NCOR2 Gene (Protein Coding)

Nuclear Receptor Corepressor 2

GC12M124324
GIFtS:
44
This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcript... See more...

Aliases for NCOR2 Gene

Aliases for NCOR2 Gene

  • Nuclear Receptor Corepressor 2 2 3 4 5
  • Thyroid-, Retinoic-Acid-Receptor-Associated Corepressor 3 4
  • T3 Receptor-Associating Factor 3 4
  • CTG Repeat Protein 26 3 4
  • SMAP270 3 4
  • N-CoR2 3 4
  • CTG26 3 4
  • SMRT 3 4
  • TRAC 3 4
  • Silencing Mediator Of Retinoic Acid And Thyroid Hormone Receptor 4
  • Silencing Mediator For Retinoid And Thyroid Hormone Receptors 3
  • Nuclear Receptor Co-Repressor 2 2
  • SMRTE-Tau 3
  • TNRC14 3
  • TRAC-1 3
  • SMRTE 3
  • TRAC1 3

External Ids for NCOR2 Gene

Previous GeneCards Identifiers for NCOR2 Gene

  • GC12M123498
  • GC12M124551
  • GC12M123162
  • GC12M123333
  • GC12M124808
  • GC12M121771

Summaries for NCOR2 Gene

Entrez Gene Summary for NCOR2 Gene

  • This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]

GeneCards Summary for NCOR2 Gene

NCOR2 (Nuclear Receptor Corepressor 2) is a Protein Coding gene. Diseases associated with NCOR2 include Acute Promyelocytic Leukemia and Lymphoma, Non-Hodgkin, Familial. Among its related pathways are Retinoic acid receptors-mediated signaling and Developmental Biology. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is NCOR1.

UniProtKB/Swiss-Prot Summary for NCOR2 Gene

  • Transcriptional corepressor (PubMed:20812024). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024).

Gene Wiki entry for NCOR2 Gene

Additional gene information for NCOR2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NCOR2 Gene

Genomics for NCOR2 Gene

GeneHancer (GH) Regulatory Elements for NCOR2 Gene

Promoters and enhancers for NCOR2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12J124563 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 758 +0.6 619 6.8 ZNF785 SIN3A SP1 CTCF ZBTB6 POLR2A NR2F6 ZNF362 MYC L3MBTL2 NCOR2 lnc-NCOR2-4 lnc-NCOR2-5 TMED2 ENSG00000247373 TCTN2 DHX37 GTF2H3 DDX55 EIF2B1
GH12J124559 Promoter/Enhancer 0.6 EPDnew dbSUPER 750.4 +8.2 8231 0.1 ZNF217 NCOR2 ENSG00000279121 ENSG00000279334 lnc-NCOR2-4 lnc-RFLNA-4
GH12J124495 Promoter/Enhancer 0.6 EPDnew dbSUPER 750.2 +72.3 72250 0.1 ADNP NCOR2 LOC105370047 piR-33614-071 lnc-NCOR2-4
GH12J124909 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 95.2 -349.7 -349736 16.4 PPP1R10 E2F8 FOXK2 GTF3C2 ZNF785 SIN3A ZNF24 ZBTB40 SP1 CTCF SCARB1 UBC MIR5188 NCOR2 DHX37 ENSG00000269938 ENSG00000270130 ENSG00000269997 ENSG00000270061 LOC100131779
GH12J124937 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 46.5 -371.9 -371928 5 FOXK2 GTF3C2 SIN3A ZNF24 ZBTB40 CTCF SREBF1 ZBTB6 LCORL MLX UBC AB330774-008 TRA-TGC4-1 TRD-GTC2-10 piR-38621 piR-36225-002 DHX37 NCOR2 BRI3BP CCDC92
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NCOR2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NCOR2 gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • ATF-2
  • c-Jun
  • GATA-6
  • HEN1
  • POU2F1a
  • RORalpha1

