Aliases for NDRG4 Gene
External Ids for NDRG4 Gene
Previous GeneCards Identifiers for NDRG4 Gene
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.[provided by RefSeq, Jun 2011]
GeneCards Summary for NDRG4 Gene
NDRG4 (NDRG Family Member 4) is a Protein Coding gene. Diseases associated with NDRG4 include Infantile Myofibromatosis and Charcot-Marie-Tooth Disease, Type 4D. Among its related pathways are PI3K / Akt Signaling and Apoptosis and Autophagy. An important paralog of this gene is NDRG2.
UniProtKB/Swiss-Prot Summary for NDRG4 Gene
Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner.