Aliases for NDN Gene
External Ids for NDN Gene
Previous GeneCards Identifiers for NDN Gene
This intronless gene is located in the Prader-Willi syndrome deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene may suppress growth in postmitotic neurons. [provided by RefSeq, Jul 2008]
GeneCards Summary for NDN Gene
NDN (Necdin, MAGE Family Member) is a Protein Coding gene. Diseases associated with NDN include Prader-Willi Syndrome and Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11q13 Type 1. Among its related pathways are Cytokine Signaling in Immune system and p75(NTR)-mediated signaling. Gene Ontology (GO) annotations related to this gene include gamma-tubulin binding. An important paralog of this gene is MAGEL2.
UniProtKB/Swiss-Prot Summary for NDN Gene
Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences (By similarity).