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This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located betw... See more...
Aliases for NCOR1 Gene
Aliases for NCOR1 Gene
External Ids for NCOR1 Gene
- HGNC: 7672
- NCBI Entrez Gene: 9611
- Ensembl: ENSG00000141027
- OMIM®: 600849
- UniProtKB/Swiss-Prot: O75376
Previous GeneCards Identifiers for NCOR1 Gene
- GC17M016297
- GC17M017045
- GC17M015877
- GC17M016135
- GC17M015875
- GC17M015933
Summaries for NCOR1 Gene
-
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]
GeneCards Summary for NCOR1 Gene
NCOR1 (Nuclear Receptor Corepressor 1) is a Protein Coding gene. Diseases associated with NCOR1 include Rett Syndrome and Mitochondrial Complex Iii Deficiency, Nuclear Type 2. Among its related pathways are Notch-mediated HES/HEY network and Androgen receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is NCOR2.
UniProtKB/Swiss-Prot Summary for NCOR1 Gene
-
Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity).
Additional gene information for NCOR1 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NCOR1 Gene
Genomics for NCOR1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for NCOR1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NCOR1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NCOR1
- Top Transcription factor binding sites by QIAGEN in the NCOR1 gene promoter:
-
- AML1a
- AP-1
- ATF-2
- ATF6
- c-Jun
- Cart-1
- NF-kappaB
- NF-kappaB1
- Pax-5
- TBP
Genomic Locations for NCOR1 Gene
Latest Assembly
- chr17:16,029,157-16,218,185
- (GRCh38/hg38)
- Size:
- 189,029 bases
- Orientation:
- Minus strand
Previous Assembly
- chr17:15,932,471-16,118,848
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 186,378 bases
- Orientation:
- Minus strand
Genomic View for NCOR1 Gene
Genes around NCOR1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p12-p11.2 by HGNC
- 17p12-p11.2 by Entrez Gene
- 17p11.2 by Ensembl
NCOR1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NCOR1 Gene
Proteins for NCOR1 Gene
-
Protein details for NCOR1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O75376-NCOR1_HUMAN
- Recommended name:
- Nuclear receptor corepressor 1
- Protein Accession:
- O75376
- B3DLF8
- E9PGV6
- Q86YY0
- Q9UPV5
- Q9UQ18
Protein attributes for NCOR1 Gene
- Size:
- 2440 amino acids
- Molecular mass:
- 270210 Da
- Quaternary structure:
-
- Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid receptor (TR) and the retinoid acid receptor (RAR) in the absence of ligand. Interacts directly with RARA; the interaction is facilitated with RARA trimethylation. Component of the N-Cor repressor complex, at least composed of CBFA2T3, HEXIM1, NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Interacts with ZBTB33; the interaction serves to recruit the N-CoR complex to promoter regions containing methylated CpG dinucleotides. Interacts with TRIM28 and KDM3A. Interacts (via the RD1 domain) with BAZ1A (via its N-terminal); the interaction corepresses a number of NCOR1-regulated genes. Interacts with BCL6, C1D, DACH1, HEXIM1, HDAC7, RORA, RORC, SAP30, SIAH2, SIN3A and SIN3B. May interact with DEAF1. Interacts with RXRA. Interacts with SETD5 (By similarity). Interacts with VDR (PubMed:28698609). Interacts with ZBTB7A (PubMed:20812024). Interacts with AR (PubMed:20812024). Interacts with HDAC3 (By similarity).
