The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms ... See more...

Aliases for NCR3 Gene

Aliases for NCR3 Gene

  • Natural Cytotoxicity Triggering Receptor 3 2 3 4 5
  • Natural Killer Cell P30-Related Protein 3 4
  • Activating Natural Killer Receptor P30 3 4
  • Lymphocyte Antigen 117 2 3
  • NK-P30 3 4
  • LY117 3 4
  • NKp30 3 4
  • 1C7 3 4
  • Activating NK-A1 Receptor 3
  • CD337 Antigen 4
  • CD337 3
  • MALS 3

External Ids for NCR3 Gene

Previous HGNC Symbols for NCR3 Gene

  • LY117

Previous GeneCards Identifiers for NCR3 Gene

  • GC06M031610
  • GC06M031327
  • GC06M031660
  • GC06M031664
  • GC06M031557
  • GC06M031343
  • GC06M031558
  • GC06M031575
  • GC06M031677

Summaries for NCR3 Gene

Entrez Gene Summary for NCR3 Gene

  • The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

GeneCards Summary for NCR3 Gene

NCR3 (Natural Cytotoxicity Triggering Receptor 3) is a Protein Coding gene. Diseases associated with NCR3 include Malaria, Mild and Malaria. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. An important paralog of this gene is NECTIN1.

UniProtKB/Swiss-Prot Summary for NCR3 Gene

  • Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.

Gene Wiki entry for NCR3 Gene

Additional gene information for NCR3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NCR3 Gene

Genomics for NCR3 Gene

GeneHancer (GH) Regulatory Elements for NCR3 Gene

Promoters and enhancers for NCR3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J031591 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 500.7 -0.1 -63 2.3 ZNF263 CTBP1 POLR2A MCM3 CBFB ARNT ZFHX2 RCOR1 POU2F2 EBF1 NCR3 piR-43325-080 DDX39B ENSG00000272221 MICA LSM2 NRM TCF19 ATP6V1G2 ENSG00000199332
GH06J031557 Enhancer 1 ENCODE 13.2 +33.4 33428 4.2 ZBTB40 SP1 GTF2E2 JUND EP300 REST ZBTB11 RELA HES1 MEF2C LTA lnc-NFKBIL1-9 CSNK2B DDX39B LST1 NCR3 UQCRHP1 LTB AIF1 SNORD117
GH06J031269 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2.2 +321.4 321360 4.7 HNRNPK ZNF217 POLR2G SP1 CTCF ZIC2 POLR2A ZBTB10 CLOCK FOS HLA-C piR-38512-004 piR-48456 PSORS1C3 PPT2 TNXB LSM2 PSORS1C2 HCG18 TCF19
GH06J031567 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 +14.6 14600 22.2 HNRNPK ZBTB40 CTCF SIN3A NRF1 USF1 SP1 NONO GTF2E2 PHF8 TNF ATP6V1G2 LST1 AB675034 LTB lnc-TNF-1 LTA DDX39B LY6G5B MDC1
GH06J031596 Enhancer 0.7 ENCODE 0.7 -4.2 -4161 0.5 CTCF ZBTB11 REST MYC RAD21 TRIM22 SMC3 MXI1 KMT2B ARNT DDX39B LST1 MICB NCR3 UQCRHP1 lnc-NCR3-2 MG828730-062
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NCR3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NCR3

Top Transcription factor binding sites by QIAGEN in the NCR3 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • COUP
  • COUP-TF
  • COUP-TF1

Genomic Locations for NCR3 Gene

Genomic Locations for NCR3 Gene
chr6:31,588,883-31,593,019
(GRCh38/hg38)
Size:
4,137 bases
Orientation:
Minus strand
chr6:31,556,660-31,560,762
(GRCh37/hg19)
Size:
4,103 bases
Orientation:
Minus strand

Genomic View for NCR3 Gene

Genes around NCR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for NCR3 Gene

  • Protein details for NCR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14931-NCTR3_HUMAN
    Recommended name:
    Natural cytotoxicity triggering receptor 3
    Protein Accession:
    O14931
    Secondary Accessions:
    • B0S8F2
    • B0S8F4
    • B0S8F5
    • O14930
    • O14932
    • O95667
    • O95668
    • O95669
    • Q5ST89
    • Q5ST90
    • Q5ST91
    • Q5ST92
    • Q5STA3

    Protein attributes for NCR3 Gene

    Size:
    201 amino acids
    Molecular mass:
    21593 Da
    Quaternary structure:
    • Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to NCR3LG1. Interacts with and is activated by binding to BAG6.

    Three dimensional structures from OCA and Proteopedia for NCR3 Gene

    Alternative splice isoforms for NCR3 Gene

neXtProt entry for NCR3 Gene

Post-translational modifications for NCR3 Gene

  • Glycosylation at Asn42 and Asn121

Antibody Products

No data available for DME Specific Peptides for NCR3 Gene

Domains & Families for NCR3 Gene

Gene Families for NCR3 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted membrane proteins

Protein Domains for NCR3 Gene

Blocks:
  • Immunoglobulin subtype
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NCR3 Gene

GenScript: Design optimal peptide antigens:
  • Natural killer cell p30-related protein (NCTR3_HUMAN)
  • Natural cytotoxicity triggering receptor 3, isoform CRA_c (Q05D23_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14931

UniProtKB/Swiss-Prot:

NCTR3_HUMAN :
  • Belongs to the natural cytotoxicity receptor (NCR) family.
Family:
  • Belongs to the natural cytotoxicity receptor (NCR) family.
genes like me logo Genes that share domains with NCR3: view

Function for NCR3 Gene

Molecular function for NCR3 Gene

UniProtKB/Swiss-Prot Function:
Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.

Phenotypes From GWAS Catalog for NCR3 Gene

Gene Ontology (GO) - Molecular Function for NCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18852879
GO:0042802 identical protein binding IPI 21444796
genes like me logo Genes that share ontologies with NCR3: view
genes like me logo Genes that share phenotypes with NCR3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NCR3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NCR3 Gene

Localization for NCR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCR3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCR3 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7590964
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NCR3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NCR3 Gene

Pathways & Interactions for NCR3 Gene

genes like me logo Genes that share pathways with NCR3: view

Gene Ontology (GO) - Biological Process for NCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002429 immune response-activating cell surface receptor signaling pathway IBA,IDA 18852879
GO:0006954 inflammatory response NAS 10941844
GO:0006955 immune response NAS 10941844
GO:0008037 cell recognition TAS 16304049
GO:0030101 natural killer cell activation IDA,IBA 18852879
genes like me logo Genes that share ontologies with NCR3: view

No data available for SIGNOR curated interactions for NCR3 Gene

Drugs & Compounds for NCR3 Gene

No Compound Related Data Available

Transcripts for NCR3 Gene

mRNA/cDNA for NCR3 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NCR3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCR3 Gene

No ASD Table

Relevant External Links for NCR3 Gene

GeneLoc Exon Structure for
NCR3

Expression for NCR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NCR3 Gene

mRNA differential expression in normal tissues according to GTEx for NCR3 Gene

This gene is overexpressed in Whole Blood (x29.7) and Spleen (x6.3).

Protein differential expression in normal tissues from HIPED for NCR3 Gene

This gene is overexpressed in NK cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NCR3 Gene



Protein tissue co-expression partners for NCR3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NCR3

SOURCE GeneReport for Unigene cluster for NCR3 Gene:

Hs.509513

mRNA Expression by UniProt/SwissProt for NCR3 Gene:

O14931-NCTR3_HUMAN
Tissue specificity: Selectively expressed by all resting and activated NK cells and weakly expressed in spleen.

Evidence on tissue expression from TISSUES for NCR3 Gene

  • Blood(4.5)
  • Spleen(4.3)
genes like me logo Genes that share expression patterns with NCR3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCR3 Gene

Orthologs for NCR3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for NCR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCR3 31 30
  • 99.5 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NCR3 31 30
  • 84.02 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NCR3 31 30
  • 82.22 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncr3 30
  • 78.64 (n)
Species where no ortholog for NCR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NCR3 Gene

ENSEMBL:
Gene Tree for NCR3 (if available)
TreeFam:
Gene Tree for NCR3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NCR3: view image

Paralogs for NCR3 Gene

genes like me logo Genes that share paralogs with NCR3: view

Variants for NCR3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for NCR3 Gene

NCTR3_HUMAN-O14931
A genetic variation in NCR3 is associated with mild malaria susceptibility [MIM:609148].

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NCR3 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
726474 Likely Benign: not provided 31,590,095(-) A/C SYNONYMOUS_VARIANT
785804 Likely Benign: not provided 31,590,114(-) A/C MISSENSE_VARIANT
rs2736191 Risk Factor: Malaria, mild, susceptibility to 31,593,133(-) C/G
rs11575840 - p.Ala103Thr
rs3179003 - p.Arg174Ser

Additional dbSNP identifiers (rs#s) for NCR3 Gene

Structural Variations from Database of Genomic Variants (DGV) for NCR3 Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv830627 CNV loss 17160897

Variation tolerance for NCR3 Gene

Residual Variation Intolerance Score: 70.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.92; 48.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NCR3 Gene

Human Gene Mutation Database (HGMD)
NCR3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCR3

SNP Genotyping and Copy Number Assay Products

Disorders for NCR3 Gene

MalaCards: The human disease database

(7) MalaCards diseases for NCR3 Gene - From: OMIM, ClinVar, GTR, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
malaria, mild
  • malaria, mild, susceptibility to
malaria
  • malaria, susceptibility to
median arcuate ligament syndrome
  • mals
antisynthetase syndrome
  • anti-jo1 syndrome
chronic intestinal vascular insufficiency
  • chronic mesenteric ischemia
- elite association - COSMIC cancer census association via MalaCards
Search NCR3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NCR3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NCR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCR3 Gene

Publications for NCR3 Gene

  1. Association analyses of NCR3 polymorphisms with P. falciparum mild malaria. (PMID: 17208487) Delahaye NF … Rihet P (Microbes and infection 2007) 3 4 41 54
  2. Identification of novel single nucleotide substitutions in the NKp30 gene expressed in human natural killer cells. (PMID: 11782277) Sato M … Yabe T (Tissue antigens 2001) 2 3 23 54
  3. Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells. (PMID: 10562324) Pende D … Moretta A (The Journal of experimental medicine 1999) 3 4 23 54
  4. Genes in a 220-kb region spanning the TNF cluster in human MHC. (PMID: 8824804) Nalabolu SR … Weissman SM (Genomics 1996) 2 3 4 54
  5. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PMID: 21946350) Soler Artigas M … Tobin MD (Nature genetics 2011) 3 41 54

Products for NCR3 Gene

Sources for NCR3 Gene