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Aliases for NDRG2 Gene

Aliases for NDRG2 Gene

  • NDRG Family Member 2 2 3 5
  • N-Myc Downstream-Regulated Gene 2 Protein 3 4
  • SYLD 3 4
  • N-Myc Downstream Regulator 2 3
  • NDR1-Related Protein NDR2 3
  • Cytoplasmic Protein Ndr1 3
  • Syld709613 Protein 3
  • Protein Syld709613 4
  • Protein NDRG2 3
  • KIAA1248 4

External Ids for NDRG2 Gene

Previous GeneCards Identifiers for NDRG2 Gene

  • GC14M018857
  • GC14M015272
  • GC14M019476
  • GC14M019477
  • GC14M019478
  • GC14M020554
  • GC14M021484
  • GC14M001606

Summaries for NDRG2 Gene

Entrez Gene Summary for NDRG2 Gene

  • This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]

GeneCards Summary for NDRG2 Gene

NDRG2 (NDRG Family Member 2) is a Protein Coding gene. Diseases associated with NDRG2 include Glioblastoma and Charcot-Marie-Tooth Disease, Type 4D. Among its related pathways are PI3K / Akt Signaling and Apoptosis and Autophagy. An important paralog of this gene is NDRG4.

UniProtKB/Swiss-Prot for NDRG2 Gene

  • Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.

Gene Wiki entry for NDRG2 Gene

Additional gene information for NDRG2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDRG2 Gene

Genomics for NDRG2 Gene

GeneHancer (GH) Regulatory Elements for NDRG2 Gene

Promoters and enhancers for NDRG2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I021068 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 -0.2 -173 5 HDGF ARID4B SIN3A DMAP1 ZBTB7B ZNF213 E2F8 ZNF143 FOS PAF1 ARHGEF40 NDRG2 TMEM253 ZNF219 RNASE7 TPPP2 RNASE13 ENSG00000255472 RNASE6 TOX4
GH14I021021 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 550.2 +45.8 45849 6.1 ZFP64 ZNF133 ARID4B SIN3A DMAP1 ZNF48 SLC30A9 SP3 RXRA SP5 ENSG00000258604 TPPP2 MIR6717 NDRG2 TRAV13-1 ENSG00000255472
GH14I021014 Enhancer 1.1 Ensembl ENCODE 11.3 +55.6 55565 1.6 PKNOX1 FOXA2 ARID4B SIN3A IRF4 ARID2 ZNF143 DEK RXRA NCOA1 RNASE7 ARHGEF40 NDRG2 ZNF219 METTL17 TMEM253 GC14M021020 GC14P021091
GH14I021043 Enhancer 0.9 ENCODE 11.5 +26.7 26696 2 FOXA2 DMAP1 ZNF48 YY1 GTF3C2 ATF7 RXRA MIER2 REST PPARG RNASE7 PARP2 PIP4P1 NDRG2 ARHGEF40 ZNF219 TMEM253 ENSG00000258515 ENSG00000258768 LOC105370398
GH14I020679 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.4 +386.3 386339 9.8 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 RNASE4 ANG TRY-GTA5-5 ENSG00000259171 TRP-TGG3-2 PIR55020 METTL3 ENSG00000258515 SUPT16H CHD8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NDRG2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NDRG2 gene promoter:

Genomic Locations for NDRG2 Gene

Genomic Locations for NDRG2 Gene
chr14:21,016,763-21,070,872
(GRCh38/hg38)
Size:
54,110 bases
Orientation:
Minus strand
chr14:21,484,922-21,539,031
(GRCh37/hg19)

Genomic View for NDRG2 Gene

Genes around NDRG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDRG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDRG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDRG2 Gene

Proteins for NDRG2 Gene

  • Protein details for NDRG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UN36-NDRG2_HUMAN
    Recommended name:
    Protein NDRG2
    Protein Accession:
    Q9UN36
    Secondary Accessions:
    • B3KUE3
    • B4DE86
    • B7WP11
    • B7WPD5
    • D3DS07
    • D3DS10
    • Q567T1
    • Q68DW2
    • Q86U08
    • Q86U46
    • Q96FD3
    • Q96FT0
    • Q96JU0
    • Q96PN0
    • Q9BQH5
    • Q9ULH2

    Protein attributes for NDRG2 Gene

    Size:
    371 amino acids
    Molecular mass:
    40798 Da
    Quaternary structure:
    • Interacts with CTNNB1.
    SequenceCaution:
    • Sequence=BAA86562.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD62350.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NDRG2 Gene

    Alternative splice isoforms for NDRG2 Gene

neXtProt entry for NDRG2 Gene

Post-translational modifications for NDRG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NDRG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NDRG2 Gene

Domains & Families for NDRG2 Gene

Gene Families for NDRG2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NDRG2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NDRG2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UN36

UniProtKB/Swiss-Prot:

NDRG2_HUMAN :
  • Belongs to the NDRG family.
Family:
  • Belongs to the NDRG family.
genes like me logo Genes that share domains with NDRG2: view

Function for NDRG2 Gene

Molecular function for NDRG2 Gene

UniProtKB/Swiss-Prot Function:
Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.

Phenotypes From GWAS Catalog for NDRG2 Gene

Gene Ontology (GO) - Molecular Function for NDRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21217774
genes like me logo Genes that share ontologies with NDRG2: view
genes like me logo Genes that share phenotypes with NDRG2: view

Animal Models for NDRG2 Gene

MGI Knock Outs for NDRG2:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NDRG2 Gene

Localization for NDRG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDRG2 Gene

Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NDRG2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
golgi apparatus 4
cytoskeleton 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Microtubule organizing center (2)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NDRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol NAS 11936845
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NDRG2: view

Pathways & Interactions for NDRG2 Gene

genes like me logo Genes that share pathways with NDRG2: view

Pathways by source for NDRG2 Gene

1 BioSystems pathway for NDRG2 Gene
3 Cell Signaling Technology pathways for NDRG2 Gene

SIGNOR curated interactions for NDRG2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NDRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001818 negative regulation of cytokine production IEA --
GO:0007165 signal transduction IBA --
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0010574 regulation of vascular endothelial growth factor production IEA --
genes like me logo Genes that share ontologies with NDRG2: view

Drugs & Compounds for NDRG2 Gene

No Compound Related Data Available

Transcripts for NDRG2 Gene

Unigene Clusters for NDRG2 Gene

NDRG family member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDRG2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c · 8d ^
SP1: - - - - - - - - - - - - -
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ExUns: 9a · 9b · 9c · 9d ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g · 11h ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g · 12h ^ 13a · 13b · 13c ·
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - -
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SP37:
SP38:
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SP40:
SP41:
SP42: - - -
SP43: -
SP44:
SP45:

ExUns: 13d · 13e ^ 14a · 14b ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24a · 24b · 24c
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - -
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SP9: - - - - - - -
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SP33: - -
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SP37:
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SP40: -
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SP42:
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SP44:
SP45:

Relevant External Links for NDRG2 Gene

GeneLoc Exon Structure for
NDRG2
ECgene alternative splicing isoforms for
NDRG2

Expression for NDRG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NDRG2 Gene

Protein differential expression in normal tissues from HIPED for NDRG2 Gene

This gene is overexpressed in Salivary gland (19.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NDRG2 Gene



Protein tissue co-expression partners for NDRG2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NDRG2 Gene:

NDRG2

SOURCE GeneReport for Unigene cluster for NDRG2 Gene:

Hs.525205

mRNA Expression by UniProt/SwissProt for NDRG2 Gene:

Q9UN36-NDRG2_HUMAN
Tissue specificity: Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level).

Evidence on tissue expression from TISSUES for NDRG2 Gene

  • Nervous system(5)
  • Liver(4.8)
  • Intestine(4.7)
  • Kidney(4.3)
  • Muscle(4.3)
  • Heart(4.2)
  • Spleen(3.1)
  • Lung(2.9)
  • Adrenal gland(2.3)
  • Thyroid gland(2.3)
  • Eye(2.2)
  • Lymph node(2.2)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with NDRG2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NDRG2 Gene

Orthologs for NDRG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NDRG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDRG2 34 33
  • 99.16 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NDRG2 33 34
  • 92.34 (n)
dog
(Canis familiaris)
Mammalia NDRG2 33 34
  • 91.73 (n)
mouse
(Mus musculus)
Mammalia Ndrg2 33 16 34
  • 90.66 (n)
rat
(Rattus norvegicus)
Mammalia Ndrg2 33
  • 90.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NDRG2 34
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDRG2 34
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDRG2 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndrg2 33
  • 70.19 (n)
Str.6843 33
African clawed frog
(Xenopus laevis)
Amphibia ndrg2-prov 33
zebrafish
(Danio rerio)
Actinopterygii ndrg2 33 34
  • 68.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta MESK2 35 34
  • 38 (a)
BcDNA:GH02439 35
  • 29 (a)
CG2082 34
  • 26 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y48G10A.3 35 34
  • 30 (a)
ZK1073.1 34
  • 23 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons NDL2 33
  • 45.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7991 34
  • 35 (a)
OneToMany
Species where no ortholog for NDRG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDRG2 Gene

ENSEMBL:
Gene Tree for NDRG2 (if available)
TreeFam:
Gene Tree for NDRG2 (if available)

Paralogs for NDRG2 Gene

Variants for NDRG2 Gene

Sequence variations from dbSNP and Humsavar for NDRG2 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000119394 -- 21,032,810(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000132361 -- 21,036,977(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000324285 -- 21,066,019(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000438847 -- 21,065,775(-) C/A genic_upstream_transcript_variant, intron_variant
rs1000546604 -- 21,046,177(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NDRG2 Gene

Variant ID Type Subtype PubMed ID
dgv1053n106 CNV deletion 24896259
esv1010817 CNV deletion 20482838
esv1716472 CNV deletion 17803354
esv2748449 CNV deletion 23290073
esv3246941 CNV deletion 24192839
esv3551208 CNV deletion 23714750
esv4248 CNV loss 18987735
esv9575 CNV loss 19470904
nsv1039369 CNV loss 25217958
nsv1070210 CNV deletion 25765185
nsv1153428 CNV deletion 26484159
nsv428293 CNV gain+loss 18775914
nsv826882 CNV gain 20364138
nsv832740 CNV gain 17160897
nsv84528 CNV deletion 16902084
nsv957516 CNV deletion 24416366

Variation tolerance for NDRG2 Gene

Residual Variation Intolerance Score: 54.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NDRG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NDRG2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDRG2 Gene

Disorders for NDRG2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NDRG2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
glioblastoma
  • glioblastoma multiforme
charcot-marie-tooth disease, type 4d
  • cmt4d
alzheimer disease
  • ad
- elite association - COSMIC cancer census association via MalaCards
Search NDRG2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NDRG2

genes like me logo Genes that share disorders with NDRG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NDRG2 Gene

Publications for NDRG2 Gene

  1. N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation. (PMID: 12845671) Deng Y … Lin MC (International journal of cancer 2003) 3 4 22 58
  2. Expression and regulation of NDRG2 (N-myc downstream regulated gene 2) during the differentiation of dendritic cells. (PMID: 14572661) Choi SC … Lim JS (FEBS letters 2003) 3 4 22 58
  3. Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family. (PMID: 11936845) Qu X … He F (Molecular and cellular biochemistry 2002) 3 4 22 58
  4. Crystal structure of the human N-Myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor. (PMID: 21247902) Hwang J … Kim MH (The Journal of biological chemistry 2011) 3 4 58
  5. NDRG2 is a candidate tumor-suppressor for oral squamous-cell carcinoma. (PMID: 20045673) Furuta H … Morishita K (Biochemical and biophysical research communications 2010) 3 22 58

Products for NDRG2 Gene