- SequenceCaution:
-
- Sequence=BAA82999.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for NCOR1 Gene
Protein Expression for NCOR1 Gene
Post-translational modifications for NCOR1 Gene
Other Protein References for NCOR1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_005256923.1
- XP_005256925.1
- XP_005256928.1
- XP_005256929.1
- XP_005256930.1
- XP_005256931.1
- XP_005256932.1
- XP_006721664.1
- XP_006721665.1
- XP_006721666.1
- XP_006721667.1
- XP_011522385.1
- XP_011522386.1
- XP_011522387.1
- XP_011522388.1
- XP_016880885.1
- XP_016880886.1
- XP_016880887.1
- XP_016880888.1
- XP_016880889.1
- XP_016880890.1
- XP_016880891.1
- XP_016880892.1
- XP_016880893.1
- XP_016880894.1
- XP_016880895.1
- XP_016880896.1
- XP_016880897.1
- XP_016880898.1
- XP_016880899.1
- XP_016880900.1
- XP_016880901.1
- XP_016880902.1
- XP_016880903.1
- XP_016880904.1
- XP_016880905.1
- XP_016880906.1
- XP_016880907.1
- XP_016880908.1
- XP_016880909.1
- XP_024306809.1
- XP_024306810.1
- XP_024306811.1
- NP_001177367.1
- NP_001177369.1
- NP_006302.2
Antibodies for research
- LifeSpan BioSciences N-CoR / NCOR1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for NCOR1
- Novus Biologicals Antibodies for NCOR1
-
Abcam antibodies for NCOR1
- Invitrogen Antibodies for NCOR1 (AFLGC-Ncor1)
-
Santa Cruz Biotechnology (SCBT) Antibodies for NCOR1
- Sino Biological Antibodies for NCOR1
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for NCOR1
- Origene Custom Protein Services for NCOR1
- Novus Biologicals proteins for NCOR1
-
Abcam proteins for NCOR1
Assay products for research
-
Boster Bio ELISA Kits for NCOR1
No data available for DME Specific Peptides for NCOR1 Gene
Domains & Families for NCOR1 Gene
Gene Families for NCOR1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for NCOR1 Gene
- InterPro:
Suggested Antigen Peptide Sequences for NCOR1 Gene
- GenScript: Design optimal peptide antigens:
-
- NCOR1 protein (A5PKW7_HUMAN)
- cDNA FLJ52302, highly similar to Nuclear receptor corepressor 1 (B4DJ25_HUMAN)
- Nuclear receptor corepressor 1 (NCOR1_HUMAN)
- NCOR1 protein (Q05CG3_HUMAN)
- NCOR1 protein (Q3B773_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O75376UniProtKB/Swiss-Prot:
NCOR1_HUMAN :- The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3).
- Belongs to the N-CoR nuclear receptor corepressors family.
- Domain:
-
- The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3).
- The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of which contains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for binding to unligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity (By similarity).
- Family:
-
- Belongs to the N-CoR nuclear receptor corepressors family.
Function for NCOR1 Gene
Molecular function for NCOR1 Gene
- UniProtKB/Swiss-Prot Function:
- Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity).
- GENATLAS Biochemistry:
- nuclear receptor co-repressor 1,homolog to SMRT,recruiting the CoR/Sin3/HDAC1/HDAC2 complex,resulting in chromatin remodeling and repression of transcription,frequently deleted in malignant disorders,localized between CMT1A and SMS
Phenotypes From GWAS Catalog for NCOR1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | ISS | -- |
| GO:0001102 | RNA polymerase II activating transcription factor binding | IPI | 19955185 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003714 | transcription corepressor activity | IDA,IMP | 12628926 |
| GO:0005515 | protein binding | IPI | 10049357 |
Phenotypes for NCOR1 Gene
- MGI mutant phenotypes for NCOR1:
-
inferred from 5 alleles
- nervous system phenotype
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cellular phenotype
- cardiovascular system phenotype
- behavior/neurological phenotype
- immune system phenotype
- mortality/aging
- liver/biliary system phenotype
- hematopoietic system phenotype
- endocrine/exocrine gland phenotype
- integument phenotype
- embryo phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for NCOR1:
-
- Increased vaccinia virus (VACV) infection
- Increased shRNA abundance (Z-score > 2)
- no effect
- Decreased vaccinia virus (VACV) infection
- Increased ionizing radiation sensitivity
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability (cell death)
- Decreased viability in non-small-cell lung cancer (NSCLC) lineage
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Reduced shRNA abundance in FBW7 KO line
Animal Models for NCOR1 Gene
- MGI Knock Outs for NCOR1:
-
- Ncor1 Ncor1<tm1Rsd>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for NCOR1 - Starting at $85 >
- * NCOR1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for NCOR1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NCOR1
-
Santa Cruz Biotechnology (SCBT) CRISPR for NCOR1
miRNA for NCOR1 Gene
- miRTarBase miRNAs that target NCOR1
-
- mmu-miR-7b-5p (MIRT009245)
- mmu-miR-340-5p (MIRT010466)
- mmu-miR-15a-5p (MIRT011703)
- mmu-let-7b-5p (MIRT012140)
- mmu-miR-9-5p (MIRT015328)
- hsa-miR-1301-3p (MIRT036031)
- hsa-miR-615-3p (MIRT040375)
