NCOR1 Gene (Protein Coding)

Nuclear Receptor Corepressor 1

GC17M016029
GIFtS:
45
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located betw... See more...

Aliases for NCOR1 Gene

Aliases for NCOR1 Gene

  • Nuclear Receptor Corepressor 1 2 3 4 5
  • Thyroid Hormone- And Retinoic Acid Receptor-Associated Corepressor 1 2 3
  • Protein Phosphatase 1, Regulatory Subunit 109 2 3
  • N-CoR1 3 4
  • N-CoR 3 4
  • Nuclear Receptor Co-Repressor 1 2
  • PPP1R109 3
  • KIAA1047 4
  • HN-CoR 3
  • TRAC1 3

External Ids for NCOR1 Gene

Previous GeneCards Identifiers for NCOR1 Gene

  • GC17M016297
  • GC17M017045
  • GC17M015877
  • GC17M016135
  • GC17M015875
  • GC17M015933

Summaries for NCOR1 Gene

Entrez Gene Summary for NCOR1 Gene

  • This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]

GeneCards Summary for NCOR1 Gene

NCOR1 (Nuclear Receptor Corepressor 1) is a Protein Coding gene. Diseases associated with NCOR1 include Rett Syndrome and Endometrial Hyperplasia. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Development NOTCH1-mediated pathway for NF-KB activity modulation. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is NCOR2.

UniProtKB/Swiss-Prot Summary for NCOR1 Gene

  • Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity).

Gene Wiki entry for NCOR1 Gene

Additional gene information for NCOR1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NCOR1 Gene

Genomics for NCOR1 Gene

GeneHancer (GH) Regulatory Elements for NCOR1 Gene

Promoters and enhancers for NCOR1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NCOR1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NCOR1

Top Transcription factor binding sites by QIAGEN in the NCOR1 gene promoter:
  • AML1a
  • AP-1
  • ATF-2
  • ATF6
  • c-Jun
  • Cart-1
  • NF-kappaB
  • NF-kappaB1
  • Pax-5
  • TBP

Genomic Locations for NCOR1 Gene

Genomic Locations for NCOR1 Gene
chr17:16,029,157-16,218,185
(GRCh38/hg38)
Size:
189,029 bases
Orientation:
Minus strand
chr17:15,932,471-16,121,499
(GRCh37/hg19)
Size:
189,029 bases
Orientation:
Minus strand

Genomic View for NCOR1 Gene

Genes around NCOR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCOR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCOR1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NCOR1 Gene

Proteins for NCOR1 Gene

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  • Protein details for NCOR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75376-NCOR1_HUMAN
    Recommended name:
    Nuclear receptor corepressor 1
    Protein Accession:
    O75376
    Secondary Accessions:
    • B3DLF8
    • E9PGV6
    • Q86YY0
    • Q9UPV5
    • Q9UQ18

    Protein attributes for NCOR1 Gene

    Size:
    2440 amino acids
    Molecular mass:
    270210 Da
    Quaternary structure:
    • Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid receptor (TR) and the retinoid acid receptor (RAR) in the absence of ligand. Interacts directly with RARA; the interaction is facilitated with RARA trimethylation. Component of the N-Cor repressor complex, at least composed of CBFA2T3, HEXIM1, NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Interacts with ZBTB33; the interaction serves to recruit the N-CoR complex to promoter regions containing methylated CpG dinucleotides. Interacts with TRIM28 and KDM3A. Interacts (via the RD1 domain) with BAZ1A (via its N-terminal); the interaction corepresses a number of NCOR1-regulated genes. Interacts with BCL6, C1D, DACH1, HEXIM1, HDAC7, RORA, RORC, SAP30, SIAH2, SIN3A and SIN3B. May interact with DEAF1. Interacts with RXRA. Interacts with SETD5 (By similarity). Interacts with VDR (PubMed:28698609). Interacts with ZBTB7A (PubMed:20812024). Interacts with AR (PubMed:20812024). Interacts with HDAC3 (By similarity).
    SequenceCaution:
    • Sequence=BAA82999.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NCOR1 Gene

    Alternative splice isoforms for NCOR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCOR1 Gene

Protein Expression for NCOR1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NCOR1 Gene

  • Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation.
  • Ubiquitination at Lys294
  • Modification sites at PhosphoSitePlus

Other Protein References for NCOR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NCOR1 Gene

Domains & Families for NCOR1 Gene

Gene Families for NCOR1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for NCOR1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NCOR1 Gene

GenScript: Design optimal peptide antigens:
  • NCOR1 protein (A5PKW7_HUMAN)
  • cDNA FLJ52302, highly similar to Nuclear receptor corepressor 1 (B4DJ25_HUMAN)
  • Nuclear receptor corepressor 1 (NCOR1_HUMAN)
  • NCOR1 protein (Q05CG3_HUMAN)
  • NCOR1 protein (Q3B773_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75376

UniProtKB/Swiss-Prot:

NCOR1_HUMAN :
  • The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3).
  • Belongs to the N-CoR nuclear receptor corepressors family.
Domain:
  • The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3).
  • The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of which contains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for binding to unligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity (By similarity).
Family:
  • Belongs to the N-CoR nuclear receptor corepressors family.
genes like me logo Genes that share domains with NCOR1: view

Function for NCOR1 Gene

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  2. CRISPR
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Molecular function for NCOR1 Gene

UniProtKB/Swiss-Prot Function:
Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity).
GENATLAS Biochemistry:
nuclear receptor co-repressor 1,homolog to SMRT,recruiting the CoR/Sin3/HDAC1/HDAC2 complex,resulting in chromatin remodeling and repression of transcription,frequently deleted in malignant disorders,localized between CMT1A and SMS

Phenotypes From GWAS Catalog for NCOR1 Gene

Gene Ontology (GO) - Molecular Function for NCOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001012 RNA polymerase II regulatory region DNA binding IBA 21873635
GO:0001102 RNA polymerase II activating transcription factor binding IPI 19955185
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IBA 21873635
GO:0003714 transcription corepressor activity IMP,IDA 12628926
genes like me logo Genes that share ontologies with NCOR1: view
genes like me logo Genes that share phenotypes with NCOR1: view

Animal Models for NCOR1 Gene

MGI Knock Outs for NCOR1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCOR1 Gene

Localization for NCOR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCOR1 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCOR1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
plasma membrane 2
extracellular 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NCOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex IDA 18326024
GO:0000790 nuclear chromatin IDA 17505061
GO:0005634 nucleus IDA,IEA 10049357
GO:0005654 nucleoplasm TAS,IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with NCOR1: view

Pathways & Interactions for NCOR1 Gene

genes like me logo Genes that share pathways with NCOR1: view

Pathways by source for NCOR1 Gene

8 GeneGo (Thomson Reuters) pathways for NCOR1 Gene
  • Development Notch Signaling Pathway
  • Development NOTCH1-mediated pathway for NF-KB activity modulation
  • Immune response MIF-JAB1 signaling
  • Signal transduction Activin A signaling regulation
  • Transcription Androgen Receptor nuclear signaling
1 R&D Systems pathway for NCOR1 Gene
4 Qiagen pathways for NCOR1 Gene
  • Estrogen Pathway
  • Glucocorticoid Receptor Signaling
  • Huntington's Disease Pathway
  • Macrophage Differentiation and Growth Inhibition by METS
1 Cell Signaling Technology pathway for NCOR1 Gene

SIGNOR curated interactions for NCOR1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NCOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS --
GO:0006325 chromatin organization IEA --
GO:0006366 transcription by RNA polymerase II TAS 7566114
GO:0007623 circadian rhythm TAS --
GO:0019216 regulation of lipid metabolic process TAS --
genes like me logo Genes that share ontologies with NCOR1: view

Drugs & Compounds for NCOR1 Gene

Products:

  1. Drug

(11) Drugs for NCOR1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for NCOR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NCOR1: view

Transcripts for NCOR1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
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mRNA/cDNA for NCOR1 Gene

3 REFSEQ mRNAs :
24 NCBI additional mRNA sequence :
27 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCOR1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^
SP1: - -
SP2: -
SP3:
SP4:
SP5:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36 ^ 37a · 37b ^ 38 ^ 39a · 39b ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46
SP1: - -
SP2: - - -
SP3:
SP4: -
SP5:

Relevant External Links for NCOR1 Gene

GeneLoc Exon Structure for
NCOR1

Expression for NCOR1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NCOR1 Gene

mRNA expression in normal human tissues for NCOR1 Gene
mRNA expression by BioGPS for NCOR1 GenemRNA expression by GTEx for NCOR1 Gene

Protein differential expression in normal tissues from HIPED for NCOR1 Gene

This gene is overexpressed in Urine (23.5), Spinal cord (18.4), and Peripheral blood mononuclear cells (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NCOR1 Gene



Protein tissue co-expression partners for NCOR1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NCOR1

SOURCE GeneReport for Unigene cluster for NCOR1 Gene:

Hs.462323

Evidence on tissue expression from TISSUES for NCOR1 Gene

  • Nervous system(4.9)
  • Liver(4.6)
  • Thyroid gland(3.2)
  • Intestine(3.1)
  • Kidney(2.4)
  • Lung(2.3)
  • Muscle(2.3)
  • Blood(2.2)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with NCOR1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCOR1 Gene

Orthologs for NCOR1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NCOR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia NCOR1 31 30
  • 99.28 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia NCOR1 31 30
  • 91.7 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Ncor1 17 31 30
  • 89.11 (n)
rat
(Rattus norvegicus)
 Mammalia Ncor1 30
  • 89.02 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia NCOR1 31
  • 87 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia NCOR1 31 30
  • 85.6 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia NCOR1 31
  • 84 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves NCOR1 31 30
  • 79.18 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia NCOR1 31
  • 77 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia ncor1 30
  • 70.6 (n)
Str.16187 30
African clawed frog
(Xenopus laevis)
 Amphibia LOC398304 30
zebrafish
(Danio rerio)
 Actinopterygii ncor1 31 30
  • 62.06 (n)
 OneToOne
zgc56355 30
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes SNT1 33 31
  • 16 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 48 (a)
 OneToOne
Species where no ortholog for NCOR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCOR1 Gene

ENSEMBL:
Gene Tree for NCOR1 (if available)
TreeFam:
Gene Tree for NCOR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NCOR1: view image

Paralogs for NCOR1 Gene

Paralogs for NCOR1 Gene

(3) SIMAP similar genes for NCOR1 Gene using alignment to 20 proteins:

  • NCOR1_HUMAN
  • A5PKW7_HUMAN
  • B4DJ25_HUMAN
  • C9JAP0_HUMAN
  • E7EVK1_HUMAN
  • E7EVU5_HUMAN
  • E7EW50_HUMAN
  • H0Y459_HUMAN
  • J3KRE4_HUMAN
  • J3KS29_HUMAN
  • J3KS51_HUMAN
  • J3KT44_HUMAN
  • J3QKP0_HUMAN
  • Q05CG3_HUMAN
  • Q3B773_HUMAN
  • Q6NTH1_HUMAN
  • Q6PDT8_HUMAN
  • Q6PGR4_HUMAN
  • Q86W52_HUMAN
  • S4R380_HUMAN

Pseudogenes.org Pseudogenes for NCOR1 Gene

genes like me logo Genes that share paralogs with NCOR1: view

Variants for NCOR1 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NCOR1 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
710458 Benign: not provided 16,057,910(-) G/T SYNONYMOUS_VARIANT
710459 Benign: not provided 16,101,427(-) C/G MISSENSE_VARIANT
712852 Benign: not provided 16,058,511(-) C/T SYNONYMOUS_VARIANT
712853 Benign: not provided 16,194,474(-) G/A SYNONYMOUS_VARIANT
716462 Benign: not provided 16,080,656(-) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for NCOR1 Gene

Structural Variations from Database of Genomic Variants (DGV) for NCOR1 Gene

Variant ID Type Subtype PubMed ID
dgv1426n106 CNV duplication 24896259
dgv3107n100 CNV gain 25217958
dgv3108n100 CNV gain 25217958
esv2661970 CNV deletion 23128226
esv2715702 CNV deletion 23290073
esv3335248 CNV insertion 20981092
esv3416216 CNV insertion 20981092
esv3554199 CNV deletion 23714750
esv3554201 CNV deletion 23714750
esv3554202 CNV deletion 23714750
esv3572431 CNV gain 25503493
esv3640096 CNV loss 21293372
esv3640097 CNV loss 21293372
esv3640098 CNV loss 21293372
esv3892973 CNV gain 25118596
nsv1070814 CNV deletion 25765185
nsv112235 CNV deletion 16902084
nsv1134603 CNV deletion 24896259
nsv1138502 CNV deletion 24896259
nsv1150926 CNV duplication 26484159
nsv522169 CNV gain 19592680
nsv528263 CNV loss 19592680
nsv833377 CNV loss 17160897
nsv960422 CNV duplication 23825009
nsv960423 CNV duplication 23825009
nsv962265 CNV duplication 23825009

Variation tolerance for NCOR1 Gene

Residual Variation Intolerance Score: 0.651% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.68; 57.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NCOR1 Gene

Human Gene Mutation Database (HGMD)
NCOR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCOR1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCOR1 Gene

Disorders for NCOR1 Gene

MalaCards: The human disease database

(14) MalaCards diseases for NCOR1 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search NCOR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NCOR1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NCOR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCOR1 Gene

Publications for NCOR1 Gene

  1. Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PMID: 19183483) Haiman CA … Press MF (BMC cancer 2009) 3 23 41 54
  2. Novel regulatory role for human Acf1 in transcriptional repression of vitamin D3 receptor-regulated genes. (PMID: 17519354) Ewing AK … Chakravarti D (Molecular endocrinology (Baltimore, Md.) 2007) 3 4 23 54
  3. JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2). (PMID: 16024779) Zhang D … Wong J (Molecular and cellular biology 2005) 3 4 23 54
  4. DACH1 inhibits transforming growth factor-beta signaling through binding Smad4. (PMID: 14525983) Wu K … Pestell RG (The Journal of biological chemistry 2003) 3 4 23 54
  5. ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex. (PMID: 9724795) Wang J … Liu JM (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 54

ExternalLinks

View latest publications for NCOR1 gene in Mastermind

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