Aliases for NCK1 Gene
External Ids for NCK1 Gene
Previous HGNC Symbols for NCK1 Gene
Previous GeneCards Identifiers for NCK1 Gene
The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010]
GeneCards Summary for NCK1 Gene
NCK1 (NCK Adaptor Protein 1) is a Protein Coding gene. Diseases associated with NCK1 include Wiskott-Aldrich Syndrome and Vaccinia. Among its related pathways are Association Between Physico-Chemical Features and Toxicity Associated Pathways and GDNF-Family Ligands and Receptor Interactions. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and protein binding, bridging. An important paralog of this gene is NCK2.
UniProtKB/Swiss-Prot Summary for NCK1 Gene
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.