Aliases for NCK2 Gene
External Ids for NCK2 Gene
Previous GeneCards Identifiers for NCK2 Gene
This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for NCK2 Gene
NCK2 (NCK Adaptor Protein 2) is a Protein Coding gene. Diseases associated with NCK2 include Craniofrontonasal Syndrome and Frank-Ter Haar Syndrome. Among its related pathways are Beta-Adrenergic Signaling and Cell junction organization. Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity and cytoskeletal adaptor activity. An important paralog of this gene is NCK1.
UniProtKB/Swiss-Prot Summary for NCK2 Gene
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.