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Aliases for NCF4 Gene

Aliases for NCF4 Gene

  • Neutrophil Cytosolic Factor 4 2 3 5
  • Neutrophil NADPH Oxidase Factor 4 2 3 4
  • SH3 And PX Domain-Containing Protein 4 3 4
  • Neutrophil Cytosolic Factor 4, 40kDa 2 3
  • P40-Phox 3 4
  • SH3PXD4 3 4
  • NCF-4 3 4
  • Neutrophil Cytosolic Factor 4 (40kD) 2
  • Neutrophil Cytosol Factor 4 3
  • P40PHOX 3
  • P40phox 4
  • CGD3 3
  • NCF 3

External Ids for NCF4 Gene

Previous GeneCards Identifiers for NCF4 Gene

  • GC22P033871
  • GC22P035500
  • GC22P035581
  • GC22P037257
  • GC22P020219

Summaries for NCF4 Gene

Entrez Gene Summary for NCF4 Gene

  • The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for NCF4 Gene

NCF4 (Neutrophil Cytosolic Factor 4) is a Protein Coding gene. Diseases associated with NCF4 include Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Iii and Chronic Granulomatous Disease. Among its related pathways are Class I MHC mediated antigen processing and presentation and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include protein dimerization activity and phosphatidylinositol-3-phosphate binding.

UniProtKB/Swiss-Prot for NCF4 Gene

  • Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.

Gene Wiki entry for NCF4 Gene

Additional gene information for NCF4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCF4 Gene

Genomics for NCF4 Gene

GeneHancer (GH) Regulatory Elements for NCF4 Gene

Promoters and enhancers for NCF4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J036859 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 668.9 +0.7 661 4.2 HDGF PKNOX1 SMAD1 RB1 KLF17 STAT5A BATF KLF5 IRF4 ZNF207 NCF4 PVALB CSF2RB CYTH4 RAC2 NCF4-AS1
GH22J036858 Enhancer 0.3 FANTOM5 657.6 -1.9 -1898 0.2 NCF4 CSF2RB CYTH4 RAC2 NCF4-AS1 PVALB
GH22J036911 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.7 +52.5 52518 3.5 HDGF ZSCAN4 MAX ZMYM3 POLR2A EED ZNF143 ZFP91 ETV6 ATF7 CSF2RB NCF4 CYTH4 NCF4-AS1 RAC2 LOC105373022
GH22J037281 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.4 +422.8 422797 4.3 HDGF IRF4 ZNF143 ATF7 ETV6 IKZF2 RUNX3 CREM SMARCA5 ELF1 CYTH4 CSF2RB GGA1 RPS15AP38 NCF4 EIF3L EIF3D RAC2 LGALS2 SH3BP1
GH22J037014 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10.8 +159.7 159685 12.5 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B MPST TST ENSG00000229971 RBFOX2 LL22NC01-81G9.3 GGA1 KCTD17 ENSG00000231467 TMPRSS6 NCF4-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NCF4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NCF4 gene promoter:
  • NRSF form 2
  • NRSF form 1
  • Lmo2
  • Egr-1

Genomic Locations for NCF4 Gene

Genomic Locations for NCF4 Gene
chr22:36,860,988-36,878,017
(GRCh38/hg38)
Size:
17,030 bases
Orientation:
Plus strand
chr22:37,257,030-37,274,059
(GRCh37/hg19)
Size:
17,030 bases
Orientation:
Plus strand

Genomic View for NCF4 Gene

Genes around NCF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCF4 Gene

Proteins for NCF4 Gene

  • Protein details for NCF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15080-NCF4_HUMAN
    Recommended name:
    Neutrophil cytosol factor 4
    Protein Accession:
    Q15080
    Secondary Accessions:
    • A8K4F9
    • O60808
    • Q86U56
    • Q9BU98
    • Q9NP45

    Protein attributes for NCF4 Gene

    Size:
    339 amino acids
    Molecular mass:
    39032 Da
    Quaternary structure:
    • Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. NCF4 interacts primarily with NCF2 to form a complex with NCF1.

    Three dimensional structures from OCA and Proteopedia for NCF4 Gene

    Alternative splice isoforms for NCF4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCF4 Gene

Post-translational modifications for NCF4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NCF4 Gene

No data available for DME Specific Peptides for NCF4 Gene

Domains & Families for NCF4 Gene

Gene Families for NCF4 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q15080

UniProtKB/Swiss-Prot:

NCF4_HUMAN :
  • The PB1 domain mediates the association with NCF2/p67-PHOX.
Domain:
  • The PB1 domain mediates the association with NCF2/p67-PHOX.
  • The PX domain mediates interaction with membranes enriched in phosphatidylnositol 3-phosphate.
genes like me logo Genes that share domains with NCF4: view

Function for NCF4 Gene

Molecular function for NCF4 Gene

UniProtKB/Swiss-Prot Function:
Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.
GENATLAS Biochemistry:
neutrophil cytosolic factor 4 (component of NADPH oxidase system),p40-phox,oxygen dependent mechanism of phagocytosis

Phenotypes From GWAS Catalog for NCF4 Gene

Gene Ontology (GO) - Molecular Function for NCF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005086 ARF guanyl-nucleotide exchange factor activity IBA --
GO:0005515 protein binding IPI 9365277
GO:0008289 lipid binding IEA --
GO:0016176 superoxide-generating NADPH oxidase activator activity IMP 8280052
GO:0032266 phosphatidylinositol-3-phosphate binding IDA 11684018
genes like me logo Genes that share ontologies with NCF4: view
genes like me logo Genes that share phenotypes with NCF4: view

Human Phenotype Ontology for NCF4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NCF4 Gene

MGI Knock Outs for NCF4:
  • Ncf4 Ncf4<tm1b(KOMP)Wtsi>
  • Ncf4 Ncf4<tm2Pth>

Animal Model Products

CRISPR Products

miRNA for NCF4 Gene

miRTarBase miRNAs that target NCF4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NCF4

Clone Products

  • Addgene plasmids for NCF4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NCF4 Gene

Localization for NCF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCF4 Gene

Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCF4 gene
Compartment Confidence
plasma membrane 5
cytosol 5
endosome 5
lysosome 4
nucleus 3
golgi apparatus 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NCF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005802 trans-Golgi network IBA --
GO:0005829 cytosol TAS --
GO:0010008 endosome membrane IEA,IDA 11684018
genes like me logo Genes that share ontologies with NCF4: view

Pathways & Interactions for NCF4 Gene

genes like me logo Genes that share pathways with NCF4: view

Gene Ontology (GO) - Biological Process for NCF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006909 phagocytosis IEA --
GO:0006955 immune response TAS 8280052
GO:0016192 vesicle-mediated transport IBA --
GO:0034599 cellular response to oxidative stress TAS --
genes like me logo Genes that share ontologies with NCF4: view

No data available for SIGNOR curated interactions for NCF4 Gene

Drugs & Compounds for NCF4 Gene

(9) Drugs for NCF4 Gene - From: DrugBank, PharmGKB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dextromethorphan Approved Pharma Target, inhibitor 140
Doxorubicin Approved, Investigational Pharma Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1828
Idarubicin Approved Pharma 226

(8) Additional Compounds for NCF4 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with NCF4: view

Transcripts for NCF4 Gene

mRNA/cDNA for NCF4 Gene

Unigene Clusters for NCF4 Gene

Neutrophil cytosolic factor 4, 40kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NCF4

Clone Products

  • Addgene plasmids for NCF4

Alternative Splicing Database (ASD) splice patterns (SP) for NCF4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2:
SP3: -

Relevant External Links for NCF4 Gene

GeneLoc Exon Structure for
NCF4
ECgene alternative splicing isoforms for
NCF4

Expression for NCF4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NCF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NCF4 Gene

This gene is overexpressed in Whole Blood (x37.9).

Protein differential expression in normal tissues from HIPED for NCF4 Gene

This gene is overexpressed in Neutrophil (41.6) and Peripheral blood mononuclear cells (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NCF4 Gene



Protein tissue co-expression partners for NCF4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NCF4 Gene:

NCF4

SOURCE GeneReport for Unigene cluster for NCF4 Gene:

Hs.474781

mRNA Expression by UniProt/SwissProt for NCF4 Gene:

Q15080-NCF4_HUMAN
Tissue specificity: Expression is restricted to hematopoietic cells.

Evidence on tissue expression from TISSUES for NCF4 Gene

  • Blood(3.2)
  • Bone marrow(2.2)
  • Intestine(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for NCF4 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • respiratory
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cheek
  • ear
  • eye
  • face
  • head
  • jaw
  • lacrimal apparatus
  • lip
  • mandible
  • maxilla
  • meninges
  • middle ear
  • mouth
  • neck
  • scalp
  • sinus
  • skull
Thorax:
  • bronchus
  • chest wall
  • clavicle
  • esophagus
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
  • trachea
Abdomen:
  • intestine
  • kidney
  • large intestine
  • liver
  • small intestine
  • spleen
  • stomach
Pelvis:
  • anus
  • pelvis
  • rectum
  • ureter
  • urethra
  • urinary bladder
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • bone marrow
  • lymph node
  • skin
  • spinal column
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with NCF4: view

Orthologs for NCF4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCF4 33
  • 91.77 (n)
dog
(Canis familiaris)
Mammalia NCF4 34 33
  • 89.09 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NCF4 34 33
  • 86.73 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncf4 33
  • 84.46 (n)
mouse
(Mus musculus)
Mammalia Ncf4 16 34 33
  • 84.07 (n)
oppossum
(Monodelphis domestica)
Mammalia NCF4 34
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCF4 34
  • 31 (a)
OneToOne
chicken
(Gallus gallus)
Aves NCF4 34 33
  • 68.93 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCF4 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ncf4 33
  • 57.88 (n)
zebrafish
(Danio rerio)
Actinopterygii ncf4 34 33
  • 61.38 (n)
OneToOne
Dr.12333 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.699 33
Species where no ortholog for NCF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCF4 Gene

ENSEMBL:
Gene Tree for NCF4 (if available)
TreeFam:
Gene Tree for NCF4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NCF4: view image

Paralogs for NCF4 Gene

(3) SIMAP similar genes for NCF4 Gene using alignment to 4 proteins:

  • NCF4_HUMAN
  • B0QY04_HUMAN
  • H0Y6X8_HUMAN
  • Q6FGM9_HUMAN
genes like me logo Genes that share paralogs with NCF4: view

No data available for Paralogs for NCF4 Gene

Variants for NCF4 Gene

Sequence variations from dbSNP and Humsavar for NCF4 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs10854695 benign, likely-benign, not specified, Chronic granulomatous disease, Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type III 36,864,081(+) G/A/T 5_prime_UTR_variant, coding_sequence_variant, synonymous_variant
rs11552115 benign, not specified, Chronic granulomatous disease 36,877,700(+) G/A 3_prime_UTR_variant, coding_sequence_variant, synonymous_variant
rs141160114 uncertain-significance, Chronic granulomatous disease 36,877,726(+) G/A 3_prime_UTR_variant, coding_sequence_variant, missense_variant
rs145005349 uncertain-significance, Chronic granulomatous disease 36,877,628(+) G/T 3_prime_UTR_variant, coding_sequence_variant, missense_variant
rs146911421 uncertain-significance, Chronic granulomatous disease 36,875,672(+) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for NCF4 Gene

Variant ID Type Subtype PubMed ID
nsv588983 CNV loss 21841781
nsv459881 CNV loss 19166990
nsv3619 CNV insertion 18451855
esv3647697 CNV gain 21293372
esv3444959 CNV duplication 20981092
esv2758837 CNV gain+loss 17122850
esv2724205 CNV deletion 23290073
esv2724204 CNV deletion 23290073
esv2724203 CNV deletion 23290073

Variation tolerance for NCF4 Gene

Residual Variation Intolerance Score: 43.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NCF4 Gene

Human Gene Mutation Database (HGMD)
NCF4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCF4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCF4 Gene

Disorders for NCF4 Gene

MalaCards: The human disease database

(8) MalaCards diseases for NCF4 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type iii
  • cdg3
chronic granulomatous disease
  • bridges-good syndrome
renal tuberculosis
  • tuberculosis of kidney
ornithosis
  • psittacosis
xanthogranulomatous pyelonephritis
  • pyelonephritis, xanthogranulomatous
- elite association - COSMIC cancer census association via MalaCards
Search NCF4 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

NCF4_HUMAN
  • Granulomatous disease, chronic, cytochrome-b-positive 3, autosomal recessive (CGD3) [MIM:613960]: A disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections. {ECO:0000269 PubMed:19692703}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for NCF4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NCF4: view

No data available for Genatlas for NCF4 Gene

Publications for NCF4 Gene

  1. Genomic structure, chromosomal localization, start of transcription, and tissue expression of the human p40-phox, a new component of the nicotinamide adenine dinucleotide phosphate-oxidase complex. (PMID: 8839867) Zhan S … Chanock SJ (Blood 1996) 2 3 4 22 58
  2. Genetic polymorphisms and susceptibility to lung disease. (PMID: 16608528) Lee PL … Wang L (Journal of negative results in biomedicine 2006) 3 22 44 58
  3. Effects of p47phox C terminus phosphorylations on binding interactions with p40phox and p67phox. Structural and functional comparison of p40phox and p67phox SH3 domains. (PMID: 15657040) Massenet C … Fieschi F (The Journal of biological chemistry 2005) 3 4 22 58
  4. Identification of a splice variant mRNA of p40phox, an NADPH oxidase component of phagocytes. (PMID: 10437784) Hasebe T … Nagaoka I (FEBS letters 1999) 3 4 22 58
  5. p40(phox) is phosphorylated on threonine 154 and serine 315 during activation of the phagocyte NADPH oxidase. Implication of a protein kinase c-type kinase in the phosphorylation process. (PMID: 9804763) Bouin AP … Fuchs A (The Journal of biological chemistry 1998) 3 4 22 58

Products for NCF4 Gene

Sources for NCF4 Gene

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