Aliases for NCKAP1 Gene
External Ids for NCKAP1 Gene
Previous GeneCards Identifiers for NCKAP1 Gene
GeneCards Summary for NCKAP1 Gene
NCKAP1 (NCK Associated Protein 1) is a Protein Coding gene. Diseases associated with NCKAP1 include Autism Spectrum Disorder and Nance-Horan Syndrome. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include Rac GTPase binding. An important paralog of this gene is NCKAP1L.
UniProtKB/Swiss-Prot Summary for NCKAP1 Gene
Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.