Aliases for NCOA7 Gene

Aliases for NCOA7 Gene

  • Nuclear Receptor Coactivator 7 2 3 4 5
  • ERAP140 2 3 4
  • 140 KDa Estrogen Receptor-Associated Protein 3 4
  • TBC/LysM-Associated Domain Containing 4 2 3
  • Estrogen Nuclear Receptor Coactivator 1 3 4
  • DJ187J11.3 2 3
  • ESNA1 3 4
  • TLDC4 2 3
  • Estrogen Receptor Associated Protein 140 KDa 3
  • Putative Protein Product Of Nbla00052 3
  • Putative Protein Product Of Nbla10993 3
  • Nbla00052 3
  • Nbla10993 3
  • NCOA7-AS 3
  • NCOA7 5

External Ids for NCOA7 Gene

Previous GeneCards Identifiers for NCOA7 Gene

  • GC06P126037
  • GC06P126082
  • GC06P126144
  • GC06P126102
  • GC06P123687

Summaries for NCOA7 Gene

GeneCards Summary for NCOA7 Gene

NCOA7 (Nuclear Receptor Coactivator 7) is a Protein Coding gene. Diseases associated with NCOA7 include Oral Submucous Fibrosis and Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation, And Seizures Syndrome. Among its related pathways are AHR Pathway and Aryl Hydrocarbon Receptor. Gene Ontology (GO) annotations related to this gene include nuclear receptor transcription coactivator activity and nuclear hormone receptor binding. An important paralog of this gene is OXR1.

UniProtKB/Swiss-Prot Summary for NCOA7 Gene

  • Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA.

Gene Wiki entry for NCOA7 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NCOA7 Gene

Genomics for NCOA7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NCOA7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NCOA7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NCOA7

Top Transcription factor binding sites by QIAGEN in the NCOA7 gene promoter:
  • AhR
  • AP-1
  • AP-4
  • Arnt
  • C/EBPalpha
  • Egr-2
  • FOXD1
  • FOXJ2
  • FOXJ2 (long isoform)
  • POU3F2 (N-Oct-5b)

Genomic Locations for NCOA7 Gene

Latest Assembly
chr6:125,780,943-125,932,034
(GRCh38/hg38)
Size:
151,092 bases
Orientation:
Plus strand

Previous Assembly
chr6:126,102,261-126,253,180
(GRCh37/hg19 by Entrez Gene)
Size:
150,920 bases
Orientation:
Plus strand

chr6:126,102,307-126,252,266
(GRCh37/hg19 by Ensembl)
Size:
149,960 bases
Orientation:
Plus strand

Genomic View for NCOA7 Gene

Genes around NCOA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCOA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCOA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCOA7 Gene

Proteins for NCOA7 Gene

  • Protein details for NCOA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NI08-NCOA7_HUMAN
    Recommended name:
    Nuclear receptor coactivator 7
    Protein Accession:
    Q8NI08
    Secondary Accessions:
    • B2RNS2
    • B7Z2C4
    • B9EH71
    • G8JL91
    • Q3LID6
    • Q4G0V1
    • Q5TF95
    • Q6IPQ4
    • Q6NE83
    • Q86T89
    • Q8N1W4

    Protein attributes for NCOA7 Gene

    Size:
    942 amino acids
    Molecular mass:
    106162 Da
    Quaternary structure:
    • Interacts with ESR1, ESR2A, ESR2B, THRB, PPARG and RARA in a ligand-inducible manner. Interacts with the heterodimer AHR-ARNT.
    SequenceCaution:
    • Sequence=CAD89948.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for NCOA7 Gene

neXtProt entry for NCOA7 Gene

Post-translational modifications for NCOA7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NCOA7 Gene

Domains & Families for NCOA7 Gene

Gene Families for NCOA7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NCOA7 Gene

InterPro:
Blocks:
  • GRAM domain
  • Peptidoglycan-binding LysM

Suggested Antigen Peptide Sequences for NCOA7 Gene

GenScript: Design optimal peptide antigens:
  • Nuclear receptor coactivator 7, isoform CRA_c (E1P569_HUMAN)
  • Estrogen nuclear receptor coactivator 1 (NCOA7_HUMAN)
  • Estrogen nuclear receptor coactivator 1 (Q5JVK8_HUMAN)
  • Estrogen nuclear receptor coactivator 1 (Q5JVK9_HUMAN)
  • Estrogen nuclear receptor coactivator 1 (Q5JVL0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NI08

UniProtKB/Swiss-Prot:

NCOA7_HUMAN :
  • Belongs to the OXR1 family.
Family:
  • Belongs to the OXR1 family.
genes like me logo Genes that share domains with NCOA7: view

Function for NCOA7 Gene

Molecular function for NCOA7 Gene

UniProtKB/Swiss-Prot Function:
Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA.

Phenotypes From GWAS Catalog for NCOA7 Gene

Gene Ontology (GO) - Molecular Function for NCOA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10395741
GO:0030374 nuclear receptor transcription coactivator activity IBA,IDA 11971969
GO:0035257 nuclear hormone receptor binding IDA 11971969
genes like me logo Genes that share ontologies with NCOA7: view
genes like me logo Genes that share phenotypes with NCOA7: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NCOA7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NCOA7 Gene

Localization for NCOA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCOA7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCOA7 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NCOA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with NCOA7: view

Pathways & Interactions for NCOA7 Gene

PathCards logo

SuperPathways for NCOA7 Gene

SuperPathway Contained pathways
1 AHR Pathway
-
2 Aryl Hydrocarbon Receptor
genes like me logo Genes that share pathways with NCOA7: view

Pathways by source for NCOA7 Gene

1 BioSystems pathway for NCOA7 Gene
1 Qiagen pathway for NCOA7 Gene
  • AHR Pathway

Gene Ontology (GO) - Biological Process for NCOA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0006979 response to oxidative stress IBA 21873635
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 11971969
GO:1900408 negative regulation of cellular response to oxidative stress IEA --
GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation IEA --
genes like me logo Genes that share ontologies with NCOA7: view

No data available for SIGNOR curated interactions for NCOA7 Gene

Drugs & Compounds for NCOA7 Gene

No Compound Related Data Available

Transcripts for NCOA7 Gene

mRNA/cDNA for NCOA7 Gene

6 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NCOA7

Alternative Splicing Database (ASD) splice patterns (SP) for NCOA7 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a ·
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: -
SP5: - - - - -
SP6: -
SP7: - - -
SP8: - - - -
SP9:

ExUns: 18b ^ 19 ^ 20a · 20b · 20c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for NCOA7 Gene

GeneLoc Exon Structure for
NCOA7

Expression for NCOA7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NCOA7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NCOA7 Gene

This gene is overexpressed in Brain (14.2) and Frontal cortex (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NCOA7 Gene



Protein tissue co-expression partners for NCOA7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NCOA7

SOURCE GeneReport for Unigene cluster for NCOA7 Gene:

Hs.171426

mRNA Expression by UniProt/SwissProt for NCOA7 Gene:

Q8NI08-NCOA7_HUMAN
Tissue specificity: Highly expressed in brain. Weakly expressed in mammary gland, ovary, uterus, prostate, stomach, bladder, spinal cord and pancreas. Expressed in cancer cell line.

Evidence on tissue expression from TISSUES for NCOA7 Gene

  • Nervous system(4.7)
  • Kidney(4.5)
  • Liver(4.4)
  • Lung(4.4)
  • Muscle(4.3)
  • Intestine(2)
genes like me logo Genes that share expression patterns with NCOA7: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCOA7 Gene

Orthologs for NCOA7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCOA7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NCOA7 29 30
  • 99.26 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NCOA7 29 30
  • 89.27 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NCOA7 29 30
  • 89.05 (n)
OneToMany
-- 30
  • 86 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Ncoa7 29 16 30
  • 83.78 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ncoa7 29
  • 83.12 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia NCOA7 30
  • 75 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NCOA7 30
  • 70 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NCOA7 29 30
  • 70.85 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NCOA7 30
  • 65 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100487448 29
  • 67.55 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC569262 29
  • 69.01 (n)
NCOA7 (2 of 2) 30
  • 53 (a)
OneToMany
NCOA7 (1 of 2) 30
  • 45 (a)
OneToMany
Dr.19816 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1872 29
Species where no ortholog for NCOA7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NCOA7 Gene

ENSEMBL:
Gene Tree for NCOA7 (if available)
TreeFam:
Gene Tree for NCOA7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NCOA7: view image
Alliance of Genome Resources:
Additional Orthologs for NCOA7

Paralogs for NCOA7 Gene

Paralogs for NCOA7 Gene

(6) SIMAP similar genes for NCOA7 Gene using alignment to 12 proteins:

  • NCOA7_HUMAN
  • H0UI55_HUMAN
  • H0Y5F6_HUMAN
  • H0Y620_HUMAN
  • H0Y6T0_HUMAN
  • Q5JVL1_HUMAN
  • Q5JVL2_HUMAN
  • Q5TF96_HUMAN
  • Q5TF97_HUMAN
  • Q5TF98_HUMAN
  • Q6PK00_HUMAN
  • Q8N4U9_HUMAN
genes like me logo Genes that share paralogs with NCOA7: view

Variants for NCOA7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NCOA7 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs1567 -- p.Asp942Glu
rs35223550 -- p.Gly533Arg
rs6919947 -- p.Ser399Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NCOA7 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NCOA7 Gene

Variant ID Type Subtype PubMed ID
dgv1064n67 CNV loss 20364138
dgv10925n54 CNV loss 21841781
dgv10926n54 CNV loss 21841781
dgv10927n54 CNV loss 21841781
dgv10928n54 CNV loss 21841781
dgv10929n54 CNV loss 21841781
dgv1150e199 CNV deletion 23128226
dgv3384n106 CNV deletion 24896259
dgv403e215 CNV deletion 23714750
esv23026 CNV gain+loss 19812545
esv2421628 CNV deletion 20811451
esv2425031 CNV deletion 19546169
esv2599261 CNV loss 19546169
esv2670095 CNV deletion 23128226
esv2677863 CNV deletion 23128226
esv2732680 CNV deletion 23290073
esv3610697 CNV loss 21293372
esv3610698 CNV loss 21293372
esv3610699 CNV loss 21293372
esv3610700 CNV gain 21293372
nsv1019490 CNV loss 25217958
nsv1074959 CNV deletion 25765185
nsv1161451 OTHER complex 26073780
nsv436509 CNV deletion 17901297
nsv441685 CNV loss 18776908
nsv499628 CNV loss 21111241
nsv514387 CNV loss 21397061
nsv5467 CNV deletion 18451855
nsv604607 CNV loss 21841781
nsv604616 CNV loss 21841781
nsv820882 CNV deletion 20802225
nsv830796 CNV loss 17160897
nsv950505 CNV duplication 24416366

Variation tolerance for NCOA7 Gene

Residual Variation Intolerance Score: 17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.47; 77.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NCOA7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCOA7
Leiden Open Variation Database (LOVD)
NCOA7

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCOA7 Gene

Disorders for NCOA7 Gene

MalaCards: The human disease database

(4) MalaCards diseases for NCOA7 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
oral submucous fibrosis
  • oral cavity submucous fibrosis
deafness, onychodystrophy, osteodystrophy, mental retardation, and seizures syndrome
  • doors
martsolf syndrome
  • cataract-mental retardation-hypogonadism
brugada syndrome
  • bangungut
- elite association - COSMIC cancer census association via MalaCards
Search NCOA7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NCOA7

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with NCOA7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCOA7 Gene

Publications for NCOA7 Gene

  1. No association between the Nuclear Receptor Coactivator 7 gene and schizophrenia in the Chinese Han population. (PMID: 17079118) Liu Y … He L (Schizophrenia research 2007) 3 22 40
  2. ERAP140, a conserved tissue-specific nuclear receptor coactivator. (PMID: 11971969) Shao W … Brown M (Molecular and cellular biology 2002) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. (PMID: 12880961) Ohira M … Nakagawara A (Cancer letters 2003) 3 4

Products for NCOA7 Gene

Sources for NCOA7 Gene