Aliases for NCOR1 Gene
Aliases for NCOR1 Gene
External Ids for NCOR1 Gene
- HGNC: 7672
- Entrez Gene: 9611
- Ensembl: ENSG00000141027
- OMIM: 600849
- UniProtKB: O75376
Previous GeneCards Identifiers for NCOR1 Gene
- GC17M016297
- GC17M017045
- GC17M015877
- GC17M016135
- GC17M015875
- GC17M015933
Summaries for NCOR1 Gene
-
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]
GeneCards Summary for NCOR1 Gene
NCOR1 (Nuclear Receptor Corepressor 1) is a Protein Coding gene. Diseases associated with NCOR1 include Acute Promyelocytic Leukemia and Rett Syndrome. Among its related pathways are Gene Expression and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is NCOR2.
UniProtKB/Swiss-Prot for NCOR1 Gene
-
Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6.
Additional gene information for NCOR1 Gene
- Monarch Initiative
- Search for NCOR1 at DataMed
- Search for NCOR1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCOR1 Gene
Genomics for NCOR1 Gene
GeneHancer (GH) Regulatory Elements for NCOR1 Gene
Promoters and enhancers for NCOR1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around NCOR1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the NCOR1 gene promoter:
-
- ATF6
- AP-1
- c-Jun
- ATF-2
- NF-kappaB
- NF-kappaB1
- TBP
- AML1a
- Pax-5
- Cart-1
Regulatory Element Products
Genomic Locations for NCOR1 Gene
Genomic Locations for NCOR1 Gene
- chr17:16,029,157-16,218,185
- (GRCh38/hg38)
- Size:
- 189,029 bases
- Orientation:
- Minus strand
- chr17:15,932,471-16,121,499
- (GRCh37/hg19)
- Size:
- 189,029 bases
- Orientation:
- Minus strand
Genomic View for NCOR1 Gene
Genes around NCOR1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p12-p11.2 by Entrez Gene
- 17p12-p11.2 by HGNC
- 17p11.2 by Ensembl
NCOR1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NCOR1 Gene
Proteins for NCOR1 Gene
-
Protein details for NCOR1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O75376-NCOR1_HUMAN
- Recommended name:
- Nuclear receptor corepressor 1
- Protein Accession:
- O75376
- B3DLF8
- E9PGV6
- Q86YY0
- Q9UPV5
- Q9UQ18
Protein attributes for NCOR1 Gene
- Size:
- 2440 amino acids
- Molecular mass:
- 270210 Da
- Quaternary structure:
-
- Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid receptor (TR) and the retinoid acid receptor (RAR) in the absence of ligand. Interacts directly with RARA; the interaction is facilitated with RARA trimethylation. Component of the N-Cor repressor complex, at least composed of CBFA2T3, HEXIM1, NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Interacts with ZBTB33; the interaction serves to recruit the N-CoR complex to promoter regions containing methylated CpG dinucleotides. Interacts with TRIM28 and KDM3A. Interacts (via the RD1 domain) with BAZ1A (via its N-terminal); the interaction corepresses a number of NCOR1-regulated genes. Interacts with BCL6, C1D, DACH1, HEXIM1, HDAC7, RORA, RORC, SAP30, SIAH2, SIN3A and SIN3B. May interact with DEAF1. Interacts with RXRA. Interacts with SETD5 (By similarity). Interacts with VDR (PubMed:28698609).
- SequenceCaution:
-
- Sequence=BAA82999.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for NCOR1 Gene
Protein Expression for NCOR1 Gene
Post-translational modifications for NCOR1 Gene
- Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation.
