This gene encodes an NADPH-dependent diflavin reductase that contains both flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) binding domains. The encoded protein catalyzes the transfer of electrons from NADPH through FAD and FMN cofactors to potential redox partners. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012] See more...

Aliases for NDOR1 Gene

Aliases for NDOR1 Gene

  • NADPH Dependent Diflavin Oxidoreductase 1 2 3 5
  • NADPH-Dependent FMN And FAD-Containing Oxidoreductase 3 4
  • NADPH-Dependent Diflavin Oxidoreductase 1 3 4
  • NR1 3 4
  • NADPH Dependent FMN And FAD Containing Oxidoreductase 2
  • Novel Reductase 1 4
  • EC 1.18.1.- 4
  • BA350O14.9 3
  • CIAE1 3

External Ids for NDOR1 Gene

Previous GeneCards Identifiers for NDOR1 Gene

  • GC09M9D0102
  • GC09P137375
  • GC09P139219
  • GC09P140100
  • GC09P109559

Summaries for NDOR1 Gene

Entrez Gene Summary for NDOR1 Gene

  • This gene encodes an NADPH-dependent diflavin reductase that contains both flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) binding domains. The encoded protein catalyzes the transfer of electrons from NADPH through FAD and FMN cofactors to potential redox partners. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

GeneCards Summary for NDOR1 Gene

NDOR1 (NADPH Dependent Diflavin Oxidoreductase 1) is a Protein Coding gene. Among its related pathways are Cytosolic iron-sulfur cluster assembly and Metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and flavin adenine dinucleotide binding. An important paralog of this gene is POR.

UniProtKB/Swiss-Prot Summary for NDOR1 Gene

  • Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins (By similarity). Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1.

Gene Wiki entry for NDOR1 Gene

Additional gene information for NDOR1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NDOR1 Gene

Genomics for NDOR1 Gene

GeneHancer (GH) Regulatory Elements for NDOR1 Gene

Promoters and enhancers for NDOR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J137204 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 505.3 +0.0 3 3.3 ZBTB40 ZNF217 EP300 SIN3A TCF12 MYC POLR2G SP1 PHF8 SIX5 NDOR1 TPRN TMEM203 piR-59479 EHMT1 ENTR1 CYSRT1 SLC34A3 RNF208 ENSG00000284976
GH09J137207 Enhancer 0.3 FANTOM5 500.7 +1.9 1889 0.2 POLR2A NDOR1 TMEM203 SLC34A3 FUT7 AJM1 ENSG00000284976
GH09J137233 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 32.6 +33.5 33543 11.7 HNRNPK ZBTB40 ZNF217 CTCF SIN3A NRF1 TCF12 POLR2G USF1 SP1 TUBB4B INPP5E ANAPC2 EHMT1 DPH7 ENTR1 ENSG00000255585 SNHG7 SNAPC4 NDOR1
GH09J137292 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 29.2 +94.8 94787 15.4 HNRNPK ZNF217 CTCF SIN3A NRF1 POLR2G USF1 SP1 SIX5 ZFX NRARP EHMT1 DPH7 ENTR1 ANAPC2 EXD3 SEC16A SNHG7 INPP5E NDOR1
GH09J136398 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 20 -805.8 -805846 3 HNRNPK ZBTB40 CTCF SIN3A POLR2G SP1 PHF8 ZFX ZNF10 ZIC2 SNAPC4 INPP5E DNLZ SEC16A ENTR1 ANAPC2 MAN1B1 SNHG7 NDOR1 CARD9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NDOR1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NDOR1

Top Transcription factor binding sites by QIAGEN in the NDOR1 gene promoter:
  • ATF6
  • CREB
  • deltaCREB
  • MyoD
  • Nkx2-5
  • Nkx5-1
  • Pax-4a
  • RP58

Genomic Locations for NDOR1 Gene

Genomic Locations for NDOR1 Gene
chr9:137,205,667-137,219,361
(GRCh38/hg38)
Size:
13,695 bases
Orientation:
Plus strand
chr9:140,100,119-140,113,813
(GRCh37/hg19)
Size:
13,695 bases
Orientation:
Plus strand

Genomic View for NDOR1 Gene

Genes around NDOR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDOR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDOR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDOR1 Gene

Proteins for NDOR1 Gene

  • Protein details for NDOR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHB4-NDOR1_HUMAN
    Recommended name:
    NADPH-dependent diflavin oxidoreductase 1
    Protein Accession:
    Q9UHB4
    Secondary Accessions:
    • D3YTG6
    • D3YTH9
    • Q5VSG4
    • Q86US9
    • Q96BC6

    Protein attributes for NDOR1 Gene

    Size:
    597 amino acids
    Molecular mass:
    66763 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Cofactor:
    Name=FMN; Xref=ChEBI:CHEBI:58210;
    Quaternary structure:
    • Interacts with CIAPIN1. Interacts with DCPS.
    Miscellaneous:
    • Overexpression enhanced cytotoxicity of menadione, and consequently induced cell death, coexpression with DCPS reduced this toxicity.

