Aliases for NDRG1 Gene
External Ids for NDRG1 Gene
Previous HGNC Symbols for NDRG1 Gene
Previous GeneCards Identifiers for NDRG1 Gene
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
GeneCards Summary for NDRG1 Gene
NDRG1 (N-Myc Downstream Regulated 1) is a Protein Coding gene. Diseases associated with NDRG1 include Charcot-Marie-Tooth Disease, Type 4D and Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive. Among its related pathways are Neuroscience and Validated targets of C-MYC transcriptional repression. Gene Ontology (GO) annotations related to this gene include microtubule binding and cadherin binding. An important paralog of this gene is NDRG3.
UniProtKB/Swiss-Prot Summary for NDRG1 Gene
Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy.