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This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcript... See more...
Aliases for NCOR2 Gene
Aliases for NCOR2 Gene
External Ids for NCOR2 Gene
- HGNC: 7673
- Entrez Gene: 9612
- Ensembl: ENSG00000196498
- OMIM: 600848
- UniProtKB: Q9Y618
Previous GeneCards Identifiers for NCOR2 Gene
- GC12M123498
- GC12M124551
- GC12M123162
- GC12M123333
- GC12M124808
- GC12M121771
Summaries for NCOR2 Gene
-
This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]
GeneCards Summary for NCOR2 Gene
NCOR2 (Nuclear Receptor Corepressor 2) is a Protein Coding gene. Diseases associated with NCOR2 include Acute Promyelocytic Leukemia and Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema. Among its related pathways are Signaling by GPCR and Development NOTCH1-mediated pathway for NF-KB activity modulation. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is NCOR1.
UniProtKB/Swiss-Prot Summary for NCOR2 Gene
-
Transcriptional corepressor (PubMed:20812024). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024).
Additional gene information for NCOR2 Gene
- HGNC(7673)
- Entrez Gene(9612)
- Ensembl(ENSG00000196498)
- OMIM(600848)
- UniProtKB(Q9Y618)
- Open Targets Platform(ENSG00000196498)
- Monarch Initiative
- Search for NCOR2 at DataMed
- Search for NCOR2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NCOR2 Gene
Genomics for NCOR2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for NCOR2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NCOR2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NCOR2
- Top Transcription factor binding sites by QIAGEN in the NCOR2 gene promoter:
-
- AP-2alpha
- AP-2alphaA
- AP-2beta
- AP-2gamma
- ATF-2
- c-Jun
- GATA-6
- HEN1
- POU2F1a
- RORalpha1
Genomic Locations for NCOR2 Gene
Genomic Locations for NCOR2 Gene
- chr12:124,324,415-124,567,612
- (GRCh38/hg38)
- Size:
- 243,198 bases
- Orientation:
- Minus strand
- chr12:124,808,957-125,052,135
- (GRCh37/hg19)
- Size:
- 243,179 bases
- Orientation:
- Minus strand
Genomic View for NCOR2 Gene
Genes around NCOR2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.31 by HGNC
- 12q24.31 by Entrez Gene
- 12q24.31 by Ensembl
NCOR2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NCOR2 Gene
Proteins for NCOR2 Gene
-
Protein details for NCOR2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y618-NCOR2_HUMAN
- Recommended name:
- Nuclear receptor corepressor 2
- Protein Accession:
- Q9Y618
- O00613
- O15416
- O15421
- Q13354
- Q56D06
- Q59GM0
- Q9Y5U0
Protein attributes for NCOR2 Gene
- Size:
- 2514 amino acids
- Molecular mass:
- 273657 Da
- Quaternary structure:
-
- Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. Interacts directly with RARA in the absence of ligand; the interaction represses RARA activity. Interacts (isoform SMRT) with HDAC10. Interacts with MINT. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2 (PubMed:10809664, PubMed:10944117, PubMed:11931768, PubMed:19858209, PubMed:21240272). Interacts with CBFA2T3 and ATXN1L. Interacts with RARB; the interaction is weak and does not repress RARB transactivational activity. Interacts with HDAC7 and C1D. Interacts with NR4A2; this interaction increases in the absence of PITX3. Interacts with BCL6 (via the BTB domain), required for BCL6 transcriptional repressor activity on a subset of target genes. Forms ternary complexes with BCOR and BCL6 on target gene promoters but, on enhancer elements, interacts with BCL6 and HDAC3 to repress proximal gene expression. May interact with DEAF1. Interacts with RXRA. Interacts with MECP2 (By similarity). Interacts with ZBTB7A (PubMed:20812024). Interacts with AR (PubMed:20812024). Interacts with TBL1Y (PubMed:30341416).
- SequenceCaution:
-
- Sequence=AAB91452.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAC50236.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=AAD20946.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAD92326.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
- Miscellaneous:
-
- [Isoform 2]: Contains only the C-terminal receptor-interacting domain and acts as an antirepressor.
Three dimensional structures from OCA and Proteopedia for NCOR2 Gene
Protein Expression for NCOR2 Gene
Post-translational modifications for NCOR2 Gene
Other Protein References for NCOR2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ NCOR2 Antibody
- Novus Biologicals Antibodies for NCOR2
- Invitrogen Antibodies for NCOR2 (AFLGC-NCOR2)
- antibodies-online: Show 14 available NCOR2 Antibodies ranked by validation data
- Compare Top NCOR2 Antibodies
-
Recommended
- 50 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 IHC (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 1 IP Antibody (anti-human)
- 12 IF (p) Antibodies (anti-rat)
- 10 WB Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-mouse)
- 12 WB Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
-
Biorbyt antibodies for NCOR2
-
Santa Cruz Biotechnology (SCBT) Antibodies for NCOR2
- Sino Biological Antibodies for NCOR2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for NCOR2
- Origene Custom Protein Services for NCOR2
- Novus Biologicals proteins for NCOR2
-
Signalway Proteins for NCOR2
-
Abcam proteins for NCOR2
Assay Products
-
Signalway ELISA kits for NCOR2
No data available for DME Specific Peptides for NCOR2 Gene
Domains & Families for NCOR2 Gene
Gene Families for NCOR2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for NCOR2 Gene
- InterPro:
- Blocks:
-
- Myb DNA-binding domain
- ProtoNet:
Suggested Antigen Peptide Sequences for NCOR2 Gene
- GenScript: Design optimal peptide antigens:
-
- Thyroid-, retinoic-acid-receptor-associated corepressor (NCOR2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9Y618UniProtKB/Swiss-Prot:
NCOR2_HUMAN :- The N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor-interacting domains that are divided in two separate interaction domains (ID1 and ID2).
- Belongs to the N-CoR nuclear receptor corepressors family.
- Domain:
-
- The N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor-interacting domains that are divided in two separate interaction domains (ID1 and ID2).
- The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclear hormone receptor specificity.
- Family:
-
- Belongs to the N-CoR nuclear receptor corepressors family.
Function for NCOR2 Gene
Molecular function for NCOR2 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional corepressor (PubMed:20812024). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024).
- UniProtKB/Swiss-Prot Induction:
- Regulated during cell cycle progression.
- GENATLAS Biochemistry:
- nuclear hormone receptor co-repressor 2,silencing mediator of retinoic acid and thyroid hormone receptors,ubiquitously expressed,recruiting the histone deacytylation complex Sin3A/HDAC1/HDAC2,resulting in chromatin remodeling and repression of transcription
Phenotypes From GWAS Catalog for NCOR2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | 21873635 |
| GO:0001012 | RNA polymerase II regulatory region DNA binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IEA,IBA | 21873635 |
| GO:0003714 | transcription corepressor activity | IDA,IMP | 12628926 |
Phenotypes for NCOR2 Gene
- MGI mutant phenotypes for NCOR2:
-
inferred from 4 alleles
- nervous system phenotype
- immune system phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- digestive/alimentary phenotype
- skeleton phenotype
- hematopoietic system phenotype
- craniofacial phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for NCOR2:
Animal Models for NCOR2 Gene
- MGI Knock Outs for NCOR2:
-
- Ncor2 Ncor2<tm1Rsd>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NCOR2 - Select products 50% OFF >
- * NCOR2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NCOR2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NCOR2
-
Santa Cruz Biotechnology (SCBT) CRISPR for NCOR2
miRNA for NCOR2 Gene
- miRTarBase miRNAs that target NCOR2
-
- hsa-miR-10a-5p (MIRT005454)
- hsa-miR-10b-5p (MIRT005455)
- hsa-miR-16-5p (MIRT006651)
- mmu-miR-9-5p (MIRT015392)
- hsa-miR-9-5p (MIRT021376)
- hsa-miR-2110 (MIRT035758)
- hsa-miR-130b-5p (MIRT038284)
- hsa-miR-20a-5p (MIRT050519)
- hsa-miR-125b-5p (MIRT053093)
- hsa-miR-100-5p (MIRT054500)
- hsa-miR-30c-5p (MIRT054824)
- hsa-miR-4459 (MIRT487117)
- hsa-miR-6757-5p (MIRT487118)
- hsa-miR-6780a-5p (MIRT487119)
- hsa-miR-6779-5p (MIRT487120)
- hsa-miR-3689c (MIRT487121)
- hsa-miR-3689b-3p (MIRT487122)
- hsa-miR-3689a-3p (MIRT487123)
- hsa-miR-30b-3p (MIRT487124)
- hsa-miR-1273h-5p (MIRT487125)
- hsa-miR-3178 (MIRT487126)
- hsa-miR-6799-5p (MIRT487127)
- hsa-miR-6785-5p (MIRT487128)
- hsa-miR-6883-5p (MIRT487129)
- hsa-miR-4728-5p (MIRT487130)
- hsa-miR-149-3p (MIRT487131)
- hsa-miR-7106-5p (MIRT487132)
- hsa-miR-25-5p (MIRT487133)
- hsa-miR-6797-5p (MIRT487134)
- hsa-miR-1249-5p (MIRT487135)
- hsa-miR-658 (MIRT487136)
- hsa-miR-2277-5p (MIRT487137)
- hsa-miR-6133 (MIRT487138)
- hsa-miR-6130 (MIRT487139)
- hsa-miR-6129 (MIRT487140)
- hsa-miR-6127 (MIRT487141)
- hsa-miR-4510 (MIRT487142)
- hsa-miR-4419a (MIRT487143)
- hsa-miR-6087 (MIRT487144)
- hsa-miR-6871-5p (MIRT487145)
- hsa-miR-4756-5p (MIRT487146)
- hsa-miR-1321 (MIRT487147)
- hsa-miR-4739 (MIRT487148)
- hsa-miR-195-5p (MIRT727094)
- hsa-miR-15b-5p (MIRT727095)
- hsa-miR-15a-5p (MIRT727096)
- hsa-miR-34a-3p (MIRT735397)
- hsa-miR-1266-5p (MIRT736706)
- hsa-miR-3197 (MIRT741101)
- hsa-miR-3612 (MIRT741586)
- hsa-miR-3937 (MIRT743130)
- hsa-miR-4274 (MIRT743662)
- hsa-miR-4313 (MIRT743961)
- hsa-miR-4443 (MIRT744587)
- hsa-miR-4518 (MIRT745779)
- hsa-miR-4530 (MIRT745968)
- hsa-miR-4802-5p (MIRT749015)
- hsa-miR-510-5p (MIRT749735)
- hsa-miR-6085 (MIRT751802)
- hsa-miR-650 (MIRT753034)
- hsa-miR-6798-5p (MIRT756264)
- hsa-miR-6807-5p (MIRT756527)
- hsa-miR-6813-5p (MIRT756738)
- hsa-miR-6858-3p (MIRT757781)
- hsa-miR-7108-3p (MIRT758919)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NCOR2
- Browse OriGene Inhibitory RNA Products For NCOR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NCOR2
Clone Products
- Applied Biological Materials (abm): Clones for NCOR2 - Select products 50% OFF >
- * NCOR2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for NCOR2
- Addgene plasmids for NCOR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NCOR2
Cell Line Products
-
Horizon Cell Lines for NCOR2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCOR2 Gene
Localization for NCOR2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NCOR2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 2 |
| cytosol | 2 |
| golgi apparatus | 2 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000118 | histone deacetylase complex | IBA | 21873635 |
| GO:0000785 | chromatin | IEA | -- |
| GO:0000790 | nuclear chromatin | IDA | 20388878 |
| GO:0005634 | nucleus | IEA,IDA | 12628926 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
Pathways & Interactions for NCOR2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by NOTCH1 | ||
| 2 | Notch Signaling Pathway (WikiPathways) | ||
| 3 | Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer | ||
| 4 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
| 5 | Development NOTCH1-mediated pathway for NF-KB activity modulation |
Development Notch Signaling Pathway
.55
Development NOTCH1-mediated pathway for NF-KB activity modulation
.55
|
Transcription Sin3 and NuRD in transcription regulation
.31
|
Pathways by source for NCOR2 Gene
1 Sino Biological pathway for NCOR2 Gene
11 BioSystems pathways for NCOR2 Gene
25 Reactome pathways for NCOR2 Gene
2 KEGG pathways for NCOR2 Gene
5 GeneGo (Thomson Reuters) pathways for NCOR2 Gene
- Development Notch Signaling Pathway
- Development NOTCH1-mediated pathway for NF-KB activity modulation
- Transcription Ligand-Dependent Transcription of Retinoid-Target genes
- Transcription PPAR Pathway
- Transcription Sin3 and NuRD in transcription regulation
1 R&D Systems pathway for NCOR2 Gene
7 Qiagen pathways for NCOR2 Gene
- AHR Pathway
- Estrogen Pathway
- Glucocorticoid Receptor Signaling
- Huntington's Disease Pathway
- Macrophage Differentiation and Growth Inhibition by METS
Interacting Proteins for NCOR2 Gene
Selected Interacting proteins:
Q9Y618-NCOR2_HUMAN
ENSP00000384018
for NCOR2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for NCOR2
SIGNOR curated interactions for NCOR2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | TAS | -- |
| GO:0007595 | lactation | IEA | -- |
| GO:0010243 | response to organonitrogen compound | IEA | -- |
| GO:0010565 | regulation of cellular ketone metabolic process | IMP | 19955185 |
| GO:0019216 | regulation of lipid metabolic process | TAS | -- |
Drugs & Compounds for NCOR2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Tretinoin | Approved, Investigational | Nutra | Agonist, Full agonist, Antagonist | 273 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for NCOR2 Gene
mRNA/cDNA for NCOR2 Gene
- 3 REFSEQ mRNAs :
- 18 NCBI additional mRNA sequence :
- 24 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000356219 7226 nts (view in UCSC)
- ENST00000404121 7175 nts (view in UCSC)
- ENST00000404621 8520 nts (view in UCSC)
- ENST00000405201 8533 nts (view in UCSC)
- ENST00000413172 532 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NCOR2 - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NCOR2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NCOR2
-
Santa Cruz Biotechnology (SCBT) CRISPR for NCOR2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NCOR2
- Browse OriGene Inhibitory RNA Products For NCOR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NCOR2
Clone Products
- Applied Biological Materials (abm): Clones for NCOR2 - Select products 50% OFF >
- * NCOR2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for NCOR2
- Addgene plasmids for NCOR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NCOR2
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP25: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP26: |
| ExUns: | 24c | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b | · | 27c | ^ | 28a | · | 28b | · | 28c | ^ | 29a | · | 29b | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33a | · | 33b | · | 33c | · | 33d | ^ | 34a | · | 34b | · | 34c | ^ | 35 | ^ | 36a | · | 36b | ^ | 37 | ^ | 38a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP19: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP25: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP26: |
| ExUns: | 38b | ^ | 39 | ^ | 40a | · | 40b | · | 40c | · | 40d | ^ | 41a | · | 41b | · | 41c | · | 41d | ^ | 42a | · | 42b | · | 42c | · | 42d |
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| SP1: | - | - | - | ||||||||||||||||||||||||
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| SP3: | - | - | - | - | - | - | - | ||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | ||||||||||||||||||||
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| SP21: | |||||||||||||||||||||||||||
| SP22: | - | ||||||||||||||||||||||||||
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| SP26: |
Relevant External Links for NCOR2 Gene
- GeneLoc Exon Structure for
- NCOR2
Expression for NCOR2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Bone marrow mesenchymal stem cell (49.8) and Cerebrospinal fluid (8.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NCOR2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NCOR2
SOURCE GeneReport for Unigene cluster for NCOR2 Gene:
Hs.137510mRNA Expression by UniProt/SwissProt for NCOR2 Gene:
Q9Y618-NCOR2_HUMAN
Tissue specificity:
Ubiquitous. High levels of expression are detected in lung, spleen and brain.
