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Aliases for NCOA4 Gene

Aliases for NCOA4 Gene

  • Nuclear Receptor Coactivator 4 2 3 5
  • Androgen Receptor-Associated Protein Of 70 KDa 3 4
  • 70 KDa Androgen Receptor Coactivator 3 4
  • RET-Activating Gene ELE1 2 3
  • 70 KDa AR-Activator 3 4
  • NCoA-4 3 4
  • ARA70 3 4
  • ELE1 3 4
  • RFG 3 4
  • Androgen Receptor Coactivator 70 KDa Protein 4
  • Ret-Activating Protein ELE1 4
  • Ret Fused 3
  • PTC3 3

External Ids for NCOA4 Gene

Previous GeneCards Identifiers for NCOA4 Gene

  • GC10P050408
  • GC10P051457
  • GC10P050916
  • GC10P051235
  • GC10P051565
  • GC10P045675

Summaries for NCOA4 Gene

Entrez Gene Summary for NCOA4 Gene

  • This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]

GeneCards Summary for NCOA4 Gene

NCOA4 (Nuclear Receptor Coactivator 4) is a Protein Coding gene. Diseases associated with NCOA4 include Differentiated Thyroid Carcinoma and Thyroid Cancer, Nonmedullary, 1. Among its related pathways are CCR5 Pathway in Macrophages and Coregulation of Androgen receptor activity. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and androgen receptor binding.

UniProtKB/Swiss-Prot for NCOA4 Gene

  • Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma.

Gene Wiki entry for NCOA4 Gene

Additional gene information for NCOA4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCOA4 Gene

Genomics for NCOA4 Gene

GeneHancer (GH) Regulatory Elements for NCOA4 Gene

Promoters and enhancers for NCOA4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I046017 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 578 +8.9 8878 8.4 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 NCOA4 AGAP4 AGAP7P MSMB GC10M046012 PIR52076
GH10I046028 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.3 302 4.8 CLOCK ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 PPARGC1A MEF2D SSRP1 LOC105378287 NCOA4 AGAP4 AGAP7P FAM21FP WASHC2C GC10M046012 PIR52076
GH10I046105 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 23.3 -75.8 -75787 2.2 HDGF ATF1 ARID4B SIN3A ZNF2 ZNF48 ZNF280A ZNF121 GLIS2 ARID2 PIR31308 NCOA4 WASHC2C AGAP7P MSMB PARGP1
GH10I046091 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 19 -63.9 -63903 7 ELF3 MLX ARID4B DMAP1 RAD21 RARA GLIS2 IKZF2 MIXL1 EGR2 MSMB NCOA4 AGAP7P BMS1P1 FAM35BP TIMM23 GC10M046105 PIR51454 RPL23AP61
GH10I046079 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 14.3 -49.6 -49636 2.4 SMARCE1 CEBPB CEBPG EP300 GATA3 POLR2A VEZF1 HMBOX1 PRDM10 ZBTB33 MSMB AGAP7P NCOA4 RPL23AP61 GC10M046105 PIR51454
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NCOA4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NCOA4 gene promoter:

Genomic Locations for NCOA4 Gene

Genomic Locations for NCOA4 Gene
chr10:46,005,088-46,030,714
(GRCh38/hg38)
Size:
25,627 bases
Orientation:
Minus strand
chr10:51,565,108-51,590,734
(GRCh37/hg19)

Genomic View for NCOA4 Gene

Genes around NCOA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCOA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCOA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCOA4 Gene

Proteins for NCOA4 Gene

  • Protein details for NCOA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13772-NCOA4_HUMAN
    Recommended name:
    Nuclear receptor coactivator 4
    Protein Accession:
    Q13772
    Secondary Accessions:
    • A8K8W5
    • B4E260
    • E9PAV7
    • J3KQN8
    • Q14239

    Protein attributes for NCOA4 Gene

    Size:
    614 amino acids
    Molecular mass:
    69726 Da
    Quaternary structure:
    • Interacts with the androgen receptor and the retinoid X receptor (RXR) in a ligand-dependent manner.

    Three dimensional structures from OCA and Proteopedia for NCOA4 Gene

    Alternative splice isoforms for NCOA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCOA4 Gene

Post-translational modifications for NCOA4 Gene

  • Ubiquitination at isoforms=3, 4, 2181, Lys255, isoforms=3, 4271, isoforms=3, 4343, isoforms=3, 4356, Lys367, Lys377, isoforms=3, 4424, Lys472, Lys490, isoforms=3, 4545, and Lys558

No data available for DME Specific Peptides for NCOA4 Gene

Domains & Families for NCOA4 Gene

Gene Families for NCOA4 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for NCOA4 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NCOA4: view

No data available for UniProtKB/Swiss-Prot for NCOA4 Gene

Function for NCOA4 Gene

Molecular function for NCOA4 Gene

GENATLAS Biochemistry:
nuclear receptor coactivator 4,in transcriptional activation of target genes upon specific induction by androgens,ligand dependent,70kDa,expressed in prostate cells,fused with RET in papillary thyroid carcinomas
UniProtKB/Swiss-Prot Function:
Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma.

Phenotypes From GWAS Catalog for NCOA4 Gene

Gene Ontology (GO) - Molecular Function for NCOA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity NAS 15572661
GO:0050681 androgen receptor binding NAS 15572661
genes like me logo Genes that share ontologies with NCOA4: view
genes like me logo Genes that share phenotypes with NCOA4: view

Animal Models for NCOA4 Gene

MGI Knock Outs for NCOA4:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCOA4 Gene

Localization for NCOA4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCOA4 gene
Compartment Confidence
nucleus 5
lysosome 5
mitochondrion 3
extracellular 2
cytosol 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NCOA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8643607
GO:0005739 mitochondrion IEA --
GO:0044754 autolysosome IDA 25327288
genes like me logo Genes that share ontologies with NCOA4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NCOA4 Gene

Pathways & Interactions for NCOA4 Gene

genes like me logo Genes that share pathways with NCOA4: view

Pathways by source for NCOA4 Gene

Interacting Proteins for NCOA4 Gene

SIGNOR curated interactions for NCOA4 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for NCOA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006622 protein targeting to lysosome IDA 25327288
GO:0006879 cellular iron ion homeostasis IEA --
GO:0008584 male gonad development TAS 8643607
genes like me logo Genes that share ontologies with NCOA4: view

Drugs & Compounds for NCOA4 Gene

(9) Drugs for NCOA4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for NCOA4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NCOA4: view

Transcripts for NCOA4 Gene

Unigene Clusters for NCOA4 Gene

Nuclear receptor coactivator 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCOA4 Gene

No ASD Table

Relevant External Links for NCOA4 Gene

GeneLoc Exon Structure for
NCOA4
ECgene alternative splicing isoforms for
NCOA4

Expression for NCOA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NCOA4 Gene

mRNA differential expression in normal tissues according to GTEx for NCOA4 Gene

This gene is overexpressed in Whole Blood (x4.0).

Protein differential expression in normal tissues from HIPED for NCOA4 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (55.6) and Islet of Langerhans (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NCOA4 Gene



Protein tissue co-expression partners for NCOA4 Gene

NURSA nuclear receptor signaling pathways regulating expression of NCOA4 Gene:

NCOA4

SOURCE GeneReport for Unigene cluster for NCOA4 Gene:

Hs.643658

mRNA Expression by UniProt/SwissProt for NCOA4 Gene:

Q13772-NCOA4_HUMAN
Tissue specificity: Widely expressed. Also detected in adipose tissues and in different cell lines. Isoform Beta is only expressed in testis.

Evidence on tissue expression from TISSUES for NCOA4 Gene

  • Nervous system(4.9)
  • Thyroid gland(4.7)
  • Blood(3.9)
  • Liver(3.7)
  • Kidney(3.5)
  • Lung(3.4)
  • Skin(2.9)
  • Lymph node(2.3)
  • Pancreas(2.2)
  • Spleen(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for NCOA4 Gene

Germ Layers:
  • endoderm
Systems:
  • endocrine
Regions:
Head and neck:
  • neck
  • thyroid
genes like me logo Genes that share expression patterns with NCOA4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NCOA4 Gene

Orthologs for NCOA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCOA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCOA4 33
  • 99.38 (n)
dog
(Canis familiaris)
Mammalia NCOA4 33
  • 87.55 (n)
cow
(Bos Taurus)
Mammalia NCOA4 33
  • 87.15 (n)
mouse
(Mus musculus)
Mammalia Ncoa4 33 16
  • 83.71 (n)
rat
(Rattus norvegicus)
Mammalia Ncoa4 33
  • 82.79 (n)
chicken
(Gallus gallus)
Aves NCOA4 33
  • 62.39 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ncoa4 33
  • 57.26 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8113 33
zebrafish
(Danio rerio)
Actinopterygii ncoa4 33
  • 53.96 (n)
-- 33
Species where no ortholog for NCOA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCOA4 Gene

ENSEMBL:
Gene Tree for NCOA4 (if available)
TreeFam:
Gene Tree for NCOA4 (if available)

Paralogs for NCOA4 Gene

Pseudogenes.org Pseudogenes for NCOA4 Gene

genes like me logo Genes that share paralogs with NCOA4: view

No data available for Paralogs for NCOA4 Gene

Variants for NCOA4 Gene

Sequence variations from dbSNP and Humsavar for NCOA4 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000106704 -- 46,020,806(-) A/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000138055 -- 46,021,123(-) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000340146 -- 46,027,162(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000621032 -- 46,032,673(-) C/T upstream_transcript_variant
rs1000920605 -- 46,013,158(-) C/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NCOA4 Gene

Variant ID Type Subtype PubMed ID
nsv550853 CNV gain 21841781
nsv521269 CNV gain 19592680
nsv510992 OTHER complex 20534489
nsv508583 CNV deletion 20534489
nsv470936 CNV gain 18288195
nsv467192 CNV gain 19166990
nsv1042912 CNV loss 25217958
nsv1041519 CNV gain 25217958
esv3623188 CNV gain 21293372
esv3623185 CNV gain 21293372
esv3577172 CNV gain 25503493

Variation tolerance for NCOA4 Gene

Residual Variation Intolerance Score: 36.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.82; 58.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NCOA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCOA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCOA4 Gene

Disorders for NCOA4 Gene

MalaCards: The human disease database

(10) MalaCards diseases for NCOA4 Gene - From: GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
differentiated thyroid carcinoma
  • papillary or follicular thyroid carcinoma
thyroid cancer, nonmedullary, 1
  • nmtc1
thyroid cancer
  • malignant neoplasm of thyroid gland
papillary carcinoma
  • papillary carcinoma nos
prostate cancer
  • prostate cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search NCOA4 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

NCOA4_HUMAN
  • Note=A chromosomal aberration involving NCOA4 is found in papillary thyroid carcinomas (PTCs). Inversion inv(10)(q11.2;q11.2) generates the RET/NCOA4 (PTC3) oncogene. {ECO:0000269 PubMed:8187085, ECO:0000269 PubMed:8290261}.

Additional Disease Information for NCOA4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NCOA4: view

No data available for Genatlas for NCOA4 Gene

Publications for NCOA4 Gene

  1. Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells. (PMID: 8643607) Yeh S … Chang C (Proceedings of the National Academy of Sciences of the United States of America 1996) 2 3 4 22 58
  2. Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma. (PMID: 8290261) Santoro M … Fusco A (Oncogene 1994) 2 3 4 22 58
  3. Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma. (PMID: 10347167) Heinlein CA … Chang C (The Journal of biological chemistry 1999) 3 4 22 58
  4. Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform. (PMID: 9892017) Alen P … Peeters B (Molecular endocrinology (Baltimore, Md.) 1999) 3 4 22 58
  5. Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas. (PMID: 8187085) Bongarzone I … Pierotti MA (Cancer research 1994) 3 4 22 58

Products for NCOA4 Gene

Sources for NCOA4 Gene

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