Aliases for NDUFB1 Gene
Aliases for NDUFB1 Gene
External Ids for NDUFB1 Gene
- HGNC: 7695
- Entrez Gene: 4707
- Ensembl: ENSG00000183648
- OMIM: 603837
- UniProtKB: O75438
Previous GeneCards Identifiers for NDUFB1 Gene
- GC14M090088
- GC14M086398
- GC14M090572
- GC14M091652
- GC14M092582
- GC14M072763
Summaries for NDUFB1 Gene
GeneCards Summary for NDUFB1 Gene
NDUFB1 (NADH:Ubiquinone Oxidoreductase Subunit B1) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include NADH dehydrogenase (ubiquinone) activity and NADH dehydrogenase activity.
UniProtKB/Swiss-Prot for NDUFB1 Gene
-
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Additional gene information for NDUFB1 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFB1 Gene
Genomics for NDUFB1 Gene
GeneHancer (GH) Regulatory Elements for NDUFB1 Gene
Promoters and enhancers for NDUFB1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around NDUFB1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the NDUFB1 gene promoter:
-
- TBP
- TFIID
- POU2F2B
Regulatory Element Products
Genomic Locations for NDUFB1 Gene
Genomic Locations for NDUFB1 Gene
- chr14:92,116,122-92,121,917
- (GRCh38/hg38)
- Size:
- 5,796 bases
- Orientation:
- Minus strand
- chr14:92,582,466-92,588,261
- (GRCh37/hg19)
- Size:
- 5,796 bases
- Orientation:
- Minus strand
Genomic View for NDUFB1 Gene
Genes around NDUFB1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q32.12 by Entrez Gene
- 14q31.3 by HGNC
- 14q32.12 by Ensembl
NDUFB1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NDUFB1 Gene
Proteins for NDUFB1 Gene
-
Protein details for NDUFB1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O75438-NDUB1_HUMAN
- Recommended name:
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
- Protein Accession:
- O75438
- A0AV68
Protein attributes for NDUFB1 Gene
- Size:
- 58 amino acids
- Molecular mass:
- 6961 Da
- Quaternary structure:
-
- Complex I is composed of 45 different subunits.
- SequenceCaution:
-
- Sequence=AAD42054.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for NDUFB1 Gene
Protein Expression for NDUFB1 Gene
Post-translational modifications for NDUFB1 Gene
Other Protein References for NDUFB1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
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Protein Products
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-
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Assay Products
No data available for DME Specific Peptides for NDUFB1 Gene
Domains & Families for NDUFB1 Gene
Gene Families for NDUFB1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for NDUFB1 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for NDUFB1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O75438- Family:
-
- Belongs to the complex I NDUFB1 subunit family.
Function for NDUFB1 Gene
Molecular function for NDUFB1 Gene
- UniProtKB/Swiss-Prot Function:
- Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
- GENATLAS Biochemistry:
- NADH ubiquinone oxidoreductase (Q reductase),7kDa,component beta 1,hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008137 | NADH dehydrogenase (ubiquinone) activity | TAS,NAS | 9878551 |
Phenotypes for NDUFB1 Gene
Animal Model Products
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-
CRISPR Products
-
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-
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miRNA for NDUFB1 Gene
- miRTarBase miRNAs that target NDUFB1
miRNA Products
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Clone Products
- Sino Biological Human cDNA Clone for NDUFB1
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NDUFB1
- Applied Biological Materials Clones for NDUFB1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for NDUFB1
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NDUFB1 Gene
Localization for NDUFB1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NDUFB1 Gene
- Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| mitochondrion | 5 |
| nucleus | 4 |
| plasma membrane | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| lysosome | 1 |
- Mitochondria (3)
- Nuclear speckles (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IDA | -- |
| GO:0005743 | mitochondrial inner membrane | TAS | -- |
| GO:0005747 | mitochondrial respiratory chain complex I | NAS | 9878551 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for NDUFB1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
.40
|
|
| 2 | Metabolism |
.37
|
|
| 3 | GABAergic synapse | ||
Pathways by source for NDUFB1 Gene
2 BioSystems pathways for NDUFB1 Gene
8 KEGG pathways for NDUFB1 Gene
Interacting Proteins for NDUFB1 Gene
GPS-Prot Interaction Network for NDUFB1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006120 | mitochondrial electron transport, NADH to ubiquinone | TAS | -- |
| GO:0032981 | mitochondrial respiratory chain complex I assembly | TAS | -- |
