Aliases for NDUFB10 Gene

Aliases for NDUFB10 Gene

  • NADH:Ubiquinone Oxidoreductase Subunit B10 2 3 5
  • NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 10 3 4
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 10, 22kDa 2 3
  • NADH-Ubiquinone Oxidoreductase PDSW Subunit 3 4
  • Complex I PDSW Subunit 2 3
  • Complex I-PDSW 3 4
  • CI-PDSW 3 4
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 10 (22kD, PDSW) 2
  • NADH Ubiquinone Oxidoreductase PDSW Subunit (RH 16p13.3) 3
  • PDSW 3

External Ids for NDUFB10 Gene

Previous GeneCards Identifiers for NDUFB10 Gene

  • GC16P002026
  • GC16P001949
  • GC16P002014
  • GC16P001933
  • GC16P002023
  • GC16P002027
  • GC16P002030
  • GC16P002053
  • GC16P002074
  • GC16P002091
  • GC16P002112
  • GC16P001976
  • GC16P001983
  • GC16P002272
  • GC16P002310
  • GC16P002339
  • GC16P001990
  • GC16P001996
  • GC16P002006
  • GC16P002127
  • GC16P002139
  • GC16P002161
  • GC16P002194
  • GC16P002227

Summaries for NDUFB10 Gene

GeneCards Summary for NDUFB10 Gene

NDUFB10 (NADH:Ubiquinone Oxidoreductase Subunit B10) is a Protein Coding gene. Diseases associated with NDUFB10 include Mitochondrial Complex I Deficiency, Nuclear Type 1 and Intermittent Squint. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and GABAergic synapse. Gene Ontology (GO) annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot Summary for NDUFB10 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Wiki entry for NDUFB10 Gene

Additional gene information for NDUFB10 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NDUFB10 Gene

Genomics for NDUFB10 Gene

GeneHancer (GH) Regulatory Elements for NDUFB10 Gene

Promoters and enhancers for NDUFB10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J001958 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +3.1 3085 8 ZBTB40 ZNF217 EP300 CTCF NRF1 TCF12 MYC POLR2G SP1 BCLAF1 ENSG00000255513 SNORA64 RPS2 NDUFB10 NONHSAG018290.2 SNORA10 lnc-RPL3L-3 CRAMP1 ENSG00000261505 TELO2
GH16J001957 Enhancer 0.6 Ensembl 500.7 -1.7 -1723 0.8 POLR2G TRIM24 TBP POLR2A SUPT5H SMAD5 ZBTB33 E4F1 NFATC3 NFYC RPL3L NDUFB10 lnc-RPS2-1 piR-61861-010 piR-58297-192 SNHG9 ENSG00000255513
GH16J001976 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 12 +20.1 20066 1.8 POLR2A GABPA EZH2 DEK KLF9 NFIC POLR2G CHD2 KLF8 ZFHX2 ENSG00000255513 NDUFB10 RPL3L MSRB1 GFER NOXO1 TBL3
GH16J001863 Enhancer 0.8 Ensembl ENCODE 12.2 -95.6 -95608 0.3 CTCF REST RAD21 SMC3 ZNF335 ZNF654 RFX5 GLIS1 ARID3A KLF10 HS3ST6 MEIOB MSRB1 RPL3L NDUFB10 SYNGR3 HE856231 ENSG00000260541
GH16J001900 Enhancer 0.8 Ensembl ENCODE 11.7 -59.0 -59005 1 SIN3A MYC ZNF592 USF1 CTCF SAP130 FOXA1 PKNOX1 TFAP4 MNT FAHD1 HS3ST6 MSRB1 NDUFB10 RPL3L HAGH lnc-NDUFB10-2 piR-55139
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NDUFB10 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NDUFB10

Top Transcription factor binding sites by QIAGEN in the NDUFB10 gene promoter:
  • c-Ets-1
  • HEN1
  • MAZR
  • MyoD
  • NF-1
  • NF-1/L
  • NF-kappaB1
  • Nkx2-5
  • Pax-5

