Aliases for NDST2 Gene
External Ids for NDST2 Gene
Previous GeneCards Identifiers for NDST2 Gene
This gene encodes a member of the N-deacetylase/N-sulfotransferase subfamily of the sulfotransferase 1 proteins. The encoded enzyme has dual functions in processing glucosamine and heparin polymers, including N-deacetylation and N-sulfation. The encoded protein may be localized to the Golgi. [provided by RefSeq, Feb 2009]
GeneCards Summary for NDST2 Gene
NDST2 (N-Deacetylase And N-Sulfotransferase 2) is a Protein Coding gene. Diseases associated with NDST2 include Microphthalmia. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include hydrolase activity and [heparan sulfate]-glucosamine N-sulfotransferase activity. An important paralog of this gene is ENSG00000272916.
UniProtKB/Swiss-Prot Summary for NDST2 Gene
Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).