Aliases for NCKAP5L Gene

Aliases for NCKAP5L Gene

  • NCK Associated Protein 5 Like 2 3 5
  • KIAA1602 2 3 4
  • Centrosomal Protein Of 169 KDa 3 4
  • Nck-Associated Protein 5-Like 3 4
  • NCKAP5-Like 3 4
  • Cep169 3 4
  • FP1193 3
  • CEP169 4

External Ids for NCKAP5L Gene

Previous HGNC Symbols for NCKAP5L Gene

  • KIAA1602

Previous GeneCards Identifiers for NCKAP5L Gene

  • GC12M048472
  • GC12M050185
  • GC12M047216

Summaries for NCKAP5L Gene

GeneCards Summary for NCKAP5L Gene

NCKAP5L (NCK Associated Protein 5 Like) is a Protein Coding gene. An important paralog of this gene is NCKAP5.

UniProtKB/Swiss-Prot Summary for NCKAP5L Gene

  • Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules (PubMed:26482847, PubMed:26485573). Both tubulin-binding and homodimer formation are required for NCKAP5L-mediated microtubule bundle formation (PubMed:26485573).

Additional gene information for NCKAP5L Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NCKAP5L Gene

Genomics for NCKAP5L Gene

GeneHancer (GH) Regulatory Elements for NCKAP5L Gene

Promoters and enhancers for NCKAP5L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J049805 Promoter 0.3 EPDnew 761.7 +23.4 23424 0.1 NCKAP5L lnc-BCDIN3D-1 LSM6P2
GH12J049740 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.4 +85.8 85832 4.3 SP1 ZBTB40 CTCF FOXA1 SMARCE1 POLR2A TCF7L2 USF2 NR2F1 NR2F6 TMBIM6 piR-39433 DDX23 KMT2D LMBR1L LOC390314 LIMA1 ENSG00000257298 BCDIN3D FAM186B
GH12J049669 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.3 +155.8 155780 7 ZBTB40 SMARCE1 ETV6 RELA L3MBTL2 DACH1 GTF2F1 CBFA2T2 ZNF687 SMARCA4 FMNL3 KANSL2 LMBR1L CCNT1 LOC390314 DDX23 KMT2D TMBIM6 NCKAP5L FAM186B
GH12J049867 Enhancer 1.4 ENCODE CraniofacialAtlas dbSUPER 10.9 -40.1 -40062 3.2 CTCF GATA3 SMARCE1 TCF7L2 ZNF217 RUNX1 MYC CC2D1A HLF L3MBTL2 KMT2D LMBR1L SMARCD1 BCDIN3D SPATS2 ATF1 PRPF40B PRKAG1 FAM186B NCKAP5L
GH12J049776 Enhancer 1 Ensembl ENCODE 11.9 +51.3 51349 2.5 CTCF CC2D1A L3MBTL2 RAD21 TEAD4 CSDE1 CEBPG MLLT1 SP7 RELA NCKAP5L FMNL3 TMBIM6 MCRS1 LSM6P2 lnc-BCDIN3D-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NCKAP5L on UCSC Golden Path with GeneCards custom track

Genomic Locations for NCKAP5L Gene

Genomic Locations for NCKAP5L Gene
chr12:49,791,139-49,828,750
(GRCh38/hg38)
Size:
37,612 bases
Orientation:
Minus strand
chr12:50,184,929-50,222,533
(GRCh37/hg19)
Size:
37,605 bases
Orientation:
Minus strand

Genomic View for NCKAP5L Gene

Genes around NCKAP5L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCKAP5L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCKAP5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCKAP5L Gene

Proteins for NCKAP5L Gene

  • Protein details for NCKAP5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCH0-NCK5L_HUMAN
    Recommended name:
    Nck-associated protein 5-like
    Protein Accession:
    Q9HCH0
    Secondary Accessions:
    • Q2TB26
    • Q71RH1
    • Q8N4W1
    • Q96HX2

    Protein attributes for NCKAP5L Gene

    Size:
    1330 amino acids
    Molecular mass:
    139013 Da
    Quaternary structure:
    • Homodimer (PubMed:26482847). Interacts with CDK5RAP2 (PubMed:26485573). Interacts with MAPRE1 (PubMed:26485573). Interacts with beta-tubulin (PubMed:26482847).
    SequenceCaution:
    • Sequence=AAQ15202.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for NCKAP5L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCKAP5L Gene

Post-translational modifications for NCKAP5L Gene

  • CDK1/Cyclin B-dependent phosphorylation mediates its dissociation from centrosomes during mitosis.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NCKAP5L Gene

No data available for DME Specific Peptides for NCKAP5L Gene

Domains & Families for NCKAP5L Gene

Gene Families for NCKAP5L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NCKAP5L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NCKAP5L Gene

GenScript: Design optimal peptide antigens:
  • Nck-associated protein 5-like (NCK5L_HUMAN)
genes like me logo Genes that share domains with NCKAP5L: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NCKAP5L Gene

Function for NCKAP5L Gene

Molecular function for NCKAP5L Gene

UniProtKB/Swiss-Prot Function:
Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules (PubMed:26482847, PubMed:26485573). Both tubulin-binding and homodimer formation are required for NCKAP5L-mediated microtubule bundle formation (PubMed:26485573).

Phenotypes From GWAS Catalog for NCKAP5L Gene

Gene Ontology (GO) - Molecular Function for NCKAP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26485573
genes like me logo Genes that share ontologies with NCKAP5L: view
genes like me logo Genes that share phenotypes with NCKAP5L: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NCKAP5L Gene

Localization for NCKAP5L Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCKAP5L Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to microtubule plus ends (PubMed:26485573, PubMed:26482847). Associates with centrosomes during interphase, but dissociates from these structures from the onset of mitosis (PubMed:26549230). {ECO:0000269 PubMed:26482847, ECO:0000269 PubMed:26485573, ECO:0000269 PubMed:26549230}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCKAP5L gene
Compartment Confidence
cytoskeleton 5
nucleus 2
cytosol 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NCKAP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 26485573
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with NCKAP5L: view

Pathways & Interactions for NCKAP5L Gene

PathCards logo

SuperPathways for NCKAP5L Gene

No Data Available

Interacting Proteins for NCKAP5L Gene

Gene Ontology (GO) - Biological Process for NCKAP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001578 microtubule bundle formation IDA 26485573
GO:0007019 microtubule depolymerization IMP 26485573
genes like me logo Genes that share ontologies with NCKAP5L: view

No data available for Pathways by source and SIGNOR curated interactions for NCKAP5L Gene

Drugs & Compounds for NCKAP5L Gene

No Compound Related Data Available

Transcripts for NCKAP5L Gene

mRNA/cDNA for NCKAP5L Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCKAP5L Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2:

Relevant External Links for NCKAP5L Gene

GeneLoc Exon Structure for
NCKAP5L
ECgene alternative splicing isoforms for
NCKAP5L

Expression for NCKAP5L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NCKAP5L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NCKAP5L Gene

This gene is overexpressed in Brain (60.2) and Bone (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NCKAP5L Gene



Protein tissue co-expression partners for NCKAP5L Gene

NURSA nuclear receptor signaling pathways regulating expression of NCKAP5L Gene:

NCKAP5L

SOURCE GeneReport for Unigene cluster for NCKAP5L Gene:

Hs.143067

Evidence on tissue expression from TISSUES for NCKAP5L Gene

  • Nervous system(4.2)
  • Skin(4.1)
  • Eye(4)
genes like me logo Genes that share expression patterns with NCKAP5L: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCKAP5L Gene

Orthologs for NCKAP5L Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCKAP5L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCKAP5L 33 32
  • 99.15 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NCKAP5L 33 32
  • 89.34 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NCKAP5L 33 32
  • 88.64 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nckap5l 17 33 32
  • 85.13 (n)
rat
(Rattus norvegicus)
Mammalia Nckap5l 32
  • 84.13 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NCKAP5L 33
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCKAP5L 33
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nckap5l 32
  • 55.2 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20266 32
zebrafish
(Danio rerio)
Actinopterygii NCKAP5L 33
  • 25 (a)
OneToOne
Species where no ortholog for NCKAP5L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCKAP5L Gene

ENSEMBL:
Gene Tree for NCKAP5L (if available)
TreeFam:
Gene Tree for NCKAP5L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NCKAP5L: view image

Paralogs for NCKAP5L Gene

Paralogs for NCKAP5L Gene

genes like me logo Genes that share paralogs with NCKAP5L: view

Variants for NCKAP5L Gene

Sequence variations from dbSNP and Humsavar for NCKAP5L Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000010146 -- 49,822,848(-) A/C intron_variant
rs1000055936 -- 49,818,100(-) C/G intron_variant
rs1000209910 -- 49,805,886(-) C/T intron_variant
rs1000345722 -- 49,794,110(-) A/G intron_variant
rs1000397994 -- 49,794,360(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NCKAP5L Gene

Variant ID Type Subtype PubMed ID
nsv522972 CNV gain 19592680

Variation tolerance for NCKAP5L Gene

Residual Variation Intolerance Score: 20.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.37; 92.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NCKAP5L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCKAP5L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCKAP5L Gene

Disorders for NCKAP5L Gene

Additional Disease Information for NCKAP5L

No disorders were found for NCKAP5L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NCKAP5L Gene

Publications for NCKAP5L Gene

  1. Phosphorylation of the centrosomal protein, Cep169, by Cdk1 promotes its dissociation from centrosomes in mitosis. (PMID: 26549230) Mori Y … Terada Y (Biochemical and biophysical research communications 2015) 3 4 56
  2. Cep169, a Novel Microtubule Plus-End-Tracking Centrosomal Protein, Binds to CDK5RAP2 and Regulates Microtubule Stability. (PMID: 26485573) Mori Y … Terada Y (PloS one 2015) 3 4 56
  3. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 56
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 56
  5. Identification of Cep169-interacting proteins and the in vivo modification sites of Cep169 via proteomic analysis. (PMID: 29269292) Shintomi M … Terada Y (Biochemical and biophysical research communications 2018) 3 56

Products for NCKAP5L Gene

Sources for NCKAP5L Gene