Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NCOA5 Gene

Aliases for NCOA5 Gene

  • Nuclear Receptor Coactivator 5 2 3 5
  • Coactivator Independent Of AF-2 2 3 4
  • NCoA-5 3 4
  • CIA 3 4
  • BA465L10.6 3
  • KIAA1637 4

External Ids for NCOA5 Gene

Previous GeneCards Identifiers for NCOA5 Gene

  • GC20M044418
  • GC20M045328
  • GC20M045375
  • GC20M044123
  • GC20M044690
  • GC20M041430

Summaries for NCOA5 Gene

Entrez Gene Summary for NCOA5 Gene

  • This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2017]

GeneCards Summary for NCOA5 Gene

NCOA5 (Nuclear Receptor Coactivator 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot for NCOA5 Gene

  • Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).

Gene Wiki entry for NCOA5 Gene

Additional gene information for NCOA5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCOA5 Gene

Genomics for NCOA5 Gene

GeneHancer (GH) Regulatory Elements for NCOA5 Gene

Promoters and enhancers for NCOA5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I046088 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 584.6 +0.5 529 2.7 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 NCOA5 TP53RK ZNF335 CD40 PCIF1 ZNF334 SNX21 ENSG00000271984 ZSWIM1 DNTTIP1
GH20I045967 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 159.4 +119.1 119078 5.8 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF335 NCOA5 SLC35C2 TP53RK ZNF334 PCIF1 ZNF663P CD40 ENSG00000271984 SPATA25
GH20I045334 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 126.1 +747.9 747872 14.4 CLOCK MLX ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC SSRP1 GLIS1 SDC4 NCOA5 PCIF1 ZNF335 ZSWIM1 CD40 SPATA25 ENSG00000271984 SNX21 DBNDD2
GH20I046080 Promoter 0.5 EPDnew 550.4 +9.4 9371 0.1 NCOA5 LOC105372632
GH20I045880 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 73.7 +208.7 208680 1.5 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B NEUROD1 SIN3A DMAP1 ZSWIM1 NCOA5 TP53RK PCIF1 CD40 ZNF335 WFDC3 SLC35C2 SPATA25 RPS2P7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NCOA5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NCOA5 gene promoter:

Genomic Locations for NCOA5 Gene

Genomic Locations for NCOA5 Gene
chr20:46,060,985-46,089,952
(GRCh38/hg38)
Size:
28,968 bases
Orientation:
Minus strand
chr20:44,689,624-44,718,591
(GRCh37/hg19)

Genomic View for NCOA5 Gene

Genes around NCOA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCOA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCOA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCOA5 Gene

Proteins for NCOA5 Gene

  • Protein details for NCOA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCD5-NCOA5_HUMAN
    Recommended name:
    Nuclear receptor coactivator 5
    Protein Accession:
    Q9HCD5
    Secondary Accessions:
    • B2RTV9
    • E1P5R0
    • Q6HA99
    • Q9H1F2
    • Q9H2T2
    • Q9H4Y9

    Protein attributes for NCOA5 Gene

    Size:
    579 amino acids
    Molecular mass:
    65536 Da
    Quaternary structure:
    • Binds HTATIP2/TIP30. Interacts with YLPM1. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and PPP1CA.
    SequenceCaution:
    • Sequence=AAG36793.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NCOA5 Gene

neXtProt entry for NCOA5 Gene

Post-translational modifications for NCOA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NCOA5 Gene

Domains & Families for NCOA5 Gene

Gene Families for NCOA5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NCOA5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NCOA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCD5

UniProtKB/Swiss-Prot:

NCOA5_HUMAN :
  • Contains one Leu-Xaa-Xaa-Leu-Leu (LxxLL) motif that is essential for the association with nuclear receptors.
Domain:
  • Contains one Leu-Xaa-Xaa-Leu-Leu (LxxLL) motif that is essential for the association with nuclear receptors.
genes like me logo Genes that share domains with NCOA5: view

Function for NCOA5 Gene

Molecular function for NCOA5 Gene

UniProtKB/Swiss-Prot Function:
Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).

Phenotypes From GWAS Catalog for NCOA5 Gene

Gene Ontology (GO) - Molecular Function for NCOA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0003723 RNA binding HDA,IDA 22681889
GO:0005515 protein binding IPI 11113208
genes like me logo Genes that share ontologies with NCOA5: view
genes like me logo Genes that share phenotypes with NCOA5: view

Animal Models for NCOA5 Gene

MGI Knock Outs for NCOA5:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCOA5 Gene

Localization for NCOA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCOA5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCOA5 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NCOA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA,IDA 22664934
GO:0005634 nucleus IDA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with NCOA5: view

Pathways & Interactions for NCOA5 Gene

SuperPathways for NCOA5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NCOA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0042593 glucose homeostasis IEA --
GO:0046627 negative regulation of insulin receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with NCOA5: view

No data available for Pathways by source and SIGNOR curated interactions for NCOA5 Gene

Drugs & Compounds for NCOA5 Gene

(1) Drugs for NCOA5 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(16ALPHA,17ALPHA)-ESTRA-1,3,5(10)-TRIENE-3,16,17-TRIOL Experimental Pharma Target 0
genes like me logo Genes that share compounds with NCOA5: view

Transcripts for NCOA5 Gene

Unigene Clusters for NCOA5 Gene

Nuclear receptor coactivator 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCOA5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - -
SP2: - - -
SP3: - -
SP4: - -
SP5: -

Relevant External Links for NCOA5 Gene

GeneLoc Exon Structure for
NCOA5
ECgene alternative splicing isoforms for
NCOA5

Expression for NCOA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NCOA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NCOA5 Gene

This gene is overexpressed in Testis (14.8), Peripheral blood mononuclear cells (11.1), and Brain (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NCOA5 Gene



Protein tissue co-expression partners for NCOA5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NCOA5 Gene:

NCOA5

SOURCE GeneReport for Unigene cluster for NCOA5 Gene:

Hs.654991

mRNA Expression by UniProt/SwissProt for NCOA5 Gene:

Q9HCD5-NCOA5_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for NCOA5 Gene

  • Nervous system(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with NCOA5: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCOA5 Gene

Orthologs for NCOA5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCOA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCOA5 34 33
  • 99.83 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NCOA5 34 33
  • 93.55 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NCOA5 34
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncoa5 33
  • 89.85 (n)
mouse
(Mus musculus)
Mammalia Ncoa5 33 16 34
  • 89.58 (n)
oppossum
(Monodelphis domestica)
Mammalia NCOA5 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCOA5 34
  • 23 (a)
OneToOne
chicken
(Gallus gallus)
Aves NCOA5 33 34
  • 69.51 (n)
lizard
(Anolis carolinensis)
Reptilia NCOA5 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ncoa5 33
  • 62.63 (n)
MGC75993 33
African clawed frog
(Xenopus laevis)
Amphibia ncoa5-prov 33
zebrafish
(Danio rerio)
Actinopterygii ncoa5 34 33
  • 58.33 (n)
OneToOne
Dr.8020 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9868 33
Species where no ortholog for NCOA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCOA5 Gene

ENSEMBL:
Gene Tree for NCOA5 (if available)
TreeFam:
Gene Tree for NCOA5 (if available)

Paralogs for NCOA5 Gene

No data available for Paralogs for NCOA5 Gene

Variants for NCOA5 Gene

Sequence variations from dbSNP and Humsavar for NCOA5 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000054566 -- 46,072,506(-) G/A intron_variant
rs1000101064 -- 46,074,500(-) T/G intron_variant
rs1000196533 -- 46,085,070(-) G/T intron_variant
rs1000210951 -- 46,088,111(-) C/T intron_variant
rs1000211537 -- 46,078,049(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NCOA5 Gene

Variant ID Type Subtype PubMed ID
esv2758796 CNV loss 17122850
nsv1063229 CNV gain 25217958
nsv833991 CNV loss 17160897

Variation tolerance for NCOA5 Gene

Residual Variation Intolerance Score: 7.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NCOA5 Gene

Human Gene Mutation Database (HGMD)
NCOA5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCOA5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCOA5 Gene

Disorders for NCOA5 Gene

Additional Disease Information for NCOA5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NCOA5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NCOA5 Gene

Publications for NCOA5 Gene

  1. CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant. (PMID: 11113208) Sauvé F … Giguère V (Molecular and cellular biology 2001) 2 3 4 58
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 2 3 4 58
  3. Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans. (PMID: 20650312) Lewis JP … Bowden DW (Genomics 2010) 3 44 58
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  5. TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription. (PMID: 15073177) Jiang C … Xiao H (The Journal of biological chemistry 2004) 3 4 58

Products for NCOA5 Gene

Sources for NCOA5 Gene

Content
Loading form....