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Aliases for NDOR1 Gene

Aliases for NDOR1 Gene

  • NADPH Dependent Diflavin Oxidoreductase 1 2 3 5
  • NADPH-Dependent FMN And FAD-Containing Oxidoreductase 3 4
  • NR1 3 4
  • NADPH Dependent FMN And FAD Containing Oxidoreductase 2
  • NADPH-Dependent Diflavin Oxidoreductase 1 3
  • Novel Reductase 1 4
  • EC 1.18.1.- 4
  • BA350O14.9 3
  • CIAE1 3

External Ids for NDOR1 Gene

Previous GeneCards Identifiers for NDOR1 Gene

  • GC09M9D0102
  • GC09P137375
  • GC09P139219
  • GC09P140100
  • GC09P109559

Summaries for NDOR1 Gene

Entrez Gene Summary for NDOR1 Gene

  • This gene encodes an NADPH-dependent diflavin reductase that contains both flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) binding domains. The encoded protein catalyzes the transfer of electrons from NADPH through FAD and FMN cofactors to potential redox partners. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

GeneCards Summary for NDOR1 Gene

NDOR1 (NADPH Dependent Diflavin Oxidoreductase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Cytosolic iron-sulfur cluster assembly. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and flavin adenine dinucleotide binding. An important paralog of this gene is MTRR.

UniProtKB/Swiss-Prot for NDOR1 Gene

  • Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins (By similarity). Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1.

Gene Wiki entry for NDOR1 Gene

Additional gene information for NDOR1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDOR1 Gene

Genomics for NDOR1 Gene

GeneHancer (GH) Regulatory Elements for NDOR1 Gene

Promoters and enhancers for NDOR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J137204 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 655.4 +0.0 45 3.3 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 ZNF207 ZNF143 SP3 NDOR1 TMEM203 PIR53478 TPRN EHMT1 ENTR1 CYSRT1 SLC34A3 RNF208 ENSG00000284976
GH09J137207 Enhancer 0.4 FANTOM5 650.7 +1.9 1889 0.2 POLR2A NDOR1 TMEM203 SLC34A3 FUT7 AJM1 ENSG00000284976
GH09J137233 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 50.6 +32.6 32639 9.9 CLOCK MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 SP3 TUBB4B EHMT1 ENTR1 ANAPC2 NDOR1 DPH7 INPP5E LOC100418938 MAN1B1 SNHG7
GH09J137193 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.6 -7.2 -7218 9.8 HDGF PKNOX1 SMAD1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B TPRN EHMT1 ANAPC2 ENTR1 LOC100418938 NDOR1 INPP5E DPH7 MAN1B1 SNAPC4
GH09J136990 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE 23 -209.7 -209652 10.9 HDGF PKNOX1 CLOCK ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B PAXX CLIC3 EHMT1 ANAPC2 SEC16A MAN1B1 ENTR1 DPH7 NDOR1 SNHG7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NDOR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NDOR1 gene promoter:
  • MyoD
  • RP58
  • Nkx2-5
  • Pax-4a
  • CREB
  • deltaCREB
  • Nkx5-1
  • ATF6

Genomic Locations for NDOR1 Gene

Genomic Locations for NDOR1 Gene
chr9:137,205,667-137,219,361
(GRCh38/hg38)
Size:
13,695 bases
Orientation:
Plus strand
chr9:140,100,119-140,113,813
(GRCh37/hg19)
Size:
13,695 bases
Orientation:
Plus strand

Genomic View for NDOR1 Gene

Genes around NDOR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDOR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDOR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDOR1 Gene

Proteins for NDOR1 Gene

  • Protein details for NDOR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHB4-NDOR1_HUMAN
    Recommended name:
    NADPH-dependent diflavin oxidoreductase 1
    Protein Accession:
    Q9UHB4
    Secondary Accessions:
    • D3YTG6
    • D3YTH9
    • Q5VSG4
    • Q86US9
    • Q96BC6

    Protein attributes for NDOR1 Gene

    Size:
    597 amino acids
    Molecular mass:
    66763 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Cofactor:
    Name=FMN; Xref=ChEBI:CHEBI:58210;
    Quaternary structure:
    • Interacts with CIAPIN1. Interacts with DCPS.
    Miscellaneous:
    • Overexpression enhanced cytotoxicity of menadione, and consequently induced cell death, coexpression with DCPS reduced this toxicity.

