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The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor... See more...
Aliases for NDUFB5 Gene
Aliases for NDUFB5 Gene
External Ids for NDUFB5 Gene
- HGNC: 7700
- Entrez Gene: 4711
- Ensembl: ENSG00000136521
- OMIM: 603841
- UniProtKB: O43674
Previous GeneCards Identifiers for NDUFB5 Gene
- GC03P176087
- GC03P180165
- GC03P180724
- GC03P180643
- GC03P180805
- GC03P179322
- GC03P176726
Summaries for NDUFB5 Gene
-
The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for NDUFB5 Gene
NDUFB5 (NADH:Ubiquinone Oxidoreductase Subunit B5) is a Protein Coding gene. Diseases associated with NDUFB5 include Night Blindness, Congenital Stationary, Type 1A. Among its related pathways are GABAergic synapse and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.
UniProtKB/Swiss-Prot Summary for NDUFB5 Gene
-
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Additional gene information for NDUFB5 Gene
- HGNC(7700)
- Entrez Gene(4711)
- Ensembl(ENSG00000136521)
- OMIM(603841)
- UniProtKB(O43674)
- Open Targets Platform(ENSG00000136521)
- Search for NDUFB5 at DataMed
- Search for NDUFB5 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NDUFB5 Gene
Genomics for NDUFB5 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for NDUFB5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NDUFB5 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NDUFB5
- Top Transcription factor binding sites by QIAGEN in the NDUFB5 gene promoter:
-
- COMP1
- Evi-1
- HFH-1
- HOXA9
- HOXA9B
- Meis-1
- Meis-1b
- MIF-1
- Nkx2-2
Genomic Locations for NDUFB5 Gene
Genomic Locations for NDUFB5 Gene
- chr3:179,604,690-179,627,647
- (GRCh38/hg38)
- Size:
- 22,958 bases
- Orientation:
- Plus strand
- chr3:179,322,478-179,345,435
- (GRCh37/hg19)
- Size:
- 22,958 bases
- Orientation:
- Plus strand
Genomic View for NDUFB5 Gene
Genes around NDUFB5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q26.33 by HGNC
- 3q26.33 by Entrez Gene
- 3q26.33 by Ensembl
NDUFB5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NDUFB5 Gene
Proteins for NDUFB5 Gene
-
Protein details for NDUFB5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O43674-NDUB5_HUMAN
- Recommended name:
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
- Protein Accession:
- O43674
- Q561V6
Protein attributes for NDUFB5 Gene
- Size:
- 189 amino acids
- Molecular mass:
- 21750 Da
- Quaternary structure:
-
- Complex I is composed of 45 different subunits.
Three dimensional structures from OCA and Proteopedia for NDUFB5 Gene
Protein Expression for NDUFB5 Gene
Post-translational modifications for NDUFB5 Gene
Other Protein References for NDUFB5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ NDUFB5 Antibody
-
Custom Antibody ServicesOriGene Antibodies for NDUFB5
- Novus Biologicals Antibodies for NDUFB5
-
Abcam antibodies for NDUFB5
- Invitrogen Antibodies for NDUFB5 (AFLGC-NDUFB5)
-
Boster Bio Antibodies for NDUFB5
-
Santa Cruz Biotechnology (SCBT) Antibodies for NDUFB5
- Sino Biological Antibodies for NDUFB5
Protein Products
-
OriGene Purified Proteins for NDUFB5
- Search Origene for MassSpec and Protein Over-expression Lysates for NDUFB5
- Origene Custom Protein Services for NDUFB5
- antibodies-online: Show 4 available NDUFB5 Proteins ranked by validation data
- Compare Top NDUFB5 Proteins
-
Quality Products:
-
Abcam proteins for NDUFB5
No data available for DME Specific Peptides for NDUFB5 Gene
Domains & Families for NDUFB5 Gene
Gene Families for NDUFB5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for NDUFB5 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for NDUFB5 Gene
- GenScript: Design optimal peptide antigens:
-
- NADH dehydrogenase (Ubiquinone) 1 beta subcomplex, 5, 16kDa, isoform CRA_e (D3DNS1_HUMAN)
- NADH-ubiquinone oxidoreductase SGDH subunit (NDUB5_HUMAN)
- NDUFB5 protein (Q05D62_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O43674- Family:
-
- Belongs to the complex I NDUFB5 subunit family.
Function for NDUFB5 Gene
Molecular function for NDUFB5 Gene
- UniProtKB/Swiss-Prot Function:
- Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008137 | NADH dehydrogenase (ubiquinone) activity | TAS,NAS | 9878551 |
Phenotypes for NDUFB5 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NDUFB5 - Select products 50% OFF >
- * NDUFB5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NDUFB5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NDUFB5
-
Santa Cruz Biotechnology (SCBT) CRISPR for NDUFB5
miRNA for NDUFB5 Gene
- miRTarBase miRNAs that target NDUFB5
-
- hsa-miR-590-3p (MIRT016164)
- hsa-miR-221-3p (MIRT024139)
- hsa-miR-26b-5p (MIRT028994)
- hsa-miR-571 (MIRT377479)
- hsa-miR-659-3p (MIRT377480)
- hsa-miR-1303 (MIRT377481)
- hsa-miR-302c-5p (MIRT486392)
- hsa-miR-218-1-3p (MIRT486393)
- hsa-miR-3143 (MIRT486394)
- hsa-miR-3688-3p (MIRT486395)
- hsa-miR-543 (MIRT486396)
- hsa-miR-607 (MIRT549921)
- hsa-miR-3671 (MIRT549922)
- hsa-miR-591 (MIRT549923)
- hsa-miR-29a-5p (MIRT549924)
- hsa-miR-4528 (MIRT549925)
- hsa-miR-6074 (MIRT549926)
- hsa-miR-4272 (MIRT549927)
- hsa-miR-10b-5p (MIRT549928)
- hsa-miR-10a-5p (MIRT549929)
- hsa-miR-6512-5p (MIRT549930)
- hsa-miR-504-5p (MIRT549931)
- hsa-miR-6736-5p (MIRT617568)
- hsa-miR-4701-3p (MIRT617569)
- hsa-miR-1262 (MIRT617570)
- hsa-miR-7703 (MIRT617571)
- hsa-miR-6720-5p (MIRT617572)
- hsa-miR-6512-3p (MIRT617573)
- hsa-miR-661 (MIRT617574)
- hsa-miR-4696 (MIRT617575)
- hsa-miR-642b-3p (MIRT617576)
- hsa-miR-642a-3p (MIRT617577)
- hsa-miR-6776-5p (MIRT617578)
- hsa-miR-4793-3p (MIRT617579)
- hsa-miR-766-3p (MIRT617580)
- hsa-miR-372-5p (MIRT617581)
- hsa-miR-371a-5p (MIRT617582)
- hsa-miR-616-5p (MIRT617583)
- hsa-miR-373-5p (MIRT617584)
- hsa-miR-371b-5p (MIRT617585)
- hsa-miR-6742-3p (MIRT617586)
- hsa-miR-6849-3p (MIRT617587)
- hsa-miR-451b (MIRT617588)
- hsa-miR-508-5p (MIRT617589)
- hsa-miR-3120-3p (MIRT617590)
- hsa-miR-4432 (MIRT617591)
- hsa-miR-4776-3p (MIRT643089)
- hsa-miR-4642 (MIRT643090)
- hsa-miR-6805-3p (MIRT643091)
- hsa-miR-5691 (MIRT643092)
- hsa-miR-4659b-5p (MIRT643093)
- hsa-miR-4659a-5p (MIRT643094)
- hsa-miR-5590-5p (MIRT643095)
- hsa-miR-6873-3p (MIRT643096)
- hsa-miR-4279 (MIRT643097)
- hsa-miR-6792-3p (MIRT643098)
- hsa-miR-4691-5p (MIRT643099)
- hsa-miR-891a-3p (MIRT643100)
- hsa-miR-3688-5p (MIRT643101)
- hsa-miR-6817-3p (MIRT643102)
- hsa-miR-7110-3p (MIRT643103)
- hsa-miR-6769b-3p (MIRT643104)
- hsa-miR-4723-3p (MIRT643105)
- hsa-miR-3183 (MIRT643106)
- hsa-miR-3607-5p (MIRT643107)
- hsa-miR-6800-3p (MIRT643108)
- hsa-miR-187-3p (MIRT783996)
- hsa-miR-3177-5p (MIRT784743)
- hsa-miR-574-5p (MIRT787872)
- hsa-miR-6867-5p (MIRT789212)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NDUFB5
- Browse OriGene Inhibitory RNA Products For NDUFB5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NDUFB5
Clone Products
- Applied Biological Materials (abm): Clones for NDUFB5 - Select products 50% OFF >
- * NDUFB5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for NDUFB5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NDUFB5
Cell Line Products
-
Horizon Cell Lines for NDUFB5
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NDUFB5 Gene
Localization for NDUFB5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NDUFB5 Gene
- Mitochondrion inner membrane. Single-pass membrane protein. Matrix side.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Mitochondria (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005739 | mitochondrion | IDA | -- |
| GO:0005743 | mitochondrial inner membrane | TAS | -- |
| GO:0005747 | mitochondrial respiratory chain complex I | NAS | 9878551 |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for NDUFB5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
.40
|
|
| 2 | Parkinson disease | ||
| 3 | Metabolism |
.40
|
|
| 4 | GABAergic synapse | ||
Pathways by source for NDUFB5 Gene
2 BioSystems pathways for NDUFB5 Gene
8 KEGG pathways for NDUFB5 Gene
Interacting Proteins for NDUFB5 Gene
Selected Interacting proteins:
O43674-NDUB5_HUMAN
ENSP00000259037
for NDUFB5 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for NDUFB5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006120 | mitochondrial electron transport, NADH to ubiquinone | TAS | -- |
| GO:0032981 | mitochondrial respiratory chain complex I assembly | TAS | -- |
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for SIGNOR curated interactions for NDUFB5 Gene
Drugs & Compounds for NDUFB5 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| QH2 |
|
56275-39-9 |
|
|||
| Sulfide |
|
18496-25-8 |
|
Transcripts for NDUFB5 Gene
mRNA/cDNA for NDUFB5 Gene
- 3 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000259037 4199 nts (view in UCSC)
- ENST00000359944 1054 nts (view in UCSC)