Evidence on tissue expression from TISSUES for NCOR2 Gene
- Nervous system(4.8)
- Liver(4.5)
- Skin(3.8)
- Lung(3.4)
- Intestine(3.3)
- Muscle(3.2)
- Pancreas(3.1)
- Blood(3.1)
- Thyroid gland(3)
- Eye(2.9)
- Kidney(2.8)
- Heart(2.7)
- Spleen(2.6)
- Bone marrow(2.5)
- Lymph node(2.5)
- Adrenal gland(2.4)
- Stomach(2.3)
Primer Products
-
OriGene qPCR primer pairs for NCOR2
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCOR2 Gene
Orthologs for NCOR2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | NCOR2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | NCOR2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | NCOR2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ncor2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Ncor2 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | NCOR2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | NCOR2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | NCOR2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | NCOR2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ncor2 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ncor2 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Smr 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | gei-8 31 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SNT1 31 |
|
OneToMany |
- Species where no ortholog for NCOR2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for NCOR2 Gene
- ENSEMBL:
- Gene Tree for NCOR2 (if available)
- TreeFam:
- Gene Tree for NCOR2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NCOR2: view image
Paralogs for NCOR2 Gene
(2) SIMAP similar genes for NCOR2 Gene using alignment to 17 proteins:
- NCOR2_HUMAN
- C9J0Q5_HUMAN
- C9J239_HUMAN
- C9J330_HUMAN
- C9J7T7_HUMAN
- C9JE98_HUMAN
- C9JFD3_HUMAN
- C9JNV9_HUMAN
- C9JQE8_HUMAN
- H0YGK8_HUMAN
- H7BZU2_HUMAN
- H7C0P3_HUMAN
- H7C184_HUMAN
- H7C1J7_HUMAN
- H7C1Y3_HUMAN
- H7C2D4_HUMAN
- H7C2R5_HUMAN
Variants for NCOR2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NCOR2 Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 800325 | Likely Pathogenic: Multiple myeloma | 124,336,959(-) | G/T | MISSENSE_VARIANT | |
| rs774775666 | Uncertain Significance: not provided | 124,340,628(-) | C/T | MISSENSE_VARIANT | |
| rs2229840 | - | p.Ala1699Thr | |||
| rs2230944 | - | p.Pro2001Ser | |||
| rs7978237 | - | p.Gly781Glu |
Residual Variation Intolerance Score:
3.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
16.65;
97.84% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NCOR2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCOR2 Gene
Disorders for NCOR2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| acute promyelocytic leukemia |
|
|
| dehydrated hereditary stomatocytosis 1 with or without pseudohyperkalemia and/or perinatal edema |
|
|
| clubfoot |
|
|
| prostate cancer |
|
|
| lung squamous cell carcinoma |
|
|
Search NCOR2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NCOR2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for NCOR2 Gene
Publications for NCOR2 Gene
- A transcriptional co-repressor that interacts with nuclear hormone receptors. (PMID: 7566127) Chen JD … Evans RM (Nature 1995) 2 3 4 23
- Genetic predictors of interindividual variability in hepatic CYP3A4 expression. (PMID: 19934400) Lamba V … Schuetz EG (The Journal of pharmacology and experimental therapeutics 2010) 3 23 41
- Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PMID: 19183483) Haiman CA … Press MF (BMC cancer 2009) 3 23 41
- Alternative mRNA splicing of SMRT creates functional diversity by generating corepressor isoforms with different affinities for different nuclear receptors. (PMID: 15632172) Goodson ML … Privalsky ML (The Journal of biological chemistry 2005) 3 4 23
- Retinoic acid receptors beta and gamma do not repress, but instead activate target gene transcription in both the absence and presence of hormone ligand. (PMID: 12554770) Hauksdottir H … Privalsky ML (Molecular endocrinology (Baltimore, Md.) 2003) 3 4 23
ExternalLinks
Products for NCOR2 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for NCOR2
- Origene Custom Protein Services for NCOR2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NCOR2
- Browse OriGene Inhibitory RNA Products For NCOR2
- OriGene qPCR primer pairs for NCOR2
- OriGene CRISPR knockouts for NCOR2