    Three dimensional structures from OCA and Proteopedia for NDOR1 Gene

    Alternative splice isoforms for NDOR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDOR1 Gene

Post-translational modifications for NDOR1 Gene

  • Ubiquitination at Lys207
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NDOR1 Gene

Domains & Families for NDOR1 Gene

Gene Families for NDOR1 Gene

Protein Domains for NDOR1 Gene

Blocks:
  • Oxidoreductase FAD/NAD(P)-binding
  • Flavoprotein pyridine nucleotide cytochrome reductase signature
  • Flavodoxin signature
  • Flavodoxin/nitric oxide synthase
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NDOR1 Gene

GenScript: Design optimal peptide antigens:
  • Novel reductase 1 (NDOR1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UHB4

UniProtKB/Swiss-Prot:

NDOR1_HUMAN :
  • Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.
Family:
  • Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.
  • In the N-terminal section; belongs to the flavodoxin family.
  • In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
genes like me logo Genes that share domains with NDOR1: view

Function for NDOR1 Gene

Molecular function for NDOR1 Gene

UniProtKB/Swiss-Prot Function:
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins (By similarity). Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=21 uM for cytochrome c {ECO:0000269 PubMed:10625700}; Vmax=1.2 umol/min/ug enzyme for cytochrome c reduction {ECO:0000269 PubMed:10625700}; pH dependence: Optimum pH is about 8.0. {ECO:0000269 PubMed:10625700};

Enzyme Numbers (IUBMB) for NDOR1 Gene

Phenotypes From GWAS Catalog for NDOR1 Gene

Gene Ontology (GO) - Molecular Function for NDOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003958 NADPH-hemoprotein reductase activity IBA 21873635
GO:0005515 protein binding IPI 16140270
GO:0010181 FMN binding IBA,IDA 10625700
GO:0016491 oxidoreductase activity IBA,IDA 10625700
GO:0016651 oxidoreductase activity, acting on NAD(P)H IEA --
genes like me logo Genes that share ontologies with NDOR1: view
genes like me logo Genes that share phenotypes with NDOR1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NDOR1 Gene

Localization for NDOR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDOR1 Gene

Cytoplasm, perinuclear region. Note=Concentrated in perinuclear structure. {ECO:0000255 HAMAP-Rule:MF_03178, ECO:0000269 PubMed:12871939}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NDOR1 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 4
mitochondrion 1
extracellular 0
endoplasmic reticulum 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Intermediate filaments (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NDOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,IEA 10625700
GO:0005829 cytosol IBA,IDA 16140270
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with NDOR1: view

Pathways & Interactions for NDOR1 Gene

PathCards logo

SuperPathways for NDOR1 Gene

genes like me logo Genes that share pathways with NDOR1: view

Pathways by source for NDOR1 Gene

2 Reactome pathways for NDOR1 Gene

Gene Ontology (GO) - Biological Process for NDOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008219 cell death IDA 16140270
GO:0016226 iron-sulfur cluster assembly IEA --
GO:0036245 cellular response to menadione IDA 16140270
GO:0055114 oxidation-reduction process IDA 10625700
genes like me logo Genes that share ontologies with NDOR1: view

No data available for SIGNOR curated interactions for NDOR1 Gene

Drugs & Compounds for NDOR1 Gene

(7) Drugs for NDOR1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Flavin Mononucleotide Approved, Investigational Pharma 11
Potassium Approved, Experimental Pharma 0
Menadione Approved Nutra 306
NADP Experimental Pharma 0

(2) Additional Compounds for NDOR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NDOR1: view

Transcripts for NDOR1 Gene

mRNA/cDNA for NDOR1 Gene

4 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDOR1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^
SP1: - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5:
SP6: -
SP7: -
SP8: -
SP9:

ExUns: 14a · 14b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for NDOR1 Gene

GeneLoc Exon Structure for
NDOR1

Expression for NDOR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NDOR1 Gene

Protein differential expression in normal tissues from HIPED for NDOR1 Gene

This gene is overexpressed in CD4 Tcells (38.5), Placenta (11.5), and Testis (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NDOR1 Gene



Protein tissue co-expression partners for NDOR1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NDOR1

SOURCE GeneReport for Unigene cluster for NDOR1 Gene:

Hs.512564

mRNA Expression by UniProt/SwissProt for NDOR1 Gene:

Q9UHB4-NDOR1_HUMAN
Tissue specificity: Low expression in brain, heart, kidney, pancreas, prostate and skeletal muscle. Highest levels in the placenta. Expressed in cancer cell lines including promyelocytic leukemia, HeLaS3, chronic myelagenous leukemia, lymphoblastic leukemia, Burkitt's lymphoma, colorectal adenocarcinoma, lung carcinoma, and melanoma G-361.