Genomic Locations for NDUFB10 Gene

Genomic Locations for NDUFB10 Gene
chr16:1,959,516-1,961,975
(GRCh38/hg38)
Size:
2,460 bases
Orientation:
Plus strand
chr16:2,009,509-2,011,976
(GRCh37/hg19)
Size:
2,468 bases
Orientation:
Plus strand

Genomic View for NDUFB10 Gene

Genes around NDUFB10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDUFB10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDUFB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFB10 Gene

Proteins for NDUFB10 Gene

  • Protein details for NDUFB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O96000-NDUBA_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
    Protein Accession:
    O96000
    Secondary Accessions:
    • Q96II6

    Protein attributes for NDUFB10 Gene

    Size:
    172 amino acids
    Molecular mass:
    20777 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.

    Three dimensional structures from OCA and Proteopedia for NDUFB10 Gene

    Alternative splice isoforms for NDUFB10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDUFB10 Gene

Post-translational modifications for NDUFB10 Gene

  • Ubiquitination at Lys91, Lys121, and Lys131
  • Modification sites at PhosphoSitePlus

Other Protein References for NDUFB10 Gene

No data available for DME Specific Peptides for NDUFB10 Gene

Domains & Families for NDUFB10 Gene

Gene Families for NDUFB10 Gene

Protein Domains for NDUFB10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NDUFB10 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92003, Homo sapiens NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10,22kDa (NDUFB10), mRNA (A8K761_HUMAN)
  • NADH-ubiquinone oxidoreductase PDSW subunit (NDUBA_HUMAN)
  • NADH ubiquinone oxidoreductase PDSW subunit (RH 16p13.3) (Q96RX5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O96000

UniProtKB/Swiss-Prot:

NDUBA_HUMAN :
  • Belongs to the complex I NDUFB10 subunit family.
Family:
  • Belongs to the complex I NDUFB10 subunit family.
genes like me logo Genes that share domains with NDUFB10: view

Function for NDUFB10 Gene

Molecular function for NDUFB10 Gene

UniProtKB/Swiss-Prot Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
GENATLAS Biochemistry:
NADH ubiquinone oxidoreductase (Q reductase),22kDa,component beta 10,hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane

Phenotypes From GWAS Catalog for NDUFB10 Gene

Gene Ontology (GO) - Molecular Function for NDUFB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14557246
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS 9878551
genes like me logo Genes that share ontologies with NDUFB10: view
genes like me logo Genes that share phenotypes with NDUFB10: view

Human Phenotype Ontology for NDUFB10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for NDUFB10 Gene

miRTarBase miRNAs that target NDUFB10

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NDUFB10

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NDUFB10 Gene

Localization for NDUFB10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFB10 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NDUFB10 gene
Compartment Confidence
mitochondrion 5
extracellular 2
nucleus 2
cytosol 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for NDUFB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS 9878551
GO:0016020 membrane IEA --
GO:0070469 respiratory chain IEA --
genes like me logo Genes that share ontologies with NDUFB10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NDUFB10 Gene

Pathways & Interactions for NDUFB10 Gene

genes like me logo Genes that share pathways with NDUFB10: view

Gene Ontology (GO) - Biological Process for NDUFB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone TAS --
GO:0032981 mitochondrial respiratory chain complex I assembly TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with NDUFB10: view

No data available for SIGNOR curated interactions for NDUFB10 Gene

Drugs & Compounds for NDUFB10 Gene

(1) Drugs for NDUFB10 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Approved Nutra Target 0
genes like me logo Genes that share compounds with NDUFB10: view

Transcripts for NDUFB10 Gene

mRNA/cDNA for NDUFB10 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NDUFB10

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB10 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4
SP1: -
SP2: -
SP3:

Relevant External Links for NDUFB10 Gene

GeneLoc Exon Structure for
NDUFB10

Expression for NDUFB10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NDUFB10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NDUFB10 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.7) and Muscle - Skeletal (x4.5).

