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The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
NCOA2 (Nuclear Receptor Coactivator 2) is a Protein Coding gene. Diseases associated with NCOA2 include Mesenchymal Chondrosarcoma and Spindle Cell Rhabdomyosarcoma. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include chromatin binding and transcription factor binding. An important paralog of this gene is NCOA3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISA | -- |
GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding | IEA | -- |
GO:0003682 | chromatin binding | IEA | -- |
GO:0003713 | transcription coactivator activity | IEA,NAS | 9430642 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | IEA,IBA | 21873635 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0016604 | nuclear body | IDA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA,NAS | 8670870 |
GO:0007623 | circadian rhythm | IEA | -- |
GO:0010468 | regulation of gene expression | IEA | -- |
GO:0010906 | regulation of glucose metabolic process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Diethylstilbestrol | Approved, Investigational | Pharma | Agonist, Antagonist, Target | 7 | ||
Estradiol acetate | Approved, Investigational, Vet_approved | Pharma | Target | 0 | ||
estradiol benzoate | Approved, Investigational, Vet_approved | Pharma | Target | 0 | ||
Estradiol cypionate | Approved, Investigational, Vet_approved | Pharma | Target | 0 | ||
Estradiol dienanthate | Approved, Investigational, Vet_approved | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: |
ExUns: | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||
SP2: | |||||||||||||
SP3: | |||||||||||||
SP4: | |||||||||||||
SP5: | |||||||||||||
SP6: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NCOA2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NCOA2 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | NCOA2 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ncoa2 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NCOA2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ncoa2 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | NCOA2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | NCOA2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ncoa2 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | ncoa2-A 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ncoa2 30 31 |
|
OneToOne | |
tif2 30 |
|
SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
720153 | Likely Benign: not provided | 70,128,911(-) | C/T | MISSENSE_VARIANT | |
723953 | Likely Benign: not provided | 70,162,841(-) | A/C | SYNONYMOUS_VARIANT | |
760989 | Likely Benign: not provided | 70,124,696(-) | G/A | SYNONYMOUS_VARIANT | |
776356 | Benign: not provided | 70,216,728(-) | T/C | SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT | |
781659 | Benign: not provided | 70,156,712(-) | C/T | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1404e214 | CNV | loss | 21293372 |
esv2737143 | CNV | deletion | 23290073 |
esv3572808 | CNV | loss | 25503493 |
esv3617565 | CNV | gain | 21293372 |
nsv1024295 | CNV | gain | 25217958 |
nsv1068714 | OTHER | inversion | 25765185 |
nsv1075557 | CNV | deletion | 25765185 |
nsv1126855 | CNV | deletion | 24896259 |
nsv1137614 | CNV | deletion | 24896259 |
nsv1145196 | CNV | deletion | 24896259 |
nsv397839 | CNV | deletion | 16902084 |
nsv472609 | CNV | novel sequence insertion | 20440878 |
nsv508513 | CNV | deletion | 20534489 |
nsv6246 | CNV | insertion | 18451855 |
nsv6247 | CNV | deletion | 18451855 |
nsv6248 | CNV | deletion | 18451855 |
nsv831352 | CNV | gain | 17160897 |
nsv951442 | CNV | duplication | 24416366 |
nsv967603 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
mesenchymal chondrosarcoma |
|
|
spindle cell rhabdomyosarcoma |
|
|
indeterminate cell histiocytosis |
|
|
chondrosarcoma |
|
|
spinal canal intradural extramedullary neoplasm |
|
|