Genomic Locations for NCOR2 Gene

Genomic Locations for NCOR2 Gene
chr12:124,324,411-124,567,589
(GRCh38/hg38)
Size:
243,179 bases
Orientation:
Minus strand
chr12:124,808,957-125,052,135
(GRCh37/hg19)
Size:
243,179 bases
Orientation:
Minus strand

Genomic View for NCOR2 Gene

Genes around NCOR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCOR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCOR2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NCOR2 Gene

Proteins for NCOR2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NCOR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y618-NCOR2_HUMAN
    Recommended name:
    Nuclear receptor corepressor 2
    Protein Accession:
    Q9Y618
    Secondary Accessions:
    • O00613
    • O15416
    • O15421
    • Q13354
    • Q56D06
    • Q59GM0
    • Q9Y5U0

    Protein attributes for NCOR2 Gene

    Size:
    2514 amino acids
    Molecular mass:
    273657 Da
    Quaternary structure:
    • Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. Interacts directly with RARA in the absence of ligand; the interaction represses RARA activity. Interacts (isoform SMRT) with HDAC10. Interacts with MINT. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2 (PubMed:10809664, PubMed:10944117, PubMed:11931768, PubMed:19858209, PubMed:21240272). Interacts with CBFA2T3 and ATXN1L. Interacts with RARB; the interaction is weak and does not repress RARB transactivational activity. Interacts with HDAC7 and C1D. Interacts with NR4A2; this interaction increases in the absence of PITX3. Interacts with BCL6 (via the BTB domain), required for BCL6 transcriptional repressor activity on a subset of target genes. Forms ternary complexes with BCOR and BCL6 on target gene promoters but, on enhancer elements, interacts with BCL6 and HDAC3 to repress proximal gene expression. May interact with DEAF1. Interacts with RXRA. Interacts with MECP2 (By similarity). Interacts with ZBTB7A (PubMed:20812024). Interacts with AR (PubMed:20812024).
    SequenceCaution:
    • Sequence=AAB91452.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAC50236.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=AAD20946.1; Type=Frameshift; Positions=787, 794; Evidence={ECO:0000305}; Sequence=BAD92326.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NCOR2 Gene

    Alternative splice isoforms for NCOR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCOR2 Gene

Protein Expression for NCOR2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NCOR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NCOR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NCOR2 Gene

Domains & Families for NCOR2 Gene

Gene Families for NCOR2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for NCOR2 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NCOR2 Gene

GenScript: Design optimal peptide antigens:
  • Thyroid-, retinoic-acid-receptor-associated corepressor (NCOR2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y618

UniProtKB/Swiss-Prot:

NCOR2_HUMAN :
  • The N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor-interacting domains that are divided in two separate interaction domains (ID1 and ID2).
  • Belongs to the N-CoR nuclear receptor corepressors family.
Domain:
  • The N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor-interacting domains that are divided in two separate interaction domains (ID1 and ID2).
  • The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclear hormone receptor specificity.
Family:
  • Belongs to the N-CoR nuclear receptor corepressors family.
genes like me logo Genes that share domains with NCOR2: view

Function for NCOR2 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
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  6. Cell Line

Molecular function for NCOR2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional corepressor (PubMed:20812024). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024).
UniProtKB/Swiss-Prot Induction:
Regulated during cell cycle progression.
GENATLAS Biochemistry:
nuclear hormone receptor co-repressor 2,silencing mediator of retinoic acid and thyroid hormone receptors,ubiquitously expressed,recruiting the histone deacytylation complex Sin3A/HDAC1/HDAC2,resulting in chromatin remodeling and repression of transcription

Phenotypes From GWAS Catalog for NCOR2 Gene

Gene Ontology (GO) - Molecular Function for NCOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0001012 RNA polymerase II regulatory region DNA binding IBA 21873635
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IBA 21873635
GO:0003714 transcription corepressor activity IDA,IMP 12628926
genes like me logo Genes that share ontologies with NCOR2: view
genes like me logo Genes that share phenotypes with NCOR2: view

Animal Models for NCOR2 Gene

MGI Knock Outs for NCOR2:

Animal Model Products

CRISPR Products

miRNA for NCOR2 Gene

miRTarBase miRNAs that target NCOR2

Clone Products

  • Addgene plasmids for NCOR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCOR2 Gene

