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NDUFB5 Gene(Protein Coding)

NADH:Ubiquinone Oxidoreductase Subunit B5

GCID:
GC03P179604
GIFtS:
43
Genes Participants
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Aliases for NDUFB5 Gene

Aliases for NDUFB5 Gene

  • NADH:Ubiquinone Oxidoreductase Subunit B5 2 3 5
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 5, 16kDa 2 3
  • NADH-Ubiquinone Oxidoreductase SGDH Subunit 3 4
  • Complex I SGDH Subunit 2 3
  • Complex I-SGDH 3 4
  • NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 5, Mitochondrial 3
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 5 (16kD, SGDH) 2
  • CI-SGDH 4
  • CISGDH 3
  • SGDH 3

External Ids for NDUFB5 Gene

Previous GeneCards Identifiers for NDUFB5 Gene

  • GC03P176087
  • GC03P180165
  • GC03P180724
  • GC03P180643
  • GC03P180805
  • GC03P179322
  • GC03P176726

Summaries for NDUFB5 Gene

Entrez Gene Summary for NDUFB5 Gene

  • The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for NDUFB5 Gene

NDUFB5 (NADH:Ubiquinone Oxidoreductase Subunit B5) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. Gene Ontology (GO) annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFB5 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Additional gene information for NDUFB5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFB5 Gene

Genomics for NDUFB5 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for NDUFB5 Gene

Promoters and enhancers for NDUFB5 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH03I179603 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 559.6 -0.1 -93 2.4 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B NDUFB5 MRPL47 TTC14 USP13 ACTL6A MFN1 ENSG00000272660
GH03I179612 Enhancer 0.9 ENCODE 9.7 +9.8 9774 3.2 HDAC1 ATF1 ARNT NCOA2 CHAMP1 TCF12 ATF7 CREM CEBPB NCOA1 ENSG00000239096 USP13 NDUFB5
GH03I179608 Enhancer 0.8 Ensembl ENCODE 6.5 +4.4 4411 1.2 CBFA2T3 ELF1 BATF NFATC1 KDM1A ZBTB33 ATF7 RUNX3 SPI1 USP13 MRPL47 NDUFB5 ENSG00000239096
GH03I179525 Enhancer 0.9 Ensembl ENCODE 4.8 -77.8 -77764 2.3 ETV1 CEBPG ZIC2 RAD21 YY1 ETS1 POLR2A ZNF143 CHD2 MAZ ENSG00000239255 GNB4 NDUFB5 ACTL6A PIR62273
GH03I179626 Enhancer 0.4 ENCODE 8.8 +22.6 22593 1.1 ATF4 ATF2 GC03P179625 USP13 NDUFB5 MRPL47 GC03P179640
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NDUFB5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NDUFB5 gene promoter:

Genomic Locations for NDUFB5 Gene

Genomic Locations for NDUFB5 Gene
chr3:179,604,690-179,627,647
(GRCh38/hg38)
Size:
22,958 bases
Orientation:
Plus strand
chr3:179,322,478-179,345,435
(GRCh37/hg19)

Genomic View for NDUFB5 Gene

Genes around NDUFB5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDUFB5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDUFB5 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NDUFB5 Gene

Proteins for NDUFB5 Gene

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  • Protein details for NDUFB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43674-NDUB5_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
    Protein Accession:
    O43674
    Secondary Accessions:
    • Q561V6

    Protein attributes for NDUFB5 Gene

    Size:
    189 amino acids
    Molecular mass:
    21750 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.

    Three dimensional structures from OCA and Proteopedia for NDUFB5 Gene

    Alternative splice isoforms for NDUFB5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDUFB5 Gene

Protein Expression for NDUFB5 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NDUFB5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NDUFB5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NDUFB5 Gene

Domains & Families for NDUFB5 Gene

Gene Families for NDUFB5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for NDUFB5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NDUFB5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43674

UniProtKB/Swiss-Prot:

NDUB5_HUMAN :
  • Belongs to the complex I NDUFB5 subunit family.
Family:
  • Belongs to the complex I NDUFB5 subunit family.
genes like me logo Genes that share domains with NDUFB5: view

Function for NDUFB5 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
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Molecular function for NDUFB5 Gene

UniProtKB/Swiss-Prot Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Ontology (GO) - Molecular Function for NDUFB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS,TAS 9878551
genes like me logo Genes that share ontologies with NDUFB5: view
genes like me logo Genes that share phenotypes with NDUFB5: view

Animal Model Products

miRNA for NDUFB5 Gene

miRTarBase miRNAs that target NDUFB5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NDUFB5 Gene

Localization for NDUFB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFB5 Gene

Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NDUFB5 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NDUFB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS 9878551
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NDUFB5: view

Pathways & Interactions for NDUFB5 Gene

genes like me logo Genes that share pathways with NDUFB5: view

Gene Ontology (GO) - Biological Process for NDUFB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone TAS --
GO:0032981 mitochondrial respiratory chain complex I assembly TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with NDUFB5: view

