NCR2 Gene (Protein Coding)

Natural Cytotoxicity Triggering Receptor 2

GC06P052193
GIFtS:
40
See more...

Aliases for NCR2 Gene

Aliases for NCR2 Gene

  • Natural Cytotoxicity Triggering Receptor 2 2 3 4 5
  • NK-P44 2 3 4
  • Lymphocyte Antigen 95 (Activating NK-Receptor; NK-P44) 2 3
  • Natural Killer Cell P44-Related Protein 3 4
  • NK Cell-Activating Receptor 3 4
  • CD336 2 3
  • LY95 3 4
  • Lymphocyte Antigen 95 Homolog (Activating NK-Receptor; NK-P44) 3
  • NK Cell Activating Receptor (NKp44) 3
  • Lymphocyte Antigen 95 Homolog 4
  • CD336 Antigen 4
  • DJ149M18.1 3
  • NKP44 3
  • NKp44 4
  • NCR2 5

External Ids for NCR2 Gene

Previous HGNC Symbols for NCR2 Gene

  • LY95

Previous GeneCards Identifiers for NCR2 Gene

  • GC06P041299
  • GC06P041350
  • GC06P041411
  • GC06P041303
  • GC06P041022
  • GC06P042925
  • GC06P043253
  • GC06P043411
  • GC06P046093
  • GC06P041522
  • GC06P041525
  • GC06P041984
  • GC06P042630
  • GC06P047499
  • GC06P049559

Summaries for NCR2 Gene

GeneCards Summary for NCR2 Gene

NCR2 (Natural Cytotoxicity Triggering Receptor 2) is a Protein Coding gene. Diseases associated with NCR2 include Newcastle Disease and Dermatitis, Atopic, 5. Among its related pathways are Innate Lymphoid Cell Differentiation Pathways and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is TREML4.

UniProtKB/Swiss-Prot Summary for NCR2 Gene

  • Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

Gene Wiki entry for NCR2 Gene

Additional gene information for NCR2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NCR2 Gene

Genomics for NCR2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for NCR2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH06J041332 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 250.7 -1.5 -1544 2.9 BCLAF1 SP1 ZNF207 ZSCAN16 ZIC2 BCL11A TRIM22 NR2C1 RAD21 IRF4 HSALNG0050010 NCR2 TFEB HSALNG0050009 TREM1
GH06J041335 Promoter/Enhancer 0.8 EPDnew dbSUPER 250.7 +0.3 273 0.1 EGR2 DPF2 ZFHX2 MLLT1 HSALNG0050010 NCR2 HSALNG0050011 FOXP4
GH06J041336 Promoter/Enhancer 0.7 EPDnew dbSUPER 250.7 0.0 -29 0.1 IKZF1 DPF2 HSALNG0050010 NCR2 TREM1
GH06J041337 Enhancer 0.5 dbSUPER 250.7 +1.9 1874 0.5 FEZF1 CBX2 RNF2 EZH2 ZNF512 NCR2 HSALNG0050011 FOXP4
GH06J041298 Enhancer 0.8 ENCODE dbSUPER 11.1 -36.3 -36334 1.6 TRIM22 ELF1 HDGF TCF7 ATF2 JUNB TARDBP CREM NBN RUNX3 NCR2 TREM1 5MWI_A-145 RNU6-643P RF00026-899
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NCR2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NCR2

Top Transcription factor binding sites by QIAGEN in the NCR2 gene promoter:
  • AREB6

Genomic Locations for NCR2 Gene

Latest Assembly
chr6:41,335,608-41,350,889
(GRCh38/hg38)
Size:
15,282 bases
Orientation:
Plus strand

Previous Assembly
chr6:41,303,346-41,318,627
(GRCh37/hg19 by Entrez Gene)
Size:
15,282 bases
Orientation:
Plus strand

chr6:41,303,393-41,318,625
(GRCh37/hg19 by Ensembl)
Size:
15,233 bases
Orientation:
Plus strand

Genomic View for NCR2 Gene

Genes around NCR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCR2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NCR2 Gene

Proteins for NCR2 Gene

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  • Protein details for NCR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95944-NCTR2_HUMAN
    Recommended name:
    Natural cytotoxicity triggering receptor 2
    Protein Accession:
    O95944
    Secondary Accessions:
    • Q9H562
    • Q9H563
    • Q9H564
    • Q9UMT1
    • Q9UMT2

    Protein attributes for NCR2 Gene

    Size:
    276 amino acids
    Molecular mass:
    30677 Da
    Quaternary structure:
    • Interacts with TYROBP/DAP12. Interacts with KMT2E isoform NKp44L.

    Three dimensional structures from OCA and Proteopedia for NCR2 Gene

    Alternative splice isoforms for NCR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCR2 Gene

Post-translational modifications for NCR2 Gene

  • Glycosylation at Asn180
  • Modification sites at PhosphoSitePlus

Other Protein References for NCR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NCR2 Gene

Domains & Families for NCR2 Gene

Gene Families for NCR2 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted membrane proteins

Protein Domains for NCR2 Gene

InterPro:
Blocks:
  • Immunoglobulin V-set
  • Immunoglobulin subtype

Suggested Antigen Peptide Sequences for NCR2 Gene

GenScript: Design optimal peptide antigens:
  • Natural killer cell p44-related protein (NCTR2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95944

UniProtKB/Swiss-Prot:

NCTR2_HUMAN :
  • Belongs to the natural cytotoxicity receptor (NCR) family.
Family:
  • Belongs to the natural cytotoxicity receptor (NCR) family.
genes like me logo Genes that share domains with NCR2: view

