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This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2017]
NCOA5 (Nuclear Receptor Coactivator 5) is a Protein Coding gene. Diseases associated with NCOA5 include Palmoplantar Keratoderma, Bothnian Type. Gene Ontology (GO) annotations related to this gene include chromatin binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003682 | chromatin binding | IEA | -- |
GO:0003723 | RNA binding | HDA | 22681889 |
GO:0005515 | protein binding | IPI | 11113208 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 22664934 |
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0015629 | actin cytoskeleton | IDA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0042593 | glucose homeostasis | IEA | -- |
GO:0046627 | negative regulation of insulin receptor signaling pathway | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
17alpha-Estriol | Experimental | Pharma | Target | 0 |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||
SP5: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NCOA5 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NCOA5 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NCOA5 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ncoa5 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Ncoa5 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | NCOA5 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | NCOA5 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | NCOA5 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | NCOA5 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ncoa5 30 |
|
||
MGC75993 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | ncoa5-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ncoa5 30 31 |
|
OneToOne | |
Dr.8020 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9868 30 |
|
SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
787493 | Benign: not provided | 46,063,531(-) | T/G | SYNONYMOUS_VARIANT | |
rs11549557 | - | p.Glu326Gly |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2758796 | CNV | loss | 17122850 |
nsv1063229 | CNV | gain | 25217958 |
nsv833991 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
palmoplantar keratoderma, bothnian type |
|
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