- ENST00000468210 824 nts (view in UCSC)
- ENST00000471112 684 nts (view in UCSC)
- ENST00000472629 744 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NDUFB5 - Select products 50% OFF >
- * NDUFB5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NDUFB5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NDUFB5
-
Santa Cruz Biotechnology (SCBT) CRISPR for NDUFB5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NDUFB5
- Browse OriGene Inhibitory RNA Products For NDUFB5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NDUFB5
Clone Products
- Applied Biological Materials (abm): Clones for NDUFB5 - Select products 50% OFF >
- * NDUFB5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for NDUFB5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NDUFB5
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | · | 1h | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | · | 8f | · | 8g | · | 8h |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - |
Relevant External Links for NDUFB5 Gene
- GeneLoc Exon Structure for
- NDUFB5
Expression for NDUFB5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Nasal epithelium (16.0), Heart (8.2), and Peripheral blood mononuclear cells (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NDUFB5 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NDUFB5
SOURCE GeneReport for Unigene cluster for NDUFB5 Gene:
Hs.730674Evidence on tissue expression from TISSUES for NDUFB5 Gene
- Nervous system(4.9)
- Heart(4.6)
- Skin(4.6)
- Liver(4.5)
- Muscle(3.2)
- Kidney(3.1)
- Lung(2.5)
- Thyroid gland(2.1)
- Intestine(2.1)
- Blood(2.1)
- Pancreas(2)
Primer Products
-
OriGene qPCR primer pairs for NDUFB5
-
OriGene qPCR primer pairs and template standards for NDUFB5
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NDUFB5 Gene
Orthologs for NDUFB5 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | NDUFB5 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | NDUFB5 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | NDUFB5 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ndufb5 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ndufb5 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | NDUFB5 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | NDUFB5 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | NDUFB5 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | NDUFB5 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ndufb5 30 |
|
||
| Str.1944 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | ndufb5-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ndufb5 30 31 |
|
OneToOne | |
| -- 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8572 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | l(3)neo18 30 31 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007297 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3719 31 |
|
OneToOne |
- Species where no ortholog for NDUFB5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for NDUFB5 Gene
- ENSEMBL:
- Gene Tree for NDUFB5 (if available)
- TreeFam:
- Gene Tree for NDUFB5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NDUFB5: view image
Paralogs for NDUFB5 Gene
Pseudogenes.org Pseudogenes for NDUFB5 Gene
No data available for Paralogs for NDUFB5 Gene
Variants for NDUFB5 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NDUFB5 Gene
| SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs4147793 | - | p.Tyr133His |
Residual Variation Intolerance Score:
65.6% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NDUFB5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NDUFB5
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NDUFB5 Gene
Disorders for NDUFB5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| night blindness, congenital stationary, type 1a |
|
|
Search NDUFB5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NDUFB5
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for NDUFB5 Gene
Publications for NDUFB5 Gene
- Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits. (PMID: 9425316) Ton C … Liew CC (Biochemical and biophysical research communications 1997) 2 3 4
- Accessory subunits are integral for assembly and function of human mitochondrial complex I. (PMID: 27626371) Stroud DA … Ryan MT (Nature 2016) 3 4
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
- Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 41
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Products for NDUFB5 Gene
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Sources for NDUFB5 Gene
- (1) GeneCards
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- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
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- (7) GeneLoc
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