This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017] See more...

Aliases for NDRG2 Gene

Aliases for NDRG2 Gene

  • NDRG Family Member 2 2 3 5
  • N-Myc Downstream-Regulated Gene 2 Protein 3 4
  • Protein NDRG2 3 4
  • SYLD 3 4
  • N-Myc Downstream Regulator 2 3
  • NDR1-Related Protein NDR2 3
  • Cytoplasmic Protein Ndr1 3
  • Syld709613 Protein 3
  • Protein Syld709613 4
  • KIAA1248 4

External Ids for NDRG2 Gene

Previous GeneCards Identifiers for NDRG2 Gene

  • GC14M018857
  • GC14M015272
  • GC14M019476
  • GC14M019477
  • GC14M019478
  • GC14M020554
  • GC14M021484
  • GC14M001606

Summaries for NDRG2 Gene

Entrez Gene Summary for NDRG2 Gene

  • This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]

GeneCards Summary for NDRG2 Gene

NDRG2 (NDRG Family Member 2) is a Protein Coding gene. Diseases associated with NDRG2 include Charcot-Marie-Tooth Disease, Type 4D and Alzheimer Disease. Among its related pathways are Validated targets of C-MYC transcriptional repression and PI3K / Akt Signaling. An important paralog of this gene is NDRG4.

UniProtKB/Swiss-Prot Summary for NDRG2 Gene

  • Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.

Gene Wiki entry for NDRG2 Gene

Additional gene information for NDRG2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NDRG2 Gene

Genomics for NDRG2 Gene

GeneHancer (GH) Regulatory Elements for NDRG2 Gene

Promoters and enhancers for NDRG2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NDRG2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NDRG2

Top Transcription factor binding sites by QIAGEN in the NDRG2 gene promoter:
  • ARP-1
  • CREB
  • deltaCREB
  • Nkx2-5
  • TBP

Genomic Locations for NDRG2 Gene

Genomic Locations for NDRG2 Gene
chr14:21,016,763-21,070,872
(GRCh38/hg38)
Size:
54,110 bases
Orientation:
Minus strand
chr14:21,484,922-21,539,031
(GRCh37/hg19)
Size:
54,110 bases
Orientation:
Minus strand

Genomic View for NDRG2 Gene

Genes around NDRG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDRG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDRG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDRG2 Gene

Proteins for NDRG2 Gene

  • Protein details for NDRG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UN36-NDRG2_HUMAN
    Recommended name:
    Protein NDRG2
    Protein Accession:
    Q9UN36
    Secondary Accessions:
    • B3KUE3
    • B4DE86
    • B7WP11
    • B7WPD5
    • D3DS07
    • D3DS10
    • Q567T1
    • Q68DW2
    • Q86U08
    • Q86U46
    • Q96FD3
    • Q96FT0
    • Q96JU0
    • Q96PN0
    • Q9BQH5
    • Q9ULH2

    Protein attributes for NDRG2 Gene

    Size:
    371 amino acids
    Molecular mass:
    40798 Da
    Quaternary structure:
    • Interacts with CTNNB1.
    SequenceCaution:
    • Sequence=BAA86562.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAD62350.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NDRG2 Gene

    Alternative splice isoforms for NDRG2 Gene

neXtProt entry for NDRG2 Gene

Post-translational modifications for NDRG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NDRG2 Gene

Domains & Families for NDRG2 Gene

Gene Families for NDRG2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NDRG2 Gene

Blocks:
  • Ndr family
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NDRG2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55190, highly similar to Protein NDRG2 (B4DE86_HUMAN)
  • Protein Syld709613 (NDRG2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UN36

UniProtKB/Swiss-Prot:

NDRG2_HUMAN :
  • Belongs to the NDRG family.
Family:
  • Belongs to the NDRG family.
genes like me logo Genes that share domains with NDRG2: view

Function for NDRG2 Gene

Molecular function for NDRG2 Gene

UniProtKB/Swiss-Prot Function:
Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.

Phenotypes From GWAS Catalog for NDRG2 Gene

Gene Ontology (GO) - Molecular Function for NDRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21217774
genes like me logo Genes that share ontologies with NDRG2: view
genes like me logo Genes that share phenotypes with NDRG2: view

Animal Models for NDRG2 Gene

MGI Knock Outs for NDRG2:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NDRG2 Gene

Localization for NDRG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDRG2 Gene

Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NDRG2 gene
Compartment Confidence
cytosol 5
nucleus 4
golgi apparatus 4
cytoskeleton 3
plasma membrane 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Centriolar satellite (2)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NDRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA 21873635
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol NAS 11936845
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NDRG2: view

Pathways & Interactions for NDRG2 Gene

genes like me logo Genes that share pathways with NDRG2: view

Pathways by source for NDRG2 Gene

1 BioSystems pathway for NDRG2 Gene
3 Cell Signaling Technology pathways for NDRG2 Gene

SIGNOR curated interactions for NDRG2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NDRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001818 negative regulation of cytokine production IEA --
GO:0007165 signal transduction IBA 21873635
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0010574 regulation of vascular endothelial growth factor production IEA --
genes like me logo Genes that share ontologies with NDRG2: view

Drugs & Compounds for NDRG2 Gene

No Compound Related Data Available

Transcripts for NDRG2 Gene

mRNA/cDNA for NDRG2 Gene

27 REFSEQ mRNAs :
28 NCBI additional mRNA sequence :
78 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDRG2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c · 8d ^
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - -
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ExUns: 9a · 9b · 9c · 9d ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g · 11h ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g · 12h ^ 13a · 13b · 13c ·
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - - - - -
SP11:
SP12: - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - - - -
SP14:
SP15:
SP16: - - - - -
SP17: - - - - -
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SP20: - - - - - -
SP21: - - - - -
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SP24: - -
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SP27: - - - - - - - - -
SP28: - - - - - - - - -
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SP30: - - - - - - - - -
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SP32: - - - - - - - - -
SP33: - - - - - - - - - - - - - - - - -
SP34: - - - - - - - - - -
SP35: - - - - -
SP36: - - - - - - - - -
SP37:
SP38:
SP39:
SP40:
SP41:
SP42: - - -
SP43: -
SP44:
SP45:

ExUns: 13d · 13e ^ 14a · 14b ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24a · 24b · 24c
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - -
SP11: - - - - -
SP12: - -
SP13: - -
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SP15: - - -
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SP33: - -
SP34:
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SP36: - -
SP37:
SP38:
SP39:
SP40: -
SP41:
SP42:
SP43:
SP44:
SP45:

Relevant External Links for NDRG2 Gene

GeneLoc Exon Structure for
NDRG2

Expression for NDRG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NDRG2 Gene

Protein differential expression in normal tissues from HIPED for NDRG2 Gene

This gene is overexpressed in Salivary gland (19.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NDRG2 Gene



Protein tissue co-expression partners for NDRG2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NDRG2

SOURCE GeneReport for Unigene cluster for NDRG2 Gene:

Hs.525205

mRNA Expression by UniProt/SwissProt for NDRG2 Gene:

Q9UN36-NDRG2_HUMAN
Tissue specificity: Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level).

Evidence on tissue expression from TISSUES for NDRG2 Gene

  • Nervous system(5)
  • Liver(4.8)
  • Intestine(4.7)
  • Kidney(4.3)
  • Muscle(4.3)
  • Heart(4.2)
  • Spleen(3.1)
  • Lung(2.9)
  • Adrenal gland(2.3)
  • Thyroid gland(2.3)
  • Eye(2.2)
  • Lymph node(2.2)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with NDRG2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NDRG2 Gene

Orthologs for NDRG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NDRG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDRG2 31 30
  • 99.16 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NDRG2 31 30
  • 92.34 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NDRG2 31 30
  • 91.73 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ndrg2 17 31 30
  • 90.66 (n)
rat
(Rattus norvegicus)
Mammalia Ndrg2 30
  • 90.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NDRG2 31
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDRG2 31
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDRG2 31
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndrg2 30
  • 70.19 (n)
Str.6843 30
African clawed frog
(Xenopus laevis)
Amphibia ndrg2-prov 30
zebrafish
(Danio rerio)
Actinopterygii ndrg2 31 30
  • 68.49 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:GH02439 32
  • 29 (a)
CG2082 31
  • 26 (a)
ManyToMany
MESK2 31 32
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y48G10A.3 31 32
  • 29 (a)
ManyToMany
ZK1073.1 31
  • 23 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons NDL2 30
  • 45.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7991 31
  • 35 (a)
OneToMany
Species where no ortholog for NDRG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDRG2 Gene

ENSEMBL:
Gene Tree for NDRG2 (if available)
TreeFam:
Gene Tree for NDRG2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NDRG2: view image

Paralogs for NDRG2 Gene

Paralogs for NDRG2 Gene

(4) SIMAP similar genes for NDRG2 Gene using alignment to 44 proteins:

  • NDRG2_HUMAN
  • B4DE86_HUMAN
  • G3V237_HUMAN
  • G3V239_HUMAN
  • G3V271_HUMAN
  • G3V280_HUMAN
  • G3V285_HUMAN
  • G3V2A6_HUMAN
  • G3V2I9_HUMAN
  • G3V2S0_HUMAN
  • G3V2T2_HUMAN
  • G3V2Y3_HUMAN
  • G3V358_HUMAN
  • G3V383_HUMAN
  • G3V392_HUMAN
  • G3V3C3_HUMAN
  • G3V3D5_HUMAN
  • G3V3L1_HUMAN
  • G3V3P1_HUMAN
  • G3V3P6_HUMAN
  • G3V3X2_HUMAN
  • G3V3X3_HUMAN
  • G3V420_HUMAN
  • G3V4S2_HUMAN
  • G3V4S9_HUMAN
  • G3V4T9_HUMAN
  • G3V4X3_HUMAN
  • G3V552_HUMAN
  • G3V578_HUMAN
  • G3V596_HUMAN
  • G3V5A6_HUMAN
  • G3V5B5_HUMAN
  • G3V5B7_HUMAN
  • G3V5D7_HUMAN
  • G3V5G0_HUMAN
  • G3V5G7_HUMAN
  • G3V5H8_HUMAN
  • G3V5L7_HUMAN
  • G3V5P9_HUMAN
  • G3V5S0_HUMAN
  • G3V5V9_HUMAN
  • H0YJ56_HUMAN
  • H0YJT9_HUMAN
  • H7C0X0_HUMAN
genes like me logo Genes that share paralogs with NDRG2: view

Variants for NDRG2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NDRG2 Gene