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NDRG3 (NDRG Family Member 3) is a Protein Coding gene. Diseases associated with NDRG3 include Erythrocytosis, Familial, 3 and Charcot-Marie-Tooth Disease, Type 4D. Among its related pathways are Angiogenesis (CST) and PI3K / Akt Signaling. An important paralog of this gene is NDRG1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003674 | molecular_function | ND | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IBA,IDA | 11936845 |
GO:0070062 | extracellular exosome | HDA | 19056867 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Angiogenesis (CST) | ||
2 | Apoptosis and Autophagy | ||
3 | PI3K / Akt Signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IBA | 21873635 |
GO:0007283 | spermatogenesis | NAS | 11406283 |
GO:0030154 | cell differentiation | NAS | 11406283 |
GO:0030308 | negative regulation of cell growth | NAS | 11406283 |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NDRG3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NDRG3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NDRG3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ndrg3 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | NDRG3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | NDRG3 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | NDRG3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ndrg4 30 |
|
||
Str.7333 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.17664 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ndrg3b 31 |
|
OneToMany | |
ndrg3a 30 31 |
|
OneToMany | |||
-- 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | MESK2 30 31 |
|
ManyToMany | |
CG2082 31 |
|
ManyToMany | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008821 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | Y48G10A.3 30 31 |
|
ManyToMany | |
ZK1073.1 31 |
|
ManyToMany | |||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | NDL1 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os06g0563000 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.7991 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2722377 | CNV | deletion | 23290073 |
esv2722378 | CNV | deletion | 23290073 |
esv2722379 | CNV | deletion | 23290073 |
esv2722380 | CNV | deletion | 23290073 |
esv3575371 | CNV | gain | 25503493 |
esv992784 | CNV | insertion | 20482838 |
nsv1057192 | CNV | loss | 25217958 |
nsv1123484 | CNV | deletion | 24896259 |
nsv833967 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
erythrocytosis, familial, 3 |
|
|
charcot-marie-tooth disease, type 4d |
|
|
transitional papilloma |
|
|
non-proliferative fibrocystic change of the breast |
|
|
charcot-marie-tooth disease |
|
|