Aliases for NCR3 Gene
External Ids for NCR3 Gene
Previous HGNC Symbols for NCR3 Gene
Previous GeneCards Identifiers for NCR3 Gene
The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
GeneCards Summary for NCR3 Gene
NCR3 (Natural Cytotoxicity Triggering Receptor 3) is a Protein Coding gene. Diseases associated with NCR3 include Malaria, Mild and Malaria. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is NECTIN2.
UniProtKB/Swiss-Prot Summary for NCR3 Gene
Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.