No data available for SIGNOR curated interactions for NDUFB5 Gene

Drugs & Compounds for NDUFB5 Gene

Products:

  1. Drug

(5) Drugs for NDUFB5 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Approved Nutra Target 0
FAD Approved Pharma 0
Ubiquinone-1 Experimental Pharma 0
Ubiquinone-2 Experimental Pharma 0
NAD Pharma Full agonist, Agonist 0

(3) Additional Compounds for NDUFB5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
 15438-31-0
QH2
  • Coenzymes QH2
  • CoQH2
  • Reduced ubiquinone
  • Ubiquinol
  • Ubiquinone-1
 56275-39-9
Sulfide
  • Sulfanediide
  • Sulfide
  • Sulfur
  • Sulphide
 18496-25-8
genes like me logo Genes that share compounds with NDUFB5: view

Transcripts for NDUFB5 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for NDUFB5 Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(690) Selected AceView cDNA sequences:
(16) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NDUFB5 Gene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g · 8h
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - - -
SP8: - - -
SP9: - - - - - -
SP10:
SP11: - -

Relevant External Links for NDUFB5 Gene

GeneLoc Exon Structure for
NDUFB5
ECgene alternative splicing isoforms for
NDUFB5

Expression for NDUFB5 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NDUFB5 Gene

mRNA expression in normal human tissues for NDUFB5 Gene
mRNA expression by BioGPS for NDUFB5 GenemRNA expression by GTEx for NDUFB5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NDUFB5 Gene

This gene is overexpressed in Nasal epithelium (16.0), Heart (8.2), and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NDUFB5 Gene



Protein tissue co-expression partners for NDUFB5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NDUFB5 Gene:

NDUFB5

SOURCE GeneReport for Unigene cluster for NDUFB5 Gene:

Hs.730674

Evidence on tissue expression from TISSUES for NDUFB5 Gene

  • Nervous system(4.9)
  • Heart(4.6)
  • Skin(4.5)
  • Liver(4.3)
  • Muscle(2.9)
  • Kidney(2.8)
  • Lung(2.5)
genes like me logo Genes that share expression patterns with NDUFB5: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NDUFB5 Gene

Orthologs for NDUFB5 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDUFB5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia NDUFB5 33 34
  • 99.29 (n)
cow
(Bos Taurus)
 Mammalia NDUFB5 33 34
  • 85.89 (n)
dog
(Canis familiaris)
 Mammalia NDUFB5 33 34
  • 85.36 (n)
mouse
(Mus musculus)
 Mammalia Ndufb5 33 16 34
  • 78.84 (n)
rat
(Rattus norvegicus)
 Mammalia Ndufb5 33
  • 78.31 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia NDUFB5 34
  • 78 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia NDUFB5 34
  • 67 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves NDUFB5 33 34
  • 67.03 (n)
lizard
(Anolis carolinensis)
 Reptilia NDUFB5 34
  • 62 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia ndufb5 33
  • 65.76 (n)
Str.1944 33
African clawed frog
(Xenopus laevis)
 Amphibia ndufb5-prov 33
zebrafish
(Danio rerio)
 Actinopterygii ndufb5 33 34
  • 59.24 (n)
-- 33
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.8572 33
fruit fly
(Drosophila melanogaster)
 Insecta l(3)neo18 33 34
  • 49.87 (n)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP007297 33
  • 47.73 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.3719 34
  • 26 (a)
 OneToOne
Species where no ortholog for NDUFB5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFB5 Gene

ENSEMBL:
Gene Tree for NDUFB5 (if available)
TreeFam:
Gene Tree for NDUFB5 (if available)

Paralogs for NDUFB5 Gene

Pseudogenes.org Pseudogenes for NDUFB5 Gene

genes like me logo Genes that share paralogs with NDUFB5: view

No data available for Paralogs for NDUFB5 Gene

Variants for NDUFB5 Gene

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Sequence variations from dbSNP and Humsavar for NDUFB5 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000033690 -- 179,616,149(+) A/T intron_variant
rs1000149418 -- 179,615,856(+) T/C intron_variant
rs1000396752 -- 179,608,837(+) T/A intron_variant
rs1000456215 -- 179,615,778(+) T/C intron_variant
rs1000504213 -- 179,622,315(+) T/C intron_variant

Variation tolerance for NDUFB5 Gene

Residual Variation Intolerance Score: 65.6% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NDUFB5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NDUFB5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NDUFB5 Gene

Disorders for NDUFB5 Gene

Additional Disease Information for NDUFB5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NDUFB5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NDUFB5 Gene

Publications for NDUFB5 Gene

  1. Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits. (PMID: 9425316) Ton C … Liew CC (Biochemical and biophysical research communications 1997) 2 3 4 58
  2. Accessory subunits are integral for assembly and function of human mitochondrial complex I. (PMID: 27626371) Stroud DA … Ryan MT (Nature 2016) 3 4 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 44 58
  5. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PMID: 18977241) Starr JM … Deary IJ (Mechanisms of ageing and development 2008) 3 44 58

Products for NDUFB5 Gene

Sources for NDUFB5 Gene

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