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Aliases for NDUFB10 Gene

Aliases for NDUFB10 Gene

  • NADH:Ubiquinone Oxidoreductase Subunit B10 2 3 5
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 10, 22kDa 2 3
  • NADH-Ubiquinone Oxidoreductase PDSW Subunit 3 4
  • Complex I PDSW Subunit 2 3
  • Complex I-PDSW 3 4
  • CI-PDSW 3 4
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 10 (22kD, PDSW) 2
  • NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 10 3
  • NADH Ubiquinone Oxidoreductase PDSW Subunit (RH 16p13.3) 3
  • PDSW 3

External Ids for NDUFB10 Gene

Previous GeneCards Identifiers for NDUFB10 Gene

  • GC16P002026
  • GC16P001949
  • GC16P002014
  • GC16P001933
  • GC16P002023
  • GC16P002027
  • GC16P002030
  • GC16P002053
  • GC16P002074
  • GC16P002091
  • GC16P002112
  • GC16P001976
  • GC16P001983
  • GC16P001990
  • GC16P001996
  • GC16P002006
  • GC16P002127
  • GC16P002139

Summaries for NDUFB10 Gene

GeneCards Summary for NDUFB10 Gene

NDUFB10 (NADH:Ubiquinone Oxidoreductase Subunit B10) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. Gene Ontology (GO) annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFB10 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Wiki entry for NDUFB10 Gene

Additional gene information for NDUFB10 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFB10 Gene

Genomics for NDUFB10 Gene

GeneHancer (GH) Regulatory Elements for NDUFB10 Gene

Promoters and enhancers for NDUFB10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I001958 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.9 930 3.2 HDGF HNRNPUL1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 NDUFB10 ENSG00000255513 SNHG9 ENSG00000261505 RPL3L CRAMP1 SRRM2 ENSG00000260051 TELO2 TSC2
GH16I001863 Enhancer 0.6 ENCODE 12.2 -95.6 -95613 0.2 CTCF ZNF654 ZNF449 REST RAD21 RFX5 ZNF121 ZNF335 GLIS1 ZNF143 HS3ST6 MEIOB MSRB1 RPL3L NDUFB10 SYNGR3 GC16M001851 LOC102723890
GH16I001900 Enhancer 0.6 ENCODE 11.7 -59.2 -59183 0.2 CTCF TFAP4 PKNOX1 ZNF687 SAP130 RNF2 SIN3A MNT ZNF592 FOXA1 FAHD1 HS3ST6 MSRB1 RPL3L NDUFB10 GC16P001892 PIR49138
GH16I001901 Enhancer 0.5 ENCODE 11.7 -59.0 -58953 0.2 TFAP4 ZNF687 SAP130 MNT ZNF592 FOXA1 FAHD1 HS3ST6 MSRB1 RPL3L NDUFB10 GC16P001892 PIR49138
GH16I001895 Enhancer 0.4 ENCODE 12.3 -63.4 -63400 0.5 ZNF217 GATA3 HSF1 GC16M001894 PIR49138 FAHD1 HS3ST6 MSRB1 NDUFB10 RPL3L IGFALS HAGH GC16P001892
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NDUFB10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NDUFB10 gene promoter:

Genomic Locations for NDUFB10 Gene

Genomic Locations for NDUFB10 Gene
chr16:1,959,508-1,961,975
(GRCh38/hg38)
Size:
2,468 bases
Orientation:
Plus strand
chr16:2,009,509-2,011,976
(GRCh37/hg19)

Genomic View for NDUFB10 Gene

Genes around NDUFB10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDUFB10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDUFB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFB10 Gene

Proteins for NDUFB10 Gene

  • Protein details for NDUFB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O96000-NDUBA_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
    Protein Accession:
    O96000
    Secondary Accessions:
    • Q96II6

    Protein attributes for NDUFB10 Gene

    Size:
    172 amino acids
    Molecular mass:
    20777 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.

    Three dimensional structures from OCA and Proteopedia for NDUFB10 Gene

    Alternative splice isoforms for NDUFB10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDUFB10 Gene

Post-translational modifications for NDUFB10 Gene

  • Ubiquitination at isoforms=291, isoforms=2121, and isoforms=2131
  • Modification sites at PhosphoSitePlus

Other Protein References for NDUFB10 Gene

No data available for DME Specific Peptides for NDUFB10 Gene

Domains & Families for NDUFB10 Gene

Gene Families for NDUFB10 Gene

Protein Domains for NDUFB10 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O96000

UniProtKB/Swiss-Prot:

NDUBA_HUMAN :
  • Belongs to the complex I NDUFB10 subunit family.
Family:
  • Belongs to the complex I NDUFB10 subunit family.
genes like me logo Genes that share domains with NDUFB10: view

Function for NDUFB10 Gene

Molecular function for NDUFB10 Gene

GENATLAS Biochemistry:
NADH ubiquinone oxidoreductase (Q reductase),22kDa,component beta 10,hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Ontology (GO) - Molecular Function for NDUFB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14557246
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS 9878551
genes like me logo Genes that share ontologies with NDUFB10: view
genes like me logo Genes that share phenotypes with NDUFB10: view

Human Phenotype Ontology for NDUFB10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for NDUFB10 Gene

miRTarBase miRNAs that target NDUFB10

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Animal Models , Transcription Factor Targets and HOMER Transcription for NDUFB10 Gene

