Aliases for NDEL1 Gene
External Ids for NDEL1 Gene
Previous GeneCards Identifiers for NDEL1 Gene
This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Mar 2012]
GeneCards Summary for NDEL1 Gene
NDEL1 (NudE Neurodevelopment Protein 1 Like 1) is a Protein Coding gene. Diseases associated with NDEL1 include Congenital Nervous System Abnormality and Miller-Dieker Lissencephaly Syndrome. Among its related pathways are Lissencephaly gene (LIS1) in neuronal migration and development and Aurora A signaling. Gene Ontology (GO) annotations related to this gene include protein complex binding and beta-tubulin binding. An important paralog of this gene is NDE1.
UniProtKB/Swiss-Prot for NDEL1 Gene
Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity).