Aliases for NDRG2 Gene
External Ids for NDRG2 Gene
Previous GeneCards Identifiers for NDRG2 Gene
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]
GeneCards Summary for NDRG2 Gene
NDRG2 (NDRG Family Member 2) is a Protein Coding gene. Diseases associated with NDRG2 include Glioblastoma and Neuronal Ceroid Lipofuscinosis. Among its related pathways are Validated targets of C-MYC transcriptional repression and PI3K / Akt Signaling. An important paralog of this gene is NDRG4.
UniProtKB/Swiss-Prot Summary for NDRG2 Gene
Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.