    Three dimensional structures from OCA and Proteopedia for NDOR1 Gene

    Alternative splice isoforms for NDOR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDOR1 Gene

Post-translational modifications for NDOR1 Gene

  • Ubiquitination at isoforms=2, 3, 4207
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NDOR1 Gene

Domains & Families for NDOR1 Gene

Gene Families for NDOR1 Gene

Suggested Antigen Peptide Sequences for NDOR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UHB4

UniProtKB/Swiss-Prot:

NDOR1_HUMAN :
  • Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.
Family:
  • Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.
  • In the N-terminal section; belongs to the flavodoxin family.
  • In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
genes like me logo Genes that share domains with NDOR1: view

Function for NDOR1 Gene

Molecular function for NDOR1 Gene

UniProtKB/Swiss-Prot Function:
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins (By similarity). Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=21 uM for cytochrome c {ECO:0000269 PubMed:10625700}; Vmax=1.2 umol/min/ug enzyme for cytochrome c reduction {ECO:0000269 PubMed:10625700}; pH dependence: Optimum pH is about 8.0. {ECO:0000269 PubMed:10625700};

Enzyme Numbers (IUBMB) for NDOR1 Gene

Phenotypes From GWAS Catalog for NDOR1 Gene

Gene Ontology (GO) - Molecular Function for NDOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003958 NADPH-hemoprotein reductase activity IEA --
GO:0005515 protein binding IPI 16140270
GO:0010181 FMN binding IDA 10625700
GO:0016491 oxidoreductase activity IDA 10625700
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IBA --
genes like me logo Genes that share ontologies with NDOR1: view
genes like me logo Genes that share phenotypes with NDOR1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NDOR1 Gene

Localization for NDOR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDOR1 Gene

Cytoplasm, perinuclear region. Note=Concentrated in perinuclear structure. {ECO:0000255 HAMAP-Rule:MF_03178, ECO:0000269 PubMed:12871939}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NDOR1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Intermediate filaments (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NDOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA,IDA 10625700
GO:0005829 cytosol IDA 16140270
GO:0045111 intermediate filament cytoskeleton IDA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with NDOR1: view

Pathways & Interactions for NDOR1 Gene

genes like me logo Genes that share pathways with NDOR1: view

Pathways by source for NDOR1 Gene

2 Reactome pathways for NDOR1 Gene

Gene Ontology (GO) - Biological Process for NDOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008219 cell death IDA 16140270
GO:0036245 cellular response to menadione IDA 16140270
GO:0055114 oxidation-reduction process IDA 10625700
genes like me logo Genes that share ontologies with NDOR1: view

No data available for SIGNOR curated interactions for NDOR1 Gene

Drugs & Compounds for NDOR1 Gene

(6) Drugs for NDOR1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Flavin Mononucleotide Approved, Investigational Pharma 8
Potassium Approved, Investigational Pharma 0
Menadione Approved Nutra 257

(3) Additional Compounds for NDOR1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NADP
  • beta-Nicotinamide adenine dinucleotide phosphate
  • NADP+
  • Nicotinamide adenine dinucleotide phosphate
  • Oxidized nicotinamide-adenine dinucleotide phosphate
  • TPN
53-59-8
genes like me logo Genes that share compounds with NDOR1: view

Transcripts for NDOR1 Gene

Unigene Clusters for NDOR1 Gene

NADPH dependent diflavin oxidoreductase 1:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDOR1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^
SP1: - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5:
SP6: -
SP7: -
SP8: -
SP9:

ExUns: 14a · 14b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for NDOR1 Gene

GeneLoc Exon Structure for
NDOR1
ECgene alternative splicing isoforms for
NDOR1

Expression for NDOR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NDOR1 Gene

Protein differential expression in normal tissues from HIPED for NDOR1 Gene

This gene is overexpressed in CD4 Tcells (38.5), Placenta (11.5), and Testis (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NDOR1 Gene



Protein tissue co-expression partners for NDOR1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NDOR1 Gene:

NDOR1

SOURCE GeneReport for Unigene cluster for NDOR1 Gene:

Hs.512564

mRNA Expression by UniProt/SwissProt for NDOR1 Gene:

Q9UHB4-NDOR1_HUMAN
Tissue specificity: Low expression in brain, heart, kidney, pancreas, prostate and skeletal muscle. Highest levels in the placenta. Expressed in cancer cell lines including promyelocytic leukemia, HeLaS3, chronic myelagenous leukemia, lymphoblastic leukemia, Burkitts lymphoma, colorectal adenocarcinoma, lung carcinoma, and melanoma G-361.