Localization for NCOR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCOR2 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCOR2 gene
Compartment Confidence
nucleus 5
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NCOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex IBA 21873635
GO:0000785 chromatin IEA --
GO:0000790 nuclear chromatin IDA 20388878
GO:0005634 nucleus IDA,IEA 12628926
GO:0005654 nucleoplasm IDA,TAS --
genes like me logo Genes that share ontologies with NCOR2: view

Pathways & Interactions for NCOR2 Gene

genes like me logo Genes that share pathways with NCOR2: view

Pathways by source for NCOR2 Gene

2 KEGG pathways for NCOR2 Gene
1 R&D Systems pathway for NCOR2 Gene
7 Qiagen pathways for NCOR2 Gene
  • AHR Pathway
  • Estrogen Pathway
  • Glucocorticoid Receptor Signaling
  • Huntington's Disease Pathway
  • Macrophage Differentiation and Growth Inhibition by METS

SIGNOR curated interactions for NCOR2 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NCOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS --
GO:0007595 lactation IEA --
GO:0010243 response to organonitrogen compound IEA --
GO:0019216 regulation of lipid metabolic process TAS --
GO:0032355 response to estradiol IEA --
genes like me logo Genes that share ontologies with NCOR2: view

Drugs & Compounds for NCOR2 Gene

Products:

  1. Drug

(13) Drugs for NCOR2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tretinoin Approved, Investigational Nutra Full agonist, Agonist, Antagonist 254

(9) Additional Compounds for NCOR2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NCOR2: view

Transcripts for NCOR2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for NCOR2 Gene

(3) REFSEQ mRNAs :
(18) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(24) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for NCOR2

Alternative Splicing Database (ASD) splice patterns (SP) for NCOR2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ·
SP1:
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SP8: -
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SP25:
SP26:

ExUns: 24c ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28a · 28b · 28c ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33a · 33b · 33c · 33d ^ 34a · 34b · 34c ^ 35 ^ 36a · 36b ^ 37 ^ 38a ·
SP1: - -
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SP17:
SP18:
SP19: -
SP20: - -
SP21: -
SP22:
SP23:
SP24:
SP25: -
SP26:

ExUns: 38b ^ 39 ^ 40a · 40b · 40c · 40d ^ 41a · 41b · 41c · 41d ^ 42a · 42b · 42c · 42d
SP1: - - -
SP2:
SP3: - - - - - - -
SP4: - - - -
SP5: -
SP6: - - - - -
SP7: - - - - - - -
SP8:
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SP10:
SP11:
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SP18:
SP19:
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SP21:
SP22: -
SP23:
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SP25:
SP26:

Relevant External Links for NCOR2 Gene

GeneLoc Exon Structure for
NCOR2
ECgene alternative splicing isoforms for
NCOR2

Expression for NCOR2 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NCOR2 Gene

mRNA expression in normal human tissues for NCOR2 Gene
mRNA expression by GTEx for NCOR2 GenemRNA expression by BioGPS for NCOR2 Gene

Protein differential expression in normal tissues from HIPED for NCOR2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (49.8) and Cerebrospinal fluid (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NCOR2 Gene



NURSA nuclear receptor signaling pathways regulating expression of NCOR2 Gene:

NCOR2

SOURCE GeneReport for Unigene cluster for NCOR2 Gene:

Hs.137510

mRNA Expression by UniProt/SwissProt for NCOR2 Gene:

Q9Y618-NCOR2_HUMAN
Tissue specificity: Ubiquitous. High levels of expression are detected in lung, spleen and brain.

Evidence on tissue expression from TISSUES for NCOR2 Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Lung(3)
  • Skin(2.9)
  • Thyroid gland(2.8)
  • Intestine(2.6)
  • Muscle(2.4)
  • Blood(2.3)
  • Pancreas(2.3)
  • Kidney(2)
genes like me logo Genes that share expression patterns with NCOR2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCOR2 Gene

Orthologs for NCOR2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NCOR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia NCOR2 33 32
  • 96.82 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia NCOR2 33 32
  • 89.11 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia NCOR2 33 32
  • 88.66 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Ncor2 32
  • 84.21 (n)
mouse
(Mus musculus)
 Mammalia Ncor2 17 33 32
  • 83.97 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia NCOR2 33
  • 65 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia NCOR2 33
  • 65 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves NCOR2 33 32
  • 75.16 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia NCOR2 33
  • 66 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia ncor2 32
  • 65.34 (n)
zebrafish
(Danio rerio)
 Actinopterygii ncor2 33 32
  • 61.06 (n)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta Smr 33
  • 12 (a)
 OneToOne
worm
(Caenorhabditis elegans)
 Secernentea gei-8 33
  • 14 (a)
 OneToOne
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes SNT1 33
  • 14 (a)
 OneToMany
Species where no ortholog for NCOR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NCOR2 Gene

ENSEMBL:
Gene Tree for NCOR2 (if available)
TreeFam:
Gene Tree for NCOR2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NCOR2: view image

Paralogs for NCOR2 Gene

Paralogs for NCOR2 Gene

(2) SIMAP similar genes for NCOR2 Gene using alignment to 17 proteins:

  • NCOR2_HUMAN
  • C9J0Q5_HUMAN
  • C9J239_HUMAN
  • C9J330_HUMAN
  • C9J7T7_HUMAN
  • C9JE98_HUMAN
  • C9JFD3_HUMAN
  • C9JNV9_HUMAN
  • C9JQE8_HUMAN
  • H0YGK8_HUMAN
  • H7BZU2_HUMAN
  • H7C0P3_HUMAN
  • H7C184_HUMAN
  • H7C1J7_HUMAN
  • H7C1Y3_HUMAN
  • H7C2D4_HUMAN
  • H7C2R5_HUMAN
genes like me logo Genes that share paralogs with NCOR2: view

Variants for NCOR2 Gene

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Sequence variations from dbSNP and Humsavar for NCOR2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs774775666 uncertain-significance, not provided 124,340,628(-) C/T coding_sequence_variant, missense_variant
rs1000004914 -- 124,367,112(-) A/C intron_variant
rs1000007316 -- 124,396,787(-) C/T intron_variant
rs1000014917 -- 124,504,715(-) C/T intron_variant
rs1000023697 -- 124,473,080(-) G/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for NCOR2 Gene

Variant ID Type Subtype PubMed ID
dgv201e201 CNV deletion 23290073
dgv2935n54 CNV loss 21841781
dgv2936n54 CNV loss 21841781
dgv2937n54 CNV gain+loss 21841781
dgv2938n54 CNV gain 21841781
dgv2939n54 CNV gain+loss 21841781
dgv2940n54 CNV gain+loss 21841781
dgv2941n54 CNV loss 21841781
dgv2942n54 CNV gain+loss 21841781
dgv2943n54 CNV loss 21841781
dgv2944n54 CNV loss 21841781
dgv2945n54 CNV loss 21841781
dgv2946n54 CNV loss 21841781
dgv928e59 CNV duplication 20981092
esv1008328 CNV insertion 20482838
esv1118928 CNV insertion 17803354
esv1449756 CNV insertion 17803354
esv1465850 CNV insertion 17803354
esv1526249 CNV deletion 17803354
esv1669172 CNV insertion 17803354
esv1772285 CNV insertion 17803354
esv2130547 CNV deletion 18987734
esv24001 CNV gain 19812545
esv2428288 CNV deletion 19546169
esv2658789 CNV deletion 23128226
esv2662504 CNV deletion 23128226
esv2664620 CNV deletion 23128226
esv2666569 CNV deletion 23128226
esv2670996 CNV deletion 23128226
esv2746527 CNV deletion 23290073
esv2746528 CNV deletion 23290073
esv2746529 CNV deletion 23290073
esv2746531 CNV deletion 23290073
esv2746532 CNV deletion 23290073
esv2746534 CNV deletion 23290073
esv2746536 CNV deletion 23290073
esv2746537 CNV deletion 23290073
esv2746538 CNV deletion 23290073
esv2746539 CNV deletion 23290073
esv2746540 CNV deletion 23290073
esv2746542 CNV deletion 23290073
esv3401431 CNV insertion 20981092
esv3549934 CNV deletion 23714750
esv3631010 CNV gain 21293372
esv3631011 CNV gain 21293372
esv3631012 CNV gain 21293372
esv3631014 CNV loss 21293372
esv3631016 CNV loss 21293372
nsv1069709 CNV deletion 25765185
nsv1069710 CNV deletion 25765185
nsv1070560 CNV deletion 25765185
nsv1112624 CNV deletion 24896259
nsv1116714 CNV tandem duplication 24896259
nsv1120270 CNV tandem duplication 24896259
nsv1125186 CNV insertion 24896259
nsv1130668 CNV deletion 24896259
nsv1134274 CNV deletion 24896259
nsv1135797 CNV deletion 24896259
nsv1136160 CNV deletion 24896259
nsv1139576 CNV duplication 24896259
nsv1141340 CNV deletion 24896259
nsv1141343 CNV deletion 24896259
nsv1146892 CNV duplication 26484159
nsv1148270 CNV duplication 26484159
nsv1149521 CNV deletion 26484159
nsv455737 CNV loss 19166990
nsv455738 CNV loss 19166990
nsv455739 CNV loss 19166990
nsv470322 CNV loss 18288195
nsv470323 CNV loss 18288195
nsv474040 CNV novel sequence insertion 20440878
nsv560540 CNV loss 21841781
nsv560541 CNV loss 21841781
nsv560542 CNV loss 21841781
nsv560543 CNV gain 21841781
nsv560544 CNV loss 21841781
nsv560545 CNV loss 21841781
nsv560566 CNV loss 21841781
nsv560573 CNV gain 21841781
nsv560574 CNV gain 21841781
nsv560575 CNV loss 21841781
nsv560581 CNV loss 21841781
nsv560584 CNV loss 21841781
nsv818930 CNV gain 17921354
nsv821299 CNV deletion 20802225
nsv826536 CNV gain 20364138
nsv826537 CNV gain 20364138
nsv832535 CNV gain 17160897
nsv832538 CNV loss 17160897
nsv832539 CNV loss 17160897
nsv916 CNV insertion 18451855
nsv952500 CNV deletion 24416366
nsv957930 CNV deletion 24416366

Variation tolerance for NCOR2 Gene

Residual Variation Intolerance Score: 3.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.65; 97.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NCOR2 Gene

Human Gene Mutation Database (HGMD)
NCOR2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCOR2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCOR2 Gene

Disorders for NCOR2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NCOR2 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acute promyelocytic leukemia
  • apl
lymphoma, non-hodgkin, familial
  • non-hodgkin lymphoma; nhl
leukemia, acute myeloid
  • aml
- elite association - COSMIC cancer census association via MalaCards
Search NCOR2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NCOR2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NCOR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCOR2 Gene

Publications for NCOR2 Gene

  1. A transcriptional co-repressor that interacts with nuclear hormone receptors. (PMID: 7566127) Chen JD … Evans RM (Nature 1995) 2 3 4 23 56
  2. Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PMID: 19183483) Haiman CA … Press MF (BMC cancer 2009) 3 23 43 56
  3. Alternative mRNA splicing of SMRT creates functional diversity by generating corepressor isoforms with different affinities for different nuclear receptors. (PMID: 15632172) Goodson ML … Privalsky ML (The Journal of biological chemistry 2005) 3 4 23 56
  4. Retinoic acid receptors beta and gamma do not repress, but instead activate target gene transcription in both the absence and presence of hormone ligand. (PMID: 12554770) Hauksdottir H … Privalsky ML (Molecular endocrinology (Baltimore, Md.) 2003) 3 4 23 56
  5. Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3. (PMID: 10944117) Li J … Wong J (The EMBO journal 2000) 3 4 23 56

ExternalLinks

View latest publications for NCOR2 gene in Mastermind

Products for NCOR2 Gene