Aliases for NCOA4 Gene
External Ids for NCOA4 Gene
Previous GeneCards Identifiers for NCOA4 Gene
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]
GeneCards Summary for NCOA4 Gene
NCOA4 (Nuclear Receptor Coactivator 4) is a Protein Coding gene. Diseases associated with NCOA4 include Differentiated Thyroid Carcinoma and Thyroid Cancer, Nonmedullary, 1. Among its related pathways are CCR5 Pathway in Macrophages and Coregulation of Androgen receptor activity. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and androgen receptor binding.
UniProtKB/Swiss-Prot for NCOA4 Gene
Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma.