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The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been f... See more...
Aliases for NCOA2 Gene
Aliases for NCOA2 Gene
External Ids for NCOA2 Gene
- HGNC: 7669
- NCBI Entrez Gene: 10499
- Ensembl: ENSG00000140396
- OMIM®: 601993
- UniProtKB/Swiss-Prot: Q15596
Previous GeneCards Identifiers for NCOA2 Gene
- GC08M070125
- GC08M070964
- GC08M070747
- GC08M071074
- GC08M071186
- GC08M071016
- GC08M066517
Summaries for NCOA2 Gene
-
The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
GeneCards Summary for NCOA2 Gene
NCOA2 (Nuclear Receptor Coactivator 2) is a Protein Coding gene. Diseases associated with NCOA2 include Mesenchymal Chondrosarcoma and Spindle Cell Rhabdomyosarcoma. Among its related pathways are Androgen receptor signaling pathway and Chromatin organization. Gene Ontology (GO) annotations related to this gene include chromatin binding and transcription factor binding. An important paralog of this gene is NCOA3.
UniProtKB/Swiss-Prot Summary for NCOA2 Gene
-
Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).
Additional gene information for NCOA2 Gene
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NCOA2 Gene
Genomics for NCOA2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for NCOA2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NCOA2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NCOA2
- Top Transcription factor binding sites by QIAGEN in the NCOA2 gene promoter:
-
- COUP
- COUP-TF
- COUP-TF1
- FOXD3
- HNF-4alpha1
- HNF-4alpha2
- Nkx2-5
- PPAR-gamma1
- PPAR-gamma2
Genomic Locations for NCOA2 Gene
Latest Assembly
- chr8:70,109,770-70,405,390
- (GRCh38/hg38)
- Size:
- 295,621 bases
- Orientation:
- Minus strand
Previous Assembly
- chr8:71,022,017-71,316,452
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 294,436 bases
- Orientation:
- Minus strand
Genomic View for NCOA2 Gene
Genes around NCOA2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q13.3 by HGNC
- 8q13.3 by Entrez Gene
- 8q13.3 by Ensembl
NCOA2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NCOA2 Gene
Proteins for NCOA2 Gene
-
Protein details for NCOA2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15596-NCOA2_HUMAN
- Recommended name:
- Nuclear receptor coactivator 2
- Protein Accession:
- Q15596
- Q14CD2
Protein attributes for NCOA2 Gene
- Size:
- 1464 amino acids
- Molecular mass:
- 159157 Da
- Quaternary structure:
-
- Present in a complex containing NCOA3, IKKA, IKKB, IKBKG and CREBBP. Interacts (via C-terminus) with CREBBP. Interacts with ESR1, HIF1A, NCOA1, APEX, NR3C1, NR3C2, CARM1, RARA, and RXRA. Present in a complex containing CARM1 and EP300/P300. Interacts with CASP8AP2 and TTLL5/STAMP. Interacts with PSMB9 and DDX5. Interacts (via LXXLL 1, 2 and 3 motifs) with RORA and RORC (via AF-2 motif). Interacts with RWDD3. Interacts with CLOCK and ARNTL/BMAL1 (By similarity). Interacts with NR4A3; potentiates the activity of the NR4A3 (By similarity). Interacts with NR1H3 (PubMed:19481530).
Protein Expression for NCOA2 Gene
Selected DME Specific Peptides for NCOA2 Gene
- Q15596:
-
- SHTFNCRML
- LEALDGFF
Post-translational modifications for NCOA2 Gene
Other Protein References for NCOA2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences NCOA2 / TIF2 Antibody (LS-B11032) and NCOA2 / TIF2 Antibody (LS-B12201)
- Novus Biologicals Antibodies for NCOA2
-
Abcam antibodies for NCOA2
- Invitrogen Antibodies for NCOA2 (AFLGC-NCOA2)
- antibodies-online: Show 20 available NCOA2 Antibodies ranked by validation data
- Compare Top NCOA2 Antibodies
-
Recommended
- 52 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 IHC (fro) Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 24 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC (fro) Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 18 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
-
Boster Bio Antibodies for NCOA2
-
Custom Antibody ServicesProSci Antibodies for NCOA2
-
Santa Cruz Biotechnology (SCBT) Antibodies for NCOA2
Protein products for research
-
OriGene Purified Proteins for NCOA2
- Search Origene for MassSpec and Protein Over-expression Lysates for NCOA2
- Origene Custom Protein Services for NCOA2
-
Abcam proteins for NCOA2
Assay products for research
Domains & Families for NCOA2 Gene
Gene Families for NCOA2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for NCOA2 Gene
- InterPro:
- Blocks:
-
- PAS domain
- Basic helix-loop-helix dimerization domain bHLH
- PAC motif
- Protein of unknown function DUF1518
Suggested Antigen Peptide Sequences for NCOA2 Gene
- GenScript: Design optimal peptide antigens:
-
- Transcriptional intermediary factor 2 (NCOA2_HUMAN)
- NCOA2 protein (Q569J4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q15596UniProtKB/Swiss-Prot:
NCOA2_HUMAN :- Contains four Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and are, at least in part, functionally redundant.
- Belongs to the SRC/p160 nuclear receptor coactivator family.
- Domain:
-
- Contains four Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and are, at least in part, functionally redundant.
- The LLXXLXXXL motif is involved in transcriptional coactivation and CREBBP/CBP binding.
- Contains 2 C-terminal transcription activation domains (AD1 and AD2) that can function independently.
- Family:
-
- Belongs to the SRC/p160 nuclear receptor coactivator family.
Function for NCOA2 Gene
Molecular function for NCOA2 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).
Enzyme Numbers (IUBMB) for NCOA2 Gene
Phenotypes From GWAS Catalog for NCOA2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
| GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0003713 | transcription coactivator activity | IEA,NAS | 9430642 |
| GO:0005102 | signaling receptor binding | IEA | -- |
Phenotypes for NCOA2 Gene
- MGI mutant phenotypes for NCOA2:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for NCOA2:
-
- Increased vaccinia virus (VACV) infection
- Increased shRNA abundance (Z-score > 2)
- no effect
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Increased viability after borna disease (rVSVΔG*/BDVG) virus infection
- Dynamic nuclei (hole, folded or small irregular), decreased viability (cell death)
Animal Models for NCOA2 Gene
- MGI Knock Outs for NCOA2:
-
- Ncoa2 Ncoa2<tm1.2Ipc>
Animal Models for research
-
Taconic Biosciences Mouse Models for NCOA2
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for NCOA2 - Starting at $85 >
- * NCOA2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for NCOA2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NCOA2
-
Santa Cruz Biotechnology (SCBT) CRISPR for NCOA2
miRNA for NCOA2 Gene
- miRTarBase miRNAs that target NCOA2
-
- hsa-miR-137 (MIRT004004)
- mmu-miR-297a-5p (MIRT012971)
- hsa-miR-193b-3p (MIRT041215)
- hsa-miR-544a (MIRT440135)
- hsa-miR-1185-5p (MIRT440136)
- hsa-miR-6864-5p (MIRT501832)
- hsa-miR-4471 (MIRT501833)
- hsa-miR-8059 (MIRT501834)
- hsa-miR-539-5p (MIRT501835)
- hsa-miR-3179 (MIRT501836)
- hsa-miR-7515 (MIRT501837)
- hsa-miR-6822-5p (MIRT501838)
- hsa-miR-6750-5p (MIRT501839)
- hsa-miR-3120-3p (MIRT501840)
- hsa-miR-429 (MIRT501841)
- hsa-miR-200b-3p (MIRT501842)
- hsa-miR-200c-3p (MIRT501843)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NCOA2
- Browse OriGene Inhibitory RNA Products For NCOA2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NCOA2
Clone products for research
- Applied Biological Materials (abm): Clones for NCOA2 - Starting at $45 >
- * NCOA2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for NCOA2
- Addgene plasmids for NCOA2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NCOA2
Cell Lines for research
-
Horizon Cell Lines for NCOA2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCOA2 Gene
Localization for NCOA2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NCOA2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nuclear bodies (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | ISA | -- |
| GO:0005634 | nucleus | IEA,IBA | 21873635 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0016604 | nuclear body | IDA | -- |
Pathways & Interactions for NCOA2 Gene
Pathways by source for NCOA2 Gene
12 BioSystems pathways for NCOA2 Gene
35 Reactome pathways for NCOA2 Gene
2 KEGG pathways for NCOA2 Gene
7 GeneGo (Thomson Reuters) pathways for NCOA2 Gene
- Development Ligand-dependent activation of the ESR1/AP-1 pathway
- Development Ligand-independent activation of ESR1 and ESR2
- Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
- Development_Glucocorticoid receptor signaling
- Immune response Function of MEF2 in T lymphocytes
3 Qiagen pathways for NCOA2 Gene
- AHR Pathway
- Androgen Signaling
- Estrogen Pathway
Interacting Proteins for NCOA2 Gene
Selected Interacting proteins:
Q15596-NCOA2_HUMAN
ENSP00000399968
for NCOA2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for NCOA2
SIGNOR curated interactions for NCOA2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA,NAS | 8670870 |
| GO:0007623 | circadian rhythm | IEA | -- |
| GO:0010468 | regulation of gene expression | IEA | -- |
| GO:0010906 | regulation of glucose metabolic process | IEA | -- |
Drugs & Compounds for NCOA2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Diethylstilbestrol | Approved, Investigational | Pharma | Target | 7 | ||
| Estradiol acetate | Approved, Investigational, Vet_approved | Pharma | Target | 0 | ||
| estradiol benzoate | Approved, Investigational, Vet_approved | Pharma | Target | 0 | ||
| Estradiol cypionate | Approved, Investigational, Vet_approved | Pharma | Target | 0 | ||
| Estradiol dienanthate | Approved, Investigational, Vet_approved | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for NCOA2 Gene
mRNA/cDNA for NCOA2 Gene
- 6 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000452400 8430 nts (view in UCSC)
- ENST00000518287 6087 nts (view in UCSC)
- ENST00000518363 1834 nts (view in UCSC)
- ENST00000519724 438 nts (view in UCSC)
- ENST00000520416 526 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for NCOA2 - Starting at $85 >
- * NCOA2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for NCOA2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NCOA2
-
Santa Cruz Biotechnology (SCBT) CRISPR for NCOA2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NCOA2
- Browse OriGene Inhibitory RNA Products For NCOA2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NCOA2
Clone products for research
- Applied Biological Materials (abm): Clones for NCOA2 - Starting at $45 >
- * NCOA2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for NCOA2
- Addgene plasmids for NCOA2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NCOA2
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
| ExUns: | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||
| SP2: | |||||||||||||
| SP3: | |||||||||||||
| SP4: | |||||||||||||
| SP5: | |||||||||||||
| SP6: |
Relevant External Links for NCOA2 Gene
- GeneLoc Exon Structure for
- NCOA2
Expression for NCOA2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
-
Blood (Cardiovascular System)
- T Helper Cells Thymus
This gene is overexpressed in Esophagus (49.8) and Serum (14.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NCOA2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NCOA2
SOURCE GeneReport for Unigene cluster for NCOA2 Gene:
Hs.446678Evidence on tissue expression from TISSUES for NCOA2 Gene
- Liver(4.5)
- Nervous system(3.3)
- Kidney(2.5)
- Thyroid gland(2.3)
- Muscle(2.2)
- Blood(2.2)
- Skin(2.2)
- Bone marrow(2.1)
- Adrenal gland(2.1)
Primer products for research
-
OriGene qPCR primer pairs for NCOA2
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCOA2 Gene
Orthologs for NCOA2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | NCOA2 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | NCOA2 29 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | NCOA2 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ncoa2 29 16 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | NCOA2 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ncoa2 29 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 30 |
|
OneToMany | |
| -- 30 |
|
OneToMany | |||
| -- 30 |
|
OneToMany | |||
| Chicken (Gallus gallus) |
Aves | NCOA2 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | NCOA2 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ncoa2 29 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | ncoa2-A 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ncoa2 29 30 |
|
OneToOne | |
| tif2 29 |
|
- Species where no ortholog for NCOA2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for NCOA2 Gene
- ENSEMBL:
- Gene Tree for NCOA2 (if available)
- TreeFam:
- Gene Tree for NCOA2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NCOA2: view image
- Alliance of Genome Resources:
- Additional Orthologs for NCOA2
Paralogs for NCOA2 Gene
Variants for NCOA2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NCOA2 Gene
| SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs115177449 | Likely Benign: not provided | 70,128,911(-) |
C/T NM_006540.4(NCOA2):c.3394G>A (p.Val1132Ile) |
MISSENSE | |
| rs1262405635 | Likely Benign: not provided | 70,124,696(-) |
G/A NM_006540.4(NCOA2):c.4086C>T (p.Gly1362=) |
SYNONYMOUS | |
| rs1585905814 | Likely Benign: not provided | 70,162,841(-) |
A/C NM_006540.4(NCOA2):c.846T>G (p.Ser282=) |
SYNONYMOUS | |
| rs2228592 | Benign: not provided | 70,128,448(-) |
A/G NM_006540.4(NCOA2):c.3666T>C (p.Pro1222=) |
SYNONYMOUS | |
| rs61753706 | Benign: not provided | 70,156,712(-) |
C/T NM_006540.4(NCOA2):c.1653G>A (p.Ser551=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1404e214 | CNV | loss | 21293372 |
| esv2737143 | CNV | deletion | 23290073 |
| esv3572808 | CNV | loss | 25503493 |
| esv3617565 | CNV | gain | 21293372 |
| nsv1024295 | CNV | gain | 25217958 |
| nsv1068714 | OTHER | inversion | 25765185 |
| nsv1075557 | CNV | deletion | 25765185 |
| nsv1126855 | CNV | deletion | 24896259 |
| nsv1137614 | CNV | deletion | 24896259 |
| nsv1145196 | CNV | deletion | 24896259 |
| nsv397839 | CNV | deletion | 16902084 |
| nsv472609 | CNV | novel sequence insertion | 20440878 |
| nsv508513 | CNV | deletion | 20534489 |
| nsv6246 | CNV | insertion | 18451855 |
| nsv6247 | CNV | deletion | 18451855 |
| nsv6248 | CNV | deletion | 18451855 |
| nsv831352 | CNV | gain | 17160897 |
| nsv951442 | CNV | duplication | 24416366 |
| nsv967603 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
13.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.06;
50.56% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NCOA2 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCOA2 Gene
Disorders for NCOA2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mesenchymal chondrosarcoma |
|
|
| spindle cell rhabdomyosarcoma |
|
|
| indeterminate cell histiocytosis |
|
|
| fallopian tube adenosarcoma |
|
|
| fallopian tube carcinosarcoma |
|
|
Search NCOA2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
NCOA2_HUMAN- Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation. {ECO:0000269 PubMed:12676584, ECO:0000269 PubMed:15657427, ECO:0000269 PubMed:9558366}.
Additional Disease Information for NCOA2
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for NCOA2 Gene
Publications for NCOA2 Gene
- TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. (PMID: 8670870) Voegel JJ … Gronemeyer H (The EMBO journal 1996) 2 3 4 22
- Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PMID: 19183483) Haiman CA … Press MF (BMC cancer 2009) 3 22 40
- Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk. (PMID: 19255064) Ahn J … Prostate, Lung, Colorectal and Ovarian Trial Project Team (Carcinogenesis 2009) 3 22 40
- Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha. (PMID: 10594042) Carrero P … Poellinger L (Molecular and cellular biology 2000) 3 4 22
- A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia. (PMID: 9558366) Carapeti M … Cross NC (Blood 1998) 3 4 22
ExternalLinks
Products for NCOA2 Gene
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