- Ubiquitination at isoforms=2, 3294
- Modification sites at PhosphoSitePlus
Other Protein References for NCOR1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_006721665.1
- XP_005256923.1
- XP_011522386.1
- XP_005256930.1
- XP_011522385.1
- XP_016880893.1
- XP_016880890.1
- XP_006721667.1
- XP_006721664.1
- XP_016880902.1
- NP_001177367.1
- XP_016880907.1
- XP_016880904.1
- XP_016880909.1
- XP_016880895.1
- XP_016880885.1
- XP_005256931.1
- XP_005256928.1
- XP_016880892.1
- XP_024306811.1
- NP_006302.2
- XP_016880897.1
- XP_016880887.1
- XP_006721666.1
- XP_011522388.1
- XP_016880894.1
- XP_016880901.1
- XP_016880906.1
- XP_005256929.1
- XP_024306809.1
- XP_016880908.1
- XP_016880899.1
- XP_016880889.1
- XP_024306810.1
- XP_005256932.1
- XP_016880903.1
- XP_011522387.1
- XP_016880891.1
- XP_016880896.1
- XP_016880886.1
- XP_016880900.1
- NP_001177369.1
- XP_016880898.1
- XP_016880888.1
- XP_016880905.1
- XP_005256925.1
Antibody Products
- R&D Systems Antibodies for NCOR1 (NCOR1)
-
Custom Antibody ServicesOriGene Antibodies for NCOR1
- Novus Biologicals Antibodies for NCOR1
-
Abcam antibodies for NCOR1
- Invitrogen Antibodies for NCOR1
- antibodies-online: Search results for 103 available NCOR1 Antibodies ranked by validation data
- Compare Top NCOR1 Antibodies
-
Recommended
- 37 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IF/ICC Antibody (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 11 WB Antibodies (anti-rat)
- 70 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- GeneTex NCOR1 Antibody for NCOR1
-
Santa Cruz Biotechnology (SCBT) Antibodies for NCOR1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for NCOR1
- Origene Custom Protein Services for NCOR1
- Novus Biologicals proteins for NCOR1
- Search GeneTex for Proteins for NCOR1
-
Abcam proteins for NCOR1
Assay Products
No data available for DME Specific Peptides for NCOR1 Gene
Domains & Families for NCOR1 Gene
Gene Families for NCOR1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for NCOR1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for NCOR1 Gene
Graphical View of Domain Structure for InterPro Entry
O75376UniProtKB/Swiss-Prot:
NCOR1_HUMAN :- The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3).
- Belongs to the N-CoR nuclear receptor corepressors family.
- Domain:
-
- The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3).
- The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of which contains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for binding to unligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity (By similarity).
- Family:
-
- Belongs to the N-CoR nuclear receptor corepressors family.
Function for NCOR1 Gene
Molecular function for NCOR1 Gene
- UniProtKB/Swiss-Prot Function:
- Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6.
- GENATLAS Biochemistry:
- nuclear receptor co-repressor 1,homolog to SMRT,recruiting the CoR/Sin3/HDAC1/HDAC2 complex,resulting in chromatin remodeling and repression of transcription,frequently deleted in malignant disorders,localized between CMT1A and SMS
Phenotypes From GWAS Catalog for NCOR1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | ISA | -- |
| GO:0001102 | RNA polymerase II activating transcription factor binding | IPI | 19955185 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003714 | transcription corepressor activity | IMP,IDA | 12628926 |
| GO:0005515 | protein binding | IPI | 10049357 |
Phenotypes for NCOR1 Gene
- MGI mutant phenotypes for NCOR1:
-
inferred from 6 alleles
- cardiovascular system phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- no phenotypic analysis
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- liver/biliary system phenotype
- embryo phenotype
- adipose tissue phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for NCOR1:
-
- Reduced shRNA abundance in FBW7 KO line
- Dynamic nuclei (hole, folded or small irregular)
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Decreased ionizing radiation sensitivity
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
Animal Models for NCOR1 Gene
- MGI Knock Outs for NCOR1:
-
- Ncor1 Ncor1<tm1Rsd>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for NCOR1
-
CRISPR Products
-
OriGene CRISPR knockouts for NCOR1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NCOR1
- genomics-online: gRNA clones - Search results for 102 available NCOR1 gene related products
- Overview of 102 available NCOR1 gene related products
- Applied Biological Materials CRISPR for NCOR1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NCOR1
- GenScript: Design CRISPR guide RNA sequences for NCOR1
miRNA for NCOR1 Gene
- miRTarBase miRNAs that target NCOR1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NCOR1
- Browse OriGene Inhibitory RNA Products For NCOR1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NCOR1
- genomics-online: shRNA clones - Search results for 102 available NCOR1 gene related products
- Overview of 102 available NCOR1 gene related products
Clone Products
-
GenScript: Next-day shipping of latest version cDNA ORF clones for NCOR1 in any vector
- XM_005256873.4
- XM_005256874.4
- XM_005256872.4
- XM_005256866.4
- XM_005256868.4
- XM_005256871.4
- XM_006721603.3
- NM_006311.3
- XM_006721601.3
- XM_005256875.3
- XM_006721604.3
- XM_006721602.3
- XM_011524083.2
- XM_011524085.2
- XM_011524086.2
- XM_011524084.2
- XM_017025410.1
- XM_017025418.1
- XM_017025404.1
- XM_017025420.1
- XM_017025412.1
- XM_017025399.1
- NM_001190438.1
- XM_017025419.1
- XM_017025415.1
- XM_017025401.1
- XM_017025416.1
- XM_017025405.1
- XM_017025409.1
- XM_017025414.1
- XM_017025400.1
- XM_017025398.1
- XM_017025402.1
- XM_017025413.1
- XM_017025417.1
- XM_017025397.1
- NM_001190440.1
- XM_017025403.1
- XM_017025406.1
- XM_017025407.1
- XM_017025408.1
- XM_017025411.1
- Sino Biological Human cDNA Clone for NCOR1
- VectorBuilder custom plasmid, inducible vectors for NCOR1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NCOR1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NCOR1
- Applied Biological Materials Clones for NCOR1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for NCOR1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCOR1 Gene
Localization for NCOR1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NCOR1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| peroxisome | 2 |
- Cytosol (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000118 | colocalizes_with histone deacetylase complex | IDA | 18326024 |
| GO:0000790 | nuclear chromatin | IDA | 17505061 |
| GO:0005634 | nucleus | IDA,IEA | 10049357 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for NCOR1 Gene
Pathways by source for NCOR1 Gene
13 BioSystems pathways for NCOR1 Gene
37 Reactome pathways for NCOR1 Gene
3 KEGG pathways for NCOR1 Gene
1 R&D Systems pathway for NCOR1 Gene
4 Qiagen pathways for NCOR1 Gene
1 Cell Signaling Technology pathway for NCOR1 Gene
Interacting Proteins for NCOR1 Gene
Selected Interacting proteins:
O75376-NCOR1_HUMAN
ENSP00000268712
for NCOR1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for NCOR1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | TAS | -- |
| GO:0006325 | chromatin organization | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006366 | transcription by RNA polymerase II | TAS | 7566114 |
Transcripts for NCOR1 Gene
mRNA/cDNA for NCOR1 Gene
- (46) REFSEQ mRNAs :
- (22) Additional mRNA sequences :
- (358) Selected AceView cDNA sequences:
- (27) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000268712 10720 bps (uc002gpo.4)
- ENST00000464381 2474 bps (uc060bqe.1)
- ENST00000470782 3987 bps (uc060bqf.1)
- ENST00000395851 7950 bps (uc002gpn.4)
- ENST00000580617 1352 bps (uc060bqg.1)
Unigene Clusters for NCOR1 Gene
- Nuclear receptor corepressor 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for NCOR1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NCOR1
- genomics-online: gRNA clones - Search results for 102 available NCOR1 gene related products
- Overview of 102 available NCOR1 gene related products
- Applied Biological Materials CRISPR for NCOR1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NCOR1
- GenScript: Design CRISPR guide RNA sequences for NCOR1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NCOR1
- Browse OriGene Inhibitory RNA Products For NCOR1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NCOR1
- genomics-online: shRNA clones - Search results for 102 available NCOR1 gene related products
- Overview of 102 available NCOR1 gene related products
Clone Products
-
GenScript: Next-day shipping of latest version cDNA ORF clones for NCOR1 in any vector
- XM_005256873.4
- XM_005256874.4
- XM_005256872.4
- XM_005256866.4
- XM_005256868.4
- XM_005256871.4
- XM_006721603.3
- NM_006311.3
- XM_006721601.3
- XM_005256875.3
- XM_006721604.3
- XM_006721602.3
- XM_011524083.2
- XM_011524085.2
- XM_011524086.2
- XM_011524084.2
- XM_017025410.1
- XM_017025418.1
- XM_017025404.1
- XM_017025420.1
- XM_017025412.1
- XM_017025399.1
- NM_001190438.1
- XM_017025419.1
- XM_017025415.1
- XM_017025401.1
- XM_017025416.1
- XM_017025405.1
- XM_017025409.1
- XM_017025414.1
- XM_017025400.1
- XM_017025398.1
- XM_017025402.1
- XM_017025413.1
- XM_017025417.1
- XM_017025397.1
- NM_001190440.1
- XM_017025403.1
- XM_017025406.1
- XM_017025407.1
- XM_017025408.1
- XM_017025411.1
- Sino Biological Human cDNA Clone for NCOR1
- VectorBuilder custom plasmid, inducible vectors for NCOR1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NCOR1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NCOR1
- Applied Biological Materials Clones for NCOR1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: |
| ExUns: | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32a | · | 32b | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36 | ^ | 37a | · | 37b | ^ | 38 | ^ | 39a | · | 39b | ^ | 40 | ^ | 41 | ^ | 42 | ^ | 43 | ^ | 44 | ^ | 45 | ^ | 46 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: |
