDA,IEA 20833797
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I IDA 12611891
GO:0005758 mitochondrial intermembrane space IEA,IDA 21310150
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NDUFB7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NDUFB7 Gene

Pathways & Interactions for NDUFB7 Gene

genes like me logo Genes that share pathways with NDUFB7: view

Gene Ontology (GO) - Biological Process for NDUFB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone TAS --
GO:0032981 mitochondrial respiratory chain complex I assembly TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with NDUFB7: view

No data available for SIGNOR curated interactions for NDUFB7 Gene

Drugs & Compounds for NDUFB7 Gene

(5) Drugs for NDUFB7 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Approved Nutra Target 0
FAD Approved Pharma 0
Ubiquinone-1 Experimental Pharma 0
Ubiquinone-2 Experimental Pharma 0
NAD Pharma Full agonist, Agonist 0

(3) Additional Compounds for NDUFB7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
QH2
  • Coenzymes QH2
  • CoQH2
  • Reduced ubiquinone
  • Ubiquinol
  • Ubiquinone-1
56275-39-9
Sulfide
  • Sulfanediide
  • Sulfide
  • Sulfur
  • Sulphide
18496-25-8
genes like me logo Genes that share compounds with NDUFB7: view

Transcripts for NDUFB7 Gene

mRNA/cDNA for NDUFB7 Gene

Unigene Clusters for NDUFB7 Gene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB7 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for NDUFB7 Gene

GeneLoc Exon Structure for
NDUFB7
ECgene alternative splicing isoforms for
NDUFB7

Expression for NDUFB7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NDUFB7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NDUFB7 Gene

This gene is overexpressed in Nasal epithelium (16.5), Heart (9.1), and Peripheral blood mononuclear cells (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NDUFB7 Gene



Protein tissue co-expression partners for NDUFB7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NDUFB7 Gene:

NDUFB7

SOURCE GeneReport for Unigene cluster for NDUFB7 Gene:

Hs.532853

Evidence on tissue expression from TISSUES for NDUFB7 Gene

  • Nervous system(4.4)
  • Muscle(2.7)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with NDUFB7: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NDUFB7 Gene

Orthologs for NDUFB7 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDUFB7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFB7 33 34
  • 99.27 (n)
cow
(Bos Taurus)
Mammalia NDUFB7 33 34
  • 89.29 (n)
dog
(Canis familiaris)
Mammalia NDUFB7 33 34
  • 87.1 (n)
mouse
(Mus musculus)
Mammalia Ndufb7 16 34 33
  • 82.97 (n)
rat
(Rattus norvegicus)
Mammalia Ndufb7 33
  • 82.24 (n)
oppossum
(Monodelphis domestica)
Mammalia NDUFB7 34
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDUFB7 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufb7 33
  • 65.33 (n)
Str.6434 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.31909 33
zebrafish
(Danio rerio)
Actinopterygii ndufb7 33 34
  • 64.44 (n)
zgc77820 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8778 33
fruit fly
(Drosophila melanogaster)
Insecta CG5548 33 34
  • 62.27 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007574 33
  • 56.11 (n)
worm
(Caenorhabditis elegans)
Secernentea D2030.4 34
  • 50 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5982 34
  • 35 (a)
OneToOne
Species where no ortholog for NDUFB7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDUFB7 Gene

ENSEMBL:
Gene Tree for NDUFB7 (if available)
TreeFam:
Gene Tree for NDUFB7 (if available)

Paralogs for NDUFB7 Gene

No data available for Paralogs for NDUFB7 Gene

Variants for NDUFB7 Gene

Sequence variations from dbSNP and Humsavar for NDUFB7 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs10405483 likely-benign, not specified 14,565,669(-) C/G/T downstream_transcript_variant
rs61732092 likely-benign, not specified 14,565,766(-) C/T downstream_transcript_variant
rs141619383 uncertain-significance, not specified 14,565,757(-) C/T downstream_transcript_variant
rs147656694 uncertain-significance, not specified 14,565,817(-) G/A downstream_transcript_variant
rs1000068699 -- 14,567,207(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NDUFB7 Gene

Variant ID Type Subtype PubMed ID
esv2678899 CNV deletion 23128226
esv3643747 CNV loss 21293372

Variation tolerance for NDUFB7 Gene

Residual Variation Intolerance Score: 80.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NDUFB7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NDUFB7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFB7 Gene

Disorders for NDUFB7 Gene

Additional Disease Information for NDUFB7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NDUFB7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NDUFB7 Gene

Publications for NDUFB7 Gene

  1. Characterization of the human complex I NDUFB7 and 17.2-kDa cDNAs and mutational analysis of 19 genes of the HP fraction in complex I-deficient-patients. (PMID: 10830904) Triepels R … van den Heuvel L (Human genetics 2000) 2 3 4 58
  2. Accessory subunits are integral for assembly and function of human mitochondrial complex I. (PMID: 27626371) Stroud DA … Ryan MT (Nature 2016) 3 4 58
  3. NDUFB7 and NDUFA8 are located at the intermembrane surface of complex I. (PMID: 21310150) Szklarczyk R … Huynen MA (FEBS letters 2011) 3 4 58
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 44 58

Products for NDUFB7 Gene

Sources for NDUFB7 Gene

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