Protein differential expression in normal tissues from HIPED for NDUFB10 Gene

This gene is overexpressed in Nasal epithelium (29.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NDUFB10 Gene



Protein tissue co-expression partners for NDUFB10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NDUFB10

SOURCE GeneReport for Unigene cluster for NDUFB10 Gene:

Hs.513266

Evidence on tissue expression from TISSUES for NDUFB10 Gene

  • Liver(4.5)
  • Skin(4.3)
  • Blood(4.2)
  • Muscle(3)
  • Nervous system(2.9)
  • Heart(2.7)
  • Intestine(2.2)
  • Kidney(2.2)
  • Spleen(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with NDUFB10: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NDUFB10 Gene

Orthologs for NDUFB10 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDUFB10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFB10 31 30
  • 99.22 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NDUFB10 31 30
  • 86.5 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NDUFB10 31 30
  • 85.65 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndufb10 30
  • 82.4 (n)
mouse
(Mus musculus)
Mammalia Ndufb10 17 31 30
  • 80.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NDUFB10 31
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDUFB10 31
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves NDUFB10 31 30
  • 67.29 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDUFB10 31
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufb10 30
  • 66.05 (n)
Str.10643 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.21405 30
zebrafish
(Danio rerio)
Actinopterygii ndufb10 31 30
  • 65.21 (n)
OneToOne
zgc73147 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8497 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007780 30
  • 51.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pdsw 31 30
  • 51.08 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_F59C6.5 30
  • 43.97 (n)
F59C6.5 31
  • 20 (a)
OneToOne
Species where no ortholog for NDUFB10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDUFB10 Gene

ENSEMBL:
Gene Tree for NDUFB10 (if available)
TreeFam:
Gene Tree for NDUFB10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NDUFB10: view image

Paralogs for NDUFB10 Gene

Pseudogenes.org Pseudogenes for NDUFB10 Gene

genes like me logo Genes that share paralogs with NDUFB10: view

No data available for Paralogs for NDUFB10 Gene

Variants for NDUFB10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NDUFB10 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
713530 Benign: not provided 1,961,506(+) C/T SYNONYMOUS_VARIANT
733377 Benign: not provided 1,961,873(+) A/G SYNONYMOUS_VARIANT
735859 Likely Benign: not provided 1,961,645(+) C/G INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for NDUFB10 Gene

Structural Variations from Database of Genomic Variants (DGV) for NDUFB10 Gene

Variant ID Type Subtype PubMed ID
dgv4858n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1160329 CNV deletion 26073780
nsv471070 CNV gain 18288195
nsv519366 CNV loss 19592680
nsv571178 CNV loss 21841781
nsv571179 CNV loss 21841781
nsv833120 CNV loss 17160897
nsv952901 CNV deletion 24416366
nsv984249 CNV duplication 23825009

Variation tolerance for NDUFB10 Gene

Residual Variation Intolerance Score: 31.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NDUFB10 Gene

Human Gene Mutation Database (HGMD)
NDUFB10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NDUFB10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFB10 Gene

Disorders for NDUFB10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NDUFB10 Gene - From: Orphanet and DISEASES

Disorder Aliases PubMed IDs
mitochondrial complex i deficiency, nuclear type 1
  • mc1dn1
intermittent squint
  • intermittent heterotropia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NDUFB10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NDUFB10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NDUFB10 Gene

Publications for NDUFB10 Gene

  1. cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. (PMID: 9878551) Loeffen JL … Smeitink JA (Biochemical and biophysical research communications 1998) 2 3 4 54
  2. Accessory subunits are integral for assembly and function of human mitochondrial complex I. (PMID: 27626371) Stroud DA … Ryan MT (Nature 2016) 3 4 54
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41 54
  4. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PMID: 18977241) Starr JM … Deary IJ (Mechanisms of ageing and development 2008) 3 41 54
  5. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PMID: 17601350) Harris SE … Deary IJ (BMC genetics 2007) 3 41 54

Products for NDUFB10 Gene

Sources for NDUFB10 Gene