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Aliases for NCR1 Gene

Aliases for NCR1 Gene

  • Natural Cytotoxicity Triggering Receptor 1 2 3 3 5
  • Natural Killer Cell P46-Related Protein 3 4
  • NK Cell-Activating Receptor 3 4
  • NK-P46 3 4
  • LY94 3 4
  • Lymphocyte Antigen 94 (Mouse) Homolog (Activating NK-Receptor; NK-P46) 2
  • Lymphocyte Antigen 94 Homolog (Activating NK-Receptor; NK-P46) 3
  • Lymphocyte Antigen 94 Homolog 4
  • CD335 Antigen 4
  • HNKp46 4
  • CD335 3
  • NKP46 3
  • NKp46 4

External Ids for NCR1 Gene

Previous HGNC Symbols for NCR1 Gene

  • LY94

Previous GeneCards Identifiers for NCR1 Gene

  • GC19P055842
  • GC19P060093
  • GC19P060008
  • GC19P060109
  • GC19P055417
  • GC19P051740
  • GC19P054906
  • GC19P054907
  • GC19P054921
  • GC19P054939
  • GC19P054964
  • GC19P054984
  • GC19P055001
  • GC19P055028

Summaries for NCR1 Gene

GeneCards Summary for NCR1 Gene

NCR1 (Natural Cytotoxicity Triggering Receptor 1) is a Protein Coding gene. Diseases associated with NCR1 include Viral Infectious Disease. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity, downstream of receptor. An important paralog of this gene is LILRA6.

UniProtKB/Swiss-Prot for NCR1 Gene

  • Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

Gene Wiki entry for NCR1 Gene

Additional gene information for NCR1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCR1 Gene

Genomics for NCR1 Gene

GeneHancer (GH) Regulatory Elements for NCR1 Gene

Promoters and enhancers for NCR1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J054905 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 659.7 +0.1 63 2 TAF9B NFRKB ZBTB40 TCF12 POLR2B CBX5 ZBTB2 ZBTB11 REST ELF1 NCR1 KIR3DL2 ENSG00000275012
GH19J055337 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 8.8 +433.8 433836 4 CLOCK MLX FEZF1 DMAP1 YY1 E2F8 ZNF143 ZNF548 SP3 NFYC KMT5C ENSG00000276831 LENG8-AS1 U2AF2 LENG8 ZNF628 ENSG00000235681 ENSG00000267523 ENSG00000267096 FAM71E2
GH19J054893 Enhancer 0.5 ENCODE 8.3 -12.2 -12204 1.3 SP1 USF1 NANOG TCF7L2 KIR2DS4 EPS8L1 RDH13 NCR1 KIR3DL2 ENSG00000268734 PIR47082
GH19J055111 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.4 +209.4 209391 8 HDGF ARNT ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 YY1 POLR2B PPP1R12C GC19M055111 EPS8L1 RDH13 U2AF2 LENG8-AS1 LENG8 ENSG00000235681 CNOT3 ENSG00000267523
GH19J055275 Enhancer 1 FANTOM5 Ensembl ENCODE 3 +370.8 370824 2.2 SRF POLR2A ZNF189 CEBPB DPF2 ZNF623 RUNX3 SPI1 HSPBP1 KIR3DL2 KIR2DS4 ZNF628 NCR1 EPN1 PPP6R1 KMT5C KIR3DL1 GC19M055263
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NCR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NCR1 gene promoter:
  • AML1a
  • SEF-1 (1)
  • PPAR-gamma2
  • PPAR-gamma1
  • Ik-1
  • Ik-2
  • AREB6
  • LyF-1
  • deltaCREB
  • CREB

Genomic Locations for NCR1 Gene

Genomic Locations for NCR1 Gene
32,217 bases
Plus strand
10,001 bases
Plus strand

Genomic View for NCR1 Gene

Genes around NCR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for NCR1 Gene

  • Protein details for NCR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Natural cytotoxicity triggering receptor 1
    Protein Accession:
    Secondary Accessions:
    • B0V3L2
    • B0V3L3
    • B0V3L4
    • B0V3L5
    • B8JL03
    • O76016
    • O76017
    • O76018

    Protein attributes for NCR1 Gene

    304 amino acids
    Molecular mass:
    34481 Da
    Quaternary structure:
    • Interacts with CD247 and FCER1G.

    Three dimensional structures from OCA and Proteopedia for NCR1 Gene

    Alternative splice isoforms for NCR1 Gene

neXtProt entry for NCR1 Gene

Post-translational modifications for NCR1 Gene

Antibody Products

  • Abcam antibodies for NCR1
  • Boster Bio Antibodies for NCR1

No data available for DME Specific Peptides for NCR1 Gene

Domains & Families for NCR1 Gene

Gene Families for NCR1 Gene

Protein Domains for NCR1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the natural cytotoxicity receptor (NCR) family.
  • Belongs to the natural cytotoxicity receptor (NCR) family.
genes like me logo Genes that share domains with NCR1: view

Function for NCR1 Gene

Molecular function for NCR1 Gene

UniProtKB/Swiss-Prot Function:
Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

Gene Ontology (GO) - Molecular Function for NCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17056548
genes like me logo Genes that share ontologies with NCR1: view
genes like me logo Genes that share phenotypes with NCR1: view

Animal Models for NCR1 Gene

MGI Knock Outs for NCR1:
  • Ncr1 Ncr1<tm1Oman>

Animal Model Products

  • Taconic Biosciences Mouse Models for NCR1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NCR1 Gene