Expression for NCOR1 Gene
This gene is overexpressed in Urine (23.5), Spinal cord (18.4), and Peripheral blood mononuclear cells (10.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NCOR1 Gene
NURSA nuclear receptor signaling pathways regulating expression of NCOR1 Gene:
NCOR1SOURCE GeneReport for Unigene cluster for NCOR1 Gene:
Hs.462323Evidence on tissue expression from TISSUES for NCOR1 Gene
- Nervous system(4.9)
- Liver(4.6)
- Thyroid gland(3.2)
- Intestine(3.1)
- Kidney(2.4)
- Lung(2.3)
- Muscle(2.3)
- Blood(2.2)
- Bone marrow(2)
Primer Products
-
OriGene qPCR primer pairs for NCOR1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCOR1 Gene
Orthologs for NCOR1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NCOR1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | NCOR1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ncor1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ncor1 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | NCOR1 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | NCOR1 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | NCOR1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NCOR1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | NCOR1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ncor1 33 |
|
||
| Str.16187 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398304 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ncor1 34 33 |
|
OneToOne | |
| zgc56355 33 |
|
||||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SNT1 36 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for NCOR1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for NCOR1 Gene
- ENSEMBL:
- Gene Tree for NCOR1 (if available)
- TreeFam:
- Gene Tree for NCOR1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NCOR1: view image
Paralogs for NCOR1 Gene
(3) SIMAP similar genes for NCOR1 Gene using alignment to 20 proteins:
- NCOR1_HUMAN
- A5PKW7_HUMAN
- B4DJ25_HUMAN
- C9JAP0_HUMAN
- E7EVK1_HUMAN
- E7EVU5_HUMAN
- E7EW50_HUMAN
- H0Y459_HUMAN
- J3KRE4_HUMAN
- J3KS29_HUMAN
- J3KS51_HUMAN
- J3KT44_HUMAN
- J3QKP0_HUMAN
- Q05CG3_HUMAN
- Q3B773_HUMAN
- Q6NTH1_HUMAN
- Q6PDT8_HUMAN
- Q6PGR4_HUMAN
- Q86W52_HUMAN
- S4R380_HUMAN
Pseudogenes.org Pseudogenes for NCOR1 Gene
Variants for NCOR1 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1057518948 | uncertain-significance, Bilateral cleft lip and palate, Camptodactyly of finger, Hypertelorism, Low-set ears, Postaxial hand polydactyly, Premature birth, Scrotal hypoplasia, Wide intermamillary distance | 16,217,402(-) | C/A | upstream_transcript_variant | |
| rs147669920 | uncertain-significance, Zunich neuroectodermal syndrome | 16,217,256(-) | G/T | upstream_transcript_variant | |
| rs150000731 | uncertain-significance, Zunich neuroectodermal syndrome | 16,217,230(-) | G/A | upstream_transcript_variant | |
| rs587784324 | uncertain-significance, Zunich neuroectodermal syndrome | 16,217,395(-) | T/C | upstream_transcript_variant | |
| rs751569508 | likely-pathogenic, Developmental delay, Hyperlaxity, Thin skin | 16,194,473(-) | G/A | coding_sequence_variant, missense_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv962265 | CNV | duplication | 23825009 |
| nsv960423 | CNV | duplication | 23825009 |
| nsv960422 | CNV | duplication | 23825009 |
| nsv833377 | CNV | loss | 17160897 |
| nsv528263 | CNV | loss | 19592680 |
| nsv522169 | CNV | gain | 19592680 |
| nsv1150926 | CNV | duplication | 26484159 |
| nsv1138502 | CNV | deletion | 24896259 |
| nsv1134603 | CNV | deletion | 24896259 |
| nsv112235 | CNV | deletion | 16902084 |
| nsv1070814 | CNV | deletion | 25765185 |
| esv3892973 | CNV | gain | 25118596 |
| esv3640098 | CNV | loss | 21293372 |
| esv3640097 | CNV | loss | 21293372 |
| esv3640096 | CNV | loss | 21293372 |
| esv3572431 | CNV | gain | 25503493 |
| esv3554202 | CNV | deletion | 23714750 |
| esv3554201 | CNV | deletion | 23714750 |
| esv3554199 | CNV | deletion | 23714750 |
| esv3416216 | CNV | insertion | 20981092 |
| esv3335248 | CNV | insertion | 20981092 |
| esv2715702 | CNV | deletion | 23290073 |
| esv2661970 | CNV | deletion | 23128226 |
| dgv3108n100 | CNV | gain | 25217958 |
| dgv3107n100 | CNV | gain | 25217958 |
| dgv1426n106 | CNV | duplication | 24896259 |
Residual Variation Intolerance Score:
0.651% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.68;
57.17% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NCOR1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCOR1 Gene
Disorders for NCOR1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| acute promyelocytic leukemia |
|
|
| rett syndrome |
|
|
| huntington disease |
|
|
| leukemia, acute myeloid |
|
|
Search NCOR1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NCOR1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for NCOR1 Gene
