Aliases for NCOA5 Gene
External Ids for NCOA5 Gene
Previous GeneCards Identifiers for NCOA5 Gene
This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2017]
GeneCards Summary for NCOA5 Gene
NCOA5 (Nuclear Receptor Coactivator 5) is a Protein Coding gene. Diseases associated with NCOA5 include Palmoplantar Keratoderma, Bothnian Type. Gene Ontology (GO) annotations related to this gene include chromatin binding.
UniProtKB/Swiss-Prot Summary for NCOA5 Gene
Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).