Aliases for NCF4 Gene
External Ids for NCF4 Gene
Previous GeneCards Identifiers for NCF4 Gene
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
GeneCards Summary for NCF4 Gene
NCF4 (Neutrophil Cytosolic Factor 4) is a Protein Coding gene. Diseases associated with NCF4 include Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Iii and Chronic Granulomatous Disease. Among its related pathways are Toxoplasmosis and Osteoclast differentiation. Gene Ontology (GO) annotations related to this gene include protein dimerization activity and phosphatidylinositol-3-phosphate binding. An important paralog of this gene is SORBS1.
UniProtKB/Swiss-Prot Summary for NCF4 Gene
Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.