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The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cy... See more...
Aliases for NCOA3 Gene
Aliases for NCOA3 Gene
- Nuclear Receptor Coactivator 3 2 3 4 5
- Thyroid Hormone Receptor Activator Molecule 1 2 3 4
- Receptor-Associated Coactivator 3 2 3 4
- BHLHe42 2 3 4
- TRAM-1 2 3 4
- SRC-3 2 3 4
- ACTR 2 3 4
- AIB1 2 3 4
- RAC3 2 3 4
- Class E Basic Helix-Loop-Helix Protein 42 3 4
- Steroid Receptor Coactivator Protein 3 3 4
- Amplified In Breast Cancer 1 Protein 3 4
- CBP-Interacting Protein 3 4
- EC 2.3.1.48 4 51
External Ids for NCOA3 Gene
- HGNC: 7670
- Entrez Gene: 8202
- Ensembl: ENSG00000124151
- OMIM: 601937
- UniProtKB: Q9Y6Q9
Previous GeneCards Identifiers for NCOA3 Gene
- GC20P045859
- GC20P046769
- GC20P046816
- GC20P045564
- GC20P046130
- GC20P042872
Summaries for NCOA3 Gene
-
The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]
GeneCards Summary for NCOA3 Gene
NCOA3 (Nuclear Receptor Coactivator 3) is a Protein Coding gene. Diseases associated with NCOA3 include Breast Cancer and Endometrial Hyperplasia. Among its related pathways are Signaling by GPCR and Androgen receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include chromatin binding and transcription coactivator activity. An important paralog of this gene is NCOA2.
UniProtKB/Swiss-Prot Summary for NCOA3 Gene
-
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.
Additional gene information for NCOA3 Gene
- HGNC(7670)
- Entrez Gene(8202)
- Ensembl(ENSG00000124151)
- OMIM(601937)
- UniProtKB(Q9Y6Q9)
- Open Targets Platform(ENSG00000124151)
- Monarch Initiative
- Search for NCOA3 at DataMed
- Search for NCOA3 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NCOA3 Gene
Genomics for NCOA3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for NCOA3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NCOA3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NCOA3
- Top Transcription factor binding sites by QIAGEN in the NCOA3 gene promoter:
-
- AP-1
- GATA-1
- MyoD
Genomic Locations for NCOA3 Gene
Genomic Locations for NCOA3 Gene
- chr20:47,501,887-47,656,877
- (GRCh38/hg38)
- Size:
- 154,991 bases
- Orientation:
- Plus strand
- chr20:46,130,601-46,285,621
- (GRCh37/hg19)
- Size:
- 155,021 bases
- Orientation:
- Plus strand
Genomic View for NCOA3 Gene
Genes around NCOA3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.12 by HGNC
- 20q13.12 by Entrez Gene
- 20q13.12 by Ensembl
NCOA3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NCOA3 Gene
Proteins for NCOA3 Gene
-
Protein details for NCOA3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y6Q9-NCOA3_HUMAN
- Recommended name:
- Nuclear receptor coactivator 3
- Protein Accession:
- Q9Y6Q9
- A4LAZ5
- Q0VF45
- Q5JYD9
- Q5JYE0
- Q9BR49
- Q9UPC9
- Q9UPG4
- Q9UPG7
Protein attributes for NCOA3 Gene
- Size:
- 1424 amino acids
- Molecular mass:
- 155293 Da
- Quaternary structure:
-
- Interacts with CARM1 (By similarity). Present in a complex containing NCOA2, IKKA, IKKB, IKBKG and the histone acetyltransferase protein CREBBP. Interacts with CASP8AP2, NR3C1 and PCAF. Interacts with ATAD2 and this interaction is enhanced by estradiol. Found in a complex containing NCOA3, AR and MAK. Interacts with DDX5. Interacts with PSMB9. Interacts with NPAS2. Interacts with NR4A3 (By similarity). Interacts with ESRRB; mediates the interaction between ESRRB and RNA polymerase II complexes and allows NCOA3 corecruitment to ESRRB, KLF4, NANOG, and SOX2 enhancer regions to trigger ESRRB-dependent gene activation involved in self-renewal and pluripotency (By similarity).
- Miscellaneous:
-
- NCOA3 is frequently amplified or overexpressed in breast and ovarian cancers.
Three dimensional structures from OCA and Proteopedia for NCOA3 Gene
Protein Expression for NCOA3 Gene
Selected DME Specific Peptides for NCOA3 Gene
- Q9Y6Q9:
-
- VTSPSGVSSSTS
- QLQQRLQGQQ
- LQEKHRILHKLLQNGNSPAEVAKITAEATGKD
- SHTFNCRML
- EKRRREQE
- ESKGHKKLLQLLTC
- MPQAPPQQF
- GDLDNLDAILGDL
- IRRCIQRF
Post-translational modifications for NCOA3 Gene
- Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors and regulates its function.
- Methylated by CARM1.
- Phosphorylated by IKK complex. Regulated its function. Phosphorylation at Ser-601 by CK1 promotes coactivator function.
-
Ubiquitination at Lys316
- NX_Q9Y6Q9 (NX_Q9Y6Q9-1)
- Modification sites at PhosphoSitePlus
Other Protein References for NCOA3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences NCOA3 / SRC-3 / AIB1 Antibody
-
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-
Boster Bio Antibodies for NCOA3
-
Santa Cruz Biotechnology (SCBT) Antibodies for NCOA3
- Sino Biological Antibodies for NCOA3
Protein Products
-
OriGene Purified Proteins for NCOA3
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-
Abcam proteins for NCOA3
Assay Products
-
Signalway ELISA kits for NCOA3
Domains & Families for NCOA3 Gene
Gene Families for NCOA3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for NCOA3 Gene
- InterPro:
- Blocks:
-
- PAS domain
- Basic helix-loop-helix dimerization domain bHLH
- PAS fold
- Protein of unknown function DUF1518
- ProtoNet:
Suggested Antigen Peptide Sequences for NCOA3 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ52175, highly similar to Nuclear receptor coactivator 3 (EC 2.3.1.48) (B4DYS9_HUMAN)
- Thyroid hormone receptor activator molecule 1 (NCOA3_HUMAN)
- Nuclear receptor coactivator 3 (Q0IIN7_HUMAN)
- Nuclear receptor coactivator 3 (Q569F6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9Y6Q9UniProtKB/Swiss-Prot:
NCOA3_HUMAN :- Contains three Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Motifs 1 and 2 are essential for the association with nuclear receptors, and constitute the RID domain (Receptor-interacting domain).
- Belongs to the SRC/p160 nuclear receptor coactivator family.
- Domain:
-
- Contains three Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Motifs 1 and 2 are essential for the association with nuclear receptors, and constitute the RID domain (Receptor-interacting domain).
- Family:
-
- Belongs to the SRC/p160 nuclear receptor coactivator family.
Function for NCOA3 Gene
Molecular function for NCOA3 Gene
- UniProtKB/Swiss-Prot Function:
- Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence={ECO:0000269|PubMed:9267036};.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Coactivator activity on nuclear receptors and NF-kappa-B pathways is enhanced by various hormones, and the TNF cytokine, respectively. TNF stimulation probably enhances phosphorylation, which in turn activates coactivator function. In contrast, acetylation by CREBBP apparently suppresses coactivation of target genes by disrupting its association with nuclear receptors. Binds to CSNK1D.
- GENATLAS Biochemistry:
- nuclear receptor coactivator 3,amplified gene in breast cancer and pancreatic cell lines,1,possessing an intrinsic histone acetyltransferase activity,interacting with CREBBP and PCAF,stimulating gene expression in a hormone dependent fashion,by facilitating the assembly of basal transcription factors into a stable preinitiation complex
Enzyme Numbers (IUBMB) for NCOA3 Gene
Phenotypes From GWAS Catalog for NCOA3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0000993 | RNA polymerase II complex binding | ISS | -- |
| GO:0003713 | transcription coactivator activity | NAS | 15572661 |
| GO:0004402 | histone acetyltransferase activity | IEA,IDA | 9267036 |
| GO:0005515 | protein binding | IPI | 10866661 |
Phenotypes for NCOA3 Gene
- MGI mutant phenotypes for NCOA3:
-
inferred from 6 alleles
- immune system phenotype
- normal phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- renal/urinary system phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- embryo phenotype
- craniofacial phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for NCOA3:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased shRNA abundance
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Increased viability
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased homologous recombination repair frequency
- Synthetic lethal with imatinib mesylate
- Increased cell number in G1, small nuclei in G1
- Increased TP53 mRNA expression
Animal Models for NCOA3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
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-
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miRNA for NCOA3 Gene
- miRTarBase miRNAs that target NCOA3
-
- hsa-miR-98-5p (MIRT004305)
- hsa-miR-21-5p (MIRT004306)
- hsa-miR-19b-3p (MIRT004310)
- hsa-miR-18a-5p (MIRT004311)
- hsa-miR-29b-3p (MIRT004312)
- hsa-miR-17-5p (MIRT005408)
- hsa-miR-33a-5p (MIRT007358)
- hsa-miR-590-3p (MIRT016187)
- hsa-miR-335-5p (MIRT018366)
- hsa-miR-215-5p (MIRT024566)
- hsa-miR-192-5p (MIRT026651)
- hsa-miR-744-5p (MIRT037458)
- hsa-miR-20a-5p (MIRT050588)
- hsa-miR-548c-3p (MIRT083622)
- hsa-miR-219a-1-3p (MIRT118606)
- hsa-miR-571 (MIRT118608)
- hsa-miR-758-3p (MIRT118609)
- hsa-miR-1252-3p (MIRT118612)
- hsa-miR-6808-3p (MIRT118617)
- hsa-miR-7973 (MIRT118619)
- hsa-miR-93-5p (MIRT153614)
- hsa-miR-106b-5p (MIRT153621)
- hsa-miR-20b-5p (MIRT153625)
- hsa-miR-519d-3p (MIRT153632)
- hsa-miR-548t-5p (MIRT153644)
- hsa-miR-548az-5p (MIRT153665)
- hsa-miR-137 (MIRT153687)
- hsa-miR-126-5p (MIRT153689)
- hsa-miR-378a-5p (MIRT153703)
- hsa-miR-608 (MIRT153722)
- hsa-miR-1200 (MIRT153737)
- hsa-miR-302f (MIRT153741)
- hsa-miR-3664-5p (MIRT153759)
- hsa-miR-3941 (MIRT153768)
- hsa-miR-4641 (MIRT153778)
- hsa-miR-4651 (MIRT153779)
- hsa-miR-219b-3p (MIRT153783)
- hsa-miR-4690-3p (MIRT153785)
- hsa-miR-4731-5p (MIRT153789)
- hsa-miR-4789-3p (MIRT153797)
- hsa-miR-4795-3p (MIRT153798)
- hsa-miR-5685 (MIRT153805)
- hsa-miR-6856-3p (MIRT153829)
- hsa-miR-8485 (MIRT153842)
- hsa-let-7a-5p (MIRT153843)
- hsa-let-7b-5p (MIRT153844)
- hsa-let-7c-5p (MIRT153845)
- hsa-let-7d-5p (MIRT153846)
- hsa-let-7e-5p (MIRT153847)
- hsa-let-7f-5p (MIRT153848)
- hsa-miR-181a-5p (MIRT153852)
- hsa-miR-181b-5p (MIRT153853)
- hsa-miR-181c-5p (MIRT153854)
- hsa-miR-214-3p (MIRT153855)
- hsa-let-7g-5p (MIRT153856)
- hsa-let-7i-5p (MIRT153857)
- hsa-miR-342-5p (MIRT153866)
- hsa-miR-181d-5p (MIRT153867)
- hsa-miR-524-5p (MIRT153869)
- hsa-miR-520d-5p (MIRT153870)
- hsa-miR-761 (MIRT153882)
- hsa-miR-3619-5p (MIRT153907)
- hsa-miR-3150b-3p (MIRT153910)
- hsa-miR-3927-3p (MIRT153911)
- hsa-miR-4433a-3p (MIRT153912)
- hsa-miR-4455 (MIRT153915)
- hsa-miR-4458 (MIRT153916)
- hsa-miR-4500 (MIRT153921)
- hsa-miR-4664-5p (MIRT153923)
- hsa-miR-4689 (MIRT153925)
- hsa-miR-4722-5p (MIRT153929)
- hsa-miR-4784 (MIRT153937)
- hsa-miR-6165 (MIRT153949)
- hsa-miR-6737-5p (MIRT153951)
- hsa-miR-6747-5p (MIRT153952)
- hsa-miR-6812-5p (MIRT153955)
- hsa-miR-6819-5p (MIRT153956)
- hsa-miR-6831-5p (MIRT153957)
- hsa-miR-6858-5p (MIRT153958)
- hsa-miR-7155-5p (MIRT153961)
- hsa-miR-580-3p (MIRT296165)
- hsa-miR-4324 (MIRT296166)
- hsa-miR-4251 (MIRT296167)
- hsa-miR-382-3p (MIRT440132)
- hsa-miR-4495 (MIRT448649)
- hsa-miR-4803 (MIRT448650)
- hsa-miR-30e-5p (MIRT448651)
- hsa-miR-30c-5p (MIRT448652)
- hsa-miR-30b-5p (MIRT448653)
- hsa-miR-30a-5p (MIRT448654)
- hsa-miR-30d-5p (MIRT448655)
- hsa-miR-4642 (MIRT457585)
- hsa-miR-488-5p (MIRT457586)
- hsa-miR-5692c (MIRT457587)
- hsa-miR-5692b (MIRT457588)
- hsa-miR-5583-3p (MIRT457589)
- hsa-miR-4517 (MIRT457590)
- hsa-miR-4796-3p (MIRT457591)
- hsa-miR-6805-3p (MIRT501824)
- hsa-miR-5691 (MIRT501825)
- hsa-miR-544b (MIRT501826)
- hsa-miR-224-5p (MIRT501827)
- hsa-miR-1294 (MIRT501828)
- hsa-miR-4316 (MIRT501829)
- hsa-miR-5589-5p (MIRT501830)
- hsa-miR-4524b-3p (MIRT501831)
- hsa-miR-603 (MIRT612734)
- hsa-miR-362-3p (MIRT612735)
- hsa-miR-329-3p (MIRT612736)
- hsa-miR-219a-2-3p (MIRT614916)
- hsa-miR-17-3p (MIRT733622)
- hsa-miR-20b-3p (MIRT733623)
- hsa-miR-3529-5p (MIRT741499)
- hsa-miR-379-5p (MIRT742781)
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- RC218992
- RC218992L1
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- RC218992L3
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- RC230715L3
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- RC218992L1V
- RC218992L2V
- RC218992L3V
- RC218992L4V
- RC230714L3V
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- RC230715L4V
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No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCOA3 Gene
Localization for NCOA3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NCOA3 Gene
- Cytoplasm. Nucleus. Note=Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 4 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | IDA,ISA | -- |
| GO:0005634 | nucleus | IBA,IDA | 17223341 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 17223341 |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for NCOA3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
| 2 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
Protein Acetylation and Deacetylation
.51
Crosstalk Between CARM1 and ESRs
.39
|
Transcription Ligand-Dependent Transcription of Retinoid-Target genes
.33
|
| 3 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
| 4 | Metabolism |
.40
|
|
| 5 | Chromatin Regulation / Acetylation | ||
Pathways by source for NCOA3 Gene
5 BioSystems pathways for NCOA3 Gene
12 Reactome pathways for NCOA3 Gene
1 PharmGKB pathway for NCOA3 Gene
5 KEGG pathways for NCOA3 Gene
4 GeneGo (Thomson Reuters) pathways for NCOA3 Gene
- Cell cycle ESR1 regulation of G1/S transition
- Development Ligand-independent activation of ESR1 and ESR2
- Transcription Ligand-dependent activation of the ESR1/SP pathway
- Transcription Ligand-Dependent Transcription of Retinoid-Target genes
6 Qiagen pathways for NCOA3 Gene
- AHR Pathway
- Crosstalk Between CARM1 and ESRs
- Estrogen Pathway
- Glucocorticoid Receptor Signaling
- Nuclear Receptor Activation by Vitamin-A
1 Cell Signaling Technology pathway for NCOA3 Gene
Interacting Proteins for NCOA3 Gene
Selected Interacting proteins:
Q9Y6Q9-NCOA3_HUMAN
ENSP00000361066
for NCOA3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for NCOA3
SIGNOR curated interactions for NCOA3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0010628 | positive regulation of gene expression | IMP | 17223341 |
| GO:0016573 | histone acetylation | IEA | -- |
| GO:0030521 | androgen receptor signaling pathway | NAS | 15572661 |
| GO:0032870 | cellular response to hormone stimulus | IBA | 21873635 |
Drugs & Compounds for NCOA3 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| acetyl-coa |
|
72-89-9 |
|
Transcripts for NCOA3 Gene
mRNA/cDNA for NCOA3 Gene
- 4 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000371997 6750 nts (view in UCSC)
- ENST00000371998 7961 nts (view in UCSC)
- ENST00000372004 7939 nts (view in UCSC)
- ENST00000490248 226 nts (view in UCSC)
- ENST00000497292 824 nts (view in UCSC)
CRISPR Products
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- MG211965
- MR211965
- MR211965L3
- MR211965L4
- RC212580
- RC212580L1
- RC212580L2
- RC212580L3
- RC212580L4
- RC218992
- RC218992L1
- RC218992L2
- RC218992L3
- RC218992L4
- RC230714
- RC230714L3
- RC230714L4
- RC230715
- RC230715L3
- RC230715L4
- RG212580
- RG218992
- RG230714
- RG230715
- MR211965L3V
- MR211965L4V
- RC212580L1V
- RC212580L2V
- RC212580L3V
- RC212580L4V
- RC218992L1V
- RC218992L2V
- RC218992L3V
- RC218992L4V
- RC230714L3V
- RC230714L4V
- RC230715L3V
- RC230715L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NCOA3
- Addgene plasmids for NCOA3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NCOA3
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18a | · | 18b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: |
| ExUns: | 18c | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | ^ | 26 | ^ | 27a | · | 27b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||
| SP10: | - | ||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||
| SP14: | - | ||||||||||||||||||||||||||
| SP15: |
Relevant External Links for NCOA3 Gene
- GeneLoc Exon Structure for
- NCOA3
Expression for NCOA3 Gene
This gene is overexpressed in Heart (33.1), Blymphocyte (10.5), Peripheral blood mononuclear cells (7.3), and Adipocyte (6.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NCOA3 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NCOA3
SOURCE GeneReport for Unigene cluster for NCOA3 Gene:
Hs.592142mRNA Expression by UniProt/SwissProt for NCOA3 Gene:
Q9Y6Q9-NCOA3_HUMAN
Tissue specificity:
Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney.
Evidence on tissue expression from TISSUES for NCOA3 Gene
- Nervous system(4.6)
- Liver(4.6)
- Lung(4.5)
- Intestine(3.1)
- Kidney(2.9)
- Muscle(2.8)
- Thyroid gland(2.8)
- Lymph node(2.7)
- Heart(2.7)
- Skin(2.7)
- Spleen(2.7)
- Blood(2.6)
- Adrenal gland(2.1)
Primer Products
-
OriGene qPCR primer pairs for NCOA3
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCOA3 Gene
Orthologs for NCOA3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | NCOA3 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | NCOA3 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | NCOA3 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ncoa3 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ncoa3 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | NCOA3 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | NCOA3 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | NCOA3 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | NCOA3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ncoa3 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398021 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ncoa3 30 31 |
|
OneToOne |
- Species where no ortholog for NCOA3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for NCOA3 Gene
- ENSEMBL:
- Gene Tree for NCOA3 (if available)
- TreeFam:
- Gene Tree for NCOA3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NCOA3: view image
Paralogs for NCOA3 Gene
Variants for NCOA3 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for NCOA3 Gene
- NCOA3_HUMAN-Q9Y6Q9
- The length of the poly-Gln region is polymorphic in the normal population.
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NCOA3 Gene
| SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 739965 | Likely Benign: not provided | 47,642,264(+) | G/A | SYNONYMOUS_VARIANT | |
| 770669 | Likely Benign: not provided | 47,651,122(+) | A/G | SYNONYMOUS_VARIANT | |
| 775436 | Benign: not provided | 47,636,061(+) | C/T | MISSENSE_VARIANT | |
| rs1052765 | - | p.Gly460Arg | |||
| rs2230781 | - | p.Pro559Ser |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv100n6 | CNV | deletion | 16902084 |
| esv2758799 | CNV | gain | 17122850 |
| esv33497 | CNV | loss | 17666407 |
| esv3428109 | CNV | insertion | 20981092 |
| esv3568000 | CNV | loss | 25503493 |
| nsv1066814 | CNV | gain | 25217958 |
| nsv1066907 | CNV | gain | 25217958 |
| nsv1116870 | CNV | deletion | 24896259 |
| nsv509772 | CNV | insertion | 20534489 |
| nsv527945 | CNV | loss | 19592680 |
| nsv833995 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.66;
89.19% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NCOA3 Gene
SNP Genotyping and Copy Number Assay Products
Disorders for NCOA3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| breast cancer |
|
|
| endometrial hyperplasia |
|
|
| estrogen-receptor positive breast cancer |
|
|
| endometrial cancer |
|
|
| metabolic myopathy |
|
|
Search NCOA3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NCOA3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for NCOA3 Gene
Publications for NCOA3 Gene
- AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. (PMID: 9252329) Anzick SL … Meltzer PS (Science (New York, N.Y.) 1997) 2 3 4 23
- Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PMID: 19183483) Haiman CA … Press MF (BMC cancer 2009) 3 23 41
- Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk. (PMID: 19255064) Ahn J … Prostate, Lung, Colorectal and Ovarian Trial Project Team (Carcinogenesis 2009) 3 23 41
- The AIB1 polyglutamine repeat does not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers. (PMID: 16434590) Spurdle AB … Epidemiological Study of Familial Breast Cancer Study Collaborators (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006) 3 23 41
- Nuclear receptor coactivator-3 alleles are associated with serum bioavailable testosterone, insulin-like growth factor-1, and vertebral bone mass in men. (PMID: 16263829) Sheu YT … Ferrell RE (The Journal of clinical endocrinology and metabolism 2006) 3 23 41
ExternalLinks
Products for NCOA3 Gene
- Custom Antibody ServicesOriGene Antibodies for NCOA3
- Browse OriGene ELISA Kits
- Custom Assay Services
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- Browse OriGene Inhibitory RNA Products For NCOA3
- OriGene qPCR primer pairs for NCOA3
- OriGene CRISPR knockouts for NCOA3
- MG211965
- MR211965
- MR211965L3
- MR211965L4
- RC212580
- RC212580L1
- RC212580L2
- RC212580L3
- RC212580L4
- RC218992
- RC218992L1
- RC218992L2
- RC218992L3
- RC218992L4
- RC230714
- RC230714L3
- RC230714L4
- RC230715
- RC230715L3
- RC230715L4
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- RG218992
- RG230714
- RG230715
- MR211965L3V
- MR211965L4V
- RC212580L1V
- RC212580L2V
- RC212580L3V
- RC212580L4V
- RC218992L1V
- RC218992L2V
- RC218992L3V
- RC218992L4V
- RC230714L3V
- RC230714L4V
- RC230715L3V
- RC230715L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NCOA3
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