Localization for NDUFB10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFB10 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NDUFB10 gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for NDUFB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS 9878551
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA,HDA 23376485
genes like me logo Genes that share ontologies with NDUFB10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NDUFB10 Gene

Pathways & Interactions for NDUFB10 Gene

genes like me logo Genes that share pathways with NDUFB10: view

Gene Ontology (GO) - Biological Process for NDUFB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone TAS --
GO:0032981 mitochondrial respiratory chain complex I assembly TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with NDUFB10: view

No data available for SIGNOR curated interactions for NDUFB10 Gene

Drugs & Compounds for NDUFB10 Gene

(1) Drugs for NDUFB10 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Approved Nutra Target 0
genes like me logo Genes that share compounds with NDUFB10: view

Transcripts for NDUFB10 Gene

Unigene Clusters for NDUFB10 Gene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB10 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4
SP1: -
SP2: -
SP3:

Relevant External Links for NDUFB10 Gene

GeneLoc Exon Structure for
NDUFB10
ECgene alternative splicing isoforms for
NDUFB10

Expression for NDUFB10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NDUFB10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NDUFB10 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.7) and Muscle - Skeletal (x4.5).

Protein differential expression in normal tissues from HIPED for NDUFB10 Gene

This gene is overexpressed in Nasal epithelium (29.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NDUFB10 Gene



Protein tissue co-expression partners for NDUFB10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NDUFB10 Gene:

NDUFB10

SOURCE GeneReport for Unigene cluster for NDUFB10 Gene:

Hs.513266

Evidence on tissue expression from TISSUES for NDUFB10 Gene

  • Liver(4.5)
  • Skin(4.3)
  • Blood(4.2)
  • Muscle(3)
  • Nervous system(2.9)
  • Heart(2.7)
  • Intestine(2.2)
  • Kidney(2.2)
  • Spleen(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with NDUFB10: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NDUFB10 Gene

Orthologs for NDUFB10 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDUFB10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFB10 33 34
  • 99.22 (n)
cow
(Bos Taurus)
Mammalia NDUFB10 33 34
  • 86.5 (n)
dog
(Canis familiaris)
Mammalia NDUFB10 34 33
  • 85.65 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndufb10 33
  • 82.4 (n)
mouse
(Mus musculus)
Mammalia Ndufb10 33 16 34
  • 80.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NDUFB10 34
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDUFB10 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves NDUFB10 33 34
  • 67.29 (n)
lizard
(Anolis carolinensis)
Reptilia NDUFB10 34
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufb10 33
  • 66.05 (n)
Str.10643 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.21405 33
zebrafish
(Danio rerio)
Actinopterygii ndufb10 33 34
  • 65.21 (n)
zgc73147 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8497 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007780 33
  • 51.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pdsw 34 33
  • 51.08 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_F59C6.5 33
  • 43.97 (n)
F59C6.5 34
  • 20 (a)
OneToOne
Species where no ortholog for NDUFB10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDUFB10 Gene

ENSEMBL:
Gene Tree for NDUFB10 (if available)
TreeFam:
Gene Tree for NDUFB10 (if available)

Paralogs for NDUFB10 Gene

Pseudogenes.org Pseudogenes for NDUFB10 Gene

genes like me logo Genes that share paralogs with NDUFB10: view

No data available for Paralogs for NDUFB10 Gene

Variants for NDUFB10 Gene

Sequence variations from dbSNP and Humsavar for NDUFB10 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000045293 -- 1,959,342(+) C/T upstream_transcript_variant
rs1000110516 -- 1,957,631(+) G/A upstream_transcript_variant
rs1000541451 -- 1,960,018(+) T/C intron_variant
rs1000846292 -- 1,959,866(+) C/T intron_variant
rs1001008825 -- 1,961,652(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NDUFB10 Gene

Variant ID Type Subtype PubMed ID
dgv4858n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1160329 CNV deletion 26073780
nsv471070 CNV gain 18288195
nsv519366 CNV loss 19592680
nsv571178 CNV loss 21841781
nsv571179 CNV loss 21841781
nsv833120 CNV loss 17160897
nsv952901 CNV deletion 24416366
nsv984249 CNV duplication 23825009

Variation tolerance for NDUFB10 Gene

Residual Variation Intolerance Score: 31.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NDUFB10 Gene

Human Gene Mutation Database (HGMD)
NDUFB10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NDUFB10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFB10 Gene

Disorders for NDUFB10 Gene

Additional Disease Information for NDUFB10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NDUFB10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NDUFB10 Gene

Publications for NDUFB10 Gene

  1. cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. (PMID: 9878551) Loeffen JL … Smeitink JA (Biochemical and biophysical research communications 1998) 2 3 4 58
  2. Accessory subunits are integral for assembly and function of human mitochondrial complex I. (PMID: 27626371) Stroud DA … Ryan MT (Nature 2016) 3 4 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PMID: 18977241) Starr JM … Deary IJ (Mechanisms of ageing and development 2008) 3 44 58
  5. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PMID: 17601350) Harris SE … Deary IJ (BMC genetics 2007) 3 44 58

Products for NDUFB10 Gene

Sources for NDUFB10 Gene

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