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for SIGNOR curated interactions for NDUFB1 Gene
Drugs & Compounds for NDUFB1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Fe2+ |
|
15438-31-0 |
|
|||
| QH2 |
|
56275-39-9 |
|
|||
| Sulfide |
|
18496-25-8 |
|
Drug Products
Transcripts for NDUFB1 Gene
mRNA/cDNA for NDUFB1 Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (118) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000553514 454 bps (uc059emo.1)
- ENST00000329559 528 bps (uc001yaf.4)
- ENST00000605997 336 bps (uc059emp.1)
- ENST00000553666 1333 bps (uc059emq.1)
- ENST00000555441 458 bps (uc059emr.1)
Unigene Clusters for NDUFB1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for NDUFB1
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- Applied Biological Materials CRISPR for NDUFB1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NDUFB1
- GenScript: Design CRISPR guide RNA sequences for NDUFB1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NDUFB1
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- genomics-online: shRNA clones - Search results for 49 available NDUFB1 gene related products
- Overview of 49 available NDUFB1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for NDUFB1
- VectorBuilder custom plasmid, inducible vectors for NDUFB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NDUFB1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NDUFB1
- Applied Biological Materials Clones for NDUFB1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for NDUFB1 Gene
This gene is overexpressed in Heart (13.4) and Peripheral blood mononuclear cells (10.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NDUFB1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of NDUFB1 Gene:
NDUFB1SOURCE GeneReport for Unigene cluster for NDUFB1 Gene:
Hs.183435Evidence on tissue expression from TISSUES for NDUFB1 Gene
- Nervous system(4.4)
- Blood(4.3)
- Pancreas(4.3)
- Heart(2.4)
- Muscle(2.4)
- Kidney(2.2)
- Liver(2.2)
- Adrenal gland(2.1)
- Stomach(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for NDUFB1
-
OriGene qPCR primer pairs for NDUFB1
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Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NDUFB1 Gene
Orthologs for NDUFB1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NDUFB1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | NDUFB1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | LOC102631912 33 |
|
||
| Ndufb1-ps 16 |
|
||||
| dog (Canis familiaris) |
Mammalia | LOC102156783 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | NDUFB1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | NDUFB1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NDUFB1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | NDUFB1 34 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.6643 33 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.3020 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | NDUFB1 34 |
|
OneToOne |
- Species where no ortholog for NDUFB1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for NDUFB1 Gene
- ENSEMBL:
- Gene Tree for NDUFB1 (if available)
- TreeFam:
- Gene Tree for NDUFB1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NDUFB1: view image
Paralogs for NDUFB1 Gene
Pseudogenes.org Pseudogenes for NDUFB1 Gene
No data available for Paralogs for NDUFB1 Gene
Variants for NDUFB1 Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000066590 | -- | 92,122,001(-) | C/G | upstream_transcript_variant | |
| rs1001472705 | -- | 92,121,377(-) | C/G | intron_variant | |
| rs1001524836 | -- | 92,121,682(-) | A/C | coding_sequence_variant, synonymous_variant | |
| rs1001573905 | -- | 92,117,459(-) | A/G | intron_variant | |
| rs1001686258 | -- | 92,123,099(-) | T/C | upstream_transcript_variant |
Residual Variation Intolerance Score:
56.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.38;
8.44% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NDUFB1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFB1 Gene
Disorders for NDUFB1 Gene
Additional Disease Information for NDUFB1
No disorders were found for NDUFB1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NDUFB1 Gene
Publications for NDUFB1 Gene
- Accessory subunits are integral for assembly and function of human mitochondrial complex I. (PMID: 27626371) Stroud DA … Ryan MT (Nature 2016) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PMID: 12611891) Murray J … Capaldi RA (The Journal of biological chemistry 2003) 3 4 58
- Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain. (PMID: 9763677) Emahazion T … Brookes AJ (Cytogenetics and cell genetics 1998) 2 3 58
Products for NDUFB1 Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 18 available NDUFB1 Antibodies ranked by validation data
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Sources for NDUFB1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
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