Function for NCR2 Gene

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  3. miRNA products for research
  4. Inhibitory RNAs for research
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  6. Cell Lines for research

Molecular function for NCR2 Gene

UniProtKB/Swiss-Prot Function:
Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

Phenotypes From GWAS Catalog for NCR2 Gene

Gene Ontology (GO) - Molecular Function for NCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 10049942
GO:0005515 protein binding IPI 10049942
GO:0038023 signaling receptor activity IBA 21873635
genes like me logo Genes that share ontologies with NCR2: view
genes like me logo Genes that share phenotypes with NCR2: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NCR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NCR2 Gene

Localization for NCR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCR2 Gene

Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCR2 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
mitochondrion 2
nucleus 2
endosome 2
cytosol 2
lysosome 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10049942
GO:0009986 cell surface IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NCR2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NCR2 Gene

Pathways & Interactions for NCR2 Gene

genes like me logo Genes that share pathways with NCR2: view

Pathways by source for NCR2 Gene

1 KEGG pathway for NCR2 Gene
1 GeneGo (Thomson Reuters) pathway for NCR2 Gene
  • Immune response Role of DAP12 receptors in NK cells

SIGNOR curated interactions for NCR2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006968 cellular defense response TAS 10049942
GO:0007165 signal transduction TAS 10049942
GO:0045087 innate immune response TAS --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with NCR2: view

Drugs & Compounds for NCR2 Gene

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(1) Drugs for NCR2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with NCR2: view

Transcripts for NCR2 Gene

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mRNA/cDNA for NCR2 Gene

3 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NCR2

Alternative Splicing Database (ASD) splice patterns (SP) for NCR2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1:
SP2: -

Relevant External Links for NCR2 Gene

GeneLoc Exon Structure for
NCR2

Expression for NCR2 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NCR2 Gene

mRNA expression in normal human tissues for NCR2 Gene
mRNA expression by GTEx for NCR2 GenemRNA expression by BioGPS for NCR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NCR2 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x4.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NCR2

SOURCE GeneReport for Unigene cluster for NCR2 Gene:

Hs.194721

mRNA Expression by UniProt/SwissProt for NCR2 Gene:

O95944-NCTR2_HUMAN
Tissue specificity: Selectively expressed by activated NK cells and by in vitro cultured (i.e. activated) TCRg/d lymphoid cells.

Evidence on tissue expression from TISSUES for NCR2 Gene

  • Blood(4.5)
  • Lymph node(2.2)
  • Kidney(2.2)
  • Spleen(2.2)
genes like me logo Genes that share expression patterns with NCR2: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCR2 Gene

Orthologs for NCR2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for NCR2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia NCR2 29 30
  • 98.79 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia NCR2 29 30
  • 76.52 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia B430306N03Rik 30
  • 19 (a)
 ManyToMany
Species where no ortholog for NCR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for NCR2 Gene

ENSEMBL:
Gene Tree for NCR2 (if available)
TreeFam:
Gene Tree for NCR2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NCR2: view image
Alliance of Genome Resources:
Additional Orthologs for NCR2

Paralogs for NCR2 Gene

Paralogs for NCR2 Gene

(1) SIMAP similar genes for NCR2 Gene using alignment to 1 proteins:

  • NCTR2_HUMAN

Pseudogenes.org Pseudogenes for NCR2 Gene

genes like me logo Genes that share paralogs with NCR2: view

Variants for NCR2 Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NCR2 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs115509322 Benign: not provided 41,350,840(+) T/C
NM_004828.4(NCR2):c.807T>C (p.Asp269=) 		SYNONYMOUS_VARIANT,THREE_PRIME_UTR
rs147357473 Benign: not provided 41,336,401(+) G/A
NM_004828.4(NCR2):c.367G>A (p.Val123Ile) 		MISSENSE
rs34345974 Benign: not provided 41,336,093(+) A/G
NM_004828.4(NCR2):c.59A>G (p.Gln20Arg) 		MISSENSE
rs2236369 -- p.Ser139Pro
rs2273961 -- p.Ile218Lys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NCR2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NCR2 Gene

Variant ID Type Subtype PubMed ID
esv3608790 CNV gain 21293372

Variation tolerance for NCR2 Gene

Residual Variation Intolerance Score: 82.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NCR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCR2
Leiden Open Variation Database (LOVD)
NCR2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCR2 Gene

Disorders for NCR2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for NCR2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
newcastle disease
  • newcastle's disease
dermatitis, atopic, 5
  • atod5
nk cell deficiency
  • nk cell defects
viral infectious disease
  • viral disease
leukemia, acute myeloid
  • aml
- elite association - COSMIC cancer census association via MalaCards
Search NCR2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NCR2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with NCR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCR2 Gene

Publications for NCR2 Gene

  1. NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily. (PMID: 10049942) Cantoni C … Biassoni R (The Journal of experimental medicine 1999) 2 3 4 22
  2. Identification of a cellular ligand for the natural cytotoxicity receptor NKp44. (PMID: 23958951) Baychelier F … Vieillard V (Blood 2013) 3 4
  3. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney SJ … AddNeuroMed Consortium (Molecular psychiatry 2011) 3 40
  4. Expressions of natural cytotoxicity receptors and NKG2D on decidual natural killer cells in patients having spontaneous abortions. (PMID: 18023431) Zhang Y … Lin Q (Fertility and sterility 2008) 3 22
  5. Expression analysis of the ligands for the Natural Killer cell receptors NKp30 and NKp44. (PMID: 18092004) Byrd A … Watzl C (PloS one 2007) 3 22

ExternalLinks

View latest publications for NCR2 gene in Mastermind

Products for NCR2 Gene

Sources for NCR2 Gene