- hsa-miR-484 (MIRT041973)
- hsa-miR-320a (MIRT044744)
- hsa-let-7b-5p (MIRT052038)
- mmu-miR-1264-3p (MIRT582247)
- mmu-miR-742-3p (MIRT582248)
- hsa-miR-34a-3p (MIRT735395)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NCOR1
- Browse OriGene Inhibitory RNA Products For NCOR1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NCOR1
Clone products for research
- Applied Biological Materials (abm): Clones for NCOR1 - Starting at $45 >
- * NCOR1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for NCOR1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NCOR1
Cell Lines for research
-
Horizon Cell Lines for NCOR1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCOR1 Gene
Localization for NCOR1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NCOR1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 4 |
| plasma membrane | 2 |
| extracellular | 2 |
| mitochondrion | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000118 | histone deacetylase complex | IBA,IDA | 18326024 |
| GO:0000785 | chromatin | IDA | 17505061 |
| GO:0005634 | nucleus | IDA | 10049357 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for NCOR1 Gene
Pathways by source for NCOR1 Gene
13 BioSystems pathways for NCOR1 Gene
37 Reactome pathways for NCOR1 Gene
3 KEGG pathways for NCOR1 Gene
8 GeneGo (Thomson Reuters) pathways for NCOR1 Gene
- Development Notch Signaling Pathway
- Development NOTCH1-mediated pathway for NF-KB activity modulation
- Immune response MIF-JAB1 signaling
- Signal transduction Activin A signaling regulation
- Transcription Androgen Receptor nuclear signaling
1 R&D Systems pathway for NCOR1 Gene
4 Qiagen pathways for NCOR1 Gene
- Estrogen Pathway
- Glucocorticoid Receptor Signaling
- Huntington's Disease Pathway
- Macrophage Differentiation and Growth Inhibition by METS
1 Cell Signaling Technology pathway for NCOR1 Gene
Interacting Proteins for NCOR1 Gene
Selected Interacting proteins:
O75376-NCOR1_HUMAN
ENSP00000268712
for NCOR1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for NCOR1
SIGNOR curated interactions for NCOR1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | TAS | -- |
| GO:0006325 | chromatin organization | IEA | -- |
| GO:0007623 | circadian rhythm | TAS | -- |
| GO:0019216 | regulation of lipid metabolic process | TAS | -- |
| GO:0045475 | locomotor rhythm | ISS | -- |
Transcripts for NCOR1 Gene
mRNA/cDNA for NCOR1 Gene
- 3 REFSEQ mRNAs :
- 24 NCBI additional mRNA sequence :
- 27 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000268712 10705 nts (view in UCSC)
- ENST00000395848 3106 nts (view in UCSC)
- ENST00000395849 3419 nts (view in UCSC)
- ENST00000395851 7950 nts (view in UCSC)
- ENST00000395857 9501 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for NCOR1 - Starting at $85 >
- * NCOR1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for NCOR1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NCOR1
-
Santa Cruz Biotechnology (SCBT) CRISPR for NCOR1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NCOR1
- Browse OriGene Inhibitory RNA Products For NCOR1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NCOR1
Clone products for research
- Applied Biological Materials (abm): Clones for NCOR1 - Starting at $45 >
- * NCOR1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for NCOR1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NCOR1
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: |
| ExUns: | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32a | · | 32b | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36 | ^ | 37a | · | 37b | ^ | 38 | ^ | 39a | · | 39b | ^ | 40 | ^ | 41 | ^ | 42 | ^ | 43 | ^ | 44 | ^ | 45 | ^ | 46 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: |
Relevant External Links for NCOR1 Gene
- GeneLoc Exon Structure for
- NCOR1
Expression for NCOR1 Gene
This gene is overexpressed in Urine (23.5), Spinal cord (18.4), and Peripheral blood mononuclear cells (10.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NCOR1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NCOR1
SOURCE GeneReport for Unigene cluster for NCOR1 Gene:
Hs.462323Evidence on tissue expression from TISSUES for NCOR1 Gene
- Nervous system(4.9)
- Liver(4.6)
- Intestine(3.5)
- Thyroid gland(3.1)
- Kidney(3)
- Lung(3)
- Muscle(3)
- Blood(2.9)
- Skin(2.8)
- Heart(2.8)
- Spleen(2.7)
- Bone marrow(2.6)
- Lymph node(2.5)
- Adrenal gland(2.4)
- Pancreas(2.3)
- Stomach(2.2)
- Eye(2.2)
Primer products for research
-
OriGene qPCR primer pairs for NCOR1
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCOR1 Gene
Orthologs for NCOR1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | NCOR1 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | NCOR1 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ncor1 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ncor1 29 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | NCOR1 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | NCOR1 29 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | NCOR1 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | NCOR1 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | NCOR1 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ncor1 29 |
|
||
| Str.16187 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398304 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ncor1 29 30 |
|
OneToOne | |
| zgc56355 29 |
|
||||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SNT1 30 32 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
OneToOne |
- Species where no ortholog for NCOR1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for NCOR1 Gene
- ENSEMBL:
- Gene Tree for NCOR1 (if available)
- TreeFam:
- Gene Tree for NCOR1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NCOR1: view image
- Alliance of Genome Resources:
- Additional Orthologs for NCOR1
Paralogs for NCOR1 Gene
(3) SIMAP similar genes for NCOR1 Gene using alignment to 20 proteins:
- NCOR1_HUMAN
- A5PKW7_HUMAN
- B4DJ25_HUMAN
- C9JAP0_HUMAN
- E7EVK1_HUMAN
- E7EVU5_HUMAN
- E7EW50_HUMAN
- H0Y459_HUMAN
- J3KRE4_HUMAN
- J3KS29_HUMAN
- J3KS51_HUMAN
- J3KT44_HUMAN
- J3QKP0_HUMAN
- Q05CG3_HUMAN
- Q3B773_HUMAN
- Q6NTH1_HUMAN
- Q6PDT8_HUMAN
- Q6PGR4_HUMAN
- Q86W52_HUMAN
- S4R380_HUMAN
Pseudogenes.org Pseudogenes for NCOR1 Gene
Variants for NCOR1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NCOR1 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 978139 | Uncertain Significance: Autistic disorder of childhood onset; Intellectual disability | 16,061,655(-) |
C/G NM_006311.4(NCOR1):c.5627G>C (p.Arg1876Thr) |
MISSENSE_VARIANT,INTRON | |
| rs111241994 | Uncertain Significance: Mitochondrial complex III deficiency, nuclear type 2 | 16,029,260(-) |
T/C NM_017775.4(TTC19):c.*1738T>C |
THREE_PRIME_UTR | |
| rs115005688 | Benign: not provided | 16,048,985(-) |
C/T NM_006311.4(NCOR1):c.6396G>A (p.Arg2132=) |
SYNONYMOUS | |
| rs115614290 | Benign: not provided | 16,057,910(-) |
G/T NM_006311.4(NCOR1):c.6165C>A (p.Ile2055=) |
SYNONYMOUS | |
| rs116977554 | Benign: not provided | 16,139,000(-) |
T/C NM_006311.4(NCOR1):c.1352+8A>G |
INTRON |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1426n106 | CNV | duplication | 24896259 |
| dgv3107n100 | CNV | gain | 25217958 |
| dgv3108n100 | CNV | gain | 25217958 |
| esv2661970 | CNV | deletion | 23128226 |
| esv2715702 | CNV | deletion | 23290073 |
| esv3335248 | CNV | insertion | 20981092 |
| esv3416216 | CNV | insertion | 20981092 |
| esv3554199 | CNV | deletion | 23714750 |
| esv3554201 | CNV | deletion | 23714750 |
| esv3554202 | CNV | deletion | 23714750 |
| esv3572431 | CNV | gain | 25503493 |
| esv3640096 | CNV | loss | 21293372 |
| esv3640097 | CNV | loss | 21293372 |
| esv3640098 | CNV | loss | 21293372 |
| esv3892973 | CNV | gain | 25118596 |
| nsv1070814 | CNV | deletion | 25765185 |
| nsv112235 | CNV | deletion | 16902084 |
| nsv1134603 | CNV | deletion | 24896259 |
| nsv1138502 | CNV | deletion | 24896259 |
| nsv1150926 | CNV | duplication | 26484159 |
| nsv522169 | CNV | gain | 19592680 |
| nsv528263 | CNV | loss | 19592680 |
| nsv833377 | CNV | loss | 17160897 |
| nsv960422 | CNV | duplication | 23825009 |
| nsv960423 | CNV | duplication | 23825009 |
| nsv962265 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
0.651% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.68;
57.17% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NCOR1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCOR1 Gene
Disorders for NCOR1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| rett syndrome |
|
|
| mitochondrial complex iii deficiency, nuclear type 2 |
|
|
| endometrial hyperplasia |
|
|
| acute promyelocytic leukemia |
|
|
| mitochondrial complex iii deficiency |
|
|
Search NCOR1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NCOR1
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for NCOR1 Gene
Publications for NCOR1 Gene
- Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PMID: 19183483) Haiman CA … Press MF (BMC cancer 2009) 3 22 40
- Novel regulatory role for human Acf1 in transcriptional repression of vitamin D3 receptor-regulated genes. (PMID: 17519354) Ewing AK … Chakravarti D (Molecular endocrinology (Baltimore, Md.) 2007) 3 4 22
- JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2). (PMID: 16024779) Zhang D … Wong J (Molecular and cellular biology 2005) 3 4 22
- DACH1 inhibits transforming growth factor-beta signaling through binding Smad4. (PMID: 14525983) Wu K … Pestell RG (The Journal of biological chemistry 2003) 3 4 22
- ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex. (PMID: 9724795) Wang J … Liu JM (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4
ExternalLinks
Products for NCOR1 Gene
- Custom Antibody ServicesOriGene Antibodies for NCOR1
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- antibodies-online: Show 29 available NCOR1 Antibodies ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for NCOR1
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Sources for NCOR1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
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