Localization for NCR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCR1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCR1 gene
Compartment Confidence
plasma membrane 5
nucleus 4
extracellular 2
lysosome 2
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 9730896
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016514 SWI/SNF complex ISS --
genes like me logo Genes that share ontologies with NCR1: view

Pathways & Interactions for NCR1 Gene

genes like me logo Genes that share pathways with NCR1: view

Gene Ontology (GO) - Biological Process for NCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006968 cellular defense response TAS 9730896
GO:0007165 signal transduction TAS 9730896
GO:0030101 natural killer cell activation NAS 9730896
GO:0042269 regulation of natural killer cell mediated cytotoxicity TAS 15654827
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with NCR1: view

No data available for SIGNOR curated interactions for NCR1 Gene

Drugs & Compounds for NCR1 Gene

No Compound Related Data Available

Transcripts for NCR1 Gene

mRNA/cDNA for NCR1 Gene

(8) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NCR1 Gene

Natural cytotoxicity triggering receptor 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCR1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
SP3: - -
SP4: -
SP5: -
SP6: - -
SP7: -

Relevant External Links for NCR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NCR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NCR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NCR1 Gene

This gene is overexpressed in Whole Blood (x35.1) and Spleen (x8.1).

NURSA nuclear receptor signaling pathways regulating expression of NCR1 Gene:


SOURCE GeneReport for Unigene cluster for NCR1 Gene:


mRNA Expression by UniProt/SwissProt for NCR1 Gene:

Tissue specificity: Selectively expressed by both resting and activated NK cells.

Evidence on tissue expression from TISSUES for NCR1 Gene

  • Blood(4.6)
  • Spleen(2.3)
genes like me logo Genes that share expression patterns with NCR1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCR1 Gene

Orthologs for NCR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NCR1 34 33
  • 99.12 (n)
(Canis familiaris)
Mammalia NCR1 34 33
  • 77.7 (n)
(Bos Taurus)
Mammalia NCR1 34 33
  • 74.13 (n)
(Rattus norvegicus)
Mammalia Ncr1 33
  • 74.11 (n)
(Mus musculus)
Mammalia Ncr1 16 34 33
  • 72.3 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 11 (a)
Species where no ortholog for NCR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NCR1 Gene

Gene Tree for NCR1 (if available)
Gene Tree for NCR1 (if available)
Evolutionary constrained regions (ECRs) for NCR1: view image

Paralogs for NCR1 Gene

(26) SIMAP similar genes for NCR1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NCR1: view

Variants for NCR1 Gene

Sequence variations from dbSNP and Humsavar for NCR1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs104895502 pathogenic, Hydatidiform mole 54,938,095(+) C/A/G/T genic_downstream_transcript_variant, intron_variant
rs104895503 pathogenic, Hydatidiform mole 54,930,571(+) T/C genic_downstream_transcript_variant, intron_variant
rs104895505 pathogenic, Hydatidiform mole 54,934,488(+) C/T genic_downstream_transcript_variant, intron_variant
rs104895506 pathogenic, Hydatidiform mole 54,938,096(+) G/A/T genic_downstream_transcript_variant, intron_variant
rs104895508 not-provided, Hydatidiform mole 54,938,203(+) T/A 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NCR1 Gene

Variant ID Type Subtype PubMed ID
dgv1819n106 OTHER inversion 24896259
esv2667609 CNV deletion 23128226
esv2718872 CNV deletion 23290073
esv2758771 CNV gain+loss 17122850
esv3893250 CNV loss 25118596
nsv1079034 OTHER inversion 25765185
nsv1150276 OTHER inversion 26484159
nsv428372 CNV gain+loss 18775914
nsv520644 CNV loss 19592680
nsv833880 CNV loss 17160897

Variation tolerance for NCR1 Gene

Residual Variation Intolerance Score: 75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.43; 54.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NCR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCR1 Gene

Disorders for NCR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NCR1 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
viral infectious disease
  • viral disease
- elite association - COSMIC cancer census association via MalaCards
Search NCR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NCR1

genes like me logo Genes that share disorders with NCR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCR1 Gene

Publications for NCR1 Gene

  1. Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity. (PMID: 9730896) Pessino A … Moretta A (The Journal of experimental medicine 1998) 2 3 4 22 58
  2. Crystal structure of the human natural killer (NK) cell activating receptor NKp46 reveals structural relationship to other leukocyte receptor complex immunoreceptors. (PMID: 12960161) Foster CE … Sun PD (The Journal of biological chemistry 2003) 3 4 22 58
  3. Expressions of natural cytotoxicity receptors and NKG2D on decidual natural killer cells in patients having spontaneous abortions. (PMID: 18023431) Zhang Y … Lin Q (Fertility and sterility 2008) 3 22 58
  4. Up-regulation of NK cell activating receptors following allogeneic hematopoietic stem cell transplantation under a lymphodepleting reduced intensity regimen is associated with elevated IL-15 levels. (PMID: 18275895) Boyiadzis M … Hakim FT (Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2008) 3 22 58
  5. The requirement for DNAM-1, NKG2D, and NKp46 in the natural killer cell-mediated killing of myeloma cells. (PMID: 17875681) El-Sherbiny YM … Cook GP (Cancer research 2007) 3 22 58

Products for NCR1 Gene

Sources for NCR1 Gene

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