B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 [PubMed 19528259]).[supplied by OMIM, Jan 2011] See more...

Aliases for NCR3LG1 Gene

Aliases for NCR3LG1 Gene

  • Natural Killer Cell Cytotoxicity Receptor 3 Ligand 1 2 3 5
  • B7 Homolog 6 2 3 4
  • B7-H6 2 3 4
  • Natural Cytotoxicity Triggering Receptor 3 Ligand 1 3 4
  • DKFZp686O24166 2 3
  • B7H6 3 4
  • Putative Ig-Like Domain-Containing Protein DKFZp686O24166/DKFZp686I21167 3
  • NCR3LG1 5

External Ids for NCR3LG1 Gene

Previous GeneCards Identifiers for NCR3LG1 Gene

  • GC11P017374

Summaries for NCR3LG1 Gene

Entrez Gene Summary for NCR3LG1 Gene

  • B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 [PubMed 19528259]).[supplied by OMIM, Jan 2011]

GeneCards Summary for NCR3LG1 Gene

NCR3LG1 (Natural Killer Cell Cytotoxicity Receptor 3 Ligand 1) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is TAPBPL.

UniProtKB/Swiss-Prot Summary for NCR3LG1 Gene

Additional gene information for NCR3LG1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NCR3LG1 Gene

Genomics for NCR3LG1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NCR3LG1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J017350 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 654.8 +1.0 962 4.3 BRCA1 CREB1 GATAD2A CTCF ATF7 PRDM10 ZNF629 TFE3 ZNF512 LEF1 NCR3LG1 ENSG00000285545 LOC105376576 piR-57461-028 KCNJ11 ENSG00000260196 RPS13 RF00017-877
GH11J017313 Enhancer 1.1 FANTOM5 Ensembl ENCODE 34.3 -37.7 -37689 2 ZNF629 ZNF692 PRDM1 ZNF600 ZNF341 ZBTB44 SP2 ZXDB CEBPB ZEB1 MN309337 piR-59425-006 NCR3LG1 RPS13 SNORD14B lnc-KCNJ11-5 NUCB2
GH11J017388 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 18.3 +37.4 37438 2.1 SP1 GATAD2A PRDM10 KDM1A CTCF ZHX2 ZNF143 POLR2A PATZ1 ZFX KCNJ11 NCR3LG1 RPS13 lnc-ABCC8-1
GH11J017382 Enhancer 1 Ensembl ENCODE dbSUPER 27.7 +31.8 31819 3.2 CTCF ZNF143 RXRB ZNF24 REST RAD21 IRF2 TRIM22 MTA3 ZNF444 NCR3LG1 KCNJ11 ENSG00000260196 lnc-ABCC8-1
GH11J017385 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 14.6 +34.7 34740 1.6 CTCF FOXA1 REST ZNF341 MNT MGA CBX3 FOXK2 FOXA2 MEF2D lnc-ABCC8-1 KCNJ11 NCR3LG1 ENSG00000260196
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NCR3LG1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NCR3LG1

Genomic Locations for NCR3LG1 Gene

Genomic Locations for NCR3LG1 Gene
chr11:17,351,800-17,377,341
(GRCh38/hg38)
Size:
25,542 bases
Orientation:
Plus strand
chr11:17,373,273-17,398,888
(GRCh37/hg19)
Size:
25,616 bases
Orientation:
Plus strand

Genomic View for NCR3LG1 Gene

Genes around NCR3LG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCR3LG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCR3LG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCR3LG1 Gene

Proteins for NCR3LG1 Gene

  • Protein details for NCR3LG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68D85-NR3L1_HUMAN
    Recommended name:
    Natural cytotoxicity triggering receptor 3 ligand 1
    Protein Accession:
    Q68D85
    Secondary Accessions:
    • Q7Z3M6

    Protein attributes for NCR3LG1 Gene

    Size:
    454 amino acids
    Molecular mass:
    50827 Da
    Quaternary structure:
    • Monomer. Interacts specifically with NCR3, but not with other natural killer cell-activating receptors, including NCR1, NCR2 and KLRK1.
    SequenceCaution:
    • Sequence=CAD97811.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NCR3LG1 Gene

neXtProt entry for NCR3LG1 Gene

Post-translational modifications for NCR3LG1 Gene

  • Glycosylation at Asn43, Asn57, Asn174, Asn208, Asn216, Asn242, and Asn260
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • NR3L1_HUMAN (642)

Other Protein References for NCR3LG1 Gene

No data available for DME Specific Peptides for NCR3LG1 Gene

Domains & Families for NCR3LG1 Gene

Gene Families for NCR3LG1 Gene

Protein Domains for NCR3LG1 Gene

InterPro:
Blocks:
  • Immunoglobulin C-type
  • Matrix protein (MA)
ProtoNet:

Suggested Antigen Peptide Sequences for NCR3LG1 Gene

GenScript: Design optimal peptide antigens:
  • B7 homolog 6 (B7H6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q68D85

UniProtKB/Swiss-Prot:

NR3L1_HUMAN :
  • The C-terminal part is similar to retroviral Gag protein. This putative protein seems to be the result of a fusion between an Ig-like domain-containing protein and a ERV.
Domain:
  • The C-terminal part is similar to retroviral Gag protein. This putative protein seems to be the result of a fusion between an Ig-like domain-containing protein and a ERV.
genes like me logo Genes that share domains with NCR3LG1: view

Function for NCR3LG1 Gene

Molecular function for NCR3LG1 Gene

UniProtKB/Swiss-Prot Function:
Triggers NCR3-dependent natural killer cell activation.

Phenotypes From GWAS Catalog for NCR3LG1 Gene

Gene Ontology (GO) - Molecular Function for NCR3LG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19528259
genes like me logo Genes that share ontologies with NCR3LG1: view
genes like me logo Genes that share phenotypes with NCR3LG1: view

miRNA for NCR3LG1 Gene

miRTarBase miRNAs that target NCR3LG1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NCR3LG1 Gene

Localization for NCR3LG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCR3LG1 Gene

Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCR3LG1 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 2
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for NCR3LG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NCR3LG1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NCR3LG1 Gene

Pathways & Interactions for NCR3LG1 Gene

genes like me logo Genes that share pathways with NCR3LG1: view

Pathways by source for NCR3LG1 Gene

Gene Ontology (GO) - Biological Process for NCR3LG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with NCR3LG1: view

No data available for SIGNOR curated interactions for NCR3LG1 Gene

Drugs & Compounds for NCR3LG1 Gene

No Compound Related Data Available

Transcripts for NCR3LG1 Gene

mRNA/cDNA for NCR3LG1 Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NCR3LG1

Alternative Splicing Database (ASD) splice patterns (SP) for NCR3LG1 Gene

No ASD Table

Relevant External Links for NCR3LG1 Gene

GeneLoc Exon Structure for
NCR3LG1

Expression for NCR3LG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NCR3LG1 Gene

mRNA differential expression in normal tissues according to GTEx for NCR3LG1 Gene

This gene is overexpressed in Brain - Cerebellum (x5.5) and Brain - Cerebellar Hemisphere (x5.3).

Protein differential expression in normal tissues from HIPED for NCR3LG1 Gene

This gene is overexpressed in Milk (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NCR3LG1 Gene



Protein tissue co-expression partners for NCR3LG1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NCR3LG1

SOURCE GeneReport for Unigene cluster for NCR3LG1 Gene:

Hs.146274

mRNA Expression by UniProt/SwissProt for NCR3LG1 Gene:

Q68D85-NR3L1_HUMAN
Tissue specificity: Not detected in any normal tissue tested. Expressed at the surface of several tumor cell lines including T and B-lymphomas, myeloid leukemias, melanomas, carcinomas and large T SV40 antigen-transformed cells (at protein level).

Evidence on tissue expression from TISSUES for NCR3LG1 Gene

  • Nervous system(4.3)
  • Lymph node(2.2)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with NCR3LG1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCR3LG1 Gene

Orthologs for NCR3LG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCR3LG1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NCR3LG1 30 31
  • 99.2 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NCR3LG1 31
  • 44 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NCR3LG1 31
  • 30 (a)
OneToOne
Species where no ortholog for NCR3LG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for NCR3LG1 Gene

ENSEMBL:
Gene Tree for NCR3LG1 (if available)
TreeFam:
Gene Tree for NCR3LG1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NCR3LG1: view image

Paralogs for NCR3LG1 Gene

Paralogs for NCR3LG1 Gene

(1) SIMAP similar genes for NCR3LG1 Gene using alignment to 1 proteins:

  • NR3L1_HUMAN
genes like me logo Genes that share paralogs with NCR3LG1: view

Variants for NCR3LG1 Gene

Additional dbSNP identifiers (rs#s) for NCR3LG1 Gene

Structural Variations from Database of Genomic Variants (DGV) for NCR3LG1 Gene

Variant ID Type Subtype PubMed ID
nsv467712 CNV loss 19166990
nsv469895 CNV loss 16826518
nsv553567 CNV gain 21841781
nsv553583 CNV loss 21841781

Variation tolerance for NCR3LG1 Gene

Gene Damage Index Score: 4.24; 62.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NCR3LG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCR3LG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NCR3LG1 Gene

Disorders for NCR3LG1 Gene

No disorders were found for NCR3LG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NCR3LG1 Gene

Publications for NCR3LG1 Gene

  1. The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans. (PMID: 19528259) Brandt CS … Levin SD (The Journal of experimental medicine 2009) 2 3 4
  2. Structure of the human activating natural cytotoxicity receptor NKp30 bound to its tumor cell ligand B7-H6. (PMID: 21422170) Li Y … Mariuzza RA (The Journal of experimental medicine 2011) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. B7-H6-mediated downregulation of NKp30 in natural killer cells contributes to HIV-2 immune escape. (PMID: 30325780) Lucar O … ANRS CO5 IMMUNOVIR-2 Study group (AIDS (London, England) 2019) 3
  5. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3

Products for NCR3LG1 Gene

Sources for NCR3LG1 Gene