Evidence on tissue expression from TISSUES for NDOR1 Gene

  • Nervous system(4.5)
  • Heart(4.1)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with NDOR1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NDOR1 Gene

Orthologs for NDOR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NDOR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDOR1 34 33
  • 99.39 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NDOR1 34 33
  • 84.42 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NDOR1 34 33
  • 83.86 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ndor1 16 34 33
  • 80.29 (n)
rat
(Rattus norvegicus)
Mammalia Ndor1 33
  • 80.23 (n)
oppossum
(Monodelphis domestica)
Mammalia NDOR1 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves NDOR1 34 33
  • 70.08 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDOR1 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndor1 33
  • 65.71 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.28148 33
zebrafish
(Danio rerio)
Actinopterygii ndor1 34 33
  • 61.12 (n)
OneToOne
zgc66159 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003889 33
  • 53.18 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13667 34 33
  • 50.69 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea fre-1 34 33
  • 47.38 (n)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL306C 33
  • 44.66 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B12155g 33
  • 43.14 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAH18 36 34 33
  • 42 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G02280 33
  • 48.29 (n)
rice
(Oryza sativa)
Liliopsida Os01g0733600 33
  • 47 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09727 33
  • 47.65 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
OneToOne
Cin.13988 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tah18 33
  • 43.05 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13988 33
Species where no ortholog for NDOR1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDOR1 Gene

ENSEMBL:
Gene Tree for NDOR1 (if available)
TreeFam:
Gene Tree for NDOR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NDOR1: view image

Paralogs for NDOR1 Gene

Paralogs for NDOR1 Gene

(2) SIMAP similar genes for NDOR1 Gene using alignment to 1 proteins:

  • NDOR1_HUMAN
genes like me logo Genes that share paralogs with NDOR1: view

Variants for NDOR1 Gene

Sequence variations from dbSNP and Humsavar for NDOR1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000011821 -- 137,212,730(+) G/A 5_prime_UTR_variant, intron_variant
rs1000246543 -- 137,216,482(+) G/A 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000316314 -- 137,205,948(+) G/A intron_variant
rs1000521730 -- 137,208,162(+) A/G intron_variant
rs1000574292 -- 137,218,334(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NDOR1 Gene

Variant ID Type Subtype PubMed ID
dgv13009n54 CNV loss 21841781
dgv13010n54 CNV loss 21841781
esv2422220 CNV deletion 17116639
esv2739415 CNV deletion 23290073
esv2739416 CNV deletion 23290073
nsv1161918 CNV duplication 26073780
nsv524322 CNV loss 19592680
nsv616007 CNV loss 21841781
nsv616012 CNV loss 21841781
nsv951207 CNV deletion 24416366

Variation tolerance for NDOR1 Gene

Residual Variation Intolerance Score: 84.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.05; 84.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NDOR1 Gene

Human Gene Mutation Database (HGMD)
NDOR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NDOR1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDOR1 Gene

Disorders for NDOR1 Gene

Additional Disease Information for NDOR1

No disorders were found for NDOR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NDOR1 Gene

Publications for NDOR1 Gene

  1. Role of a novel dual flavin reductase (NR1) and an associated histidine triad protein (DCS-1) in menadione-induced cytotoxicity. (PMID: 16140270) Kwaśnicka-Crawford DA … Vincent SR (Biochemical and biophysical research communications 2005) 3 4 22 58
  2. Identification of a functionally impaired allele of human novel oxidoreductase 1 (NDOR1), NDOR1*1. (PMID: 15900210) Finn RD … Paine MJ (Pharmacogenetics and genomics 2005) 3 4 22 58
  3. Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1. (PMID: 12871939) Kwasnicka DA … Vincent SR (The Journal of biological chemistry 2003) 3 4 22 58
  4. Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1. (PMID: 12631275) Finn RD … Scrutton NS (European journal of biochemistry 2003) 2 3 22 58
  5. Cloning and characterization of a novel human dual flavin reductase. (PMID: 10625700) Paine MJ … Wolf CR (The Journal of biological chemistry 2000) 2 3 4 58

Products for NDOR1 Gene

Sources for NDOR1 Gene

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