Aliases for NDRG3 Gene

Aliases for NDRG3 Gene

  • NDRG Family Member 3 2 3 5
  • N-Myc Downstream-Regulated Gene 3 Protein 3 4
  • Protein NDRG3 3 4

External Ids for NDRG3 Gene

Previous GeneCards Identifiers for NDRG3 Gene

  • GC20M035008
  • GC20M035918
  • GC20M035965
  • GC20M034713
  • GC20M035280
  • GC20M032016

Summaries for NDRG3 Gene

GeneCards Summary for NDRG3 Gene

NDRG3 (NDRG Family Member 3) is a Protein Coding gene. Diseases associated with NDRG3 include Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive. Among its related pathways are PI3K / Akt Signaling and Apoptosis and Autophagy. An important paralog of this gene is NDRG1.

Additional gene information for NDRG3 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NDRG3 Gene

Genomics for NDRG3 Gene

GeneHancer (GH) Regulatory Elements for NDRG3 Gene

Promoters and enhancers for NDRG3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J036744 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 750.6 +0.6 590 2.9 ZBTB40 CTCF SIX5 ZBTB6 POLR2A NR2F6 HCFC1 NFYC L3MBTL2 ZNF148 NDRG3 SLA2 RBL1 DSN1 piR-35674-307
GH20J036772 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 15.7 -27.9 -27922 3.1 E2F8 ZBTB40 CTCF MLX SMARCE1 RBPJ POLR2A NR2F6 ATF1 CREB1 DSN1 lnc-SOGA1-1 lnc-TLDC2-5 NDRG3 NONHSAG031712.2
GH20J036643 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.6 +100.2 100189 4.1 MIXL1 ZNF362 MYC HLF MAX ELF3 CEBPG PPARG HNF1A ZNF644 SLA2 NDRG3 RAB5IF RBL1 SAMHD1 TGIF2 KR153194-108 RF00017-3571
GH20J037093 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 11.8 -349.3 -349318 2.9 E2F8 ZNF785 SIN3A ZBTB40 CTCF SIX5 ZBTB6 MLX RBPJ POLR2A RBL1 ENSG00000269846 AAR2 DSN1 SOGA1 RPN2 CTNNBL1 LINC00489 MROH8 TLDC2
GH20J035951 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 11.8 +792.3 792259 3.8 ZNF785 SIN3A SP1 ZBTB40 CTCF SREBF1 SIX5 ZBTB6 FOXA1 MLX CNBD2 SCAND1 CPNE1 RBM12 AAR2 ERGIC3 RBM39 TRPC4AP EIF6 RPL36P4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NDRG3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NDRG3 gene promoter:
  • aMEF-2
  • ARP-1
  • C/EBPalpha
  • E47
  • Hand1
  • HNF-3beta
  • LCR-F1
  • MEF-2
  • MEF-2A
  • Pax-6

Genomic Locations for NDRG3 Gene

Genomic Locations for NDRG3 Gene
94,373 bases
Minus strand
94,373 bases
Minus strand

Genomic View for NDRG3 Gene

Genes around NDRG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDRG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDRG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDRG3 Gene

Proteins for NDRG3 Gene

  • Protein details for NDRG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein NDRG3
    Protein Accession:
    Secondary Accessions:
    • A2A2S8
    • E1P5U7
    • E1P5U8
    • Q5TH32
    • Q96PL8
    • Q96SM2
    • Q9BXY7
    • Q9H3N7
    • Q9H411
    • Q9H8J6

    Protein attributes for NDRG3 Gene

    375 amino acids
    Molecular mass:
    41409 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NDRG3 Gene


neXtProt entry for NDRG3 Gene

Post-translational modifications for NDRG3 Gene

  • Ubiquitination at Lys13
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NDRG3 Gene

Domains & Families for NDRG3 Gene

Gene Families for NDRG3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NDRG3 Gene


Suggested Antigen Peptide Sequences for NDRG3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54521, highly similar to Protein NDRG3 (B7Z341_HUMAN)
  • NDRG3 protein (B7ZLZ9_HUMAN)
  • Protein NDRG3 (NDRG3_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NDRG family.
  • Belongs to the NDRG family.
genes like me logo Genes that share domains with NDRG3: view

Function for NDRG3 Gene

Phenotypes From GWAS Catalog for NDRG3 Gene

Gene Ontology (GO) - Molecular Function for NDRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with NDRG3: view

Phenotypes for NDRG3 Gene

genes like me logo Genes that share phenotypes with NDRG3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NDRG3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NDRG3

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NDRG3 Gene

Localization for NDRG3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NDRG3 gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 0
peroxisome 0

Gene Ontology (GO) - Cellular Components for NDRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IBA 11936845
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with NDRG3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for NDRG3 Gene

Pathways & Interactions for NDRG3 Gene

PathCards logo

SuperPathways for NDRG3 Gene

genes like me logo Genes that share pathways with NDRG3: view

Pathways by source for NDRG3 Gene

3 Cell Signaling Technology pathways for NDRG3 Gene

Gene Ontology (GO) - Biological Process for NDRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA 21873635
GO:0007283 spermatogenesis NAS 11406283
GO:0030154 cell differentiation NAS 11406283
GO:0030308 negative regulation of cell growth NAS 11406283
genes like me logo Genes that share ontologies with NDRG3: view

No data available for SIGNOR curated interactions for NDRG3 Gene

Drugs & Compounds for NDRG3 Gene

No Compound Related Data Available

Transcripts for NDRG3 Gene

mRNA/cDNA for NDRG3 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NDRG3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDRG3 Gene

No ASD Table

Relevant External Links for NDRG3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NDRG3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NDRG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NDRG3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.2).

Protein differential expression in normal tissues from HIPED for NDRG3 Gene

This gene is overexpressed in Frontal cortex (7.9) and Adrenal (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NDRG3 Gene

Protein tissue co-expression partners for NDRG3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NDRG3 Gene:


SOURCE GeneReport for Unigene cluster for NDRG3 Gene:


mRNA Expression by UniProt/SwissProt for NDRG3 Gene:

Tissue specificity: Ubiquitous. Highly expressed in brain.

Evidence on tissue expression from TISSUES for NDRG3 Gene

  • Liver(4.3)
  • Spleen(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with NDRG3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NDRG3 Gene

Orthologs for NDRG3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NDRG3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NDRG3 33 32
  • 99.91 (n)
(Canis familiaris)
Mammalia NDRG3 33 32
  • 92.71 (n)
(Bos Taurus)
Mammalia NDRG3 33 32
  • 92.18 (n)
(Mus musculus)
Mammalia Ndrg3 17 33 32
  • 89.96 (n)
(Monodelphis domestica)
Mammalia NDRG3 33
  • 85 (a)
(Gallus gallus)
Aves NDRG3 33
  • 81 (a)
(Anolis carolinensis)
Reptilia NDRG3 33
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ndrg4 32
  • 71.67 (n)
Str.7333 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.17664 32
(Danio rerio)
Actinopterygii ndrg3b 33
  • 78 (a)
ndrg3a 33 32
  • 71.34 (n)
-- 32
fruit fly
(Drosophila melanogaster)
Insecta MESK2 33 32
  • 51.89 (n)
CG2082 33
  • 26 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008821 32
  • 49.41 (n)
(Caenorhabditis elegans)
Secernentea Y48G10A.3 33 32
  • 47.68 (n)
ZK1073.1 33
  • 28 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons NDL1 32
  • 45.26 (n)
(Oryza sativa)
Liliopsida Os06g0563000 32
  • 46.36 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7991 33
  • 38 (a)
Species where no ortholog for NDRG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDRG3 Gene

Gene Tree for NDRG3 (if available)
Gene Tree for NDRG3 (if available)
Evolutionary constrained regions (ECRs) for NDRG3: view image

Paralogs for NDRG3 Gene

Paralogs for NDRG3 Gene

(4) SIMAP similar genes for NDRG3 Gene using alignment to 6 proteins:

  • B7Z341_HUMAN
  • Q5TH29_HUMAN
  • Q5TH30_HUMAN
genes like me logo Genes that share paralogs with NDRG3: view

Variants for NDRG3 Gene

Sequence variations from dbSNP and Humsavar for NDRG3 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000052300 -- 36,699,353(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000059160 -- 36,747,158(-) G/A upstream_transcript_variant
rs1000077093 -- 36,654,132(-) A/G intron_variant
rs1000096508 -- 36,697,854(-) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000107424 -- 36,739,963(-) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NDRG3 Gene

Variant ID Type Subtype PubMed ID
esv2722377 CNV deletion 23290073
esv2722378 CNV deletion 23290073
esv2722379 CNV deletion 23290073
esv2722380 CNV deletion 23290073
esv3575371 CNV gain 25503493
esv992784 CNV insertion 20482838
nsv1057192 CNV loss 25217958
nsv1123484 CNV deletion 24896259
nsv833967 CNV loss 17160897

Variation tolerance for NDRG3 Gene

Residual Variation Intolerance Score: 29.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NDRG3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDRG3 Gene

Disorders for NDRG3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NDRG3 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search NDRG3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NDRG3

genes like me logo Genes that share disorders with NDRG3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NDRG3 Gene

Publications for NDRG3 Gene

  1. Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family. (PMID: 11936845) Qu X … He F (Molecular and cellular biochemistry 2002) 3 4 23 56
  2. Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart. (PMID: 11352569) Zhou RH … Miyata T (Genomics 2001) 3 4 23 56
  3. Differential expression patterns of NDRG family proteins in the central nervous system. (PMID: 17998568) Okuda T … Miyata T (The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2008) 2 3 56
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 56

Products for NDRG3 Gene

Sources for NDRG3 Gene