Aliases for NDRG3 Gene

Aliases for NDRG3 Gene

  • NDRG Family Member 3 2 3 5
  • N-Myc Downstream-Regulated Gene 3 Protein 3 4
  • Protein NDRG3 3 4
  • NDRG3 5

External Ids for NDRG3 Gene

Previous GeneCards Identifiers for NDRG3 Gene

  • GC20M035008
  • GC20M035918
  • GC20M035965
  • GC20M034713
  • GC20M035280
  • GC20M032016

Summaries for NDRG3 Gene

GeneCards Summary for NDRG3 Gene

NDRG3 (NDRG Family Member 3) is a Protein Coding gene. Diseases associated with NDRG3 include Erythrocytosis, Familial, 3 and Charcot-Marie-Tooth Disease, Type 4D. Among its related pathways are Angiogenesis (CST) and PI3K / Akt Signaling. An important paralog of this gene is NDRG1.

Additional gene information for NDRG3 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NDRG3 Gene

Genomics for NDRG3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NDRG3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J036744 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.6 579 2.9 HNRNPL GATAD2A PRDM10 SIX5 KDM1A POLR2A NFRKB RCOR2 ZIC2 RBFOX2 NDRG3 DSN1 piR-35674-307 SLA2
GH20J036772 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 15.8 -27.9 -27933 3.1 HNRNPL CREB1 GATAD2A CTCF ZBTB33 PRDM10 ZNF629 TFE3 IKZF1 ZNF692 DSN1 lnc-SOGA1-1 lnc-TLDC2-5 NDRG3 RBL1 SRC NONHSAG031712.2 SOGA1
GH20J036643 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.6 +100.2 100178 4.1 GATAD2A ZNF7 POLR2A CEBPA KMT2B EED SOX13 RUNX3 TGIF2 KAT7 SLA2 NDRG3 RAB5IF RBL1 SAMHD1 TGIF2 KR153194-107 RF00017-3573
GH20J037093 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 10.8 -349.3 -349329 2.9 HNRNPL CREB1 ATF7 PRDM10 ZNF629 TFE3 SIX5 LEF1 IKZF1 POLR2A RBL1 ENSG00000269846 TTI1 DSN1 MROH8 ENSG00000232406 SOGA1 NDRG3 SRC RPN2
GH20J036454 Enhancer 1.4 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.3 +290.7 290728 2 TEAD4 PRDM10 TFE3 SP1 PBX2 ZNF341 MNT ZNF444 FOXA2 RCOR1 NDRG3 ENSG00000232406 EPB41L1 NORAD MYL9 DLGAP4 SOGA1 piR-43955 piR-57460-409
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NDRG3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NDRG3

Top Transcription factor binding sites by QIAGEN in the NDRG3 gene promoter:
  • aMEF-2
  • ARP-1
  • C/EBPalpha
  • E47
  • Hand1
  • HNF-3beta
  • LCR-F1
  • MEF-2
  • MEF-2A
  • Pax-6

Genomic Locations for NDRG3 Gene

Genomic Locations for NDRG3 Gene
chr20:36,651,766-36,746,127
(GRCh38/hg38)
Size:
94,362 bases
Orientation:
Minus strand
chr20:35,280,169-35,374,541
(GRCh37/hg19)
Size:
94,373 bases
Orientation:
Minus strand

Genomic View for NDRG3 Gene

Genes around NDRG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDRG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDRG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDRG3 Gene

Proteins for NDRG3 Gene

  • Protein details for NDRG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGV2-NDRG3_HUMAN
    Recommended name:
    Protein NDRG3
    Protein Accession:
    Q9UGV2
    Secondary Accessions:
    • A2A2S8
    • E1P5U7
    • E1P5U8
    • Q5TH32
    • Q96PL8
    • Q96SM2
    • Q9BXY7
    • Q9H3N7
    • Q9H411
    • Q9H8J6

    Protein attributes for NDRG3 Gene

    Size:
    375 amino acids
    Molecular mass:
    41409 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NDRG3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDRG3 Gene

Post-translational modifications for NDRG3 Gene

  • Ubiquitination at Lys13
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for NDRG3
  • Boster Bio Antibodies for NDRG3
  • Santa Cruz Biotechnology (SCBT) Antibodies for NDRG3

No data available for DME Specific Peptides for NDRG3 Gene

Domains & Families for NDRG3 Gene

Gene Families for NDRG3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NDRG3 Gene

InterPro:
Blocks:
  • Ndr family
ProtoNet:

Suggested Antigen Peptide Sequences for NDRG3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54521, highly similar to Protein NDRG3 (B7Z341_HUMAN)
  • NDRG3 protein (B7ZLZ9_HUMAN)
  • Protein NDRG3 (NDRG3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UGV2

UniProtKB/Swiss-Prot:

NDRG3_HUMAN :
  • Belongs to the NDRG family.
Family:
  • Belongs to the NDRG family.
genes like me logo Genes that share domains with NDRG3: view

Function for NDRG3 Gene

Phenotypes From GWAS Catalog for NDRG3 Gene

Gene Ontology (GO) - Molecular Function for NDRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with NDRG3: view
genes like me logo Genes that share phenotypes with NDRG3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NDRG3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NDRG3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NDRG3 Gene

Localization for NDRG3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NDRG3 gene
Compartment Confidence
extracellular 4
nucleus 3
cytosol 3
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for NDRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,IDA 11936845
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with NDRG3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for NDRG3 Gene

Pathways & Interactions for NDRG3 Gene

PathCards logo

SuperPathways for NDRG3 Gene

genes like me logo Genes that share pathways with NDRG3: view

Pathways by source for NDRG3 Gene

3 Cell Signaling Technology pathways for NDRG3 Gene

Gene Ontology (GO) - Biological Process for NDRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA 21873635
GO:0007283 spermatogenesis NAS 11406283
GO:0030154 cell differentiation NAS 11406283
GO:0030308 negative regulation of cell growth NAS 11406283
genes like me logo Genes that share ontologies with NDRG3: view

No data available for SIGNOR curated interactions for NDRG3 Gene

Drugs & Compounds for NDRG3 Gene

No Compound Related Data Available

Transcripts for NDRG3 Gene

mRNA/cDNA for NDRG3 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NDRG3

Alternative Splicing Database (ASD) splice patterns (SP) for NDRG3 Gene

No ASD Table

Relevant External Links for NDRG3 Gene

GeneLoc Exon Structure for
NDRG3

Expression for NDRG3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NDRG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NDRG3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.2).

Protein differential expression in normal tissues from HIPED for NDRG3 Gene

This gene is overexpressed in Frontal cortex (7.9) and Adrenal (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NDRG3 Gene



Protein tissue co-expression partners for NDRG3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NDRG3

SOURCE GeneReport for Unigene cluster for NDRG3 Gene:

Hs.437338

mRNA Expression by UniProt/SwissProt for NDRG3 Gene:

Q9UGV2-NDRG3_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in brain.

Evidence on tissue expression from TISSUES for NDRG3 Gene

  • Liver(4.4)
  • Nervous system(4.4)
  • Spleen(4.3)
  • Heart(2.3)
  • Kidney(2.2)
  • Muscle(2.1)
  • Intestine(2)
genes like me logo Genes that share expression patterns with NDRG3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NDRG3 Gene

Orthologs for NDRG3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NDRG3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NDRG3 30 31
  • 99.91 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NDRG3 30 31
  • 92.71 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NDRG3 30 31
  • 92.18 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ndrg3 30 17 31
  • 89.96 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NDRG3 31
  • 85 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NDRG3 31
  • 81 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NDRG3 31
  • 82 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ndrg4 30
  • 71.67 (n)
Str.7333 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.17664 30
Zebrafish
(Danio rerio)
Actinopterygii ndrg3b 31
  • 78 (a)
OneToMany
ndrg3a 30 31
  • 71.34 (n)
OneToMany
-- 30
Fruit Fly
(Drosophila melanogaster)
Insecta MESK2 30 31
  • 51.89 (n)
ManyToMany
CG2082 31
  • 26 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008821 30
  • 49.41 (n)
Worm
(Caenorhabditis elegans)
Secernentea Y48G10A.3 30 31
  • 47.68 (n)
ManyToMany
ZK1073.1 31
  • 28 (a)
ManyToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons NDL1 30
  • 45.26 (n)
Rice
(Oryza sativa)
Liliopsida Os06g0563000 30
  • 46.36 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.7991 31
  • 38 (a)
OneToMany
Species where no ortholog for NDRG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for NDRG3 Gene

ENSEMBL:
Gene Tree for NDRG3 (if available)
TreeFam:
Gene Tree for NDRG3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NDRG3: view image

Paralogs for NDRG3 Gene

Paralogs for NDRG3 Gene

(4) SIMAP similar genes for NDRG3 Gene using alignment to 6 proteins:

  • NDRG3_HUMAN
  • B7Z341_HUMAN
  • B7ZLZ9_HUMAN
  • F8WBF9_HUMAN
  • Q5TH29_HUMAN
  • Q5TH30_HUMAN
genes like me logo Genes that share paralogs with NDRG3: view

Variants for NDRG3 Gene

Additional dbSNP identifiers (rs#s) for NDRG3 Gene

Structural Variations from Database of Genomic Variants (DGV) for NDRG3 Gene

Variant ID Type Subtype PubMed ID
esv2722377 CNV deletion 23290073
esv2722378 CNV deletion 23290073
esv2722379 CNV deletion 23290073
esv2722380 CNV deletion 23290073
esv3575371 CNV gain 25503493
esv992784 CNV insertion 20482838
nsv1057192 CNV loss 25217958
nsv1123484 CNV deletion 24896259
nsv833967 CNV loss 17160897

Variation tolerance for NDRG3 Gene

Residual Variation Intolerance Score: 29.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NDRG3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NDRG3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NDRG3 Gene

Disorders for NDRG3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for NDRG3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
erythrocytosis, familial, 3
  • ecyt3
charcot-marie-tooth disease, type 4d
  • cmt4d
transitional papilloma
  • transitional cell papilloma
non-proliferative fibrocystic change of the breast
  • non-proliferative fibrocystic change
charcot-marie-tooth disease
  • peroneal muscular atrophy
- elite association - COSMIC cancer census association via MalaCards
Search NDRG3 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with NDRG3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NDRG3 Gene

Publications for NDRG3 Gene

  1. Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family. (PMID: 11936845) Qu X … He F (Molecular and cellular biochemistry 2002) 3 4 23
  2. Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart. (PMID: 11352569) Zhou RH … Miyata T (Genomics 2001) 3 4 23
  3. Differential expression patterns of NDRG family proteins in the central nervous system. (PMID: 17998568) Okuda T … Miyata T (The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2008) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. Cloning and expression pattern of the human NDRG3 gene. (PMID: 11406283) Zhao W … Mao Y (Biochimica et biophysica acta 2001) 3 23

Products for NDRG3 Gene

Sources for NDRG3 Gene