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NCR2 (Natural Cytotoxicity Triggering Receptor 2) is a Protein Coding gene. Diseases associated with NCR2 include Newcastle Disease and Viral Infectious Disease. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Hematopoietic Stem Cells and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is TREML4.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH06J041332 | Promoter/Enhancer | 1.6 | FANTOM5 Ensembl ENCODE dbSUPER | 600.7 | -1.5 | -1544 | 2.9 | SP1 BACH1 LARP7 ZNF143 RELA ZIC2 TCF12 IKZF2 RCOR1 TRIM22 | NCR2 TFEB HSALNG0050009 TREM1 | |
GH06J041335 | Promoter/Enhancer | 0.8 | EPDnew dbSUPER | 600.7 | +0.3 | 273 | 0.1 | DPF2 ZFHX2 EGR2 MLLT1 | NCR2 HSALNG0050012 FOXP4 | |
GH06J041336 | Promoter/Enhancer | 0.7 | EPDnew dbSUPER | 600.7 | 0.0 | -29 | 0.1 | DPF2 IKZF1 | NCR2 HSALNG0050009 TREM1 | |
GH06J041337 | Enhancer | 0.5 | dbSUPER | 600.7 | +1.9 | 1874 | 0.5 | RNF2 ZNF512 CBX2 FEZF1 EZH2 | NCR2 HSALNG0050012 FOXP4 | |
GH06J041298 | Enhancer | 0.8 | ENCODE dbSUPER | 11.1 | -36.3 | -36334 | 1.6 | TRIM22 RELB RUNX3 ELF1 NBN HDGF JUNB ATF2 TBX21 ATF7 | NCR2 TREM1 5MWI_A-150 RF00026-932 RNU6-643P |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | TAS | 10049942 |
GO:0005515 | protein binding | IPI | 10049942 |
GO:0038023 | signaling receptor activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS | 10049942 |
GO:0009986 | cell surface | IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Immune response Role of DAP12 receptors in NK cells |
Immune response Role of DAP12 receptors in NK cells
.32
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2 | Innate Immune System |
.61
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3 | Hematopoietic Stem Cells and Lineage-specific Markers | ||
4 | Innate Lymphoid Cells Differentiation | ||
5 | Class I MHC mediated antigen processing and presentation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006968 | cellular defense response | TAS | 10049942 |
GO:0007165 | signal transduction | TAS | 10049942 |
GO:0045087 | innate immune response | TAS | -- |
GO:0045088 | regulation of innate immune response | IBA | 21873635 |
GO:0050776 | regulation of immune response | TAS | -- |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||
SP2: | - |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NCR2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NCR2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | B430306N03Rik 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
714313 | Benign: not provided | 41,336,093(+) | A/G | MISSENSE_VARIANT | |
778229 | Benign: not provided | 41,350,840(+) | T/C | SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT | |
791266 | Benign: not provided | 41,336,401(+) | G/A | MISSENSE_VARIANT | |
rs2236369 | - | p.Ser139Pro | |||
rs2273961 | - | p.Ile218Lys |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3608790 | CNV | gain | 21293372 |
Disorder | Aliases | PubMed IDs |
---|---|---|
newcastle disease |
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viral infectious disease |
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myeloma, multiple |
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leukemia, acute myeloid |
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