Evidence on tissue expression from TISSUES for NDOR1 Gene

  • Nervous system(4.5)
  • Heart(4.1)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with NDOR1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NDOR1 Gene

Orthologs for NDOR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NDOR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDOR1 31 30
  • 99.39 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NDOR1 31 30
  • 84.42 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NDOR1 31 30
  • 83.86 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ndor1 17 31 30
  • 80.29 (n)
rat
(Rattus norvegicus)
Mammalia Ndor1 30
  • 80.23 (n)
oppossum
(Monodelphis domestica)
Mammalia NDOR1 31
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves NDOR1 31 30
  • 70.08 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDOR1 31
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndor1 30
  • 65.71 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.28148 30
zebrafish
(Danio rerio)
Actinopterygii ndor1 31 30
  • 61.12 (n)
OneToOne
zgc66159 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003889 30
  • 53.18 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13667 31 30
  • 50.69 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea fre-1 31 30
  • 47.38 (n)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL306C 30
  • 44.66 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B12155g 30
  • 43.14 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAH18 33 31 30
  • 42 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G02280 30
  • 48.29 (n)
rice
(Oryza sativa)
Liliopsida Os01g0733600 30
  • 47 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09727 30
  • 47.65 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 44 (a)
OneToOne
Cin.13988 30
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tah18 30
  • 43.05 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13988 30
Species where no ortholog for NDOR1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDOR1 Gene

ENSEMBL:
Gene Tree for NDOR1 (if available)
TreeFam:
Gene Tree for NDOR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NDOR1: view image

Paralogs for NDOR1 Gene

Paralogs for NDOR1 Gene

(2) SIMAP similar genes for NDOR1 Gene using alignment to 1 proteins:

  • NDOR1_HUMAN
genes like me logo Genes that share paralogs with NDOR1: view

Variants for NDOR1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NDOR1 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs62587579 - p.Val522Ile

Additional dbSNP identifiers (rs#s) for NDOR1 Gene

Structural Variations from Database of Genomic Variants (DGV) for NDOR1 Gene

Variant ID Type Subtype PubMed ID
dgv13009n54 CNV loss 21841781
dgv13010n54 CNV loss 21841781
esv2422220 CNV deletion 17116639
esv2739415 CNV deletion 23290073
esv2739416 CNV deletion 23290073
nsv1161918 CNV duplication 26073780
nsv524322 CNV loss 19592680
nsv616007 CNV loss 21841781
nsv616012 CNV loss 21841781
nsv951207 CNV deletion 24416366

Variation tolerance for NDOR1 Gene

Residual Variation Intolerance Score: 84.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.05; 84.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NDOR1 Gene

Human Gene Mutation Database (HGMD)
NDOR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NDOR1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDOR1 Gene

Disorders for NDOR1 Gene

Additional Disease Information for NDOR1

No disorders were found for NDOR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NDOR1 Gene

Publications for NDOR1 Gene

  1. Role of a novel dual flavin reductase (NR1) and an associated histidine triad protein (DCS-1) in menadione-induced cytotoxicity. (PMID: 16140270) Kwaśnicka-Crawford DA … Vincent SR (Biochemical and biophysical research communications 2005) 3 4 23 54
  2. Identification of a functionally impaired allele of human novel oxidoreductase 1 (NDOR1), NDOR1*1. (PMID: 15900210) Finn RD … Paine MJ (Pharmacogenetics and genomics 2005) 3 4 23 54
  3. Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1. (PMID: 12871939) Kwasnicka DA … Vincent SR (The Journal of biological chemistry 2003) 3 4 23 54
  4. Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1. (PMID: 12631275) Finn RD … Scrutton NS (European journal of biochemistry 2003) 2 3 23 54
  5. Cloning and characterization of a novel human dual flavin reductase. (PMID: 10625700) Paine MJ … Wolf CR (The Journal of biological chemistry 2000) 2 3 4 54

Products for NDOR1 Gene

Sources for NDOR1 Gene