Publications for NCOR1 Gene
- Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PMID: 19183483) Haiman CA … Press MF (BMC cancer 2009) 3 22 44 58
- Novel regulatory role for human Acf1 in transcriptional repression of vitamin D3 receptor-regulated genes. (PMID: 17519354) Ewing AK … Chakravarti D (Molecular endocrinology (Baltimore, Md.) 2007) 3 4 22 58
- JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2). (PMID: 16024779) Zhang D … Wong J (Molecular and cellular biology 2005) 3 4 22 58
- DACH1 inhibits transforming growth factor-beta signaling through binding Smad4. (PMID: 14525983) Wu K … Pestell RG (The Journal of biological chemistry 2003) 3 4 22 58
- ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex. (PMID: 9724795) Wang J … Liu JM (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 58
Products for NCOR1 Gene
- R&D Systems Antibodies for NCOR1 (NCOR1)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
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- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for NCOR1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for NCOR1
- Origene Custom Protein Services for NCOR1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NCOR1
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- OriGene qPCR primer pairs for NCOR1
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- OriGene ORF clones in human for NCOR1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NCOR1
- GenScript: Next-day shipping of latest version cDNA ORF clones for NCOR1 in any vector
- XM_005256873.4
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- NM_006311.3
- XM_006721601.3
- XM_005256875.3
- XM_006721604.3
- XM_006721602.3
- XM_011524083.2
- XM_011524085.2
- XM_011524086.2
- XM_011524084.2
- XM_017025410.1
- XM_017025418.1
- XM_017025404.1
- XM_017025420.1
- XM_017025412.1
- XM_017025399.1
- NM_001190438.1
- XM_017025419.1
- XM_017025415.1
- XM_017025401.1
- XM_017025416.1
- XM_017025405.1
- XM_017025409.1
- XM_017025414.1
- XM_017025400.1
- XM_017025398.1
- XM_017025402.1
- XM_017025413.1
- XM_017025417.1
- XM_017025397.1
- NM_001190440.1
- XM_017025403.1
- XM_017025406.1
- XM_017025407.1
- XM_017025408.1
- XM_017025411.1
- GenScript Custom Purified and Recombinant Proteins Services for NCOR1
- GenScript Custom Assay Services for NCOR1
- GenScript Custom overexpressing Cell Line Services for NCOR1
- GenScript: Design CRISPR guide RNA sequences for NCOR1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for NCOR1
- Sino Biological Human cDNA Clone for NCOR1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for NCOR1
- Novus Biologicals proteins for NCOR1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for NCOR1
- Abcam proteins for NCOR1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cyagen custom Knockout/knockin (KOKI) mouse models for NCOR1
- VectorBuilder custom plasmid, inducible vectors for NCOR1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NCOR1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 103 available NCOR1 Antibodies ranked by validation data
- Compare Top NCOR1 Antibodies
- Recommended
- 37 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IF/ICC Antibody (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 11 WB Antibodies (anti-rat)
- 70 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- antibodies-online: Search results for 16 available NCOR1 Elisa Kits ranked by validation data
- Compare Top NCOR1 Elisa Kits
- antibodies-online: Search results for 2 available NCOR1 Proteins ranked by validation data
- Compare Top NCOR1 Proteins
- GeneTex NCOR1 Antibody for NCOR1
- Search GeneTex for Proteins for NCOR1
- Santa Cruz Biotechnology (SCBT) Antibodies for NCOR1
- Search Santa Cruz Biotechnology (SCBT) for NCOR1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NCOR1
- Horizon Cell Lines for NCOR1
- genomics-online: cdna clones - Search results for 102 available NCOR1 gene related products
- Overview of 102 available NCOR1 gene related products
- orf clones - Search results for 102 available NCOR1 gene related products
- Overview of 102 available NCOR1 gene related products
- genomics-online: gRNA clones - Search results for 102 available NCOR1 gene related products
- Overview of 102 available NCOR1 gene related products
- genomics-online: primer clones - Search results for 102 available NCOR1 gene related products
- Overview of 102 available NCOR1 gene related products
- genomics-online: shRNA clones - Search results for 102 available NCOR1 gene related products
- Overview of 102 available NCOR1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NCOR1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NCOR1
- GeneCopoeia miRNA 3'UTR Target clone products for NCOR1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NCOR1
Sources for NCOR1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt